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1  that this substance is unstable in wine and must.
2 fication of new varietal thiol precursors in must.
3                    The synthesis of location must account for this frequency dependence, but it is no
4 Efficient optical frequency mixing typically must accumulate over large interaction lengths because n
5 s that as the tendrils twist or bend, strain must accumulate until nucleation of a grain boundary is
6                  To grow faster cancer cells must activate aerobic glycolysis for energy generation a
7 o maintain high photosynthetic rates, plants must adapt to their light environment on a timescale of
8                 As sessile organisms, plants must adapt to variations in the environment.
9             When flying or swimming, animals must adjust their own movement to compensate for displac
10                                      Viruses must also adapt to novel conditions while establishing t
11  protection layer, can prevent corrosion but must also allow low-resistance carrier transport, genera
12 c excitation and ac ejection frequency scans must also be applied and scanned in order to reject arti
13                      On the other hand, they must also exhibit input compensation: their period must
14  occlusion (ELVO), efficient systems of care must also exist for patients with ELVO who first present
15 CSF) should not only focus on livestock, but must also include wild boar.
16 ensembles reorganize to support learning but must also maintain stable representations to facilitate
17                        To do this, the virus must alter and repurpose the normal cellular balance of
18 , the mitotic reorganization of PCP proteins must alter not only proteins intrinsic to the dividing c
19  to periods of ECM detachment), cancer cells must alter their metabolism in a fashion that promotes s
20               Thus, measurements of dormancy must always be accompanied by analysis of environmental
21 tiers of health care; the idea that the data must and will speak for themselves is fast becoming a ne
22 thresholds were 10microg/L and 11microg/L in must and wine model solution, respectively.
23                                  All viruses must antagonize antiviral signaling events for survival.
24         To make an appropriate decision, one must anticipate potential future rewarding events, even
25 er to spread on a surface or to crawl, cells must apply traction forces to the underlying substrate v
26           Fundamentally, collective behavior must arise from the actions of individual cells.
27 terest in each discovered locus, researchers must assess the magnitude of allelic heterogeneity withi
28 he efficacy of de-escalation is striking and must, at least in part, be credited to the lack of a cle
29 ften exist in complex communities where they must avoid predation and compete for favorable niches.
30                   A transcrustal perspective must balance slow (plate tectonic) rates of melt generat
31                        In nature, HIV-1 Envs must balance the requirements to maintain the noncovalen
32  implies a network structure, so the grammar must be a network and so must sentence structure.
33 , the network of microtubules in the spindle must be able to apply and sustain large forces to mainta
34                             Circadian clocks must be able to entrain to time-varying signals to keep
35        To perform this task effectively they must be able to integrate multiple stimuli and distingui
36 l organisms wishing to survive and reproduce must be able to respond adaptively to a complex, changin
37 ealthcare professionals and cleaning methods must be acceptable and safe for intermittent catheter us
38 ill always have residual interactions, which must be accounted for when designing logical operations.
39 , at least for most animals, these molecules must be acquired from their environment.
40 the minimum number of mechanoreceptors which must be activated to elicit a behavioural response.
41 ignificant risk for hemorrhage and therefore must be addressed promptly once discovered.
42 ogy, critical limitations of current methods must be addressed.
43 , and statistical epidemiological approaches must be addressed.
44 nsmission, and highlight knowledge gaps that must be addressed.
45 at effects of climate change on biodiversity must be analyzed in the context of historical human impa
46  techniques and advanced radiation protocols must be applied.
47  to be acceptable, evidence based guidelines must be available for healthcare professionals and clean
48 al imaging appearance that every radiologist must be aware of.
49 elayed CCY is a cost-effective strategy that must be balanced against the risk of loss to follow-up,
50  in skeletal density, we conclude that there must be biochemical influences that probably include bin
51                             Airborne bacilli must be capable of surviving in the external environment
52             In addition, the analysis method must be carefully considered, as this choice can profoun
53 herently destructive enzymes, their activity must be carefully controlled.
54                  Accordingly, Mn homeostasis must be carefully maintained.
55 identified are at particularly high risk and must be carefully managed.
56 easome, the assembly of this 2.5MDa complex must be carefully orchestrated to ensure its correct for
57                             These challenges must be characterized and planned for now so that clinic
58 SDGs) recognize that current sanitation gaps must be closed to better serve those without access to s
59  honeycomb geometry and material wettability must be considered in practical dosage form design.
