ライフサイエンスコーパス: muscarinic receptor

1 HT(2A)) or scopolamine (an antagonist of the muscarinic receptor).

2 not exhibit SOCE following activation of the muscarinic receptor.

3 ovary cells stably expressing the human M(2) muscarinic receptor.

4 rdinate both processes for the Gq-coupled M1 muscarinic receptor.

5 ransiently transfected with TRPC5 and the M1 muscarinic receptor.

6 he quaternary organization of the related M3 muscarinic receptor.

7 ta2-adrenergic receptor (beta2AR) and the M2 muscarinic receptor.

8 uately explained solely by its antagonism at muscarinic receptors.

9 eric activation and allosteric modulation of muscarinic receptors.

10 ation mechanism and allosteric modulation of muscarinic receptors.

11 sure of the agonist to a wider population of muscarinic receptors.

12 cells, which express the beta-adrenergic and muscarinic receptors.

13 t involves direct antagonism of M1 and/or M3 muscarinic receptors.

14 edominantly by parasympathetic activation of muscarinic receptors.

15 pharmacological inhibition of purinergic and muscarinic receptors.

16 t evoked by activation of expressed m1 or m3 muscarinic receptors.

17 d acetylcholine release via activation of M1 muscarinic receptors.

18 tivity on signal transduction via Gq-coupled muscarinic receptors.

19 parasympathetic ACh slows the heart through muscarinic receptors.

20 iny GABAergic neurons that primarily express muscarinic receptors.

21 gonists, we identified these receptors as M2 muscarinic receptors.

22 n astrocytes was due to the activation of M3 muscarinic receptors.

23 ions (basket cells, BCs) were depolarized by muscarinic receptors.

24 that this effect is mediated exclusively by muscarinic receptors.

25 ing cholinergic system through nicotinic and muscarinic receptors.

26 This effect was mainly mediated by muscarinic receptors.

27 Solely by Synthetic Ligand (RASSL) forms of muscarinic receptors.

28 were mediated by co-activation of M1 and M3 muscarinic receptors.

29 CNQ channels and is known to be inhibited by muscarinic receptors.

30 acetylcholine, the latter occurring through muscarinic receptors.

31 al proliferation and tumorigenesis in an ACh muscarinic receptor-3 (M3R)-dependent manner, in part th

32 l subunits [Cacna1c and Cacnb2], cholinergic muscarinic receptor 4 [Chrm4)], dopamine receptor D2 [Dr

33 The X-ray crystal structure of the M2 muscarinic receptor, a key GPCR that regulates human hea

34 beta1AR) and activating autoantibodies to M2 muscarinic receptors (AAM2R) in the genesis of atrial fi

35 ium channels is sufficient to reconstitute a muscarinic receptor-activated inward aftercurrent in hum

36 tro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and s

37 We tested whether M1 muscarinic receptor activation enhances glutamatergic sy

38 Muscarinic receptor activation facilitates the induction

39 Insulin secretion was shown to be induced by muscarinic receptor activation in a pancreatic beta cell

40 Muscarinic receptor activation in these cells appears to

41 receptor type contributions, we find that m2 muscarinic receptor activation increases glomerular sens

42 In contrast, muscarinic receptor activation increases mitral cell spi

43 Previous studies have suggested that muscarinic receptor activation modulates glutamatergic t

44 Muscarinic receptor activation resulting from ACh releas

45 d from lacrimal glands, we demonstrated that muscarinic receptor activation stimulates a phospholipas

46 omponents of the signalling pathway coupling muscarinic receptor activation to changes in chemorecept

47 Although PV BCs were also excited by muscarinic receptor activation, they more frequently res

48 nt in Tg.sgk-SCG neurons was counteracted by muscarinic receptor activation.

49 ayed increase in excitability in response to muscarinic receptor activation.

50 trinsic glial properties related to enhanced muscarinic receptor activation.

51 ter the stimulation paradigm and were due to muscarinic receptor activation.

52 d theta oscillations, and both nicotinic and muscarinic receptor activity contributed to this process

53 that these drugs potently inhibited in situ muscarinic receptor activity.

