ライフサイエンスコーパス: muscle mass

1 cently identified as a positive regulator of muscle mass).

2 n-6 and MCP-1 levels, and decreased skeletal muscle mass.

3 Myostatin is a negative regulator of muscle mass.

4 this ligand as a negative regulator of adult muscle mass.

5 .007] were independent predictors of reduced muscle mass.

6 emale gravidity and increased male hind limb muscle mass.

7 n excretion, reflecting the loss of skeletal muscle mass.

8 body weight, total body protein and fat, and muscle mass.

9 nhibit protein synthesis, leading to loss of muscle mass.

10 mor-induced inflammation and loss of fat and muscle mass.

11 e primary outcome was change in appendicular muscle mass.

12 o be the best performer in the estimation of muscle mass.

13 ted with fat-free mass, which is a marker of muscle mass.

14 synthesis is essential to preserve skeletal muscle mass.

15 to underestimate SM among those with larger muscle mass.

16 h which mechanical stimuli regulate skeletal muscle mass.

17 ) protein BRD4 as an epigenetic regulator of muscle mass.

18 t the BMP pathway is a positive regulator of muscle mass.

19 as significantly reduced after adjusting for muscle mass.

20 ating inquiries into molecular regulation of muscle mass.

21 terized by impaired regeneration and loss of muscle mass.

22 essive mitochondrial dysfunction and loss of muscle mass.

23 , and this leads to only a small increase in muscle mass.

24 splice variant PGC1alpha4 increase skeletal muscle mass.

25 1 are potent negative regulators of skeletal muscle mass.

26 protein could also be important enhancers of muscle mass.

27 y member, and negative regulator of skeletal muscle mass.

28 resistance exercise, promote an increase in muscle mass.

29 cephalopathy through an increase in skeletal muscle mass.

30 ed with increased body weight, bone size and muscle mass.

31 hat SNARK may function in the maintenance of muscle mass.

32 b bud where they form the dorsal and ventral muscle masses.

33 in vitro Unexpectedly, a marked decrease in muscle mass (10%) was found after Alk4 AON treatment in

34 achectic patients had reduced (appendicular) muscle mass (-10%), muscle fiber atrophy (-27%), and dec

35 ght TA muscles exhibited 20 +/- 3% decreased muscle mass, 2-fold decreased phosphorylated (P)-Akt, an

36 antially less muscle atrophy, an increase in muscle mass after denervation, and reorganization of mot

37 P signaling is essential for conservation of muscle mass after disruption of the neuromuscular juncti

38 deletion of Pak1 and Pak2 results in reduced muscle mass and a higher proportion of myofibers with a

39 ental ablation of these cells causes loss of muscle mass and a reduction of B-lymphopoiesis and eryth

40 th ACVR2B/Fc showed significant increases in muscle mass and amelioration of fibrotic changes normall

41 Sod1(-/-) mice) leads to accelerated loss of muscle mass and contractile force during aging.

42 ibit myopathic features, including decreased muscle mass and contractile force.

43 ass, improved grip strength, higher skeletal muscle mass and diameter, and an increase in type 2 fibe

44 was significantly associated with decreased muscle mass and exercise tolerance; untreated LH/FSHD wa

45 ircumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differ

46 d, dnOrai1 mice exhibit reduced body weight, muscle mass and fibre cross-sectional area.

47 Sod1(-/-) mice leads to accelerated loss of muscle mass and force during aging, but the losses do no

48 ve mechanical loading attenuates the loss of muscle mass and force-generation capacity associated wit

49 nhibition would improve recovery of skeletal muscle mass and function after cerebral ischemia.

50 Age-associated declines in muscle mass and function are major risk factors for an i

51 tegies that can slow the age-related loss of muscle mass and function are needed to help older adults

52 lated oxidative damage or rescue the loss of muscle mass and function associated with aging of skelet

53 ave been used in clinical trials to increase muscle mass and function but most showed limited efficac

54 essential for our ability to restore loss of muscle mass and function in cases where the natural abil

55 n-3 PUFA therapy slows the normal decline in muscle mass and function in older adults and should be c

56 Physical inactivity triggers a rapid loss of muscle mass and function in older adults.

57 sefulness of techniques based on measures of muscle mass and function in women.

