ライフサイエンスコーパス: mutability

1 e mutability without requiring any change in mutability.

2 ously found to have elevated post-UV plasmid mutability.

3 sequences and elevated levels of spontaneous mutability.

4 of the PKD1 gene may be responsible for its mutability.

5 s other than the one that led to its initial mutability.

6 of slippage, are the strongest predictors of mutability.

7 lar isochore do not influence microsatellite mutability.

8 he tumors exhibit the phenotype of increased mutability.

9 m appears to favor a certain innate level of mutability.

10 suggested that growth limitation stimulates mutability.

11 murine germline V genes to predict regional mutabilities.

12 of the cj1139 tract from G8 to G11 increased mutability 10-fold and changed the mutational pattern fr

13 t bias is revealed by a defined hierarchy of mutability among di- and trinucleotide sequences located

14 also incorporated variation in the degree of mutability among genes, using either gamma-distributed m

15 regional genomic factors to the variation in mutability among orthologous human-chimpanzee microsatel

16 ltogether, our analyses suggest that epitope mutability and accessibility to immune complex assembly

17 oximately 90% of variation in microsatellite mutability and can generate useful predictions for the s

18 riggers spontaneous DNA breakage, leading to mutability and cancer predisposition.

19 ctivities, suggesting an influence on genome mutability and functional variation.

20 f phase variation demonstrated links between mutability and genetic diversity but could not replicate

21 tudy was to estimate the relative effects of mutability and selection on SNP density in transcribed r

22 chimpanzee, aiming to dissect the impact of mutability and selection on their evolution.

23 gated, but the reason for the high degree of mutability and specificity at these sites is uncertain.

24 High mutability and the likelihood of cancer can be caused by

25 a moderate correlation between the relative mutability and thermodynamic stability of DNA triplets e

26 Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo.

27 aracterized by chromosome fragility, altered mutability, and abnormal regulation of the nonhomologous

28 s results in a large increase in spontaneous mutability, and in the case of mice and men, predisposit

29 s of lowering fidelity on virus replication, mutability, and in vivo fitness.

30 Interestingly, much of this mutability appears to be focused on the third codon posi

31 The primary cause of mutability appears to be hydrolytic deamination.

32 npaired during transcription, their relative mutabilities are calculated using a new computer algorit

33 This study has explored intrinsic mutability as a consequence of sequence-specific repair

34 phase variation without increases in overall mutability, as they possessed low rates of spontaneous m

35 nd nonredundant roles in suppressing C --> T mutability at non-CpG sites.

36 pair-defective strains also showed increased mutability at the hotspot, consistent with the notion th

37 rfibrillar stiffness (EIF), the mechanism of mutability at the nanoscale can be demonstrated directly

38 ts a systematic variation of mutation rates (mutability) at exon flanks, depending on the local CpG c

39 om these mutants arise from general adaptive mutability available to any chromosomal gene.

40 that captures the structural constraints on mutability based on the extent of its inter-residue inte

41 Nevertheless, the relative mutabilities both within this set and within the SAN (S

42 nfirm earlier observations regarding residue mutabilities but also suggest that in addition to the es

43 the contrary, stress has no direct effect on mutability but favors only growth of cells that amplify

44 on increased both cellular resistance to and mutability by nitrous acid.

45 ither intragenic recombination nor increased mutability can explain the observed patterns.

46 Localized hyper-mutability caused by accumulation of lesions in persiste

47 mutations reveal rather similar patterns of mutability compared with point mutations, being rare at

48 This finding is consistent with the modest mutability conferred by inactivation of the MutSalpha PC

49 22, Asn-226, and Asn-229 exhibited the least mutability, consistent with x-ray data showing that each

50 combined effects of Darwinian selection and mutability contribute substantially to, but do not fully

51 itivity to UV-B irradiation increased and UV mutability decreased by 12- to 14-fold.

52 prominent systems for the study of adaptive mutability depend on the specialized activities of genet

53 Mutability depends on hotspots, not secondary structure.

54 We determine what factors contribute to this mutability difference and characterize the strength of s

55 n preferences in VH genes, observed relative mutability differences between regions are more extreme

56 ingly, sheep sequences show extremely strong mutability differences, consistent with the role of soma

57 ing enrichment from 1.8- to 90-fold of local mutability distributed across 283 sites in the genome th

58 independent of the site-by-site variation in mutability due to different CpG contexts.

59 , we discuss a number of issues (e.g., locus mutability, failure to saturate, number of gametes to sc

60 rease in survival and a 200-fold increase in mutability following a UV-B dose of 1,900 J m(-2).

