ライフサイエンスコーパス: muscarinic acetylcholine receptor

1 oding potassium voltage-gated channels and a muscarinic acetylcholine receptor.

2 volved in the recycling of the M4 subtype of muscarinic acetylcholine receptor.

3 of the inactive and active state of the M(3) muscarinic acetylcholine receptor.

4 402-421 in transmembrane helix 7 of the M(1) muscarinic acetylcholine receptor.

5 adhesion kinase, by the G protein-coupled m1 muscarinic acetylcholine receptor.

6 beta2 adrenergic receptor (hbeta2AR) and M2 muscarinic acetylcholine receptor.

7 ies of cysteine (Cys)-substituted mutant M 3 muscarinic acetylcholine receptors.

8 a series of cysteine-substituted mutant M(3) muscarinic acetylcholine receptors.

9 y acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors.

10 er reaction and are allosteric modulators at muscarinic acetylcholine receptors.

11 d which is inhibited following activation of muscarinic acetylcholine receptors.

12 lated, and only weakly inhibited, through M1 muscarinic acetylcholine receptors.

13 effect on internalization of either m2 or m3 muscarinic acetylcholine receptors.

14 amine, indicating that it was mediated by M4 muscarinic acetylcholine receptors.

15 consistent with activation of endogenous M2 muscarinic acetylcholine receptors.

16 otein in phospholipid vesicles containing M2 muscarinic acetylcholine receptors.

17 y changes in glycolysis and by activation of muscarinic acetylcholine receptors.

18 phenotype can be rescued by an antagonist of muscarinic acetylcholine receptors.

19 ulated with type 1 protease activated and M1 muscarinic acetylcholine receptors.

20 ergic G protein-coupled receptors, including muscarinic acetylcholine receptors.

21 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors.

22 n upon stimulation with nafenopin, including muscarinic acetylcholine receptor 3, intermediate filame

23 , we find that the Chrm4 transcript encoding muscarinic acetylcholine receptor 4 (M4) is excessively

24 nergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosi

25 ation of transferrin receptor [5] and of the muscarinic acetylcholine receptor [6].

26 eviously undisclosed antagonists of the M(2) muscarinic acetylcholine receptor, a G-protein coupled r

27 Herein we address these topics for the M1 muscarinic acetylcholine receptor, a key molecular targe

28 To address this issue, we used the M(3) muscarinic acetylcholine receptor, a prototypical class

29 ting to their active state, we used the M(3) muscarinic acetylcholine receptor, a prototypical class

30 By applying this method to the M(2) muscarinic acetylcholine receptor, a prototypical GPCR,

31 ces, we show that endogenous Galphaq-coupled muscarinic acetylcholine receptors activate PKA.

32 HEK 293 cells was induced via recombinant M2 muscarinic acetylcholine receptors activated by carbacho

33 Acetylcholine binding to muscarinic acetylcholine receptors activates G-proteins,

34 omain 3 (TM3) plays a crucial role mediating muscarinic acetylcholine receptor activation by acetylch

35 e rat dentate gyrus to examine the effect of muscarinic acetylcholine receptor activation on the intr

36 on the unknown transduction pathway linking muscarinic acetylcholine receptor activation to M-channe

37 rom intracellular stores and triggered by M1 muscarinic acetylcholine receptor activation was critica

38 Disruption of NAc muscarinic acetylcholine receptor activity attenuated, w

39 ese results propose a new mechanism by which muscarinic acetylcholine receptors affect cognition and

40 bath application of 3 mum carbachol (CCh), a muscarinic acetylcholine receptor agonist, reduces evoke

41 with oxotremorine-M (Oxo-M), a nonselective muscarinic acetylcholine receptor agonist.

42 aperitoneal administration of pilocarpine, a muscarinic acetylcholine receptor agonist.

43 aperitoneal administration of pilocarpine, a muscarinic acetylcholine receptor agonist.

