ライフサイエンスコーパス: muscle-specific

1 relative abundances of sarcomeric Tmods are muscle specific.

2 e wasting and lethality, and this effect was muscle specific.

3 Skeletal muscle-specific 4E-BP1 mediated metabolic protection dir

4 PLCepsilon scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), alon

5 andial glucose disposal in mice, whereas its muscle-specific ablation impaired insulin action and led

6 Last, mice with muscle-specific ablation of IL-10 receptor (M-IL10R(-/-)

7 Muscle-specific ablation of Pik3c2b, but not Pik3c3, res

8 creases in satellite cell number and several muscle-specific abnormalities of hypertrophic signaling.

9 In double mutants the muscle-specific actin binding protein Filamin Ca is up-r

10 Ms1/STARS is a novel muscle-specific actin-binding protein that specifically

11 Mutations in the muscle-specific, actin-severing protein cofilin (unc-60)

12 Altogether, these results suggest that muscle-specific adaptations in contractile speed allow c

13 occur in the 68-residue insert unique to the muscle-specific, alternatively spliced isoform of vincul

14 n-mediated IL-6-EGFP reduction was normal in muscle-specific AMP-activated protein kinase (AMPK) alph

15 Evoked muscle contraction may prevent muscle-specific AMPK failure, restore GLUT4 disposition,

16 in glucose tolerance by cIH was abolished in muscle-specific AMPKalpha1alpha2-deficient mice.

17 Myomerger is skeletal muscle-specific and genetic deletion in mice results in

18 accumulation and metabolism per se influence muscle-specific and systemic metabolic homeostasis and i

19 Additional muscle-specific ankyrin isoforms, ankB and ankG, are loc

20 Interaction between obscurin and the muscle-specific ankyrin sAnk1.5 regulates the organizati

21 ng modules, one of which mediates binding to muscle-specific ankyrins.

22 ppressed mTORC2 but not Nox4, induced smooth muscle-specific apoptosis in small pulmonary arteries, a

23 ation experiments, binds to Cheerio, and the muscle-specific attenuation of cheerio leads to CryAB-li

24 issues; yet the role of skeletal and cardiac muscle-specific autophagy on the benefits of exercise tr

25 integrin activation, although levels of the muscle-specific beta1D-integrin isoform were reduced by

26 n in HSPB8-based PQC machinery may represent muscle-specific biomarkers useful to assess SBMA progres

27 Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO mode

28 ing single and dual AAV vector delivery of a muscle-specific Cas9 cassette together with single-guide

29 The muscle specific caveolin3 (Cav-3) and the caveolae have

30 live zebrafish embryos revealed that loss of muscle-specific Cavin-1 or expression of a dystrophy-ass

31 ty to membrane tension, which was rescued by muscle-specific Cavin-1 reexpression.

32 Heart- and muscle-specific circulating miRNAs (myomirs) increased u

33 esponsible for its production, and created a muscle-specific conditional knockout of the class III ph

34 In studying mice with muscle-specific constitutive ROCK1 activation (mCaROCK1)

35 , Met participants showed significantly less muscle-specific corticospinal sensitivity during action

36 We used skeletal muscle-specific Cpt1b knockout mouse model where the inh

37 Using Myf5-Cre, a muscle-specific Cre driver, and the Cre-loxP recombinati

38 pha combined with tamoxifen-inducible smooth muscle-specific Cre recombinase expression.

39 d1-knockout (mKO) mouse to determine whether muscle-specific CuZnSOD deletion is sufficient to cause

40 Skeletal muscle-specific decrease of Dnm2 during embryogenesis or

41 Conversely, mice with global or muscle-specific deficiency in Nur77 exhibited reduced mu

42 Mice with systemic and smooth muscle-specific deficiency of KLF15 exhibited an aggress

43 mic glucose, we studied mice with a skeletal muscle-specific deficiency of long-chain acyl-CoA synthe

44 Indeed, muscle-specific deletion of Bax, but not the apoptosis r

45 g mice that allow for the inducible skeletal muscle-specific deletion of Bmal1 (iMSBmal1).

46 of smooth muscle from mice harboring smooth muscle-specific deletion of Brg1 revealed altered expres

47 ring aging, but the losses do not occur with muscle-specific deletion of CuZnSOD.

