ライフサイエンスコーパス: murine

1 ated using conditional knockdown of Arl15 in murine 3T3-L1 (pre)adipocytes.

2 that blocking Abeta function, by using anti-murine Abeta antibodies or APP knock-out mice, prevents

3 tasbnD mutants using competition assays in a murine abscess model and invasion and replication assays

4 med preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retro

5 ical neuronal precursors into the brain of a murine AD model.

6 ) we demonstrate snoRNA expression levels in murine ageing and OA joints and serum for the first time

7 promote leukocyte recruitment when added to murine air pouches (p < 0.05).

8 The effect of Neu5Gc was examined in murine airway inflammation and colitis models, and the r

9 ine kinase expression was found in human and murine airway smooth muscle cells.

10 Delivery of an alpha5beta1 inhibitor into murine airways abrogated the exaggerated bronchoconstric

11 ts of ARHGAP29 in vivo, we generated a novel murine allele by inserting a point mutation identified i

12 lls, and primary human B cells as well as in murine allogeneic skin transplant and alloantigen-induce

13 Murine alveolar macrophages (AMs) were cultured ex vivo

14 performed a secondary screen in a syngeneic murine AML model driven by the MLL-AF9 oncogenic fusion

15 ion, and significantly prolonged survival in murine AML xenografts.

16 3-induced gene expression in asthma-relevant murine and human cells.

17 teraction between STAT5A and PDC subunits in murine and human cultured adipocytes, as well as in adip

18 Murine and human ETV6-RUNX1 pB-ALL revealed recurrent ge

19 We designed novel PET imaging probes for the murine and human granzyme B isoforms that specifically a

20 Here we show, using murine and human induced pluripotent stem cell models, t

21 d is a component of active enhancers in both murine and human islets.

22 Murine and human lupus studies revealed a role for IFN-a

23 ally above the immunomodulatory threshold in murine and human lymphocytes.

24 tion, MEKi treatment significantly increased murine and human macrophage efferocytosis of apoptotic c

25 ine directly modulated the phenotype of both murine and human MDMs.

26 Using the Transwell system, both murine and human monocytes sorted with magnetic beads in

27 y impair the functions of tumor-infiltrating murine and human myeloid dendritic cells (TIDC) in ovari

28 performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent

29 Here, we used in vivo murine and human tumor models to identify the tumor-supp

30 loped preparations of purified, recombinant, murine Arl13b protein.

31 me that the Igf1r plays an important role in murine asthma, mediating both AHR and mucus secretion af

32 (2+) homeostasis and electrical stability in murine atria under stress conditions.

33 ial apoptosis and is shared by all preimmune murine B cell subsets and CD27- human B cells.

34 xamine chromosomal rearrangements in primary murine B cells and discovered that RAG1/2 causes aberran

35 Expression of hCD22 on transgenic murine B cells is comparable to expression on human prim

36 mma1 junctions from CH12F3 cells and primary murine B cells, respectively.

37 nd1 expression contributes to maintenance of murine B-ALL cells with compromised Ikaros function.

38 hmarking our approach, we analyse individual murine B1a cells using a custom multiplexing strategy.

39 mutations, and p53 loss markedly accelerates murine BCC carcinogenesis.

40 ously that PGE2 inhibits IL-27 production in murine bone marrow-derived DCs.

41 CD44(+/+) murine bone marrow-derived macrophages produced higher T

42 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAM

43 Recent work in a TP53(-/-)BRCA1-mutant murine breast cancer model indicates that double blockad

44 Employing a lung metastasis model of murine breast cancer, we found that TNFalpha-activated M

45 to monitor thermogenesis in BAs derived from murine brown fat precursors and in human brown fat cells

46 Ab) LE2E9 revealed overlapping epitopes with murine C1-specific group A mAbs including 2A9.

47 Depletion of murine CAFs from PDX restored sensitivity to HT, with a

48 Utilizing a murine calvarial model, Mk2(+/+) and Mk2(-/-) mice were

49 naling regulated chemokines CCL3 and CCL4 in murine calvarial tissue.

