ライフサイエンスコーパス: muscarine

1 hat could be antagonized by cotreatment with muscarine.

2 tential (EPP) amplitude normally produced by muscarine.

3 beling techniques, are profoundly excited by muscarine.

4 amide to inhibit the contractile response to muscarine.

5 lar to that seen in response to bath-applied muscarine.

6 n sympathetic neurones was its modulation by muscarine.

7 ation of ACh to B neurones were unchanged by muscarine.

8 prevented the modulation of Ca2+ currents by muscarine.

9 d by CaN420 was different from the effect of muscarine.

10 Muscarine (10 microM) did not affect the SOR or the RD.

11 Muscarine (10 microM) inhibited N- and Q- but not R-, T-

12 Muscarine (10 microM) inhibited release by 70 +/- 3% (n

13 ogue 8-bromo-cAMP (1 mM), and application of muscarine (100 microM).

14 From dose-response curves for muscarine a mean dissociation constant of K(D) = 1.95 +/

15 neuromodulation was significantly altered as muscarine abolished respiratory network activity in alph

16 Immunocytochemistry utilizing muscarine acetylcholine receptor (mAChR) subtype-specifi

17 and CNQX, MK-801, or AP-7; ACh, nicotine or muscarine; ACh and alpha-bungarotoxin (Bgt) or methyllyc

18 It is concluded that muscarine acts on M3 muscarinic acetylcholine receptors

19 The formal total synthesis of the muscarine alkaloids (-)-allomuscarine and (+)-epimuscari

20 Muscarine also depolarizes dentate granule cells and ele

21 Muscarine also increased Mn2+ quenching of intracellular

22 diated fast excitation, but were mimicked by muscarine and antagonized by atropine, indicating that i

23 ummary, we present a novel biphasic role for muscarine and implicate M3 receptors in the inhibition a

24 nd two muscarinic receptor (mAChR) agonists, muscarine and McN-A-343 (M1-selective), but not by nicot

25 tion between any changes in V(m) response to muscarine and morphology, as determined by reconstructio

26 s and classical muscarinic agonists, such as muscarine and oxotremorine, had higher affinity versus o

27 Efferent-mediated slow excitation or muscarine application enhanced the sensitivity of CD aff

28 channels.Cholinergic agents (ACh, nicotine, muscarine, bethanechol and pilocarpine) increased [Ca2+]

29 Dopamine and muscarine both increased the paired-pulse ratio of GABAA

30 e (by up to 29%; IC50 = 16 +/- 3 microM) and muscarine (by up to 41%; IC50 = 1.0 +/- 0.4 microM).

31 We found that bath application of muscarine caused a direct depolarization in approximatel

32 Muscarine ((+)-muscarine chloride) reversibly inhibited the current wit

33 h, at a concentration of 100 nM, shifted the muscarine concentration-response curve to the right by a

34 evident under current clamp, where 10 microM muscarine depolarized granule neurons such that action p

35 Muscarine elevates the firing rate of inhibitory cells,

36 ne, serotonin, and the acetylcholine agonist muscarine, evoked direct inhibitory actions.

37 Peak muscarine-evoked rises of [Ca2+]i were variable, but the

38 The SHNs excited by muscarine had a broad range of conduction velocities (0.

39 ethanechol depressed this excitation whereas muscarine had inconsistent effects.Atropine and C6 depre

40 Muscarine had no effect on EPSCs in C neurones.

41 the most significant effect of dopamine and muscarine in the STN is to reduce inhibitory synaptic in

42 Muscarine increased the coefficient of variation (c.v.)

43 Muscarine-induced activation of M3 receptors (0-12 min)

44 se C (PLC) inhibitor U-73122 all blocked the muscarine-induced Ca2+ signal but had little or no effec

45 ion of 2-AG to PGE2-G by COX-2 underlies the muscarine-induced enhancement of neurotransmitter releas

46 The muscarine-induced excitations in SHNs were found not to

47 eptor antagonist 4-DAMP effectively reversed muscarine-induced inhibition of IPSCs with an IC50 of 0.

48 ections of cholinergic agonists carbachol or muscarine into HVc strongly affected discharge rates and

49 ]i elevations arising out of Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular st

50 Muscarine, methacholine, and arecaidine propargyl ester

51 Muscarine ((+)-muscarine chloride) reversibly inhibited

52 physiological and pharmacological effects of muscarine on antidromically identified septohippocampal

53 The action of muscarine on IK(SO) was unaffected by the M2 receptor an

54 y type of hippocampal neuron, the effects of muscarine on SHNs would also have a profound effect on h

55 ive and antiallodynic actions of intrathecal muscarine or neostigmine in normal rats and in a rat mod

56 significantly attenuated the effect of both muscarine or neostigmine in normal rats.

57 Intrathecal injection of muscarine or neostigmine significantly increased the wit

58 The effect of intrathecal muscarine or neostigmine was examined through pretreatme

59 Application of 20 microM muscarine produced a mean 78 +/- 1.4% inhibition of the

60 ocytotic vesicle fraction may have a role in muscarine receptor endocytosis.

61 The data suggest that the muscarine receptor stimulated release of the alpha-synuc

62 Targeted blockade of muscarine receptors over these neurons profoundly reduce

63 Bath-applied muscarine reduced the amplitude of EPSCs recorded at < 0

64 that in vitro gamma oscillations induced by muscarine require activation of M1 receptors on hippocam

65 Muscarine reversibly reduced the amplitude of GABAA IPSC

66 Central muscarinic cholinergic activation by muscarine, the M1 receptor agonist McN-A-343, and the M2

67 ine also reversed the inhibition of IPSCs by muscarine, this effect was only observed at relatively h

68 rent recordings revealed that application of muscarine to NB neurons induced a GIRK current, and this

69 ) receptors in the antinociceptive action of muscarine was also determined.

70 Inhibition of IPSCs by muscarine was completely blocked by scopolamine (10 micr

71 odynic effect of intrathecal neostigmine and muscarine was largely eliminated by CGP55845 in diabetic

72 e and himbacine indicated that the effect of muscarine was mediated by the M(1) class of muscarinic r

73 tinociceptive action produced by intrathecal muscarine was significantly reduced by CGP55845 pretreat

74 in 0.5 mM Ca2+, but inhibition by 10 microM muscarine was significantly reduced.

75 The inhibition by muscarine was unaffected by pre-incubation for 17-20 h w

76 The current and its inhibition by muscarine were unaffected by 100 microM Cd2+.

77 These cells responded to muscarine with extended periods of excitation, received