48 Here we report that muscle-specific deletion of FoxO members protects from m

49 Combined muscle-specific deletion of FoxO1, FoxO3, and FoxO4 in M

50 Tamoxifen-induced smooth muscle-specific deletion of HIF-1alpha attenuated pulmon

51 Skeletal muscle-specific deletion of MED13 in mice conferred resi

52 generating mutant mice harboring a skeletal muscle-specific deletion of MRTF-B and a global deletion

53 skeletal muscle atrophy in response to LPS, muscle-specific deletion of MyD88 is not protective.

54 in bladder smooth muscle containing a smooth muscle-specific deletion of MYPT1 in adult mice.

55 smooth muscle in adult mice with (1) smooth muscle-specific deletion of MYPT1; (2) non-phosphorylata

56 In addition, smooth muscle-specific deletion of NFATc1 led to decreased cycl

57 In addition, smooth muscle-specific deletion of NFATc1 prevented the capacit

58 However, combined muscle-specific deletion of Pak1 and Pak2 results in red

59 Muscle-specific deletion of Pik3c3 did not disturb embry

60 Likewise, in young mice, muscle-specific deletion of PKCdelta did not rescue high

61 scle increased, and by 6 to 7 months of age, muscle-specific deletion of PKCdelta improved whole-body

62 Muscle-specific deletion of the glucocorticoid receptor

63 Using mice with muscle-specific deletion of the insulin receptor (M-IR-/

64 Through skeletal muscle-specific deletion of the Mediator subunit MED13 i

65 Antithetically, muscle-specific deletion of the Slc8a1 (NCX1) gene dimin

66 Muscle-specific depletion of klarsicht (nesprin) or klar

67 c mice harboring a ligand-activated skeletal muscle-specific derivative of the eIF2alpha protein kina

68 , and specifically for diseases, the related muscle-specific desmin IF networks.

69 Myf5 is a member of the muscle-specific determination genes and plays a critical

70 lished in transgenic mice with expression of muscle specific dominant-negative AMPK.

71 ohumeral muscular dystrophy mouse model with muscle-specific doxycycline-regulated DUX4 expression.

72 proteasome and messenger RNA expressions of muscle-specific E3 ligases.

73 Up-regulation of specific genes, such as the muscle-specific E3 ubiquitin ligase MAFbx, by FoxO trans

74 Here, we show that skeletal muscle-specific EcSOD transgenic mice are protected from

75 Smooth muscle-specific Efemp2 loss in mouse (termed SMKO) resul

76 em and present evidence supporting a cardiac muscle-specific effect of n-6 PUFAs.

77 ogenesis, but the functions of this striated muscle-specific enzyme in more differentiated skeletal m

78 regeneration in wild-type (M-ERRalphaWT) and muscle-specific ERRalpha(-/-) (M-ERRalpha(-/-)) mice aft

79 s isolated from wild-type (M-ERRgammaWT) and muscle-specific ERRgamma(-/-) (M-ERRgamma(-/-)) mice.

80 Muscle-specific excision prevented weight loss, motor ph

81 showed that that PTBP1 represses many smooth muscle specific exons.

82 Muscle-specific expression of alphaLNNd in dy2J mice res

83 Here, we developed transgenic dy2J mice with muscle-specific expression of alphaLNNd, a laminin/nidog

84 clusion, metabolic improvements arising from muscle-specific expression of AMPKgamma3(R225Q) are insu

85 We determined whether skeletal muscle-specific expression of AMPKgamma3(R225Q) prevents

86 Here we generate transgenic mice with muscle-specific expression of dominant-negative Orai1 (d

87 d in clhm-1 mutant animals can be rescued by muscle-specific expression of either C. elegans CLHM-1 o

88 and Kv1.5(-/-) and WT with inducible, smooth muscle-specific expression of Kv1.5 channels), we measur

89 nimals, these deficits were fully rescued by muscle-specific expression of LARGE, which resulted in r

90 EFIP), which exhibited a heart- and skeletal muscle-specific expression profile.

91 Given that many AUF1 target mRNAs encode muscle-specific factors, we investigated the function of

92 Mutations in the gene encoding the muscle-specific family member calpain 3 (CAPN3) underlie

93 inhibit mTORC1) and in mice with a skeletal muscle-specific FKBP12 deficiency.

94 roved voluntary exercise, increased skeletal muscle specific force and tetanic Ca(2+) transients, dec

95 in generator of NO in skeletal muscle is the muscle-specific form of neuronal nitric oxide synthase (

96 to answer critical questions concerning the muscle-specific function of BIN1 in vertebrates, robust

97 may interact with other partners to perform muscle-specific functions.

98 -specific protein isoforms needed to sustain muscle-specific functions.