58 RATIONALE: Loss of skeletal muscle mass and function is a common consequence of crit

59 Age-related loss of skeletal muscle mass and function is a key contributor to physica

60 Age-related loss of skeletal muscle mass and function is a major contributor to morbi

61 Loss of skeletal muscle mass and function occurs with increasing age.

62 timately contributes to the systemic loss of muscle mass and function termed sarcopenia.

63 icial effects of metallothionein blockade on muscle mass and function was also observed in the settin

64 ng, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity

65 estigated the effects on age-related loss of muscle mass and function, changes in redox homeostasis,

66 In addition to impairing muscle mass and function, Folfiri had severe negative ef

67 sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear.

68 ch may contribute to the age-induced loss of muscle mass and function, sarcopenia.

69 Age-related loss of muscle mass and function, termed sarcopenia, is a catast

70 ission precede a clinically-relevant loss of muscle mass and function.

71 nts with severe COPD by enhancing quadriceps muscle mass and function.

72 progressive and generalized loss of skeletal muscle mass and function.

73 A therapy to slow the age-associated loss of muscle mass and function.

74 unexplored dietary strategy to help maintain muscle mass and function.

75 may attenuate loss, or enhance recovery, of muscle mass and function.

76 now emerged as a major regulator of skeletal muscle mass and function.

77 in severe loss of motor ability and skeletal muscle mass and function.

78 aralysis, or bed rest leads to rapid loss of muscle mass and function; however, the molecular mechani

79 ir essential functions in maintaining normal muscle mass and hematopoiesis, respectively.

80 (Does a Drug Allopurinol Reduce Heart Muscle Mass and Improve Blood Vessel Function in Patient

81 in airway remodeling, with increased smooth muscle mass and increased fibrosis in the absence of air

82 in is a major negative regulator of skeletal muscle mass and initiates multiple metabolic changes, in

83 However, creatinine is a product of muscle mass and is therefore associated with body mass.

84 tration and significantly increased skeletal muscle mass and lean body mass over time.

85 d no significant difference in both skeletal muscle mass and lean body mass.

86 k of bed rest substantially reduces skeletal muscle mass and lowers whole-body insulin sensitivity, w

87 In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported following mo

88 regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes.

89 nown if there are age-related differences in muscle mass and muscle anabolic and catabolic responses

90 Sarcopenia (AWGS) criteria that include both muscle mass and muscle function/physical activity.

91 statin antibody (ATA 842) for 4 wk increased muscle mass and muscle strength in both groups.

92 receptor NOR1 (Nr4a3) had minimal effect on muscle mass and myofiber size.

93 ecific deficiency in Nur77 exhibited reduced muscle mass and myofiber size.

94 biomarkers and evaluate its association with muscle mass and patient outcomes.

95 ce, concomitant with increased airway smooth muscle mass and peribronchial collagen deposition.

96 RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly men.In this

97 ctive of how sarcopenia is defined, both low muscle mass and poor muscle strength are clearly highly

98 tor 2B signaling, has been shown to preserve muscle mass and prolong survival in tumor hosts, and to

99 that YAP positively regulates basal skeletal muscle mass and protein synthesis.

100 er, D2O heralds promise for coupling MPS and muscle mass and providing insight into the control of hy

101 raining was very effective in restoring both muscle mass and qualitative muscle changes, indicating t

102 animals had proportionally less contractile muscle mass and smaller gills and foot compared with you

103 hways are essential for maintaining skeletal muscle mass and strength and for protection against canc

104 s in mice showed that hyperammonemia reduced muscle mass and strength and increased myostatin express

105 Sarcopenia, the loss of muscle mass and strength during normal aging, involves c

106 ition, little is known about the recovery of muscle mass and strength following disuse.