54 The muscarinic receptor agonist 'BuTAC' was previously shown

55 RTN chemoreceptors to ACh was mimicked by a muscarinic receptor agonist (oxotremorine; 1 mum), and b

56 The muscarinic receptor agonist carbachol activated ERK1/2 b

57 Here we demonstrate that the muscarinic receptor agonist carbachol activates AMPKalph

58 ncreased as rapidly as that initiated by the muscarinic receptor agonist carbachol, which promoted an

59 Effects of a muscarinic receptor agonist oxotremorine-M (oxo-M) on bl

60 Carbachol, a known nAChR and muscarinic receptor agonist, up-regulated both alpha4bet

61 uction following injection of pilocarpine, a muscarinic receptor agonist.

62 served more than 30 min after removal of the muscarinic receptor agonist.

63 ationship between the efficacy of seven M(3) muscarinic receptor agonists and their rate of dissociat

64 Muscarinic receptor agonists are characterized by appare

65 rat following injection of small amounts of muscarinic receptor agonists into the caudal oral pontin

66 currently limited to medications (e.g., the muscarinic receptor agonists pilocarpine and cevimeline)

67 salivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpine and cevimeline

68 20 to probe specifically the human M2 and M4 muscarinic receptor allosteric binding sites.

69 scarinic receptors, and stimulation of these muscarinic receptors also correlated with a 2-fold incre

70 GABAA-LTP requires the activation of M1-muscarinic receptors and an increase in cytosolic Ca(2+)

71 Moreover, at least in the airways, muscarinic receptors and beta-adrenoceptors are expresse

72 Muscarinic receptors and beta-adrenoceptors are physiolo

73 suggested that lipid rafts colocalized both muscarinic receptors and channel subunits to enable rece

74 erreactivity to contraction mediated by M(3)-muscarinic receptors and diminished relaxation mediated

75 hat this population expressed adrenergic and muscarinic receptors and displayed transcriptional profi

76 to the efficient coupling between endogenous muscarinic receptors and GIRK channels, we found that fi

77 re, we investigated the regulation of native muscarinic receptors and Kir3 channels expressed in NGF-

78 These effects are mediated by M1-type muscarinic receptors and occur in a casein kinase-2-depe

79 -regulated lung expression of M1, M2, and M3 muscarinic receptors and phosphodiesterase (PDE)4D5 isoz

80 garding the intrinsic voltage sensitivity of muscarinic receptors and the consequences of this intrig

81 tor rolipram attenuates the increase in AHR, muscarinic receptors, and PDE4D5, but fails to down-regu

82 ologically to involve endogenously expressed muscarinic receptors, and stimulation of these muscarini

83 Here we show that muscarinic receptor antagonism at the hypoglossal motor

84 In both experiments, nucleus accumbens muscarinic receptor antagonism caused subsequent avoidan

85 In addition, a muscarinic receptor antagonist reduces LID.

86 ction would improve depressive symptoms, the muscarinic receptor antagonist scopolamine manifested an

87 ing iontophoretic application of the general muscarinic receptor antagonist scopolamine with single-c

88 This study tests the hypothesis that muscarinic receptor antagonist therapy with tiotropium b

89 studies have suggested that the long-acting muscarinic receptor antagonist tiotropium, a drug widely

90 gonist), or methoctramine (a selective M2/M4 muscarinic receptor antagonist).

91 Here, we show that the muscarinic receptor antagonist, atropine, eliminated the

92 treatment with solifenacin, an FDA-approved muscarinic receptor antagonist, increased oligodendrocyt

93 0, 0.03, or 0.1 mg/kg, intraperitoneally), a muscarinic receptor antagonist, or mecamylamine (0, 0.75

94 es report that scopolamine, an acetylcholine muscarinic receptor antagonist, produces rapid antidepre

95 herapy with tiotropium bromide, an M1 and M3 muscarinic receptor antagonist, will decrease the airway

96 either saline or scopolamine, a nonselective muscarinic receptor antagonist.

97 haled bronchodilators, including long-acting muscarinic receptor antagonists (LAMA) and long-acting b

98 ntribute to a rationale for a combination of muscarinic receptor antagonists and beta-adrenoceptor ag

99 Muscarinic receptor antagonists and beta-adrenoceptor ag

100 The novel inhaled muscarinic receptor antagonists are potentially useful t

101 Nicotinic but not muscarinic receptor antagonists block allergen- or nicot

102 nd can be reliably and completely blocked by muscarinic receptor antagonists.

103 rendered ineffective by either nicotinic or muscarinic receptor antagonists.

104 c activation is less well understood, though muscarinic receptors are implicated in olfactory learnin

105 3), we used carbachol, a ligand specific for muscarinic receptor, as the secretagogue.