50 Real-time imaging of the embryonic murine cardiovascular system is challenging due to the s

51 mine affinity and binding kinetics of 15a on murine CCR2.

52 e characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates

53 The Akt/mTOR pathway is a key driver of murine CD4(+) T cell differentiation, and induction of r

54 nd Rheb-deficient CD4(+) T cells, as well as murine CD4(+) T cells activated in the presence of rapam

55 nal antibody standard RM 8670 derived from a murine cell line expression system resulted in detection

56 rs (TLRs) and integrins, in a gp96-deficient murine cell line.

57 Studies in murine cell lines and in mouse models suggest that IL-15

58 d, a detailed picture of C5aR2 expression in murine cells and tissues is still lacking.

59 d solely to IIRMIs because it was evident in murine cells lacking the interferon receptor (IFNAR).

60 Mechanistically, in both primary human and murine cells, the IL-17A-driven increase in IL-13-induce

61 d protective efficacy when tested in a novel murine challenge model and may be developed into future

62 apply distinct mechanical stimuli to primary murine chondrocytes, stretch of the membrane and deflect

63 of healthy WT mice treated with recombinant murine CIRP, but not in the lungs of TLR4 KO mice.

64 eplication and lytic infection and restricts murine CMV replication in vivo.

65 as inhibiting OXPHOS reduces the severity of murine colitis and psoriasis.

66 in the inflammatory infiltrate in human and murine colitis.

67 INTS: Interstitial cells of Cajal (ICC) from murine colonic muscles express genes encoding inwardly r

68 Consistent with data in the murine context, silencing of AID in human bone marrow ce

69 Using a murine controlled cortical impact model, we used adoptiv

70 rkers are localized in basal layer of entire murine corneal epithelium.

71 and biomechanical drivers of angiogenesis in murine corneal neovessels.

72 ous and evoked calcium transients in primary murine cortical neuron cultures transduced with an adeno

73 uman EC gene regulation not present in their murine counterparts.

74 l a previously unknown effect of Arhgap29 in murine craniofacial development.

75 yte transmigration across the endothelium in murine CRC tumors.

76 ammaRs on brain-resident microglia following murine cytomegalovirus (MCMV) infection.

77 In this study, murine cytomegalovirus (MCMV) was used as a persistent i

78 Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppres

79 Murine cytomegalovirus triggers both apoptosis and necro

80 plify both inflammasome and IFN-I to control murine cytomegalovirus.

81 This convergence of human and murine data provides compelling evidence that the T2D ri

82 hat ligation of TLR3, TLR4, and TLR9 induces murine DC production of complement components and local

83 hagy regulators modulated by diabetes in the murine developing neuroepithelium.

84 we demonstrated that a ubiquitin E3 ligase, murine double minute-2 (Mdm2), is required for Gp1 mGluR

85 Here, using a murine DVT model of inferior vena cava (IVC) stenosis, w

86 H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis.

87 to-LCC ratio was rescued in FKBP65-deficient murine embryonic fibroblasts by reconstitution with wild

88 9, 10, 12, or 14 in tetraploid immortalized murine embryonic fibroblasts.

89 ds to gene promoters upon differentiation of murine embryonic stem cells (ESCs) to neural progenitor

90 Murine embryos lacking EPH receptor A4 (Epha4KO/KO), whi

91 ss I molecules to brain atrophy in Theiler's murine encephalomyelitis virus (TMEV)-infected transgeni

92 lfate proteoglycan accumulation in Theiler's murine encephalomyelitis virus-induced demyelinating dis

93 e model of multiple sclerosis, the Theiler's murine encephalomyelitis virus-induced demyelinating dis

94 We find that the repression of specific murine endogenous retroviruses is dependent on DAXX, but

95 erexpression of miR-497 approximately 195 in murine endothelium alleviates age-related reduction of t

96 o block the injurious increase of Angpt-2 in murine endotoxemia in vivo.

97 phenylephrine at 18 hours after induction of murine endotoxic shock.

98 d Wnt/beta-catenin target gene expression in murine enteroids and colonoid cultures and TNF-induced b

99 CTIP1) is highly expressed in the developing murine epidermis.

100 not yet been dissected in P0106-125-induced murine experimental autoimmune neuritis.