99 and intracellular trafficking of GAA during muscle-specific GAA expression with an adeno-associated

100 nin I is required for the expression of this muscle-specific gene and that multiple classes of MRF-re

101 Our results demonstrate that AAV-mediated muscle-specific gene editing has significant potential f

102 an unscheduled differentiation by repressing muscle-specific gene expression and is downregulated dur

103 the enzymatic activity of UTX in activating muscle-specific gene expression during myofiber regenera

104 TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with

105 lation and negatively correlates with smooth muscle-specific gene expression.

106 ounts of TFIID-TBP being required to promote muscle-specific gene expression.

107 ed high coverage and efficient enrichment of muscle specific genes, with low background noise.

108 cells are proliferating but are recruited to muscle-specific genes as differentiation initiates and t

109 pecific genes while repressing white fat and muscle-specific genes in adipocytes.

110 ned exon microarray containing probes for 57 muscle-specific genes to assay the transcriptional profi

111 h-related immediate-early, cytoskeletal, and muscle-specific genes to control growth, differentiation

112 vel role in suppressing expression of smooth muscle-specific genes, including smooth muscle alpha-act

113 otein synthesis and widespread activation of muscle-specific genes, many of which are targets of MEF2

114 HDAC5 to myogenic gene promoters to repress muscle-specific genes.

115 and thereby attenuating expression of smooth muscle-specific genes.

116 directly control the expression of a set of muscle-specific genes.

117 s (TADs) that are significantly enriched for muscle-specific genes.

118 Muscle-specific genetic interventions can induce systemi

119 MCK/SOCS3 mice develop impaired systemic and muscle-specific glucose homeostasis and insulin action b

120 and hypertrophic growth were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that

121 In this study we generated a novel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(

122 Finally, we show that skeletal muscle-specific human UCP3 expression is able to signifi

123 Bax-null Lama2(Dy-w)mice that overexpressed muscle-specific IGF-1 (Lama2(Dy-w)Bax(-/-)+IGF-1tg).

124 In nonendotoxemic muscle-specific IkappaBalpha super-repressor diaphragms,

125 In muscle-specific IkappaBalpha super-repressor mice subjec

126 Wild-type and transgenic (muscle-specific IkappaBalpha super-repressor) mice with

127 Wild-type (ILK(lox/lox)) and muscle-specific ILK-deficient (ILK(lox/lox)HSAcre) mice

128 duced exercise tolerance in association with muscle-specific impairments in substrate oxidation.

129 Skeletal muscle-specific inactivation of FAS protected mice from

130 We used a tamoxifen-activated, smooth muscle-specific inactivation of MLCK expression in adult

131 Moreover, mice with muscle-specific inactivation of the SIRT1 deacetylase do

132 Muscle-specific inducible Rac1 knockout (KO) mice and ph

133 in soleus and EDL muscles, respectively, of muscle-specific inducible Rac1 knockout mice.

134 Consistent with these findings, muscle-specific inhibition of Armadillo, the downstream

135 paBalpha super-repressor) mice with skeletal muscle-specific inhibition of the classical nuclear fact

136 greatly reduced in fibroblasts, suggesting a muscle-specific interaction.

137 Here, we demonstrate that the muscle-specific isoform cofilin-2 promotes actin filamen

138 ices associated with actin filaments and the muscle-specific isoform of alpha-actinin at the PM of di

139 nformatic analysis approach and identified a muscle-specific isoform of an RNA splicing regulator, RB

140 eased expression and alternative splicing of muscle-specific isoforms of ANK1.

141 We next characterized muscle-specific isoforms of BIN1 and DNM2.

142 We have previously isolated a muscle-specific Kelch gene, Kelch repeat and BTB domain

143 ting the acetylcholine receptor (AChR-MG) or muscle specific kinase (MuSK-MG).

144 nsity lipoprotein receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway.

145 The level of agrin and muscle-specific kinase (MuSK) was assessed at denervated

146 scular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinas

147 ceptors, the neurotransmitter receptor, (ii) muscle-specific kinase (MuSK), a receptor tyrosine kinas

148 k-7) is essential for the full activation of muscle-specific kinase and consequently for dense cluste

149 In non-injured muscle, muscle-specific kinase expression was significantly decr

150 The muscle-specific kinase MuSK is one of the key molecules

151 uated transcript levels of the post-synaptic muscle-specific kinase signalling complex.

152 ly the acetylcholine receptor (AChR) and the muscle-specific kinase.