106 usly shown that dendritic cells (DC) express muscarinic receptors, as well as the enzymes responsible

107 To assess the role played by the muscarinic receptors at the hippocampal-frontal cortex s

108 t study, by expressing an arrestin-biased M3 muscarinic receptor-based DREADD (M3D-arr) in stable hER

109 tudy, we describe the development of an M(3) muscarinic receptor-based DREADD [Rq(R165L)] that is no

110 orylation site in a region homologous to the muscarinic receptor-binding site of Tau suggests that MA

111 Alternatively, muscarinic receptor blockade may cause a negative hedoni

112 Here, we examined the effects of muscarinic receptor blockade on rule-related activity in

113 Overall, our results suggest that muscarinic receptor blockade results in a bona fide lear

114 iated since they were eliminated by systemic muscarinic receptor blockade.

115 -like behavior and which are reversed by the muscarinic receptor blockade.

116 port the crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotr

117 Transient activation of muscarinic receptors by carbachol results in a long-last

118 Furthermore, we demonstrate that the M3-muscarinic receptor can be differentially phosphorylated

119 Recently, we found that bivalent agonists of muscarinic receptors can simultaneously occupy both the

120 (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene.

121 A-343 in the mouse ileum included a non-M(3) muscarinic receptor component.

122 e et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine

123 um and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.

124 xperiments, whereas blockade of nicotinic or muscarinic receptors decreased perceptual discrimination

125 bdivision; 3) distinct kainate, alpha2 , and muscarinic receptor densities that rendered distinctive

126 disease brain usurp endogenous acetylcholine muscarinic receptor-dependent long-term depression, to e

127 elial cell adhesion molecule expression in a muscarinic receptor-dependent manner.

128 odulate the SCA-induced locomotor rhythm via muscarinic receptor-dependent mechanisms and that the mo

129 r cholinergic constraint that is mediated by muscarinic receptor-dependent regulation of mitochondria

130 1) quinone reductase 2 (QR2) expression is a muscarinic-receptor-dependent removable constraint on me

131 Blocking muscarinic receptors depressed taste-evoked responses in

132 Block of muscarinic receptors did not affect action potentials or

133 We found that stimulation of muscarinic receptors, either by an agonist or by the syn

134 Muscarinic receptors endogenous to HEK293 cells were ide

135 l class I GPCRs, the beta2 adrenergic and M3 muscarinic receptors, enter cells constitutively by clat

136 f these agents depends on the blockade of M3 muscarinic receptors expressed on airway smooth muscle c

137 40 diminished eNOS and nNOS as well as M1-M4 muscarinic receptor expression and also affected puriner

138 eased AHR might reflect increased PDE4D5 and muscarinic receptor expression, the mechanisms underlyin

139 These results suggest that activation of muscarinic receptors facilitates mechano-sensitive, caps

140 Each subtype of the muscarinic receptor family of G protein-coupled receptor

141 orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in t

142 The alteration of PSC muscarinic receptor functions also persists during the p

143 Here we identify a muscarinic receptor (GAR-2) and the GABA(B) receptor dim

144 and chrm5b, isolated here, as well as other muscarinic receptor genes and their duplicates and sugge

145 Blockade of muscarinic receptors had no effect on evoked dopamine re

146 Nicotinic and muscarinic receptors have been found on both the sensory

147 Although muscarinic receptors have been implicated in executive p

148 lidal MSN activity via a Gq-coupled human M3 muscarinic receptor (hM3Dq), a type of designer receptor

149 Using the activatory Gq-coupled human M3 muscarinic receptor (hM3Dq), we found that chemogenetic

150 Antagonizing the human M3 muscarinic receptor (hM3R) over a long time is a key fea

151 ocus, using viral expression of the modified muscarinic receptor hM4Di.

152 Activation of these endogenous muscarinic receptors however, failed to suppress express

153 Blocking muscarinic receptors impairs learning for nearly all odo

154 muscarinic acetylcholine receptor, the major muscarinic receptor in beta cells.

155 79 or AKAP15, rescued suppression of I(M) by muscarinic receptors in AKAP150(-/-) neurons.