44 study we have generated mice lacking the M1 muscarinic acetylcholine receptor and examined the effec

45 evaluating the binding sites of both the M2 muscarinic acetylcholine receptor and the D2 dopamine re

46 limiting the active conformation of the M(2) muscarinic acetylcholine receptor and thereby regulate s

47 ptor (LGR7), G-proteins (Galpha(q/11/o/13)), muscarinic acetylcholine receptor and vanilloid (TRPV1)

48 ure activation of recombinant and endogenous muscarinic acetylcholine receptors and activation of rec

49 ovary (CHO) cells stably transfected with M1 muscarinic acetylcholine receptors and currents were rec

50 an M(2)-selective competitive antagonist of muscarinic acetylcholine receptors and exhibits alloster

51 ugh a slowly activating pathway linked to M1 muscarinic acetylcholine receptors and Galphaq/11 protei

52 ular solution, indicating the involvement of muscarinic acetylcholine receptors and InsP(3)-sensitive

53 analysis showed the highest similarity to M2 muscarinic acetylcholine receptors and overall low homol

54 mechanism describing the interaction of M(2) muscarinic acetylcholine receptors and the guanine nucle

55 Dysfunction of muscarinic acetylcholine receptors and their downstream

56 amine receptors, 5-HT (serotonin) receptors, muscarinic acetylcholine receptor, and adrenergic recept

57 .5 +/- 8.5% of controls), insensitive to the muscarinic acetylcholine receptor antagonist atropine (1

58 Following treatment with the muscarinic acetylcholine receptor antagonist biperiden,

59 Scopolamine (hyoscine) is a muscarinic acetylcholine receptor antagonist that has tr

60 demonstrate that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces r

61 ve revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces r

62 el tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs).

63 Muscarinic acetylcholine receptor antagonists are widely

64 studies show that systemic administration of muscarinic acetylcholine receptor antagonists selectivel

65 piperazines was discovered as highly potent muscarinic acetylcholine receptor antagonists via high t

66 l quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excel

67 waves, MC calcium transients were blocked by muscarinic acetylcholine receptor antagonists, whereas d

68 structurally and physicochemically distinct muscarinic acetylcholine receptor antagonists.

69 Compounds acting at both nicotinic and muscarinic acetylcholine receptors appear to have antino

70 Muscarinic acetylcholine receptors are common throughout

71 rhelical constraint contacts, using the M(1) muscarinic acetylcholine receptor as a model.

72 Among these, we identified CHRM3, a M3R muscarinic acetylcholine receptor, as being restricted t

73 ous work has demonstrated that activation of muscarinic acetylcholine receptors at the lizard neuromu

74 rs (mGluRs, alpha1 adrenergic receptors, and muscarinic acetylcholine receptors), attained by superfu

75 um anti-Ro/SSA, anti-La/SSB, and anti-type 3 muscarinic acetylcholine receptor autoantibodies or in t

76 These results indicate a reduction in muscarinic acetylcholine receptor availability in vivo i

77 It is concluded that muscarine acts on M3 muscarinic acetylcholine receptors both to inhibit IK(SO

78 is implicated in reward, whereas blockade of muscarinic acetylcholine receptors by scopolamine suppre

79 ssed in human embryonic kidney cells with M2 muscarinic acetylcholine receptors, Ca channels encoded

80 protein-coupled receptors, including the M3 muscarinic acetylcholine receptor, can form homo-oligome

81 Muscarinic acetylcholine receptors comprise a family of

82 Thus, m3 muscarinic acetylcholine receptors couple to both growth

83 receptors (metabotropic glutamate receptors, muscarinic acetylcholine receptors, dopamine receptors,

84 Here we show that activation of m3 muscarinic acetylcholine receptors ectopically expressed

85 Previous studies have shown that muscarinic acetylcholine receptors evoke both inhibition

86 In HEK293 cells, activation of the M1 muscarinic acetylcholine receptor evokes tyrosine phosph

87 nce the binding of acetylcholine to the M(1) muscarinic acetylcholine receptor expressed in intact CH

88 CRT attenuated the increased M2 subtype of muscarinic acetylcholine receptor expression and Galphai

89 The patches are matched to a pattern of M2 muscarinic acetylcholine receptor expression at fixed lo

90 Galphai coupling and enhanced M3 subtype of muscarinic acetylcholine receptor expression in associat

91 /AL border coincides with a change in type 2 muscarinic acetylcholine receptor expression in layer 4

92 ic receptor is the most recent member of the muscarinic acetylcholine receptor family (M(1)-M(5)) to

93 Members of the muscarinic acetylcholine receptor family (M1-M5) are kno

94 Members of the muscarinic acetylcholine receptor family are thought to

95 The muscarinic acetylcholine receptor family exemplifies the

96 matic search of the intracellular loops of a muscarinic acetylcholine receptor for domains that gover

97 mine (NMS) bind to the binding pocket of the muscarinic acetylcholine receptor formed by transmembran

98 Postsynaptically, the muscarinic acetylcholine receptor GAR-3 acts in RIA to c

99 resynaptic signaling pathway composed of the muscarinic acetylcholine receptor GAR-3, the heterotrime

100 The expression of the cm2 muscarinic acetylcholine receptor gene increases dramati

101 amined the interaction of REST with the M(4) muscarinic acetylcholine receptor gene.