60 diative forcing and resultant warming level, must be considered when assessing the impacts of global
61 edictor of outcome for both IST and BMT, and must be considered when designing therapeutic strategies
62 een without issue, revealing challenges that must be considered when undertaking an integrative taxon
63       We suggest that source entropy changes must be considered whenever interpreting changes in info
64 ices on pulp delta(15)N was demonstrated and must be considered with attention when evaluating data.
65 prehensive, multiple dimensions of diversity must be considered.
66 ons, the age structures of those populations must be considered.
67  of individual risk stratification, patients must be continually monitored and thus carry the burden
68  lagging-strand polymerases in the replisome must be coordinated to avoid the formation of significan
69                        Chromatid segregation must be coordinated with cytokinesis to preserve genomic
70 present at the midzone.Chromatid segregation must be coordinated with cytokinesis to preserve genomic
71                 Ribosomal protein (RP) genes must be coordinately expressed for proper assembly of th
72 - inducing respiratory acidosis in fish that must be corrected through branchial ion transport.
73                        Scientific categories must be created or updated on the basis of evidence.
74 re medium component, is replete with EVs and must be depleted prior to EV-related experiments.
75 roaches of cardiovascular disease prevention must be directed also to the family environment of the d
76       Cancer SVs and viral integration sites must be discovered in a genome-wide scale for clarifying
77 are stable enough to organize the genome yet must be dynamically displaced and reassembled to allow a
78  we discuss several untested conditions that must be empirically validated before it is certain that
79 ction contingencies and their relative value must be encoded to establish a value-biased state of pre
80  and (2) pulling models, in which the ligand must be endocytosed after it binds Notch to exert force
81 re (1) recycling models, in which the ligand must be endocytosed to be modified or repositioned befor
82  Eurotransplant Senior Program, but outcomes must be evaluated.
83 Dependence of cell cultures on "whole serum" must be examined carefully along with other experimental
84 row chimera studies show that aberrant Pkhd1 must be expressed in the target tissue (cholangiocytes)
85 ction in different lineages where that locus must be expressed.
86                          However, the method must be extended to allow for germline variant filtering
87 n eukaryotic genomes, but their mobilization must be finely tuned to maintain host organism fitness a
88 lytical technique operating at the nanoscale must be flexible regarding variable experimental conditi
89  number of critical steps are addressed that must be followed in order to prepare highly viable myoca
90 coexpressed at these inhibitory synapses and must be genetically inactivated together with Syt2 to ac
91 olution reaction in acid-based electrolyzers must be guided by the proper balance between activity, s
92                          The anchoring group must be hydrolytically stable and oxidation resistant un
93 ins the same, that is, a mathematical method must be implemented to reconstruct the 3D structure of a
94 geared toward having a balanced social skill must be implemented.
95 ntal sustainability, agricultural production must be improved by high yield and high resource utiliza
96 e computational speed of alignment softwares must be improved.
97                                       Vps13p must be in complex with the small calcium-binding protei
98 ion mechanisms contributing to cell survival must be in place.
99                          However, these data must be integrated and analyzed if they are to produce m
100 designs for new transplant immunosuppression must be intelligently restructured to ensure that short-
101                          Therefore, NGS data must be interpreted by multidisciplinary decision-suppor
102 int defects such as impurities and vacancies must be investigated and corrected for.
103  complex dissociates rapidly, the antibiotic must be kept constantly at a concentration that prevents
104 ance R N as a function of the chain length N must be known.
105 The overall activation energy of the process must be large enough to prevent frequent and nonspecific
106  responses, suggesting that other mechanisms must be limiting the immune response.
107                                       Clamps must be loaded onto primer-template DNA (ptDNA) by clamp
108 uring HR, but to accomplish this task, RAD51 must be loaded onto the single-stranded DNA.
109 d nonspecific spontaneous fusion events, yet must be low enough to allow it to be overcome upon deman
110 t practical limitations and compromises that must be made when designing an SRM experiment.
111 ient histories from which clinical decisions must be made.
112 and asked respondents to identify those that must be measured in all studies.
113  progress made and remaining challenges that must be met to ensure a fair and meritocratic approach t
114                                This compound must be metabolized into hydroxylamine intermediate for
115  Technical variation in metagenomic analysis must be minimized to confidently assess the contribution
116 3 does not adopt canonical conformations and must be modeled de novo.
117 attain maximal utility, a decoding framework must be open-ended, systematic, and context-sensitive-th
118 RHOA-GEFs --> RHOA/C --> actomyosin pathways must be optimally tuned to compromise between generation
119                         This complementarity must be optimized both for functional interactions and a
120  vaccine research, potential challenges that must be overcome along the way, and a literature review
121 tegrin transmembrane and cytoplasmic domains must be overcome by cellular energy input to stabilize e
122 represents an effective species barrier that must be overcome by zoonotic viruses.