156 lexander disease patients, and that blocking muscarinic receptors in Alexander disease model mice red

157 rtaken to investigate whether stimulation of muscarinic receptors in astrocytes would modulate neurit

158 tter ACh targets nicotinic (nAChRs), but not muscarinic receptors in bone cells, affecting mainly ost

159 These results demonstrate that blockade of muscarinic receptors in DLPFC creates deficits in workin

160 The finding that blockade of muscarinic receptors in mPFC impaired trace conditioning

161 synaptic activity mediated by M(1) and M(2) muscarinic receptors in MSNs, consisting of an increase

162 x behavior of oligomers is characteristic of muscarinic receptors in myocardial preparations.

163 del suggests that the roles of nicotinic and muscarinic receptors in olfactory bulb are both distinct

164 ts encourage a more general understanding of muscarinic receptors in PR and they motivate additional

165 ed M2 muscarinic receptor were compared with muscarinic receptors in sarcolemmal membranes for the ef

166 In contrast, stimulation of endogenous muscarinic receptors in SH-SY5Y cells did not regulate p

167 These results indicate that muscarinic receptors in striatal output neurons reliably

168 is potently reduced by signaling through M1 muscarinic receptors in striatopallidal neurons, but not

169 direct activation of G protein-coupled, M(3) muscarinic receptors in the absence of exogenous agonist

170 Pharmacological blockade of muscarinic receptors in the nucleus accumbens reduces fo

171 ral blockade of cholinergic nicotinic and/or muscarinic receptors in the OB.

172 The present study evaluated the role of PR muscarinic receptors in trace fear conditioning.

173 chol was blocked by antagonists of M1 and M3 muscarinic receptors in two subpopulations of BF GABAerg

174 , previous work suggested a role of ACh, via muscarinic receptors, in the modulation of information t

175 on with a three-dimensional model of the M 3 muscarinic receptor, indicate that M 3 receptor activati

176 from their striatal terminals, activation of muscarinic receptors induced Ca2+ mobilization and inwar

177 estigated the molecular basis underlying the muscarinic receptor-induced afterdepolarization using mo

178 RPC5 or TRPC6 enhances, the amplitude of the muscarinic receptor-induced inward aftercurrent.

179 ults indicate that TRPC channels mediate the muscarinic receptor-induced slow afterdepolarization see

180 ically encoded biosensor, that activation of muscarinic receptor induces the breakdown of phosphatidy

181 nt of cells expressing such mutants with the muscarinic receptor inverse agonist atropine increased c

182 The M2 muscarinic receptor is the prototypic model of allostery

183 Acetylcholine (ACh) modulation, through muscarinic receptors, is a particularly widespread mecha

184 which is a known allosteric modulator of the muscarinic receptors, is also shown to be a modulator of

185 For the M(2) muscarinic receptor, it was further shown that depolariz

186 Q K(+) channel current by activation of M(1) muscarinic receptors; KCNQ channels require PIP(2) for t

187 Surprisingly, these upregulated muscarinic receptor/Kir3 signaling complexes were functi

188 activity was measured on the ileum from M(2) muscarinic receptor knockout mice, a convenient assay fo

189 tussis toxin or in myocytes from M2- or M1/3-muscarinic receptor knockout mice, atropine increased cA

190 or genetic disruption of the stromal type 1 muscarinic receptor, leading to improved survival of the

191 ein kinase C-dependent event promoted by the muscarinic receptor ligand carbachol in freshly disperse

192 to bind acetylcholine (ACh), the endogenous muscarinic receptor ligand, but can be efficiently activ

193 (1)-adrenergic receptor (beta(1)AR) and M(2) muscarinic receptor (M(2)R) activation involve compartme

194 )-coupled DOR and the Galpha(q)-coupled M(3) muscarinic receptor (M(3)R) was increased but not signal

195 e specificity of RGS2, -3, -4, -5, or -8 for muscarinic receptors (M(1), M(3), and M(5)).

196 Chronic stimulation of M(2) muscarinic receptors (M(2)Rs) causes internalization of

197 ress and most colon cancers overexpress M(3) muscarinic receptors (M(3)R).

198 and Galpha(1)(3) coupled receptors (such as muscarinic receptor, m1, and thrombin receptor, PAR-1) a

199 ct the PM localization or function of the M1 muscarinic receptor (M1R)/Gq signaling cascade.

200 orded with another cognate G protein-coupled muscarinic receptor, M1R.

201 ized the oligomeric status of eGFP-tagged M2 muscarinic receptor (M2R) and Gi1 by single-particle pho

202 -2 regulates expression of the C. elegans M2 muscarinic receptor (m2R) ortholog, GAR-2.

