ライフサイエンスコーパス: mutagenic

1 between the repeats, and hence is relatively mutagenic.

2 t block to DNA replication and are extremely mutagenic.

3 cy, although increasing cytotoxicity, is not mutagenic.

4 d2Ih likely causes this lesion to be highly mutagenic.

5 5-hydroxymethyl-2'-deoxycytidine, should be mutagenic.

6 f microhomology-mediated pathways, which are mutagenic.

7 osopiperazine and 1-nitropiperazine were not mutagenic.

8 investigated whether NB disruption might be mutagenic.

9 data suggest that iPSC reprogramming is not mutagenic.

10 Here we demonstrate that mutagenic 7,12-dimethylbenz(a)anthracene (DMBA), cisplat

11 The highly mutagenic A:8-oxoguanine (oxoG) base pair is generated m

12 The highly mutagenic A:oxoG (8-oxoguanine) base pair in DNA most fr

13 Therefore, the mutagenic ability of 5ClC documented in the present stud

14 Paradoxically, mutagenic action of mismatch repair has been implicated

15 CRISPR target sequences with their relative mutagenic activities.

16 Observed differences in mutagenic activity are likely the result of dynamic meta

17 Our findings therefore identify the highly mutagenic activity of benznidazole metabolites in T. cru

18 Generally, the mutagenic activity of food samples was low, but exhibite

19 formation of HAAs and significantly lowered mutagenic activity of fried burgers.

20 Mutagenic activity of synthetic PAH mixtures that mimic

21 say-based approach that employs the in vitro mutagenic activity of the soil fractions to determine le

22 Mutagenic activity results are presented in our companio

23 grades A3F and, in some cases, overcomes A3G mutagenic activity to replicate.

24 Significant mutagenic activity was detected in all nonpolar neutral

25 Predictions of mutagenic activity, calculated as the sum of the contrib

26 For increased mutagenic activity, formation of a dimer was more import

27 ndicated that the selected compounds have no mutagenic activity.

28 id state followed by an examination of their mutagenic activity.

29 ; and (iii) neither nonspecific toxicity nor mutagenic activity.

30 tions and in patients' samples where AraC is mutagenic, addition of CHK1i appears to eliminate the ge

31 Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descenda

32 Population-wide resistance to these mutagenic agents did not arise after serial passage of i

33 by stimulating the endogenous production of mutagenic aldehydes and N-nitroso compounds.

34 e zeta (Polzeta) is responsible for a highly mutagenic alternative mechanism.

35 However, a mutagenic alternative NHEJ pathway, microhomology-mediat

36 ote inappropriate chromosome fusions via the mutagenic alternative non-homologous end joining (A-NHEJ

37 ocyclic aromatic amines (HAAs) classified as mutagenic amines by the International Agency for Researc

38 ensitive determination of six representative mutagenic amines was developed.

39 Mutagenic analysis and atomic force microscopy imaging,

40 amics simulations and based on a comparative mutagenic analysis of AQPs 1, 3, and 4, suggest that loo

41 Mutagenic analysis of K6a confirmed that the site-specif

42 Mutagenic analysis shows H3 tail residues 11-27 to be th

43 rogen-deuterium exchange studies followed by mutagenic analysis to test the activation mechanism.

44 A comprehensive mutagenic analysis, guided by homology mapping in atomic

45 with reduced protection against potentially mutagenic and carcinogenic DNA damage.

46 polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects.

47 methylimidazo[4,5-f]quinoline (IQ), a highly mutagenic and carcinogenic heterocyclic amine found in c

48 enzyme responsible for initiating removal of mutagenic and cytotoxic abasic lesions as part of the ba

49 ic sites are ubiquitous DNA lesions that are mutagenic and cytotoxic but are removed by the base exci

50 BER counters the mutagenic and cytotoxic effects of damage that occurs co

51 A glycosylase (hTDG), which initiates BER of mutagenic and cytotoxic G:T and G:U mispairs in DNA.

52 Our mutagenic and kinetic studies further demonstrate that t

53 Etheno adducts are mutagenic and may contribute to the initiation of severa

54 However, such vectors are potentially mutagenic and might want to be avoided under some circum

55 e alleles together with the contamination of mutagenic and nonmutagenic chemical pollution offers new

56 position of endogenous retroelements through mutagenic and nonmutagenic mechanisms.