61 We also observed a trend for high predicted mutability for codon positions 1 and 2 in complementarit

62 y, gonadal dysgenesis and P-element-mediated mutability; however, individual lines carrying these con

63 lular phenotype, we examined post-UV plasmid mutability in 31 lymphoblastoid cell lines from 6 famili

64 pothesis whereby adaptive mutation is normal mutability in amplified DNA.

65 ow that SIRs confer an increase in localized mutability in breast cancer, which is domain-dependent w

66 Thus, alt-NHEJ, which contributes to genetic mutability in cancer cells, also plays a novel role in e

67 found an abnormally elevated post-UV plasmid mutability in cell lines from 13 of 13 patients with CM

68 of somatic hypermutation results in greater mutability in complementarity-determining regions of the

69 st three decades has described an impressive mutability in dendritic-spine number and morphology unde

70 A genome-wide view of sequence mutability in mice is still limited, although biologists

71 Overall mutability in Neisseriae can be described by measuring b

72 iation were accompanied by increased overall mutability in some N. meningitidis isolates including st

73 dative stress as a potential source of hyper-mutability in ssDNA by modulation of the endogenous ROS

74 thers have speculated that an enhancement of mutability in the complementarity-determining regions (C

75 e of being advantageous) and/or decrement of mutability in the framework regions (FR; where mutations

76 r, none had any effect on P-element-mediated mutability in the male germ line.

77 ted the influence of nucleosome stability on mutability in vivo.

78 iously observed enhanced radioresistance and mutability in WTK1 cells must be attributed to a more co

79 Second, mutability increases nonuniformly with length, suggestin

80 unpaired during transcription; and (ii) the mutability index (MI) for each base, expressed as an abs

81 Increased mutability is an intrinsic property of SIRs as evidenced

82 e provide evidence indicating that this high mutability is due to a saturation of the DNA mismatch re

83 the intermediate range (34-37 repeats), the mutability is increased, frequently leading to alleles o

84 Mutability is influenced by factors that increase the li

85 ence; and a state of elevated microsatellite mutability is interspersed across the genome.

86 fall into three distinct categories: 1) The mutability is sharply higher at CG dinucleotides under m

87 show that a feature of the Lac(+) and Trp(+) mutability is the accumulation of Trp(+) and Lac(+) reve

88 Adaptive mutability is the apparent alteration in specificity or

89 Apparent directed mutability, its recombination requirement, and its appar

90 th extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to

91 These results suggest that inducible mutability may present a reasonable strategy for adaptiv

92 or-free DNA repair in a DR region of minimal mutability (MMDR region).

93 The mutability modulated by AID hotspots and coldspots chang

94 ination is not the cause, the high degree of mutability must presumably reflect the inherent properti

95 e microsatellite instability and spontaneous mutability observed in the msh2 mutant, yeast cells harb

96 which is domain-dependent with the greatest mutability observed within spacer sequences ( approximat

97 e two sets of patterns are very similar: the mutabilities of nucleotide triplets are positively corre

98 ed nucleotide variants is asymmetric and the mutabilities of the different amino acids are very diffe

99 We examined the mutability of 328 amino acids in the mature PorB protein

100 MBD4 might function in vivo to minimize the mutability of 5-methylcytosine by removing its deaminati

101 We explored this issue by testing the mutability of a non-Ig transcription cassette in Ig and

102 t the identity of the 3' base can affect the mutability of a purine by oxidative damage by as much as

103 e odds from the perspective of the intrinsic mutability of AIV rather than the ecological constraints

104 The mutability of bacteriophages offers a particular advanta

105 nfluences not only the survival but also the mutability of cells in response to IR.

106 two knock-in models to directly compare the mutability of core Smu and VDJ exon sequences and their

107 The mutability of cortical function implies a continual proc

108 cting protein domains, but suggests that the mutability of different regions of a protein in such a t

109 ng flanking sequences modifying the relative mutability of dispersed expanded human triplet repeats.

110 In this study, we analyzed the mutability of each residue using an approach that captur

111 atch repair in vivo and suggest that the low mutability of exonuclease-deficient strains is a consequ

112 bust to different models of variation in the mutability of genes.

113 The enormous genetic diversity and mutability of HIV has prevented effective control of thi

114 elopment and observed an average decrease in mutability of less than 10 percent over time.