107 rical muscle stimulation appears to preserve muscle mass and strength in long-stay participants and i

108 KEY POINTS: Loss of muscle mass and strength in the growing population of el

109 rategies for preventing declines in skeletal muscle mass and strength with age.

110 ACVR2B/Fc prevented the loss of muscle mass and strength, and the loss of trabecular bon

111 to ageing, could also accelerate decrease of muscle mass and strength, and this effect could be a mai

112 Aging reduces skeletal muscle mass and strength, but the underlying molecular m

113 copenia, the age-associated loss of skeletal muscle mass and strength.

114 cked adipose tissue browning and the loss of muscle mass and strength.

115 of E2F results in a significant reduction in muscle mass and thinner myofibrils.

116 to overestimate SM among women with smaller muscle mass and to underestimate SM among those with lar

117 (Delta/Delta) ) would exhibit an increase in muscle mass and total force production, a reduction in s

118 pinning this finding, such as a low skeletal muscle mass and/or fluid overload.

119 ecretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation.

120 e) is common in humans and reduces strength, muscle mass, and fast-twitch fiber diameter, but increas

121 maximum tetanic tension, decreased tibialis muscle mass, and fiber diameter due to inflammation alon

122 ta = -0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but th

123 ith high muscle mass, low adiposity with low muscle mass, and HA-LM-and a subclassification of the ph

124 nicotinic acetylcholine receptor expression, muscle mass, and histologic changes (structural paramete

125 s another family member negatively regulates muscle mass, and its blockade enhances muscle growth see

126 for mechanically induced changes in skeletal muscle mass, and previous studies have suggested that me

127 activin A as a second negative regulator of muscle mass, and suggest that inhibition of both ligands

128 Inhibition of myostatin signaling increases muscle mass, and therapeutic approaches based on this ar

129 e/degenerative status of the muscle, overall muscle mass, and tissue expression levels.

130 The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant

131 yostatin induced a more profound increase in muscle mass ( approximately 45%), demonstrating a more p

132 extracellular matrix (ECM) and larger smooth muscle mass are correlated with increased airway respons

133 Bone and skeletal muscle mass are highly correlated in mammals, suggesting

134 ed to prevent age-dependent loss of skeletal muscle mass associated with myofiber atrophy or alter a

135 emographic, tumor, and treatment factors and muscle mass at diagnosis.

136 Surprisingly, mKO mice maintain muscle masses at or above those of wild-type control mic

137 stronger effect in preventing aging-related muscle mass attenuation and leg strength loss in older p

138 de decreased body and facial hair, decreased muscle mass, breast growth, and redistribution of fat.

139 dipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation or increa

140 a mechanically induced increase in skeletal muscle mass, but the mechanism(s) through which mechanic

141 ls play a critical role in the regulation of muscle mass, but the molecules that sense mechanical sig

142 etary protein was positively associated with muscle mass, but the relation of this distribution to ph

143 AV vector) expressing the beta2-AR increased muscle mass by >20% within 4 weeks.

144 ked, further indicating that TP53INP2 alters muscle mass by activating autophagy.

145 uggest a novel role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factor

146 hic (CT) metrics of bone mineral density and muscle mass can improve the prediction of noncancer deat

147 hypertrophy that was sufficient to preserve muscle mass comparable to that of untreated sham-operate

148 In an exploratory analysis, muscle mass corrected for height was a significant predi

149 was down-regulated in adult wild-type mice, muscle mass decreased even more.

150 Immobilization-induced loss of tibialis muscle mass, decreased fiber diameter, and tetanic fade

151 Skeletal muscle mass decreases in end-stage heart failure and is

152 -knockout (Mstn(-/-)) mice exhibit increased muscle mass due to both hypertrophy and hyperplasia, and

153 even though gene expression of regulators of muscle mass (e.g., MAFbx, MURF1, and myostatin) had peak

154 The sarcopenia index is a fair measure for muscle mass estimation among ICU patients and can modest

155 rovement in TA muscle morphology and gain in muscle mass evident in the WT mice was not noticeable in

156 perfusion during high intensity and/or large muscle mass exercise in older adults.