102 Although muscarinic acetylcholine receptors have been studied in

103 Activation of m1 muscarinic acetylcholine receptors (i.e. application of

104 The m2 muscarinic acetylcholine receptor in the cerebral cortex

105 Here, we describe a role for central muscarinic acetylcholine receptors in the activation of

106 The G protein-coupled m1 and m3 muscarinic acetylcholine receptors increase tyrosine pho

107 ity, which we tentatively have called MARIA (muscarinic acetylcholine receptor-inducing activity) is

108 The drug scopolamine was used to block muscarinic acetylcholine receptors involved in working m

109 The muscarinic acetylcholine receptor is an important modula

110 The M5 muscarinic acetylcholine receptor is suggested to be a p

111 acterized GPCRs coupled to either G(q) (M(1) muscarinic acetylcholine receptor (M(1)AchR) and P2y(1)

112 on) address this question in relation to the muscarinic acetylcholine receptor (M(1)AchR) and the B(2

113 he regulation of endogenously expressed M(3) muscarinic acetylcholine receptor (M(3) mAChR).

114 lar location of NKCC1, Na(+)-K(+)-ATPase, M3 muscarinic acetylcholine receptor (M(3)AChR) and lysosom

115 Muscarinic acetylcholine receptors (M(1)-M(5)) regulate

116 itive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promi

117 sed biosensor to detect activation of the M1 muscarinic acetylcholine receptor (M1 mAChR) in vitro an

118 acetylcholine receptors, particularly the M1 muscarinic acetylcholine receptor (M1 mAChR), which was

119 1)-coupled receptors - prototypically the M1 muscarinic acetylcholine receptor (M1-mAChR).

120 an be recapitulated with blockade of M1-type muscarinic acetylcholine receptors (M1-AChR); however, t

121 Galphaq-coupled receptors, including the M1 muscarinic acetylcholine receptor (M1R), and opposes the

122 consistent with beta-arrestin binding to M1 muscarinic acetylcholine receptors (M1Rs) in two differe

123 tween polymorphisms in the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) and EROs.

124 hisms genotyped across a candidate gene, the muscarinic acetylcholine receptor M2 gene (CHRM2).

125 stence of a second allosteric site on the M2 muscarinic acetylcholine receptor (M2 mAChR).

126 for several allosteric modulators of the M2 muscarinic acetylcholine receptor (M2 receptor), a proto

127 G betagamma), and efficiently translate M(2) muscarinic acetylcholine receptor (M2R) activation into

128 Following m2-muscarinic acetylcholine receptor (M2R) stimulation, KAC

129 The M2 muscarinic acetylcholine receptor (M2R) was found to exh

130 We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44)

131 Human acini preferentially expressed the muscarinic acetylcholine receptor M3 and maintained phys

132 gical interventions, we demonstrate that the muscarinic acetylcholine receptor M3 mediates these acti

133 ed inflammatory cytokines and decreased M3R (Muscarinic Acetylcholine receptor M3) and AQP5 (Aquapori

134 major role in the regulation of the human M3 muscarinic acetylcholine receptor (M3 mAChR) in the huma

135 n and lung function regulated through the M3-muscarinic acetylcholine receptor (M3-mAChR).

136 ts, CCK-8 and gastrin, and an agonist for m3 muscarinic acetylcholine receptors (m3 AchR), carbachol.

137 We previously reported that type 3 muscarinic acetylcholine receptors (M3-Rs) physically in

138 f family A GPCR dimers, we used the rat M(3) muscarinic acetylcholine receptor (M3R) as a model syste

139 (SMG), production of antinuclear and anti-M3 muscarinic acetylcholine receptor (M3R) autoantibodies a

140 The M muscarinic acetylcholine receptor (M3R) regulates many f

141 d light on this issue, we have used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

142 ionally critical amino acids in the rat M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

143 To address this issue, we used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic cl

144 , can inhibit signal transduction via the M3 muscarinic acetylcholine receptor (M3R).

145 that autoantibodies reactive with the type 3 muscarinic acetylcholine receptors (M3Rs) expressed on s

146 L to modulate the activity of beta-cell M(3) muscarinic acetylcholine receptors (M3Rs), which play an

147 reward, potentially mediated through the M5 muscarinic acetylcholine receptor (M5R).