101 to these cytokines are reported to suppress murine FA development.

102 served a 30% loss in levels of NAD(+) in the murine failing heart of both DCM and transverse aorta co

103 duced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and

104 erobic Firmicutes and Melainabacteria in the murine foregut and hindgut.

105 te the ligand specificities of the human and murine forms of the myeloid C-type lectin receptor lange

106 si sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) are members of the Rh

107 his technique to rescue the replication of a murine gammaherpesvirus engineered with a mutation in th

108 In the murine gastrocnemius, the estimated methylation fraction

109 e shifts, we created a quantitative index of murine Giardia-induced microbial dysbiosis.

110 cycle metabolites, and slowed progression of murine gliomas.

111 Murine Gravin rescued chromosome misalignment and micron

112 a (GVL) effects in allogeneic and xenogeneic murine GVHD models.

113 ell cohesion in cardiac myocyte cultures and murine heart slices.

114 ydrolipoyl succinyltransferase (DLST) in the murine heart was performed by means of an adeno-associat

115 3-dimentional reconstruction of the "digital murine heart" to assess aberrant cardiac structures as w

116 at five time points in four weeks from male murine hearts subjected to transverse aorta banding surg

117 Leukocytes in murine hearts, pericardial AT, spleen, mediastinal lymph

118 prolonged overall survival without affecting murine hematopoiesis.

119 Murine hematopoietic progenitor cells overexpressing MPP

120 scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny

121 Overall, our data suggest murine hepatitis virus (MHV) ExoN activity is required f

122 S-TLR4 signaling in human hepatoma cells and murine hepatocytes and may contribute to the ability of

123 very of blood vessel perfusion function in a murine hindlimb ischemia model.

124 le complementary reporter molecules from the murine Hmox1 locus, including firefly luciferase, to all

125 t on A. phagocytophilum acquisition from the murine host but affected the bacterial survival in tick

126 id not develop a persistent infection in the murine host.

127 t can lead to human hematopoiesis within the murine host.

128 ctions that place their respective human and murine hosts at risk for cancer.

129 Here, the authors show in murine HSCs that the telomere binding protein POT1a inhi

130 study, a novel rabies vaccine that expressed murine IL-7 was developed.

131 nfection outcomes in vitro and in an in vivo murine infection model.

132 anscripts expressed by the spirochete during murine infection.

133 used to test the activity of TR1 cells in a murine inflammatory bowel disease model, a model that re

134 o-factor, and genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the pres

135 Murine Inpp5e ablation is embryonically lethal and recap

136 constitutively active Hedgehog signaling in murine intermediate mesoderm-derived renal progenitors r

137 owed that Mule/Huwe1/Arf-BP1 (Mule) controls murine intestinal stem and progenitor cell proliferation

138 signature for oncogenic KRAS derived from a murine isogenic cell line with a coexpression network de

139 nd characterize type I and type III bones in murine jaws.

140 Here, we counted all individual glomeruli in murine kidneys and sized the capillary tufts by combinin

141 r East Asian GWAS; in contrast BVES and CAP2 murine knockouts caused cardiac conduction defects.

142 ligands augmented by structural insight into murine langerin.

143 enhancement of the photonic inactivation of Murine Leukemia Virus (MLV) via 805 nm femtosecond pulse

144 h show that tetherin does not affect Moloney murine leukemia virus (MoMLV) spread, and only minimally

145 ells are shown to restrict the expression of murine leukemia virus genomes but not retroviral genomes

146 B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is a com

147 ents derived from three retroviruses (HIV-1, murine leukemia virus, and Mason-Pfizer monkey virus), t

148 -mediated arthritis in 2 mast cell-deficient murine lines: KitWsh/Wsh, which develops robust arthriti

149 une surveillance was observed in Igfbp7(-/-) murine livers, which was associated with a marked inhibi

150 genes, has been inserted into the equivalent murine locus, corresponding to a locus swap.

151 steonecrotic defects in the diaphysis of the murine long bones.