123 ty and, we propose, serves as a barrier that must be overcome for tumor formation.BRCA2 mutations pro
124 uss some of the significant challenges which must be overcome in realizing a practical magnesium batt
125 rming factors is a nontrivial challenge that must be overcome to establish soil magnetism as a truste
126 cance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed
127 but to achieve this, the identified barriers must be overcome.
128  not necessitate the pairing of samples that must be performed using traditional analysis methods in
129 sult is nonreactive a second treponemal test must be performed, which may actually lead to inefficien
130 the strategic placement of filling materials must be performed.
131 , certain tRNAs with specific d-arm residues must be present in the peptidyl site, e.g., tRNA(Pro).
132 llmark intermediate in DNA recombination and must be processed by dissolution (for double HJ) or reso
133 ny situations such as fast-moving sports, we must be ready to act fast in response to sensory events
134 ensory events demand fast action choices, we must be ready to prioritize higher-value courses of acti
135 he DNA channel, whereas T. maritima sigma1.1 must be rearranged to fit therein.
136 rd, predictive accuracy and interpretability must be recognized as complements, not substitutes, when
137 he drug-cue memory, which becomes labile and must be reconsolidated into long-term storage.
138 ed in the future, the costs of the procedure must be reduced.
139 r allowing cell-cycle progression itself and must be regulated dynamically during cyclic re-entry to
140 lular environment and their protein turnover must be regulated via an alternate pathway.
141 ed from its environment; the molecular cargo must be removed to a separate physical space.
142 els, empirical parameters in existing models must be replaced with physics- and biology-based terms a
143 ffective trigger, a subinterval of magmatism must be responsible for driving deleterious environmenta
144 nt, both excitation and ejection frequencies must be scanned, whereas in the former the ejection freq
145 oral and spatial resolution, the neural code must be smooth at the voxel and functional level such th
146                             Correct bindings must be stable enough to promote the desired function ev
147 to establish a productive infection, virions must be stable in the environment but flexible to disass
148 s of the TDP-43 NTD, indicating that the NTD must be stably folded for TDP-43's physiological functio
149  reporting and definitions of modes of death must be standardized and tailored to the HFpEF populatio
150 nerated an unprecedented amount of data that must be stored, processed, and communicated.
151 static conditions, billions of cells die and must be swiftly cleared by phagocytes.
152         The electrical and thermal transport must be synergistically optimized.
153 s carbon emissions from tropical forests and must be taken into account when analysing the role of ve
154 tle differences in earlier deformation paths must be taken into account when deciphering the cell mec
155 d prior to ordering C. difficile testing and must be taken into account when interpreting test result
156                                Thus, caution must be taken when predicting antiviral activity based o
157 uired to interrupt tuberculosis transmission must be targeted to high-risk groups and settings.
158 ion-isomerization, implying that the "cycle" must be terminating faster than it is propagating!
159 C pools and processes that proxies represent must be thoughtfully considered in order to minimize unc
160             Hence, the cellular iron balance must be tightly controlled.
161            However, epithelial cell division must be tightly linked to cell death to preserve barrier
162                                Thus, T cells must be tightly regulated from their development onward.
163 re inflammation and leukocyte transmigration must be tightly regulated.
164 CTL can kill multiple targets, degranulation must be tightly regulated.
165 ity is detrimental to the host and therefore must be tightly regulated.
166 clerosis, and other cardiovascular diseases, must be translated into changes in food patterns, aiming
167  eukaryotic cells, one-third of all proteins must be transported across or inserted into the endoplas
168 virus-host interactions, a relationship that must be understood to better comprehend virus pathogenes
169 in reactivity mediated by different 1,2-DHBs must be understood.
170 e across hydrophobic membrane bilayers, they must be unfolded and translocated by a membrane-embedded
171           Multidimensional algorithms, which must be validated in primary and urgent care settings, m
172  relationship to tumor growth or progression must be validated.
173 erature dependence of continental weathering must be weaker than commonly assumed.
174 s of resected DNA, the replication machinery must catch up with the preceding processing nucleases, i
175  for anemia globally and that anemia control must combine iron interventions with control of infectio
176  supporting a mechanism where CglI complexes must communicate along the one-dimensional DNA contour b
177                               Social animals must communicate to define group membership and coordina
178  influence of climate change on biodiversity must consider a broad array of ecological processes.
179                    These designs and methods must consider a very integrated use of the multiple cont
180 t therapies designed at targeting glycolysis must consider both dehydrogenases.