157 tant across O2 delivery conditions for large muscle mass exercise, but this consistency is equivocal

158 tant across O2 delivery conditions for small muscle mass exercise.

159 ut this consistency is equivocal for smaller muscle mass exercise.

160 atures of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fib

161 rcise capacity (6-min-walk distance [6MWD]), muscle mass (fat-free mass [FFM]), and systemic inflamma

162 and immobilization, the decrease in tibialis muscle mass, fiber diameter, and maximum tetanic tension

163 Many factors contribute to the erosion of muscle mass following burn trauma and we propose that an

164 Many factors contribute to the erosion of muscle mass following burn trauma, and we have previousl

165 resumed habitual physical activity, restored muscle mass from a reduction of 51% after 14 d TTX to a

166 er survival, GTx-026 treatment increased the muscle mass, function and survival, indicating that andr

167 Skeletal muscle mass, function, and repair capacity all progressi

168 ut rather they mediate host regeneration and muscle mass gain in a paracrine manner.

169 ABSTRACT: Significant skeletal muscle mass guarantees functional wellbeing and is impor

170 ombination of the 2 [high adiposity with low muscle mass (HA-LM)] are relevant phenotypes, but data o

171 mposition phenotypes-low adiposity with high muscle mass, high adiposity with high muscle mass, low a

172 The 13-wk change in appendicular muscle mass, however, was different in the intervention

173 been associated with reduced adult skeletal muscle mass; however, the mechanisms responsible for thi

174 Smad7(-/-) mice showed reduced muscle mass, hypotrophy and hypoplasia of muscle fibres,

175 increased body fat, (ii) decreased relative muscle mass, (iii) redistributed muscle mass to lower li

176 sty, a new technique to reduce airway smooth muscle mass, improves symptoms and reduces exacerbations

177 The relation between muscle mass in advanced age and telomere length, however

178 se training (RET) is widely used to increase muscle mass in athletes and also aged/cachectic populati

179 e growth restriction (IUGR) reduces skeletal muscle mass in fetuses and offspring.

180 s a conserved negative regulator of skeletal muscle mass in mammals.

181 been shown to underlie the loss of skeletal muscle mass in many acquired and genetic muscle disorder

182 yte apoptosis contributes toward the loss of muscle mass in myocardial pathologies.

183 ER stress and UPR in regulation of skeletal muscle mass in naive conditions and during cancer cachex

184 th isocaloric control preserves appendicular muscle mass in obese older adults during a hypocaloric d

185 re modifiable factors associated with higher muscle mass in older adults but not with losses over 2 y

186 ve interventions with the aim of maintaining muscle mass in older men.

187 arch directives designed to protect skeletal muscle mass in physically active, normal-weight adults.

188 anistically, the better recovery of skeletal muscle mass in PINTA745-MCAO mice involved an increased

189 ght novel methods for potentially modulating muscle mass in settings of disease.

190 causes muscle wasting, PGC-1alpha preserves muscle mass in several conditions, including functional

191 ABSTRACT: Reduced skeletal muscle mass in the fetus with intrauterine growth restri

192 therapeutic potential in the preservation of muscle mass in type 2 diabetes.

193 )-Fn14 system are key regulators of skeletal muscle mass in various catabolic states.

194 ular models, has a direct impact on skeletal muscle mass in vivo.

195 tivated transcriptional profiles to increase muscle mass in wild type and R6/2 mice but did little to

196 statin deficiency (Mstn(tm1Sjl/+)) increases muscle mass in wild-type offspring, suggesting an intrau

197 hat road salt runoff can result in increased muscle mass (in males) and neural investment (in females

198 connective tissue locations adjacent to the muscle masses, including cells in the vasculature wall.

199 gs had apparent DM phenotype, and individual muscle mass increased by 100% over their wild-type contr

200 induced a synergistic response, resulting in muscle mass increasing by as much as 150%.