152 ue to the absence of embryonic phenotypes in murine loss-of-function studies.

153 may exacerbate allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway.

154 which this cytokine promotes autoimmunity in murine lupus.

155 s for longitudinal intravital imaging of the murine lymph node and surrounding structures for up to 1

156 vivo macrophage M1-like polarization within murine lymph nodes.

157 Finally, in vitro IH exposures of murine macrophages and LLC1 cells showed that both cell

158 h Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced levels of IL-18 and a

159 Experiments using murine macrophages showed that FPW extract is able to re

160 , we examined its regulation and function in murine macrophages, compared it to the LD adipose differ

161 c DNA DSBs act as signaling intermediates in murine macrophages, regulating innate immune responses t

162 mmatory and anti-inflammatory cytokines from murine mDCs and PBMCs from patients with birch allergy.

163 iated depletion of GNB1 (encoding Gbeta1) in murine megakaryocytes reduced protease-activated recepto

164 The present work shows the role of SOCS1 in murine melanoma development and the potential of SOCS1-s

165 The new murine model enabled the identification of a distinctive

166 inducible nitric oxide synthase (iNOS) in a murine model of A. actinomycetemcomitans-induced periodo

167 on DC subsets in the lung and lymph nodes in murine model of allergic airway inflammation.

168 The murine model of BA, employing rhesus rotavirus (RRV), pa

169 ole of CYP24A1 on malignant progression of a murine model of Braf(V600E) -induced papillary thyroid c

170 Taking advantage of a murine model of chronic immune activation, we demonstrat

171 g heterotrophic cardiac transplantation in a murine model of chronic rejection.

172 nflammatory pathology in the IL-10-deficient murine model of colitis relative to mice fed a low salt

173 In the caerulein-induced murine model of CP, administration of ruxolitinib for on

174 rmed our results in vivo by treating the mdx murine model of DMD with repeated i.m. injections of PDG

175 rum longus muscles in dystrophic mdx mice, a murine model of Duchenne muscular dystrophy.

176 d investigated the requirement for CCL7 in a murine model of IgE-mediated allergic conjunctivitis.

177 cessfully inhibit P. aeruginosa infection in murine model of implant-associated infection.

178 entify genes that contribute to fitness in a murine model of infection.

179 We employed a murine model of influenza infection to identify these me

180 In a murine model of lymphoid-specific EZH2 deficiency we fou

181 pes in determining therapeutic response in a murine model of mBC resistance to the antiangiogenic tyr

182 se in an inducible RAF-driven, autochthonous murine model of melanoma incorporating a fluorescent rep

183 We used a murine model of MS, experimental autoimmune encephalomye

184 iments in mice and conferred protection in a murine model of Mycobacterium tuberculosis infection.

185 on in CKD developed in a clinically relevant murine model of nonischemic hypertrophic CHF, transverse

186 tumour samples, patient-derived xenografts, murine model of NSCLC, NSCLC cell lines and The Cancer G

187 celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1)

188 This unique murine model of PAH-like plexiform/obliterative arteriop

189 nhibition of the SHH and CXCR4 pathways in a murine model of SHH-subtype medulloblastoma exerts poten

190 Here, we report in a murine model of skin squamous cell carcinoma (SCC) that

191 s therapeutically effective in a preclinical murine model of steatosis-associated liver cancer.

192 We revisited this hypothesis using the NOD murine model of type 1 diabetes.

193 Consequently, GLIS3 deficiency in a murine model prevented the development of goiter as well

194 in the brains of HD patients as well as in a murine model that recapitulates the polyQ pathology of H

195 In a murine model with unilateral ureteric obstruction, pretr

196 interactions with IgE and food allergy in a murine model.

197 d in nonobese asthma patients and in the OVA murine model.

198 AA progression and rupture was assessed in a murine model.

199 umab was further investigated in a humanized murine model.

200 painful conditions evaluated in CCI and STZ murine model.

201 xpressed in reactive cholangiocytes, in both murine models and patients with PSC.