57 an important role in the evolution of these mutagenic and pathogenic agents.

58 midine (O(4)-alkyldT) are known to be highly mutagenic and persistent in mammalian tissues.

59 Such bursts are mutagenic and thus potentially deleterious.

60 d genetic approaches, we have quantified the mutagenic and toxic properties of 5ClC, showing that thi

61 identity, these polymerases display distinct mutagenic and translesion specificities.

62 unds have been demonstrated to be cytotoxic, mutagenic, and carcinogenic.

63 This mutagenic approach helped to identify key regions implic

64 Herein, we use a structure-based mutagenic approach to demonstrate that cobalamin riboswi

65 By using a high-throughput, signature-tagged mutagenic approach, we created 5,088 mutants of Y. pesti

66 dentified 14 amines including the two potent mutagenic aromatic amines 2,3- and 2,8-phenazinediamine,

67 ironmental contaminants including two weakly mutagenic aromatic amines, and the known alkaloid comuta

68 Given the fact that most conventional mutagenic assays were negative for PFOS, we propose that

69 Notably, extension from the mutagenic base pair is favored over the non-mutagenic ba

70 mutagenic base pair is favored over the non-mutagenic base pair.

71 This report evaluates the pro-mutagenic behavior of 8-oxo-guanine (8-oxo-G) by quantif

72 a dynamic and complex system, we carried out mutagenic, biochemical, hydrodynamic and structural stud

73 resent work shows that 5ClC is intrinsically mutagenic, both in vitro and, at a level of a single mol

74 DBAN is not mutagenic but causes DNA breaks and elevates sister chro

75 These DNA cross-links can be mutagenic by damaging the integrity of the DNA structure

76 B, a translesion polymerase, facilitates the mutagenic bypass of both lesions.

77 Strikingly, POLRMT shows a high mutagenic bypass rate, which is exacerbated by TEFM (tra

78 es into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism.

79 Here, we describe a battery of mutagenic cassettes that can be applied in conjunction w

80 We have developed a method called the mutagenic chain reaction (MCR), which is based on the CR

81 vector Anopheles stephensi, adapted from the mutagenic chain reaction (MCR).

82 th an efficiency of >40%, without unintended mutagenic changes at the targeted genetic loci.

83 IP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensa

84 However, testing all potentially mutagenic compounds in cell-based assays is tedious and

85 To identify the mutagenic compounds, we applied effect-directed analysis

86 avor faithful Watson-Crick base pairing over mutagenic configurations.

87 Here we propose a hypothesis that the mutagenic consequences associated with performing metabo

88 n insight into this process, we analyzed the mutagenic consequences of replication fork stalling at a

89 In this review, we focus specifically on the mutagenic consequences of transcription.

90 as a cause of cancer development through its mutagenic consequences.

91 o been shown to cut at off-target sites with mutagenic consequences.

92 e C residue in C:oxoG would actually promote mutagenic conversion to A:oxoG.

93 e find direct evidence that recombination is mutagenic: Crossovers carry more de novo mutations than

94 Here, we show that mutagenic damage accounts for the majority of the errone

95 DNA damage sites resulting in error-free or mutagenic damage bypass.

96 Because much mutagenic damage is expressed following cell division, m

97 has implications for the control of another mutagenic deaminase, human AID, and provides a rationale

98 atients is proportional to the extent of the mutagenic destabilization.

99 sine (gamma-OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation.

100 rming translesion DNA synthesis past the pro-mutagenic DNA adduct O(6)-benzylguanine (O(6)-BnG).

101 O(6)-Methylguanine (O(6)-MeG) is a highly mutagenic DNA adduct that forms in human genomic DNA upo

102 S with 8-oxo-guanine (8-oxo-G), a highly pro-mutagenic DNA lesion formed by reactive oxygen species.

103 Potentially mutagenic DNA lesions induced by UVB (wavelengths 280-32

104 pol V) began with an attempt to identify the mutagenic DNA polymerase responsible for copying damaged

105 recombination and somatic hypermutation, two mutagenic DNA processes used to generate antibody divers

106 some structural aberrations, and error-prone mutagenic DNA repair following exposure to ICL-inducing

107 This occurred via a mutagenic DNA repair pathway that included DNA double-st

108 dictate preferential use of the potentially mutagenic double-strand break repair pathway.