181 rstand the properties of neural systems, one must consider how perceptual circuits put information at
182                     Resource-limited nations must consider their response to potential contractions i
183 In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens
184 ual patients, treatment at the genomic level must contend with substantial inter-individual natural g
185                           However, the field must continue to characterize the specific role pro-infl
186 nt methods evolve, these new systems of care must continue to serve the needs of children.
187 ng component of the replication complex that must continuously bind to and unbind from transiently ex
188 e difficult to find because millions of SNPs must currently be compared to thousands of transcripts.
189                           All visual animals must decide whether approaching objects are a threat.
190                                   Rather, we must design and rigorously evaluate interventions to hal
191 tial variation of mechanical properties, one must determine the deformation of a tissue in response t
192 w & Brentari (G-M&B) assert that researchers must differentiate between sign/speech and gesture.
193     To begin breaking into language, infants must discern subtle statistical differences about people
194 ion-dishabituation paradigm in which animals must discriminate between two urine stimuli in successiv
195             Obligate intracellular parasites must efficiently invade host cells in order to mature an
196 thin the middle of the BER pathway, Pol beta must efficiently locate its substrates before damage is
197                                       Muskeg must either be entirely excavated, or for direct constru
198 le presynaptic LGN cells, suggesting that it must emerge exclusively from the combined input of all p
199                                    Cannibals must ensure avoiding their own offspring and targeting o
200                                      Viruses must establish an intimate relationship with their hosts
201  months after the clearance of viremia, ZIKV must establish infection in the seminiferous tubules, th
202        To survive, microbes exposed to serum must evade the complement response.
203  50% and poor outcomes following dropout, we must explore innovative strategies for enhancing retenti
204                            Quantum toolflows must expose more physical details between layers, so the
205 r oxidation of phenols by VAO to occur, they must first be bound in the active site of the enzyme in
206 heir effects on cellular RNA processing they must first cross the plasma membrane by endocytosis.
207                                Future trials must focus on interventions/agents with robust preclinic
208  as stress signals doxorubicin and H2O2 each must free p53 from PEPD in order to achieve robust p53 a
209 btained by spontaneous fermentation of grape must from Vranec and Cabernet Sauvignon varieties collec
210 ination repairs DNA double-strand breaks and must function even on actively transcribed DNA.
211                             These processors must generate, incubate, and sort droplets for continuou
212  a subcritical gap-spanning tube, which then must grow to cross the barrier.
213                      Clinicians and patients must have accurate and realistic expectations about the
214 s that the activity for the affected pathway must have an optimum level, the value of which varies ac
215                            Included articles must have assessed TCS phobia in patients with atopic de
216                    Thus, the gas-giant cores must have formed before dissipation of the solar nebula,
217 s a guide, most models assume that the Earth must have formed from a heterogeneous assortment of embr
218     For inclusion in this study, individuals must have had a peripheral blood or mononuclear cell sam
219 ourth, implementation of the outcome measure must have little chance of inducing unintended adverse c
220 nificant gene-flow from east to west Eurasia must have occurred early during the Iron Age.
221 elationships suggest that the deep arc crust must have primarily involved significant igneous accumul
222     Any discussion of water as life's matrix must, however, begin with an acknowledgment that our und
223                              The spliceosome must identify the correct splice sites (SS) and branchsi
224 rder to succeed, retrotransposon transcripts must identify the subset of nuclei that will be transmit
225 e durable products and their quality control must include antioxidant capacity assays.
226  eight, the provision of quality care to all must include usually underserved groups, including peopl
227  increasing climate variability, crop yields must increase faster than the current rates.
228 hrocyte invasion, the intracellular pathogen must increase host cell uptake of nutrients from plasma.
229 osquito-borne Plasmodium spp. parasites that must infect and survive within mosquito salivary glands
230                                     Research must integrate each component of the brain-gut axis and
231    Neural networks that control reproduction must integrate social and hormonal signals, tune motivat
232                            Urodynamic status must interact with arousal and attentional processes so
233 ses and for readers and journal editors, who must interpret the findings and gauge methodological qua
234 ng the doctrine that high-quality resonances must invariably be narrowband and providing the possibil
235                                  This effort must involve natural history, ecology, and evolutionary
236 till not fully understood, but the processes must involve small changes in the capsid structure that
237                    Health care professionals must maintain a high suspicion for EFE, as patients are
238 ns living beyond childhood, which means they must make the transition from children's to adult servic
239                                         They must manage the dual obligation of caring for dying pati
240 s that experiments with intact human embryos must not allow them to develop beyond 14 days or the app
241 estigations on precious ancient samples that must not be altered by the analytical procedure.