202 In murine models of A. baumannii pneumonia, RAGE signaling

203 tes with disease severity in two established murine models of acute pancreatitis induced by either ce

204 Here, we demonstrate, using murine models of allogeneic BMT, that type 2 innate lymp

205 Here, we used murine models of AMD to examine the contribution of CFH

206 ith RP805, a commonly used pan-MMP tracer in murine models of aneurysm.

207 antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg

208 ry cytokine TNFalpha in a set of established murine models of cancer.

209 e of the JCI, Ni and colleagues used several murine models of GVHD to evaluate the effect of CD4+ T c

210 GAS does not result in virulence defects in murine models of infection, suggesting that CpsY functio

211 We translated our findings to two murine models of lung cancer, including orthotopic human

212 A hallmark of autoimmunity in murine models of lupus is the formation of germinal cent

213 l1 in endothelium and hematopoietic cells in murine models of microvascular and macrovascular injury.

214 Transplantable murine models of ovarian high grade serous carcinoma (HG

215 ers a microbe-mediated survival advantage in murine models of sepsis.

216 Using this approach with a number of murine models of slowed aging shows that, compared to co

217 Two murine models of synucleinopathy (a Gaucher-related synu

218 ltiple aspects of psoriasis in two different murine models of the disease.

219 Both patients and murine models revealed an impaired epidermal structure,

220 Numerous findings in murine models suggest a predominantly protumoral role fo

221 However, to the best of our knowledge murine models to study the biologic effects of various a

222 miRNAs were differentially regulated in both murine models.

223 across different diseases and corresponding murine models.

224 onstructs showed efficient immunogenicity in murine models.

225 risk of graft-versus-host disease (GVHD) in murine models.

226 g cancer cells and inhibited tumor growth in murine models.

227 rounding the nucleus pulposus, especially in murine models.

228 fibrosis compared to WT mice in two separate murine models: CCl4 and bile duct ligation.

229 in vitro inflammatory responses in RAW 264.7 murine monocyte/macrophage cells challenged with the TLR

230 d function of LPA that transfigures CD11b(+) murine monocytes into F4/80(+) macrophages.

231 The effect of HA-coatings on murine MSC was functionally determined both, in vitro an

232 Current methods to culture murine MSCs (mMSCs) select for rapidly dividing colonies

233 as 2'-O-ribose-methylation, is increased in murine muscle tissue during postischemic neovascularizat

234 ZFP423 in neurogenesis, we analyzed allelic murine mutants in which distinct functional domains are

235 ary human nasal epithelial cells (HNECs) and murine nasal epithelial cells (MNECs) and isolated murin

236 in B1 levels modulate the differentiation of murine neural stem cells (NSCs) into neurons and astrogl

237 is and the numbers of activated infiltrating murine neutrophils but not neutrophil cellularity.

238 ut is required for NET production in primary murine neutrophils.

239 n-1 and -2 proteins as central regulators of murine NKT cell fate decisions.

240 themselves affect key oxidase components in murine non-CF cells.

241 However, recent work in the murine norovirus (MNV) model of persistent infection dem

242 lambda-mediated sterilizing immunity against murine norovirus requires the capacity of IECs to respon

243 We also present a uniform murine OCT layer naming nomenclature system that is cons

244 man retina layer designations to standardize murine OCT, which will facilitate data evaluation across

245 ed autophagy induction in human OLT and in a murine OLT model with extended (20 hours) cold storage,

246 se and a second metalloproteinase, MMP-9, in murine optic gliomas relative to normal non-neoplastic o

247 ol A. actinomycetemcomitans infection in the murine oral cavity and to prevent subsequent alveolar bo

248 Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has an unexpected function in

249 we show that a microfluidic system supports murine ovarian follicles to produce the human 28-day men

250 Here we constructed a mutant murine P-gp with a shortened linker to facilitate struct

251 ciated endotoxemia upregulates miR-155-5p in murine pancreatic beta-cells, which improved glucose met

252 udy, we investigated the ontogeny of TAMs in murine pancreatic ductal adenocarcinoma (PDAC) models.

253 ncreatic beta-cells, as well as in human and murine pancreatic islets, via AKT/BCL2 signaling.