203 tic regulation of HR and the prototypical M2 muscarinic receptor (M2R)-dependent signaling pathway in

204 eceptor that activates KACh channels, the M2 muscarinic receptor (M2R).

205 Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basolate

206 Based on our expertise with type 3 muscarinic receptor (M3), we used carbachol, a ligand sp

207 with the third intracellular loop of the M3 muscarinic receptor (M3-MR), and SET knockdown with smal

208 evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLCbeta3.

209 esonance energy transfer studies with the M3 muscarinic receptor (M3R), a prototypic class A GPCR, th

210 beta-Cell M3 muscarinic receptors (M3Rs) are known to play an essenti

211 monstrated that activation of beta-cell M(3) muscarinic receptors (M3Rs) greatly promotes glucose-sti

212 endogenous cholinergic signaling through M4 muscarinic receptors (M4Rs) promoted long-term depressio

213 In this study, we determined which muscarinic receptor (mAChR) subtypes are present in the

214 We partially cloned three subtypes of muscarinic receptors (mAChR2, -3, and -4) from brain tis

215 odulates glutamate release via activation of muscarinic receptors (mAchRs), although the consequences

216 tylcholine receptors, nicotinic (nAChRs) and muscarinic receptors (mAChRs), are expressed by vestibul

217 We propose that the M3 muscarinic receptor maximizes the efficiency of PLCbeta3

218 Both receptors mediate Ca2+ influx whereas muscarinic receptors may also recruit Ca2+-sensitization

219 sleep control mechanisms down stream of the muscarinic receptors may be the responsible factors.

220 duplicates and suggests previously described muscarinic receptors may need to be reclassified.

221 ayers of primary motor cortex (M1) through a muscarinic-receptor mediated mechanism, gamma oscillatio

222 A similar loss of muscarinic receptor-mediated suppression of M current na

223 h excited c-ACs, but inhibited NGFCs through muscarinic receptor-mediated, IP3 receptor-dependent ele

224 The G-protein-coupled muscarinic receptor mimetic carbachol, the phorbol ester

225 This interaction was specific with regard to muscarinic receptor (MR) and AGAP subtypes, and mediated

226 Sites labeled for the three muscarinic receptor mRNAs were found in various brain re

227 electivity, has been increasingly applied to muscarinic receptors (MRs).

228 ergic tone or antagonizing postsynaptic M(1) muscarinic receptors normalized synaptic activity.

229 Activation of M1 muscarinic receptors occurs through orthosteric and allo

230 (ACh) from medial septal afferents activates muscarinic receptors on both vasoactive intestinal pepti

231 g through the thalamic radiation activate M1 muscarinic receptors on TC projections and sustain gluta

232 arasympathetic nerves blocks inhibitory M(2) muscarinic receptors on the parasympathetic nerves, incr

233 e-dependent inhibition of DA release through muscarinic receptors only in the shell, where higher act

234 uire inhibitory action of either presynaptic muscarinic receptors or presynaptic cannabinoid receptor

235 l, inhibiting the effects of ACh by blocking muscarinic receptors, or by selectively activating hyper

236 ACh accessibility to a select population of muscarinic receptors, possibly only those expressed by I

237 be partially attributed to the M2 subtype of muscarinic receptors, possibly through a combination of

238 Stimulation of muscarinic receptors promotes memory consolidation in se

239 ts with selective affinity for acetylcholine muscarinic receptors provide a potentially new mechanism

240 r, the majority of the VF neurons express M2 muscarinic receptors, raising the possibility that the e

241 Activation of muscarinic receptors recruits CPI-17, but not MYPT1-medi

242 Muscarinic receptors regulate airway smooth muscle tone,

243 , Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates striatal plasticity.

244 enol-stimulated NCX current, indicating that muscarinic receptor regulation operates via protein phos

245 Muscarinic receptors represent a promising therapeutic t

246 tylcholine (ACh) that bind to purinergic and muscarinic receptors, respectively.

247 Genetic deletion of muscarinic receptors resulted in significantly diminishe

248 ffects on prominent events downstream of the muscarinic receptor second messengers diacylglycerol (de

249 y and underlie the K(+) current sensitive to muscarinic receptor signaling (the M current) in sympath

250 Endothelial-dependent muscarinic receptor signaling also acted largely through

251 Although M(1) muscarinic receptor signaling was a factor, it was not s

252 be a complex pattern of the regulation of M3 muscarinic receptor signaling.