153 ibility, we generated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TS

154 in muscles from both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice

155 didates that we classify using fat body- and muscle-specific knockdown and biochemical assays.

156 Here, we show that heart/muscle-specific knockdown of MED13 or MED12, another Med

157 Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO) mice display decreas

158 gical inhibition or genetic deletion of Rac1.Muscle-specific knockout (mKO) of Rac1, a kinase-dead al

159 e effects were not found in AMPKalpha1alpha2 muscle-specific knockout mice.

160 nl1; Mbnl2) and triple (Mbnl1; Mbnl2; Mbnl3) muscle-specific knockout models that recapitulate the co

161 In high-fat diet-fed mice with skeletal muscle-specific knockout of CEPT1, systemic and muscle-b

162 P methodology to generate mice with skeletal muscle-specific knockout of E1a-binding protein (mKO).

163 We discovered a putative muscle-specific long noncoding RNA that encodes a peptid

164 Muscle-specific loss of E2F results in a significant red

165 The Kelch protein Klhl31 is expressed in a muscle-specific manner under control of the transcriptio

166 Ubiquitous or neuron- and muscle-specific Marf ablation was lethal, altering mitoc

167 myogenic activity and that MEF2Calpha2, the muscle-specific MEF2C isoform, was required for efficien

168 Myostatin is a muscle-specific member of the TGF-beta superfamily and a

169 t ablation in mice, we show that myomaker, a muscle specific membrane protein essential for myoblast

170 us studies identified myomaker (Tmem8c) as a muscle-specific membrane protein essential for fusion.

171 Myomaker is a muscle-specific membrane protein required for fusion of

172 Here we identify a muscle-specific membrane protein, named myomaker, that c

173 The muscle-specific membrane proteins myomaker and myomixer

174 tructure and function of vinculin and of its muscle-specific metavinculin splice variant.

175 Here, we aged skeletal muscle-specific micro-dystrophin transgenic mdx mice to

176 ion), a smORF encoding an essential skeletal muscle specific microprotein.

177 how that microRNA-1 (miR-1), a member of the muscle-specific microRNA (myomiR) family, is responsible

178 The skeletal muscle-specific microRNA miR-206 is upregulated in satel

179 secretome that are directly targeted by the muscle-specific microRNA-1 (miR-1), and thus reflect the

180 ostnatal regeneration of skeletal muscle and muscle-specific microRNAs (miR-1 and -206) to further ac

181 MyomiRs are muscle-specific microRNAs (miRNAs) that regulate myoblas

182 ative regulation of BAF60a and BAF60b by the muscle-specific microRNAs (myomiRs) miR-133 and miR-1/20

183 n of the ryanodine receptor 1, a decrease in muscle-specific microRNAs and a considerable up-regulati

184 ession of cardiac transcription factors with muscle-specific microRNAs and represent a step toward po

185 R1 mutations exhibit decreased expression of muscle-specific microRNAs, increased DNA methylation and

186 Skeletal muscle-specific miR-486 overexpression in Dmdmdx-5Cv ani

187 terestingly, the levels of the four exosomal muscle-specific miRNAs are associated with the progressi

188 Here we show that the four muscle-specific miRNAs are encapsulated within exosomes

189 s to characterise the ontology of these four muscle-specific miRNAs in the blood circulation of DM1 p

190 We propose that exosomal muscle-specific miRNAs may be useful molecular biomarker

191 The levels of the four muscle-specific miRNAs were elevated in the serum of DM1

192 In one of these, our group identified four muscle-specific miRNAs, miR-1, miR-133a, miR-133b and mi

193 together, our results show that circulating muscle-specific miRNAs, miR-378a-3p and miR-434-3p, are

194 xhibited decreased expression of RYR1 and of muscle-specific miRNAs, whereas acute knock-down of RYR1

195 expression of 3 myogenic regulatory factors-muscle-specific myogenic factor 5, myoblast determinatio

196 In this study, we show that six fast muscle-specific myosin heavy chain genes have unique exp

197 n vivo although nuclear reprogramming of the muscle-specific myosin light chain promoter did occur.

198 envelope-genome contacts, we show that three muscle-specific NETs, NET39, Tmem38A, and WFS1, direct s

199 Muscle-specific neural drive was at low frequencies (<5

200 ncy causes a decrease and mislocalization of muscle-specific neuronal nitric oxide synthase (nNOSmu),

201 A muscle-specific nonkinase anchoring protein (alphakap),

202 It has been shown that muscle specific O2 binding protein, Myoglobin (Mb), is l

203 Mouse lines with smooth muscle-specific or ubiquitous expression of cGi500 were

204 Skeletal muscles from constitutive, muscle-specific Orai-KO mice exhibited normal postnatal

205 Using tamoxifen-inducible, muscle-specific Orai-KO mice, these functional deficits

206 s revealed reduced endurance in constitutive muscle-specific Orai-KO mice.