254 ctive immunity against a naturally occurring murine pathogen that infects the thymus and establish a

255 In a PTEN-null murine PCa model, WHSC1 overexpression in prostate epith

256 t of endogenous Kras to maintain survival of murine PDAC cells, using an inducible shRNA-based system

257 e risk of disease relapse after resection of murine PDAC, suggesting this concept for future clinical

258 aggregation was decreased in PP1calpha(-/-) murine platelets and in human platelets treated with a s

259 are required for the activation of human and murine platelets by oxPCCD36.

260 LDL and targeted genetic deletion of ERK5 in murine platelets prevented oxLDL-induced platelet deposi

261 gene coding for middle T antigen (MT) is the murine polyomavirus oncogene most responsible for tumor

262 ort that neural-specific inactivation of two murine post-transcriptional regulators, Pumilio 1 (Pum1)

263 on of GFI1 impedes the in vitro expansion of murine pre-leukemic cells.

264 tes graft-versus-host disease (GvHD) in both murine preclinical transplant models and in human clinic

265 tency and protective efficacy of 5C4 and the murine precursor of palivizumab, antibody 1129.

266 derived RPE-like cell line ARPE-19, cultured murine primary RPE cells, and RPE samples from live mice

267 (177)Lu-PSMA-617 RLT in a syngeneic model of murine prostate cancer.

268 , the organoid-forming capacity of Spop-null murine prostate cells was more sensitive to c-MYC inhibi

269 recapitulated this finding in co-cultures of murine PSCs and PDA organoids, and demonstrated that org

270 kade and nanoparticle-based drug delivery in murine pulmonary carcinoma.

271 pluripotent stem cells (iPSCs) derived from murine rod photoreceptors.

272 lial KIT(+) progenitor cell expansion during murine salivary gland organogenesis.

273 i-ductal network of the developing human and murine salivary gland, we demonstrate an unexpected role

274 small conductance K(+) (SK) channels in the murine SAN.

275 k-in cell fate mapping strategy in different murine SCI models.

276 In experimental murine sepsis, pHi of blood neutrophils was analogously

277 sion on S. aureus virulence was studied in a murine skin infection model.

278 xpected tumor-suppressive activity of MIF in murine skin.-

279 ver that neural stem cells, derived from the murine spinal cord and organized as neurospheres, can be

280 During murine systemic infection, LipA suppresses pro-inflammat

281 effectively inhibited IL-17A production from murine T helper type 17-differentiated T lymphocytes.

282 atory factor 4 (Irf4) is highly expressed in murine thymic epithelium and is required to prime thymic

283 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene homolog 1 (AKT1), and the

284 we performed an array of genetic analyses in murine tooth development, where Lrp4 and Wise play impor

285 man orthologues selected on the basis of the murine transcript signature allowed prediction of respon

286 A murine transgenerational asthma model was used to identi

287 nasal epithelial cells (MNECs) and isolated murine trigeminal ganglial neurons.

288 d these findings in vitro and in vivo in two murine tumor models, in primary human breast and lung ca

289 ine CX3CL1 was upregulated in both human and murine tumors following VEGF signaling blockade, resulti

290 Reliable reporting of the status of primary murine tumors treated with the selective MEK1/2 inhibito

291 d at birth, we first defined the features of murine UCB cells and demonstrated that they are capable

292 We then assessed the effectiveness of murine UCB cells transplantation in busulfan-conditioned

293 oxide synthase (nNOS) in nerve fibers of the murine vaginal wall.

294 the capacity to cause immunopathology during murine vaginitis to this avirulent hypofilamentous strai

295 We focus on PARP3 as it is dispensable for murine viability and has druggable catalytic activity.

296 By analyzing activated murine wild-type and Rheb-deficient CD4(+) T cells, as w

297 igns of toxicity and potent activity in both murine xenograft and patient-derived breast tumor explan

298 d extramedullary myeloma manifestations in a murine xenograft model in vivo.

299 cells controlled leukemia cells in vivo in a murine xenograft model.

300 vivo HGF ELISA experiments were performed on murine xenografts of U87MG (HGF-positive, MET-positive)