242 or people intolerant to gluten, their amount must not exceed the regulatory threshold levels.
243                                 Such methods must not only extract snippets of text that relate to mo
244                          Free-living animals must not only regulate the amount of food they consume b
245 ations of the eddy-covariance systems, which must now be questioned for their accuracy in desert ecos
246 bunits, some portion of 30S and 50S assembly must occur in the context of the 70S ribosome.
247                     Similarly, the treatment must often be tailored to each patient by targeting the
248 deling of the energy barrier that the system must overcome at the stage of membrane budding by an ass
249 he nucleus challenge the resident genome and must overcome cellular responses, including the DDR.
250 he human intestinal pathogen Vibrio cholerae must overcome noxious compounds that damage the bacteria
251                                   Thymocytes must pass both positive and negative selections to becom
252                   All below ground resources must pass through this dynamic zone prior to their captu
253       Hence, future generations of catalysts must perform at temperatures that are 100 degrees C lowe
254 e amounts of calcium in vitro, calsequestrin must polymerize and then depolymerize to release it.
255 material to a new host, nonenveloped viruses must protect their genomes by packaging them into an out
256          Kidney transplant candidates (KTCs) must provide informed consent to accept kidneys from inc
257 nd the evolution of the viral population, we must quantify the heritability of set-point viral load,
258 f the Multicenter Uveitis Steroid Treatment (MUST) randomized clinical trial comparing the alternativ
259  thermodynamic properties of hydration water must reflect on the properties of the heterogeneous prot
260 tematic study of antibody specificities that must rely mainly or exclusively on other protective mech
261 nternal sense of direction is disrupted, she must rely on external cues to regain her bearings, a pro
262            The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste pro
263 mate change, invasion, and their interaction must rely on understanding underlying mechanisms.
264 lso exhibit input compensation: their period must remain approximately one day in different constant
265  the sex chromosome karyotype, early embryos must remain gender-naive; our findings show that the mir
266 s) may represent one such signal, these RNAs must remain unrecognized under non-pathological conditio
267                        During mitosis, cells must segregate the replicated copies of their genome to
268 obeying traffic lights, in everyday life, we must select items based on color.
269 ure, so the grammar must be a network and so must sentence structure.
270 allenges expectedly arise, and our focus now must shift to determining the best strategy by which to
271 urons of the peripheral nervous system (PNS) must signal to the motor circuits of the central nervous
272 cient handling of wastewater pollutants is a must, since they are continuously defiling limited fresh
273       To navigate through the world, animals must stabilize their path against disturbances and chang
274                           Healthcare workers must strive to adapt bereavement follow-up to each indiv
275                                   Viral RNAs must successfully evade this host RNA decay machinery to
276 anscriptional suppression.IMPORTANCE Viruses must suppress host antiviral responses to replicate and
277         However, realizing single-DNA arrays must tackle the challenge of capturing structurally high
278          Interpretation of the LOF phenotype must take into account the biological process that is ta
279 ts of a changing climate on tropical forests must take into account this environmental heterogeneity
280   An accurate analysis of communicative acts must take this third category into account.
281 k the oncogenic effect of aerobic glycolysis must target reactions upstream of PKM.
282                                           It must therefore be avoided, and two recent papers highlig
283 ate a free 5' end, stalled replication forks must therefore be cleaved.
284                          Sediment levitation must therefore be considered when evaluating the formati
285                                         Dyes must therefore be designed to encourage these interfacia
286 ity, but also spatially constrain cells, and must therefore be modified to allow cellular expansion.
287 the emergence of completely new active sites must therefore either plausibly exist or at least have e
288                                 Compensation must therefore occur to overcome the loss of K(ATP) chan
289                        Most P. vivax studies must therefore rely on patient samples, which typically
290         Developing high-capacity anodes is a must to improve the energy density of lithium batteries
291             The host's mucosal immune system must tolerate commensals while fighting pathogens.
292                              Neural circuits must transform new inputs into outputs without premature
293     To prevent somatic differentiation, PGCs must transiently silence their genome, an early developm
294 duce abortion, orally ingested Campylobacter must translocate across the intestinal epithelium, sprea
295 lanoblasts originating from the neural crest must traverse the dermis to reach the epidermis of the s
296       To understand visual consciousness, we must understand how the brain represents ensembles of ob
297 th care provider organizations, stakeholders must understand the implications of misaligned top-down
298 tion of these neurotransmitter receptors, we must understand their interactions with other proteins.
299 ed to model iceberg distributions accurately must vary according to distance from the calving front.
300              The titratable acidity of apple must was significantly higher for the pre-commercial har

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