207 Here, we used constitutive and inducible muscle-specific Orai1-knockout (KO) mice to determine th

208 In agreement, muscle-specific overexpression of Drosophila Tsp or mous

209 Muscle-specific overexpression of EcSOD by somatic gene

210 metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M(IL10)) and in

211 Muscle-specific overexpression of IL-10 in ob/ob mice (M

212 the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (M(IL10

213 Intriguingly, muscle-specific overexpression of PGC-1alpha also preven

214 This study used mice with muscle-specific overexpression of PGC-1alpha, a transcri

215 n obesity, we generated transgenic mice with muscle-specific overexpression of SOCS3 (MCK/SOCS3 mice)

216 Animals with muscle-specific overexpression of Tp53inp2 exhibited enh

217 ransgenic mouse models, we demonstrated that muscle-specific overexpression of Tp53inp2 reduced muscl

218 ownstream of PGC-1alpha and ERRs to regulate muscle-specific pathways important for energy metabolism

219 d myogenesis, we discovered an 84-amino acid muscle-specific peptide that we call Myomixer.

220 Using muscle-specific PGC-1alpha knock-out mice, we show that

221 In response to kidney injury, mice with muscle-specific PGC-1alpha overexpression (mPGC-1alpha)

222 ression in the plantaris muscle of sedentary muscle-specific Pgc-1alpha transgenic mice, a genetic mo

223 Because XLMTM patients have a predominantly muscle-specific phenotype a number of pathogenic mechani

224 the LGMD1D mutant, F93L, in DNAJB6b under a muscle-specific promoter became weak, had early lethalit

225 al muscle-restricted expression by using new muscle-specific promoters that include the CAPN3 promote

226 is, we find that nucleosomes are depleted at muscle-specific promoters upon differentiation and that

227 yeast two-hybrid screens and identified the muscle-specific protein archvillin as a gamma-SG and dys

228 Myomaker is the only muscle-specific protein known to be absolutely essential

229 Recently, we showed that the muscle-specific protein myoglobin (Mb) interacts with co

230 Myomaker (Tmem8c) is a muscle-specific protein required for myoblast fusion.

231 ker [Transmembrane protein 8c (TMEM8c)] is a muscle-specific protein that is essential for myoblast f

232 Xin is a striated muscle-specific protein that is localized to the myotend

233 We report that STAC3, a skeletal muscle-specific protein that localizes to T tubules, is

234 unrelated peptide derived from the striated muscle-specific protein titin.

235 onin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated wit

236 Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member 40 (KL

237 e the expression of a so far uncharacterized muscle-specific protein, PGC-1- and ERR-induced regulato

238 Ms) develop autoimmunity to FHL1, which is a muscle-specific protein.

239 ls unexpectedly express ferlins, a family of muscle-specific proteins capable of regulating the fusio

240 esults provide new insights into the role of muscle-specific proteins on the structural arrangement o

241 However, the identity of muscle-specific proteins that directly govern this fusio

242 ed by the expression of a number of skeletal muscle-specific proteins, including MyoD and muscle alph

243 elegans strains expressing blue-fluorescent muscle-specific proteins, which enabled identification o

244 dromes that have been mapped to mutations in muscle-specific proteins.

245 ss, bedside manoeuvres to evaluate myotonia, muscle specific quality of life instruments and short ex

246 horylates the receptor tyrosine kinase MuSK (muscle specific receptor tyrosine kinase) at the neuromu

247 Finally, we identify a muscle-specific regulatory element of p57(kip2) directly

248 As are thought to move between cells because muscle-specific rescue of rde-4 using repetitive transge

249 has lost its ancestral function and became a muscle-specific resident of the inner nuclear membrane.

250 These data also underscore the muscle-specific responses to dystrophin deficiency and t

251 that the AMPKalpha2 isoform is necessary for muscle-specific ring finger protein 1 (MuRF1) up-regulat

252 In a proof-of-concept study in a muscle-specific ring finger protein-1 (MuRF-1) knockout

253 amed myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncodi

254 (<5 Hz) drive comprised shared (primary) and muscle-specific (secondary) components.