109 This approach uses mutagenic drugs to increase viral mutation rates and bur

110 The polyphenolic extract did not showed mutagenic effect by Ames test against Salmonella typhimu

111 xygenase 2 (COX-2) expression as well as the mutagenic effect in bystander cells.

112 mans, but few studies have ever examined its mutagenic effect in vivo.

113 ing of multiple DT40 clones to determine the mutagenic effect of eight common cytotoxics used for the

114 an important contribution to determining the mutagenic effect of environmental agents or genetic defe

115 utagenesis assays to validate or predict the mutagenic effect of environmental and iatrogenic exposur

116 However, evidence for a local mutagenic effect of recombination from population sequen

117 Thus, a mutagenic effect of their repair could constitute a seri

118 t smoking has a transient and dose-dependent mutagenic effect on LOY status.

119 oxorubicin and paclitaxel have no measurable mutagenic effect.

120 e generation of neoplastic cells through its mutagenic effect.

121 that recombination does not have observable mutagenic effects after gene conversion is accounted for

122 vated carbon (GAC) significantly reduced the mutagenic effects as well as the concentrations of remai

123 Compared to the relatively moderate mutagenic effects of UVR, acute UV exposure induced subs

124 air is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which

125 genic basis of AFB1 has been ascribed to its mutagenic effects, the mutagenic property of the primary

126 such functions are associated with moderate mutagenic effects, we observe the evolution of reproduct

127 owed no inhibition of CYP17 and CYP19 and no mutagenic effects.

128 Given the exceptional mutagenic efficiency and specificity of the Cas9 strains

129 sequence to the gene confirmed to have high mutagenic efficiency.

130 ns of jumping and intersegmental transfer to mutagenic efficiency.

131 Our results suggest that the input of a mutagenic effluent from a WWTP resulted in a strong incr

132 ADAT2/3 is a highly mutagenic enzyme, but we also show that when co-expresse

133 Instead, mutagenic epitope deletion yields a spectrum of designs

134 ver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders.

135 implications of this model toward increasing mutagenic events in lung cancer are discussed.

136 sis, suggesting a requirement for additional mutagenic events or microenvironmental stimuli, includin

137 pressed state the virus DNA is vulnerable to mutagenic events that affect the host cell and have the

138 Duplex sequencing detects rare mutagenic events, independent of selection and in multip

139 but also to further accumulation of similar mutagenic events.

140 Furthermore all previous experimental mutagenic evidence is highly consistent with the identif

141 ranslational fidelity of coding RNAs and the mutagenic evolution of viral RNA genomes.

142 ire spermatogenic cycle can be at risk after mutagenic exposure.

143 viding new insights into the contribution of mutagenic exposures to cancer incidence.

144 , and various other endogenous and exogenous mutagenic factors.

145 These compounds have shown to be toxic and mutagenic for procaryotic and eucaryotic cells.

146 of whole-genome sequence data and that this mutagenic form of DNA repair may play a role in genetic

147 utagen benzyl(diphenyl) phosphine oxide in a mutagenic fraction.

148 se excision repair, TDG removes thymine from mutagenic G .: T mispairs caused by 5-methylcytosine (mC

149 TDG removes thymine from mutagenic G.T mispairs arising from deamination of 5-met

150 agonistic/antagonistic endocrine activities, mutagenic/genotoxic activities, cytotoxic activities, fu

151 xhaust and organic extract were found to act mutagenic/genotoxic, but the amplitudes of the effects d

152 ference between faithful repair and wreaking mutagenic havoc on the genome lies in the accurate discr

153 Lucidin is a genotoxic and mutagenic hydroxyanthraquinone metabolite, which origina

154 of photoproducts in DNA that are potentially mutagenic if not properly removed by the nucleotide exci

155 fficiently recognizes and excises the highly mutagenic imidazole ring-opened AFB1-deoxyguanosine addu

156 ortantly, these dNTP imbalances are strongly mutagenic in genetic backgrounds where DNA polymerase fu

157 er-associated POLD1-R689W allele is strongly mutagenic in human cells.