115 In vivo, MBD4 functions to reduce the mutability of methyl-CpG sites in the genome and mice de

116 The dynamic mutability of microsatellite repeats is implicated in th

117 Fourth, mutability of mononucleotide microsatellites is impacted

118 We present evidence that mutability of motif A has been conserved during evolutio

119 The mutability of motif II in 210 active mutants has paralle

120 y which inherited polymorphism regulates the mutability of nearby sequences.

121 ion frequency of Hb receptors or the general mutability of Neisserial strains.

122 d in nontumorous human lung and to study the mutability of p53 codons 157, 248, 249, and 250 to benzo

123 g the metabolism of palindromic repeats, the mutability of quasipalindromic triplet repeats, and the

124 Because of the high mutability of retroviruses, it is not the generation of

125 However, a molecular basis for the high mutability of RGYW was not known until recently.

126 Our work forges ground in showing that the mutability of RNA viruses does have an upper limit, wher

127 ost species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of eme

128 It is also apparent that changes in the mutability of specific loci can be influenced by alterat

129 amino acid substitutions, we determined the mutability of the 13 constituent amino acids Val(700)-Ar

130 nvestigated whether natural selection and/or mutability of the antibody variable region contributed s

131 etermined experimentally correlated with the mutability of the bases as predicted by mfg.

132 an important role in determining the overall mutability of the clinical isolates.

133 Furthermore, the mutability of the CpG dinucleotide has led to the deplet

134 addition there were striking differences in mutability of the different nucleotides within the restr

135 chance (p = 1.2 x 10(-8)) given the size and mutability of the gene.

136 Since the relative mutability of the GNN-encoded amino acids does not expla

137 However, the high mutability of the influenza virus represents a design ch

138 ironmental factors can modify the number and mutability of the MMR-deficient stem cells.

139 The high mutability of the polymerase active site in vivo and the

140 a gene is polymorphic mostly depends on the mutability of the site.

141 We describe the mutability of the Trp(-) chromosomal +1 frameshift mutat

142 peared substantially guided by the intrinsic mutability of the VH1-46 gene, which closely resembled V

143 ile the rarity of CG is ascribed to the high mutability of this dinucleotide, the rarity of TA in cod

144 Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are im

145 he phenomenon can be explained by the higher mutability of unprotected cytosines.

146 w that Hot can also cause an increase in the mutability of various E. coli strains (mutator effect).

147 V(beta) sequences resemble immunoglobulin in mutability pattern, suggesting one of several alternativ

148 We find that the mutability patterns in a number of species are similar t

149 s suggests that some sequences have inherent mutability, possibly due to sequence-related differences

150 ere we report that the di- and trinucleotide mutability preference pattern is shared by mouse introni

151 A transfer may be a prominent feature in the mutability process that occurs during nonlethal selectio

152 des evidence that, during transcription, the mutability (propensity to mutate) of a base in a DNA sec

153 fects of selection (functional category) and mutability (relative mutation rate) on the PSSs and foun

154 herichia coli, in which the stationary-phase mutability requires homologous recombination functions.

155 We compiled a mutability score that reflects the degree to which a par

156 pparent alteration in specificity or rate of mutability seen in bacteria during stress.

157 mononucleotide tracts seemed to affect their mutability significantly.

158 genes exhibit microsatellite instability and mutability similar to that in the msh2 mutant.

159 Despite their high mutability, stable allele frequency distributions are ty

160 -avoidance systems results in extremely high mutability that can lead to error catastrophe.

161 ulting in a subset of bacteria with elevated mutability that often remain hypermutable for the durati

162 ardless of its original phenotype, increased mutability to a level seen in the fast strain.

163 d to calculate expected DNA and protein site mutability to decouple relative contributions of mutagen

164 UV mutability to rifampin resistance (Rif(r)) was detected

165 opposed to its proposed role as a source of mutability to select specific tumor-prone aneuploid cell

166 Changing CAGGTG to AAGGTG reduces the mutability to that of the non-RS transgenes without alte

167 onstructs, we determined that rulAB restored mutability to the Escherichia coli umuDC deletion mutant

168 Third, mutability varies among microsatellites with different m

169 f the CpG dinucleotide, which makes arginine mutability very much higher than other amino acids) rath

170 rulAB-induced UV mutability was also tracked in phyllosphere populations

171 No effect on apoptosis, radiosensitivity or mutability was observed when the HPV16 E6 gene was intro

172 Searching for general adaptive mutability, we have investigated the behavior of Salmone

173 t of serogroup A isolates possessed elevated mutability, which could be divided into two classes: int

174 enetics, forensics, etc.), due to their high mutability within and between species.

175 e growth can give the appearance of adaptive mutability without requiring any change in mutability.