201 graphy data available, unilateral pectoralis muscle mass indexed to body surface area and attenuation

202 vation prevented the severe loss of skeletal muscle mass induced in mice engrafted with Lewis lung ca

203 known or potential circulating modulators of muscle mass--insulin-like growth factor-1, myostatin, an

204 Age-related progressive loss of muscle mass is an increasing problem in our aging societ

205 Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (

206 The maintenance of skeletal muscle mass is critical for sustaining health; however,

207 ABSTRACT: The maintenance of skeletal muscle mass is essential for health and quality of life.

208 use attenuating the extent to which skeletal muscle mass is lost during energy deficit could prevent

209 On the basis of study results showing that muscle mass is only moderately related to functional out

210 Low muscle mass is present in approximately 40% of patients

211 ammonia restores proteostasis and increases muscle mass is unknown.

212 ion of skeletal muscle protein synthesis and muscle mass, it does not appear to be a prerequisite for

213 In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and less efficie

214 ompositions such as high adiposity (HA), low muscle mass (LM), or a combination of the 2 [high adipos

215 Skeletal muscle mass loss and dysfunction have been linked to man

216 is associated with cachexia-induced skeletal muscle mass loss in cancer.

217 etal muscle atrophy is a severe condition of muscle mass loss.

218 discordant combinations such as obesity with muscle mass loss.

219 h high muscle mass, high adiposity with high muscle mass, low adiposity with low muscle mass, and HA-

220 Muscle mass maintenance is largely regulated by basal mu

221 The relationship between bone and skeletal muscle mass may be affected by physical training.

222 est impact of myostatin in the regulation of muscle mass may not be to induce atrophy directly, but r

223 scle depletion is characterized by a reduced muscle mass (myopenia) and increased infiltration by int

224 l performance (n = 24) were more common than muscle mass (n = 8).

225 Although a gradual loss of muscle mass normally occurs with advancing age, its incr

226 mon peroneal nerve-resulted in reductions in muscle mass of 7, 29, and 51% with corresponding reducti

227 Correlation of the gene expression versus muscle mass or age changes, and functional annotation an

228 eatinine independent of GFR (eg, extremes of muscle mass or diet), or interference with the assay, cy

229 ng creatinine excretion, such as extremes of muscle mass or diet, the albumin excretion rate should b

230 0% that of control mice, but no reduction in muscle mass or isometric force was observed in SynTgSod1

231 than control littermates, no differences in muscle mass or strength were observed between genotypes

232 pplementation did not affect the increase in muscle mass or the acute change in protein synthesis, bu

233 Loss of muscle mass, or sarcopenia, is nearly universal in cirrh

234 fore, PGC1beta activation negatively affects muscle mass over time, particularly fast-twitch muscles,

235 (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution of fat (P

236 ed muscles, and SIRT1 levels correlated with muscle mass, paired box protein 7 (Pax7), proliferating

237 ty, and only following exercise with a large muscle mass (PEI following leg cycling) is there a contr

238 at PGC1beta progressively decreases skeletal muscle mass predominantly associated with loss of type 2

239 ucine-, and vitamin D-enriched supplement on muscle mass preservation during intentional weight loss

240 produced significant increases in body mass, muscle mass, quadriceps myofiber size, and survival, but

241 isons between number of muscle deficits (low muscle mass, quadriceps strength and physical performanc

242 ring muscles account for <3% of total flight muscle mass, raising the question of how they can modula

243 Muscle mass reconstitution did not correlate with resolu

244 Loss of Smad7 results in decreased muscle mass, reduced force generation, fibre type switch

245 Muscle mass reflects and influences health status.

246 us into the biochemical events that regulate muscle mass remain ill-defined.

247 phosphorylation) that drive the increase in muscle mass remain undefined.

248 In addition, increases in muscle mass, requirements for nutrition and rest, malada

249 are surrogates for bone mineral density and muscle mass, respectively, were independent predictors o

250 d minor atrophic and hypertrophic changes in muscle mass, respectively.