158 -dihydro-2'-deoxyguanine (8-oxoG), is highly mutagenic in vivo due to its anti-conformation forming a

159 Transcription is mutagenic, in part because the R-loop formed by the bind

160 the product of C-nitrosation of tyramine is mutagenic, in the present article tyramine nitrosation m

161 at lower concentrations of the mixtures (not mutagenic individually), and decreased MF at higher conc

162 the consideration for obviating the risk of mutagenic insertion and enables more accurate controllin

163 media and by cryogenic storage, (2) identify mutagenic insertion sites and physical coordinates in th

164 simultaneous mapping of tens of thousands of mutagenic insertion sites in the eukaryotic unicellular

165 Fungal LTR retrotransposons prevent mutagenic insertions through diverse targeting mechanism

166 nd the incoming dATP, which would facilitate mutagenic lesion bypass.

167 s in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes.

168 n species generate potentially cytotoxic and mutagenic lesions in DNA, both between and within the nu

169 Etheno (epsilon) DNA base adducts are highly mutagenic lesions produced endogenously via reactions wi

170 ropose that saturation mutagenesis under low mutagenic loads, followed by whole-genome sequencing, sh

171 lysis of concatemeric channels, which permit mutagenic manipulation of individual pores, show that ea

172 anocytes are primed for transformation via a mutagenic mechanism involving an excess of T>G substitut

173 ses-have revealed a remarkable complexity of mutagenic mechanisms.

174 Cadmium is a well known mutagenic metal that can enter cells via nonspecific met

175 ted as the sum of the contributions from the mutagenic mixture components, were all within 2-fold of

176 e findings indicate that HR factors suppress mutagenic MMEJ following DSB resection.

177 he virus' specific infectivity, indicating a mutagenic mode of action.

178 Polzeta together with Rev1 mediates a highly mutagenic mode of TLS.

179 rmed during chlorination, such as the highly mutagenic MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H

180 uring S phase, which would otherwise promote mutagenic NHEJ and genome instability.

181 on activities of 53BP1 are rate-limiting for mutagenic NHEJ but not for physiological CSR.

182 RNF168 or 53BP1 impacts physiological versus mutagenic NHEJ.

183 eI, our estimated frequencies of accurate or mutagenic non-homologous end-joining and gene correction

184 nucleotide insertions/deletions (indels) via mutagenic nonhomologous end joining.

185 gation reveals that Msd specifically acts on mutagenic nucleobases such as 5-azacytosine and isoguani

186 (HF)) mutant virus was more resistant to the mutagenic nucleoside analogs ribavirin and 5-fluorouraci

187 le for the use of favipiravir derivatives or mutagenic nucleosides in the clinical treatment of norov

188 erated by increasing the mutation rate using mutagenic nucleotide analogs.

189 l mechanism is unveiled to explain why a pro-mutagenic nucleotide lesion (oxidized guanine, 8-oxoG) c

190 n strains obtained by selective pressure via mutagenic nucleotides or adaptation approaches.

191 )G) DNA glycosylase 1 (hOGG1), which repairs mutagenic (o)G lesions in DNA.

192 ylguanine-DNA alkyltransferase (AGT) repairs mutagenic O6-alkylguanine and O4-alkylthymine adducts in

193 wn heretofore if 5ClC directly perpetrates a mutagenic outcome within the cell.

194 ested, DAMP requires proteins scavenging the mutagenic oxidised nucleotide 8-oxo-dGTP.

195 Regulation of the BER pathway for mutagenic oxidized bases, initiated by NEIL1 and other D

196 ing further errors that continue to fuel the mutagenic pathway.

197 here has been increased understanding of the mutagenic pathways as they occur in living cells.

198 Activation-induced deaminase (AID) initiates mutagenic pathways to diversify the antibody genes durin

199 open reading frames and a large quantity of mutagenic peptides highly distinct from self, might cont

200 n creates excited states in DNA that lead to mutagenic photoproducts.

