ライフサイエンスコーパス: mustard oil

1 n (garlic), and allyl isothiocyanate (AITC) (mustard oil).

2 e to ligands of TRPV1 (capsaicin) and TRPA1 (mustard oil).

3 sory neurons sensitive to the TRPA1 agonist, mustard oil.

4 hey are exposed to noxious compounds such as mustard oil.

5 lgesia to punctate stimuli on treatment with mustard oil.

6 ungent chemicals, such as cinnamaldehyde and mustard oil.

7 esponses of sensory neurons to capsaicin and mustard oil.

8 n the range of 48.5 to 54.2% was observed in mustard oil..

9 on of capsaicin (1 microm; 8 of 9 LF cells), mustard oil (100 microm; 10 of 12 LF cells), and low pH

10 Topical application of mustard oil (100%) to the lateral surface of the hind le

11 rents were sensitized by capsaicin (3 of 9), mustard oil (2 of 7), or low pH (1 of 6) application.

12 jority additionally responded to 5-HT (70%), mustard oil (79%), and capsaicin (71%).

13 ted capsaicin (a specific TRPV1 agonist) and mustard oil (a specific TRPA1 agonist) behavioral respon

14 ow that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaici

15 annel is a sole target through which WIN and mustard oil activate sensory neurons.

16 Topical application of mustard oil (allyl isothiocyanate) to the skin activates

17 in lamina II neurons that also responded to mustard oil (allyl isothiocyanate), indicating a presyna

18 rring electrophilic plant compounds, such as mustard oil and cinnamaldehyde, are TRPA1 agonists, it i

19 show that derivatives of two such compounds, mustard oil and cinnamaldehyde, covalently bind mouse TR

20 activated by electrophilic compounds such as mustard oil and cinnamaldehyde.

21 his channel is the sole target through which mustard oil and garlic activate primary afferent nocicep

22 eralgesia produced by topical application of mustard oil and measuring the nociceptive tail-flick ref

23 fants receiving topical cord applications of mustard oil and other potentially unclean substances, re

24 is study, the erucic acid content in several mustard oils and prepared mustard samples from Germany a

25 d molecular target for the pungent action of mustard oils and support an emerging role for TRP channe

26 ere we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of

27 pounds that cause a burning sensation (e.g., mustard oil) and, indirectly, by components of the infla

28 The majority also responded to SLIGRL-NH(2), mustard oil, and capsaicin.

29 in cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger all activate TRPA1 (ANKTM1).

30 of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and t

31 tagonist proglumide (10 micrograms) prior to mustard oil application completely blocked both the less

32 In support, topical mustard oil application or colonic inflammation increase

33 t the spontaneous pain reaction after rectal mustard oil application to mice (ED50=2.35 mg/kg).

34 al and/or thermal hyperalgesia after topical mustard oil application, carrageenan inflammation, or ne

35 phosphate depletion after capsaicin, but not mustard oil, application.

36 spinalised, pentobarbitone-sedated animals, mustard oil applied to any site on the ipsilateral hind

37 reflexes of an acute noxious stimulus (20 % mustard oil) applied to a number of locations around the

38 ted cells that respond to capsaicin (but not mustard oil) as well as large-diameter myelinated neuron

39 The "mustard oil bomb" is a major defense mechanism in the Br

40 that reduces plant predation, the so-called "mustard oil bomb," in which vacuole breakage in cells ha

41 cosinolate-myrosinase system, the so-called "mustard-oil bomb." Tissue damage caused by insect feedin

42 uR1, markedly reduced the activity evoked by mustard oil, but not that elicited by brushing of the re

43 by the TRPA1 agonists allyl-isothiocyanate (mustard oil), carvacrol, and polyunsaturated fatty acids

44 osensor, we establish that capsaicin, unlike mustard oil, consistently activates phospholipase C in s

45 Diets rich in vegetables and use of mustard oil could contribute to the lower risk of IHD am

46 lowing stimulation of peripheral nerves with mustard oil, demonstrating that NMB contributes to neuro

47 Here we show that mustard oil depolarizes a subpopulation of primary senso

48 ibition of the tail-flick reflex produced by mustard oil following spinal or supraspinal administrati

49 ist L-365260 i.t. dose-dependently inhibited mustard oil hyperalgesia (ID50 = 364 ng) at doses approx

50 R48692 (3.5 micrograms) into the RVM blocked mustard oil hyperalgesia and inhibited the tail-flick re

51 Mustard oil hyperalgesia was also inhibited in animals t

52 s in outward rectification of single channel mustard oil (I(MO)) current-voltage relationships (I-V)

53 zation of TRPV1 after TRPA1 stimulation with mustard oil in a calcium and cAMP/protein kinase A (PKA)

54 In contrast, NPD1 had no effect on mustard oil-induced TRPA1 currents.

55 n is regulated by TRPV1, and it appears that mustard oil-induced TRPA1 internalization is prevented b

56 Mustard oil injected into the lumen of the colon produce

57 lumbosacral spinal cord of rats subjected to mustard oil irritation of the colon.

58 gest that secondary hyperalgesia produced by mustard oil is mediated largely by a central, centrifuga

59 al desensitization of TRPA1 by capsaicin and mustard oil is not influenced by activation of protein p

60 Allyl isothiocyanate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica

61 so exhibited by ART-OE mice to capsaicin and mustard oil, measured using a two-choice drinking test.

62 supratentorial dura mater were activated by mustard oil (MO) and the responses of second-order neuro

63 Application of the C-fibre activator mustard oil (MO) to the cutaneous receptive field or sub

64 g behavior following masseteric injection of mustard oil (MO) was quantified in lightly anesthetized

65 ects of ACEA on the TRPA1-selective agonist, mustard oil (MO), for calcitonin gene-related peptide (C

66 cular injection of an inflammatory irritant, mustard oil (MO), induces significant edema formation in

67 e injury [application of a C-fiber irritant, mustard oil (MO), to the hindpaw].

68 ion, NGF evoked a time-dependent increase of mustard oil (MO)-evoked TRPA1 activation in trigeminal g

69 ling and by activating TRPA1 with the ligand mustard oil (MO).

70 Saturating activation by cinnamaldehyde or mustard oil occluded potentiation but did not interfere

71 Mustard oil on the contralateral limb had no effect on a

72 ts allyl isothiocyanate (AITC; also known as mustard oil) or capsaicin.

73 arts of this species as one of the possible "mustard oil" precursors.

74 e, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an exci

75 d with pierid butterflies that specialize on mustard-oil-producing plants.

76 A1 and, by doing so, attenuate capsaicin and mustard oil responses.

77 are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory neurons and are required

78 Seven of nine mustard oil samples exceeded the permitted maximum level

79 on of Ca(2+) influx and membrane currents in mustard oil-sensitive sensory neurons.

80 racolonic application of either capsaicin or mustard oil, stimuli known to evoke sustained nociceptor

81 fibre brush stimulus and a noxious C fibre (mustard oil) stimulus were extracellularly recorded and

82 e display behavioral deficits in response to mustard oil, to cold ( approximately 0 degrees C), and t

83 uced Fos expression in the spinal cord after mustard oil treatment but significantly increased the re

84 Use of mustard oil, which is rich in alpha-linolenic acid, was