148 the phosphorylation and regulation of the M3 muscarinic acetylcholine receptor (mACh) endogenously ex

149 Here we show that muscarinic acetylcholine receptor (mAChR) activation als

150 ation of vestibular afferents is mediated by muscarinic acetylcholine receptor (mAChR) activation and

151 Muscarinic acetylcholine receptor (mAChR) activation in

152 e identity of signaling elements that couple muscarinic acetylcholine receptor (mAChR) activation to

153 on populations are differentially engaged by muscarinic acetylcholine receptor (mAChR) activation.

154 mulating evidence suggests that selective M4 muscarinic acetylcholine receptor (mAChR) activators may

155 action between the functionally selective M1 muscarinic acetylcholine receptor (mAChR) agonist xanome

156 Oxotremorine, an m2 muscarinic acetylcholine receptor (mAChR) agonist, mimic

157 Nanoinjections of the muscarinic acetylcholine receptor (mAChR) agonist, oxotr

158 ity in response to continuous application of muscarinic acetylcholine receptor (mAChR) agonists.

159 ) protein-coupled receptors such as the M(2) muscarinic acetylcholine receptor (mAChR) and A(1) adeno

160 fibers, we investigated the function of the muscarinic acetylcholine receptor (mAchR) and G(alpha)q.

161 The abilities of the M(3) muscarinic acetylcholine receptor (mAChR) and Rac1 to re

162 X-198321) is a single molecule composed of a muscarinic acetylcholine receptor (mAChR) antagonist moi

163 Muscarinic acetylcholine receptor (mAChR) blockade by sc

164 The activation of the muscarinic acetylcholine receptor (mAChR) family, consis

165 Phosphorylation of the M(2) muscarinic acetylcholine receptor (mAChR) has been shown

166 pe-selective allosteric modulators of the M5 muscarinic acetylcholine receptor (mAChR) have been desc

167 t deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefron

168 ue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with

169 siccating environmental stress with systemic muscarinic acetylcholine receptor (mAChR) inhibition.

170 Activation of the M1 muscarinic acetylcholine receptor (mAChR) is a prospecti

171 Here, the extracellular vestibule of the M2 muscarinic acetylcholine receptor (mAChR) is targeted fo

172 (NGF) up-regulated steady-state levels of m4 muscarinic acetylcholine receptor (mAChR) mRNA in PC12 c

173 rallel synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allos

174 es alpha activity when the actions of either muscarinic acetylcholine receptor (mAChR) or metabotropi

175 Novel bitopic hybrids, based on the M1/M4 muscarinic acetylcholine receptor (mAChR) orthosteric ag

176 In this study, we characterized a muscarinic acetylcholine receptor (mAChR) potentiator, L

177 We demonstrate that a G alpha(q)-coupled muscarinic acetylcholine receptor (mAChR) signaling path

178 We have studied the effects of m1 muscarinic acetylcholine receptor (mAChR) stimulation, w

179 positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5)

180 Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s) med

181 The generation of muscarinic acetylcholine receptor (mAChR) subtype-select

182 Identification of the specific muscarinic acetylcholine receptor (mAChR) subtypes media

183 77-LH-28-1 are selective agonists of the M1 muscarinic acetylcholine receptor (mAChR) that may gain

184 Selective activation of the M1 muscarinic acetylcholine receptor (mAChR) via a positive

185 Muscarinic acetylcholine receptor (mAChR), a member of t

186 sitive allosteric modulator (PAM) for the M1 muscarinic acetylcholine receptor (mAChR), but it posses

187 t manner, some receptors, including the M(2) muscarinic acetylcholine receptor (mAChR), can also exhi

188 -coupled receptors (GPCRs), including the m1 muscarinic acetylcholine receptor (mAChR), regulate a ty

189 nction in part by signaling through the M(1) muscarinic acetylcholine receptor (mAChR).

190 the interactions of arrestins with the M(2) muscarinic acetylcholine receptor (mAChR).

191 d by signaling from the G-protein-coupled m1 muscarinic acetylcholine receptor (mAChR).

192 tive positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).

193 osteric modulator of acetylcholine at the M1 muscarinic acetylcholine receptor (mAChR).

194 a strict, two-state MWC mechanism at the M1 muscarinic acetylcholine receptor (mAChR).