201 in the same transcript, reducing the size of mutagenic plasmids and simultaneously simplifying their

202 ns do not arise as a result of the increased mutagenic plasticity of cancer cells.

203 Mutagenic Polycyclic aromatic hydrocarbons (PAHs) are pr

204 enes, suggesting that the inhibition of this mutagenic polymerase represents a valid therapeutic aven

205 We find that PrimPol is a mutagenic polymerase, with a unique error specificity th

206 sed significantly the DBP concentrations and mutagenic potencies for most pools and spas.

207 evidence that human precursors can increase mutagenic potencies of pools and spas and that this incr

208 The mutagenic potencies of samples from a brominated site co

209 Mutagenic potencies of samples from a chlorinated site c

210 onically exposed to PAH mixtures (p.o.), and mutagenic potency (MP) values were determined for five t

211 es that dose-additive predictions of mixture mutagenic potency based on the concentrations and potenc

212 sed from finished to tap to pool to spa; and mutagenic potency increased from finished/tap to pools t

213 ydroxy-2'-deoxyguanosine (8-oxo-dG) has high mutagenic potential as it is prone to mispair with deoxy

214 However, none of the food extracts showing mutagenic potential induced DNA damage in vitro using th

215 chemical assays that allow prediction of the mutagenic potential of deoxyribonucleoside analogues.

216 onse, may be important for understanding the mutagenic potential of food and the etiology of diet-ass

217 search for cellular factors that augment the mutagenic potential of Poldelta-R696W, we discovered tha

218 lication at stalled forks, thus reducing the mutagenic potential of PrimPol during genome replication

219 Consistent with the low mutagenic potential of the beta-anomer in vitro, the mut

220 s containing a site-specific DNA adduct, the mutagenic potential was determined in primate cells.

221 g a superior pharmacological profile with no mutagenic potential.

222 cular environments and furthermore that this mutagenic process can be regulated through histone acety

223 ent rNMPs give rise to short deletions via a mutagenic process initiated by Topoisomerase 1 (Top1).

224 This mutagenic process requires the mismatch recognition fact

225 at maintains telomeres, acts upon a DSB in a mutagenic process termed telomere healing.

226 As a result, the combination of mutagenic processes can be identified in any query sampl

227 Rev1 also is involved in mutagenic processes during somatic hypermutation of immu

228 rs and can, for example, elucidate different mutagenic processes in different cancer groups.

229 tal exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implicatio

230 ion classes supporting a role for additional mutagenic processes in melanoma development in individua

231 s, identifies the combinations of underlying mutagenic processes including those related to infidelit

232 These mutagenic processes often produce characteristic mutatio

233 to identify the mutagens, and to reveal the mutagenic processes responsible for human cancer.

234 Elucidation of mutagenic processes shaping cancer genomes is a fundamen

235 , and tissues carried signatures of distinct mutagenic processes such as oxidative DNA damage and tra

236 ield of molecular epidemiology are to assign mutagenic processes to orphan and newly discovered tumou

237 respect to their vulnerability to different mutagenic processes, and helped us to uncover pairs of g

238 pes, we reveal widespread asymmetries across mutagenic processes, with transcriptional ("T-class") as

239 dy of spontaneous or environmentally induced mutagenic processes.

240 n tyramine is C-nitrosation, which generates mutagenic products.

241 R in RNase HII-deficient cells and the known mutagenic profile of DnaE, we propose that misincorporat

242 These compounds present carcinogenic and/or mutagenic properties and offer a risk to human health.

243 Overall, our data reveal that the bimodal mutagenic properties of KP1212 result from its unique sh

244 ortant new knowledge about the cytotoxic and mutagenic properties of the O(4)-alkyldT lesions and def

245 ults are consistent with previously observed mutagenic properties of these regions and counter a prev

246 The mutagenic properties of ultraviolet radiation drive the

247 l use of NMs is limited because of their own mutagenic properties.

248 The mutagenic property of KP1212 was hypothesized to origina

249 been ascribed to its mutagenic effects, the mutagenic property of the primary AFB1-DNA adduct, AFB1-

250 itizes the skin and causes the production of mutagenic reactive oxygen species.