251 What is the relationship between low muscle mass (sarcopenia) or sarcopenic obesity and cance

252 Low muscle mass (sarcopenia) was defined as fat-free mass in

253 discrimination of patients with low skeletal muscle mass (sarcopenic patients) using computed tomogra

254 as having at least two of the following: low muscle mass, self-reported exhaustion, low energy expend

255 d >/= three of the following conditions: low muscle mass, self-reported exhaustion, low energy expend

256 regional fat distribution and the amount of muscle mass should be introduced into regular clinical p

257 ng LLC-induced cachexia, skm-gp130 regulates muscle mass signaling through STAT3 and p38 for the acti

258 in hypertrophy and negatively correlate with muscle mass, SIRT1 and Nampt levels.

259 aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regenerative c

260 on equations to quantify whole-body skeletal muscle mass (SM) in adults.

261 ms were to characterize deficits in skeletal muscle mass, strength and physical performance, and exam

262 progressive and generalized loss of skeletal muscle mass, strength, and function.

263 Whilst smokers demonstrated lower muscle mass than non-smokers, differences were abolished

264 The term sarcopenia refers to the loss of muscle mass that occurs with ageing.

265 MIGIRKO mice displayed a marked reduction in muscle mass that was linked to increases in proteasomal

266 that TP53INP2 negatively regulates skeletal muscle mass through activation of autophagy.

267 ough endurance-based exercise) and increased muscle mass (through resistance-based exercise), typical

268 f cellular senescence, and imaging to assess muscle mass to detect sarcopenia, may provide insight in

269 Returning muscle mass to levels observed at 7 d TTX administration

270 ed relative muscle mass, (iii) redistributed muscle mass to lower limbs, and (iv) decreased relative

271 of an adaptive mechanism aimed at preserving muscle mass under conditions in which insulin action is

272 A rapid and early loss of skeletal muscle mass underlies the physical disability common amo

273 vely evaluated for skeletal muscle deficits: muscle mass using bioelectrical impedance, quadriceps, r

274 We measured body fat and skeletal muscle mass using whole-body dual X-ray absorptiometry i

275 values of fat mass and appendicular skeletal muscle mass utilizing the LMS statistical procedure.

276 Mechanistically, we show that YAP regulates muscle mass via interaction with TEAD transcription fact

277 -beta proteins to the negative regulation of muscle mass via their activation of the Smad2/3 signalin

278 correlation (r) between sarcopenia index and muscle mass was 0.62 and coefficient of determination (r

279 Specifically, muscle mass was decreased in the soft palates of Tgfbr2

280 The gold standard for muscle mass was quantified with the paraspinal muscle su

281 mong obese patients, cachexia, as defined by muscle mass, was common, with 56% of those with BMI abov

282 tin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal muscle i

283 that determine the recuperative capacity of muscle mass, we studied offspring of FVB mouse dams fed

284 otein requirements, particularly to maintain muscle mass.We investigated whether controlled protein c

285 mposition (lean mass and total body skeletal muscle mass), weight, and walking capacity.

286 Participants' LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorp

287 Training-related increases in muscle mass were related to increases in periosteal bone

288 Muscle loading is important for maintaining muscle mass; when load is removed, atrophy is inevitable

289 IR-/- mice displayed a moderate reduction in muscle mass whereas M-IGF1R-/- mice did not.

290 d by a continuous loss of locomotor skeletal muscle mass, which causes profound muscle weakness.

291 activins are negative regulators of skeletal muscle mass, which have been reported to primarily signa

292 dominantly results from the loss of skeletal muscle mass, which is in part associated with apoptosis.

293 restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance

294 uscle ablation resulted in a 40% increase in muscle mass, which was associated with a significant inc

295 -specific overexpression of Tp53inp2 reduced muscle mass, while deletion of Tp53inp2 resulted in musc

296 K in myocyte survival and the maintenance of muscle mass with age.

297 s developed and grew normally, had increased muscle mass with decreased fat accumulation compared wit

298 reases muscle protein synthesis acutely, and muscle mass with training, but the role of translational

299 d increased autophagy and completely rescued muscle mass without changing proteasomal activity.

300 en, -2.12; P=0.011), lower right ventricular muscle mass (women, 1.58; men 2.45; P=0.001), poorer pea