195 Muscarinic acetylcholine receptors (mAChR) are G protein

196 High affinity muscarinic acetylcholine receptors (mAChR) have been fou

197 2) purinergic receptors and transfected M(3) muscarinic acetylcholine receptors (mAChR) in Chinese ha

198 Muscarinic acetylcholine receptors (mAChR) in the centra

199 Although muscarinic acetylcholine receptors (mAChR) regulate the

200 eceptors (AR) in BF; and AC5/6, beta1-AR, M4-muscarinic acetylcholine receptors (mAChR), mu-opioid re

201 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChR).

202 this study we showed that stimulation of M1 muscarinic acetylcholine receptors (mAChRs) activates en

203 The activation and blockade of muscarinic acetylcholine receptors (mAChRs) affects reti

204 The M3 and M2 muscarinic acetylcholine receptors (mAChRs) and beta-2-a

205 EPF is enabled by the activation of muscarinic acetylcholine receptors (mAChRs) and is trigg

206 Although muscarinic acetylcholine receptors (mAChRs) and NMDA rec

207 It has long been recognized that muscarinic acetylcholine receptors (mAChRs) are crucial

208 s to determine the extent to which m1 and m2 muscarinic acetylcholine receptors (mAChRs) are expresse

209 cotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs) are expresse

210 Muscarinic acetylcholine receptors (mAChRs) are known to

211 Muscarinic acetylcholine receptors (mAChRs) are known to

212 Muscarinic acetylcholine receptors (mAChRs) are widely e

213 Stimulation of muscarinic acetylcholine receptors (mAChRs) by elevated

214 Muscarinic acetylcholine receptors (mAChRs) can be diffe

215 The 2nd outer loop (o2) of muscarinic acetylcholine receptors (mAChRs) contains a h

216 re, we show that physiological activation of muscarinic acetylcholine receptors (mAChRs) controls the

217 oncentration-dependent mechanism by which m3 muscarinic acetylcholine receptors (mAChRs) differential

218 Gq-coupled, M1 muscarinic acetylcholine receptors (mAChRs) facilitate h

219 Activation of muscarinic acetylcholine receptors (mAChRs) has been sho

220 Muscarinic acetylcholine receptors (mAChRs) have been im

221 y transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant

222 Activation of muscarinic acetylcholine receptors (mAChRs) in the spina

223 Both GABA(B) and muscarinic acetylcholine receptors (mAChRs) influence hi

224 Activation of spinal muscarinic acetylcholine receptors (mAChRs) inhibits noc

225 Stimulation of muscarinic acetylcholine receptors (mAChRs) inhibits noc

226 Activation of striatal muscarinic acetylcholine receptors (mAChRs) is known to

227 gency and frequency, presumably by acting on muscarinic acetylcholine receptors (mAChRs) located in b

228 at subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a

229 elective antagonists of specific subtypes of muscarinic acetylcholine receptors (mAChRs) may provide

230 Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide

231 M(1) muscarinic acetylcholine receptors (mAChRs) may represen

232 Muscarinic acetylcholine receptors (mAChRs) modulate syn

233 Spinal muscarinic acetylcholine receptors (mAChRs) play an impo

234 Muscarinic acetylcholine receptors (mAChRs) play an impo

235 Although muscarinic acetylcholine receptors (mAChRs) regulate pro

236 M(1) muscarinic acetylcholine receptors (mAChRs) represent a

237 cholinergic innervation from the septum, and muscarinic acetylcholine receptors (mAChRs) share some s

238 Activation of muscarinic acetylcholine receptors (mAChRs) significantl

239 etabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) synergistica

240 rugs (DREADDs) are chemogenetically modified muscarinic acetylcholine receptors (mAChRs) that have mi

241 Activation of muscarinic acetylcholine receptors (mAChRs) with carbach

242 endent mechanisms, whereas others, like M(2) muscarinic acetylcholine receptors (mAChRs), are interna

243 G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs).

244 (123)I-iododexetimide is used for imaging muscarinic acetylcholine receptors (mAchRs).

245 receptors and allosterically interacts with muscarinic acetylcholine receptors (mAChRs).

246 frontal cortex (PFC) and their modulation by muscarinic acetylcholine receptors (mAChRs).

247 mory formation are largely performed through muscarinic acetylcholine receptors (mAChRs).