255 lation state of two Z-disc kinases (striated muscle-specific serine/threonine protein kinase and obsc

256 Specifically, we recreated skeletal muscle specific signaling networks in healthy and chroni

257 t appear to affect Ca(2+) sparks in skeletal muscle, specific silencing of the type 1 IP(3)R leads to

258 Our findings show that klotho undergoes muscle-specific silencing at the acute onset of mdx path

259 Using muscle-specific SirT1-deficient (KO) mice and a cell cul

260 AT), astrocyte-specific (ASTRO), or skeletal-muscle-specific (SKM) D2 knockout (D2KO) mice that were

261 ed both SLN knockout (Sln(-/-)) and skeletal muscle-specific SLN overexpression (Sln(OE)) mice to exp

262 wo models of mutant Bmpr2 expression, smooth muscle-specific (Sm22(R899X)) and universal expression (

263 The well-known, muscle-specific smooth muscle myosin light chain kinase

264 ox targeted approach to establish a skeletal muscle-specific Sod1-knockout (mKO) mouse to determine w

265 of metavinculin (MVt) upon actin binding, a muscle-specific splice isoform that suppresses actin bun

266 norhabditis elegans Rbfox1 homolog regulates muscle-specific splicing.

267 Skeletal muscles harbor quiescent muscle-specific stem cells (MuSCs) capable of tissue reg

268 Myofibers from muscle-specific STIM1 transgenic mice showed a significa

269 , including Myf5, MyoD (Myod1) and Myog, are muscle-specific transcription factors that orchestrate m

270 were mediated by up-regulation of the smooth muscle-specific transcriptional activator myocardin at m

271 (s) by which PGC-1 and ERR proteins regulate muscle-specific transcriptional programs is not fully un

272 mouse models we generated mice expressing a muscle specific transgene for MCD (Tg-fMCD(Skel)) stabil

273 Here, we generated skeletal-muscle-specific transgenic (TG) mice expressing the Na(+

274 Likewise, muscle-specific transgenic animals expressing a SNARK do

275 this regulation in muscle, we used mice with muscle-specific transgenic expression of a truncated TUG

276 Muscle-specific transgenic expression of Baf60c activate

277 We also show that both exercise training and muscle-specific transgenic expression of EcSOD result in

278 ed cardiac dysfunction in WT mice but not in muscle-specific transgenic mice expressing dominant-nega

279 By using skeletal muscle-specific transgenic mice for PGC-1alpha1 and -alp

280 Consistent with these results, skeletal muscle-specific transgenic mice overexpressing Ctss show

281 We also generated MAPK kinase 6 (MKK6) muscle-specific transgenic mice to model heightened p38a

282 Serpina3n muscle-specific transgenic mice were generated to model

283 sensitive green fluorescent protein (pHGFP)] muscle-specific transgenic mouse was developed to examin

284 Here, we determined that muscle-specific transgenic overexpression of miR-486 in

285 In contrast, muscle-specific transgenic overexpression of the related

286 ously demonstrated that myomaker, a skeletal muscle-specific transmembrane protein necessary for myob

287 In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout

288 d a defect in the splicing regulation of the muscle-specific Troponin T3 (TNNT3) mutually exclusive e

289 onstrate that with progressive age, skeletal muscle-specific TWEAK-transgenic (TWEAK-Tg) mice gain in

290 ouse models of total body (TKO) and skeletal muscle-specific (TXNIP(SKM-/-)) Txnip deficiency.

291 racts with LRP4, an obligate co-receptor for muscle-specific tyrosine kinase (MuSK).

292 icotinic acetylcholine receptor (AChR) or to muscle-specific tyrosine kinase (MuSK).

293 The muscle-specific ubiquitin ligase atrogin-1 targets signa

294 Muscle RING finger protein 1 (MuRF1), a muscle-specific ubiquitin ligase, is implicated in many

295 Muscle-specific ubiquitin ligases (muscle RING-finger pr

296 vity and expression of Atrogin-1 and MuRF-1, muscle-specific ubiquitin ligases that are upregulated w

297 he induction of key atrogenes, including the muscle-specific ubiquitin ligases, atrogin1 and MuRF1, a

298 Male wild-type (WT) and muscle-specific UCP3-overexpressing transgenic (UCP3 Tg)

299 Changes in arteriolar function that are muscle specific underlie age-induced changes in blood fl

300 ere abolished in skeletal muscle lacking the muscle-specific, ZMP-sensitive AMPK-gamma3 subunit and i