253 Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor ne

254 sal striatum and pharmacological blockade of muscarinic receptors, specifically postsynaptic M1 and M

255 um nitroprusside was ultimately dependent on muscarinic receptor stimulation as all effects were bloc

256 and this response was reversed by concurrent muscarinic receptor stimulation with the addition of car

257 SS use secretagogues to induce secretion via muscarinic receptor stimulation.

258 and docking studies based on recently solved muscarinic receptor structures, further support the defi

259 tanding of the potential that members of the muscarinic receptor subtype family hold as therapeutic d

260 However, the specific muscarinic receptor subtype involved and the critical in

261 striatal cholinergic interneurons (ChIs) and muscarinic receptor subtypes (mAChRs) in the occurrence

262 ere we examine the localization of m1 and m2 muscarinic receptor subtypes across subpopulations of GA

263 Mutational modification of distinct muscarinic receptor subtypes has yielded novel designer

264 s, due to indiscriminate activation of other muscarinic receptor subtypes, are common.

265 Of the five muscarinic receptor subtypes, the M5 receptor is the onl

266 ating agents show high affinity for all five muscarinic receptor subtypes, thus increasing the likeli

267 ckers that have little or no effect on other muscarinic receptor subtypes.

268 rthosteric binding pocket at any of the five muscarinic receptor subtypes.

269 provide the initial activation of MLCK with muscarinic receptors supporting sustained responses.

270 ion releases presynaptic gating through M(1) muscarinic receptors that downregulate adenosine inhibit

271 this notion, we find that sAHP inhibition by muscarinic receptors that increase phosphoinositide turn

272 First, we used cell lines with M1 (muscarinic) receptors that couple to phospholipase C's (

273 Monomers and oligomers of the M2 muscarinic receptor therefore have been compared to iden

274 nese hamster ovary cells that expressed M(3) muscarinic receptors; this enhancement was observed for

275 tylcholine release at these synapses allowed muscarinic receptors to faithfully encode physiological

276 hin the orthosteric pockets of M(1) and M(2) muscarinic receptors to identify where acetylcholine mus

277 carbachol and that these agents act through muscarinic receptors to induce pigment granule dispersio

278 We find that the ability of muscarinic receptors to induce the inward aftercurrent u

279 ACh then activates MAPK/ERK via muscarinic receptors to promote neurite outgrowth.

280 1 cascade plays a key role in the ability of muscarinic receptors to signal the inward aftercurrent.

281 In both cell types activation of their muscarinic receptors triggers a general increase of exci

282 rough distinct actions at both nicotinic and muscarinic receptors, triggers a procession of neural os

283 ium-dependent vasodilatations in response to muscarinic receptor, TRPV4 (transient receptor potential

284 vasodilatations in response to activation of muscarinic receptors, TRPV4 channels or IK/SK channels w

285 n's Syndrome (SS) and HCV, presence of anti- muscarinic receptor type 3 (M3R) antibodies in SS, the r

286 Here we show that muscarinic receptor type-1 (Chrm1) signaling in the hypo

287 erved in principal neurons were dependent on muscarinic receptors type 1, engaging different intracel

288 One pathway shown for KCNQ2 and muscarinic receptors uses PKC, recruited to the channels

289 Thus, during submaximal activation of muscarinic receptors, V(m) can modulate Ca(2+) entry thr

290 ed previously that amiodarone interacts with muscarinic receptors via a novel allosteric site.

291 Stimulation of the M(3)-muscarinic receptor was shown to inhibit the ability of

292 t a classical G(q/11)-coupled GPCR, the M(3)-muscarinic receptor, was able to regulate apoptosis thro

293 tructure-based docking against the M2 and M3 muscarinic receptors, we screened 3.1 million molecules

294 To study the role of cochlear muscarinic receptors, we studied receptor localization w

295 ed monomers and tetramers of the purified M2 muscarinic receptor were compared with muscarinic recept

296 ral GPCRs, including beta2-adrenergic and M2 muscarinic receptors, which are commonly used as represe

297 Astrocytes express muscarinic receptors whose activation stimulates a robus

298 eversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitati

299 anced calcium mobilization after stimulating muscarinic receptors with carbachol and after stimulatin

300 reatment of cells expressing either m1 or m3 muscarinic receptors with methyl-beta-cyclodextrin produ