248 ution of BK channels to control of M2- or M3-muscarinic acetylcholine receptor mediated airway smooth

249 CIH-induced HIF-alpha isoform imbalance via muscarinic acetylcholine receptor-mediated Ca(2+) influx

250 er suggests that GRK2 may selectively impair muscarinic acetylcholine receptor-mediated function in v

251 ts also potentiated both opioid receptor and muscarinic acetylcholine receptor-mediated stimulation o

252 Muscarinic acetylcholine receptors modulate the function

253 This Mendelian disease caused by a muscarinic acetylcholine receptor mutation strikingly ph

254 Stimulation of muscarinic acetylcholine receptors on oligodendrocytes i

255 ly, signaling and function mediated by m2/m3 muscarinic acetylcholine receptors or prostaglandin E(2)

256 when activated via either the endogenous M3 muscarinic acetylcholine receptor, or via coexpressed mG

257 lternative strategy is to selectively target muscarinic acetylcholine receptors, particularly the M1

258 Transmembrane domain VI of muscarinic acetylcholine receptors plays an important ro

259 Additionally, blocking nicotinic, but not muscarinic, acetylcholine receptors prevents SCC-mediate

260 Activation of muscarinic acetylcholine receptors produces a significan

261 report that activation of the M4 subtype of muscarinic acetylcholine receptor reduces transmission a

262 Muscarinic acetylcholine receptors regulate the activity

263 The m4 subtype of muscarinic acetylcholine receptor regulates many physiol

264 model, we have observed that both m1 and m2 muscarinic acetylcholine receptors, representative of th

265 Activation of the muscarinic acetylcholine receptors requires agonist bind

266 through an acetylcholine-gated channel and a muscarinic acetylcholine receptor, respectively.

267 Here I show that activation of muscarinic acetylcholine receptors results in waves of c

268 tractile GPCRs, but selectively inhibited M3 muscarinic acetylcholine receptor signaling ( approximat

269 he potential role of cPLA2 as an effector in muscarinic acetylcholine receptor signaling was investig

270 has important functions in both hippocampal muscarinic acetylcholine receptor signalling and in cort

271 to physiological effector systems of the m2 muscarinic acetylcholine receptor site-directed mutant Y

272 agonist-bound, active state of the human M2 muscarinic acetylcholine receptor stabilized by a G-prot

273 otype previously used for the preparation of muscarinic acetylcholine receptor subtype 1 positive all

274 The rat muscarinic acetylcholine receptor subtype 3 was modified

275 nd functional assays using the wild-type rat muscarinic acetylcholine receptor subtype 3.

276 ubstantia nigra pars reticulata (SNr) act on muscarinic acetylcholine receptor subtype 4 (M4) to oppo

277 f the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M

278 The m2 subtype is the predominant muscarinic acetylcholine receptor subtype expressed in h

279 t mutant mice that selectively lack the M(3) muscarinic acetylcholine receptor subtype in the brain (

280 The muscarinic acetylcholine receptor subtype M3 (CHRM3) gen

281 We found that the muscarinic acetylcholine receptor subtype M3 (M3R) inter

282 ed from rat cortical neuroepithelium express muscarinic acetylcholine receptor subtype mRNAs.

283 gG reactivity in patients with PV toward the muscarinic acetylcholine receptor subtypes 3, 4, and 5 a

284 essed in HEK293 cells with each of the known muscarinic acetylcholine receptor subtypes.

285 tant versions of bovine rhodopsin and the M3 muscarinic acetylcholine receptor suggested that the cyt

286 diolabeled species from all five subtypes of muscarinic acetylcholine receptors, suggesting allosteri

287 tion of Gq-coupled receptors, such as the m1 muscarinic acetylcholine receptor, suppresses the M-curr

288 In cells expressing the M3 muscarinic acetylcholine receptor, the agonist carbachol

289 Among these is the M3 muscarinic acetylcholine receptor, the major muscarinic

290 Therefore, we coupled m2-muscarinic acetylcholine receptors to GIRK channels in X

291 c stimulation of the heart acts through M(2)-muscarinic acetylcholine receptors to regulate ion chann

292 ex can inhibit Ca2+ mobilization elicited by muscarinic acetylcholine receptor type 3 (M3R), but not

293 ble to influence agonist binding to the M(1) muscarinic acetylcholine receptor via a cross-talk that

294 The M2 subtype of muscarinic acetylcholine receptors was upregulated in hu

295 onist-induced internalization of subtypes of muscarinic acetylcholine receptors, we analyzed the role

296 ion depended on local activation of cortical muscarinic acetylcholine receptors, whereas the increase

297 CHRM3 encodes the M3 muscarinic acetylcholine receptor, which we show is pres

298 nous activation of metabotropic glutamate or muscarinic acetylcholine receptors with submaximal TBF u

299 e distribution of profiles containing the m2-muscarinic acetylcholine receptor within the aged human

300 Autoantibodies against the muscarinic acetylcholine receptors would provide a link