251 s DSB repair, enhancing efficiency of likely mutagenic repair, and enabling radiation and cisplatin t

252 poisomerase 1 (Top1) by either error-free or mutagenic repair.

253 A model is proposed for enhanced pro-mutagenic replication catalyzed by pol eta that couples

254 s in the replicating genome, thus preventing mutagenic replication.

255 Pool and spa samples were 2.4 and 4.1x more mutagenic, respectively, than corresponding tap waters.

256 We determined the mutagenic response to mixtures of BaP and PhIP at concen

257 Hypervariation occurs via a mutagenic retrotransposition process from a template rep

258 nding how metazoa protect their genomes from mutagenic retrovirus infection is therefore of fundament

259 iversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to gener

260 ombined properties are consistent with a pro-mutagenic role for pol eta when replicating this DNA les

261 Here, we performed a large-scale insertional mutagenic screen of injury-resistant podocytes isolated

262 sed sgRNA library and Cas9 allows functional mutagenic screening.

263 ed subjects can be differentiated from other mutagenic signatures, we included data from an ultraviol

264 rm of STAT5 (Stat5b-CA) with mice in which a mutagenic Sleeping Beauty transposon (T2/Onc) was mobili

265 challenges, including changes in exposure to mutagenic solar radiation.

266 on of improved mutant chromosomes due to the mutagenic SOS response and possible recombination of the

267 By iteratively introducing libraries of mutagenic ssDNAs targeting multiple sites, MAGE can gene

268 orces long-term suppression of an inherently mutagenic stage of B cell differentiation that gammaherp

269 onal germinal center reaction, an inherently mutagenic stage of B cell differentiation that is though

270 The modeled structure of MxB guided our mutagenic studies and led to the discovery of several Mx

271 The crystal structure of the DN6 TCR and mutagenic studies reveal a requirement of five complemen

272 with those from bacterial Phys combined with mutagenic studies support a toggle model for photoconver

273 Based upon these and mutagenic studies, we propose an allosteric mechanism wh

274 A mutagenic study guided by the structures revealed that R

275 The formed potentially mutagenic substances were hitherto not identified and ma

276 we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step

277 or-prone Pol32-dependent synthesis, but that mutagenic synthesis is limited to within a few kilobases

278 odel to generate tumors upon activation of a mutagenic T2Onc2 transposon via expression of a transpos

279 into viral transcription and a possible low mutagenic target for antiretroviral therapy.

280 ing the accumulation of damaging radicals or mutagenic tautomers.

281 Rubisco biogenesis in tobacco hindered their mutagenic testing by chloroplast transformation.

282 of brominated pool/spa waters were 1.8x more mutagenic than chlorinated ones; spa waters were 1.7x mo

283 chlorinated ones; spa waters were 1.7x more mutagenic than pools.

284 R is conservative, less processive, and more mutagenic than replicative DNA synthesis.

285 nitrosamines were approximately 15-fold more mutagenic than their N-nitramine analogues.

286 Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication m

287 In contrast to its role in mutagenic TLS in yeast, Rev1 promotes predominantly erro

288 n dNTP elevation is needed to facilitate non-mutagenic tolerance pathways, while Polzeta synthesis re

289 However, a short mutagenic tract is introduced in the vicinity of the les

290 it requires an increased involvement of the mutagenic translesion DNA polymerase zeta during DNA rep

291 to tolerate unrepaired lesions: potentially mutagenic translesion synthesis (TLS) and nonmutagenic d

292 While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination acti

293 his hybrid RNA-cDNA molecule is required for mutagenic transposition, revealing a unique mechanism of

294 The mutagenic uncoupling of femtosecond motions between cata

295 ve DNA fidelity by catalyzing the removal of mutagenic uracils.

296 ficantly inhibits the removal of potentially mutagenic UVB-induced DNA photolesions by nucleotide exc

297 ds aiming to identify aromatic amines in six mutagenic wastewater effluents from a chemical-industria

298 Because 3' transductions are potentially mutagenic, we explored the extent to which they occur so

299 Insertion of 8-oxoG is mutagenic when opposite adenine but not when opposite cy

300 show that the replicative polymerase DnaE is mutagenic within the sequence context identified in RER-