ライフサイエンスコーパス: mutagenic effect

1 e generation of neoplastic cells through its mutagenic effect.

2 oligomers and their metabolites exhibited no mutagenic effect.

3 oxorubicin and paclitaxel have no measurable mutagenic effect.

4 l locus showed that ionizing radiation had a mutagenic effect.

5 sferase should be tested for their potential mutagenic effects.

6 owed no inhibition of CYP17 and CYP19 and no mutagenic effects.

7 ed mechanisms to combat retrotransposition's mutagenic effects.

8 ster (RME) for their emissions and bacterial mutagenic effects.

9 vivo can result from both direct and delayed mutagenic effects.

10 that recombination does not have observable mutagenic effects after gene conversion is accounted for

11 vated carbon (GAC) significantly reduced the mutagenic effects as well as the concentrations of remai

12 by eosinophil peroxidase exert cytotoxic and mutagenic effects at eosinophil-rich sites of inflammati

13 In addition to the carcinogenic and mutagenic effects, BaP and other PAHs, including 7,12-di

14 The polyphenolic extract did not showed mutagenic effect by Ames test against Salmonella typhimu

15 strand, S(6)mG exhibited both inhibitory and mutagenic effects during transcription mediated by singl

16 uclease activity, which could be a source of mutagenic effects if this ion were selected as the natur

17 xygenase 2 (COX-2) expression as well as the mutagenic effect in bystander cells.

18 mans, but few studies have ever examined its mutagenic effect in vivo.

19 This mutagenic effect is particularly strong for extreme ther

20 ntial to trigger carcinogenesis owing to its mutagenic effects mediated through oxidative DNA damage.

21 The DOC reduced mutagenic effects most effectively in the gas phase.

22 ons, we first tested the hypothesis that the mutagenic effect of 5-Aza-dC may be directly mediated th

23 epair and mismatch repair defend against the mutagenic effect of 8-oxoG lesions in a cooperative mann

24 first demonstration for potentiation of the mutagenic effect of a cytosine analog by A3G expression,

25 en shown to protect cells from the toxic and mutagenic effect of alkylating agents by removing lesion

26 t how loss of MMR affects sensitivity to the mutagenic effect of chemotherapeutic agents.

27 ant role in protecting against the toxic and mutagenic effect of cyclophosphamide and suggests that a

28 ad only a minor effect on sensitivity to the mutagenic effect of DDP as measured by the appearance of

29 Sensitivity to the cytotoxic and mutagenic effect of DDP was assessed using a panel of su

30 P and 2.3- to 5.1-fold hypersensitive to the mutagenic effect of DDP.

31 ing of multiple DT40 clones to determine the mutagenic effect of eight common cytotoxics used for the

32 an important contribution to determining the mutagenic effect of environmental agents or genetic defe

33 utagenesis assays to validate or predict the mutagenic effect of environmental and iatrogenic exposur

34 The mutagenic effect of environmental carcinogens has been w

35 f p53 and MMR function on sensitivity to the mutagenic effect of H(2)O(2) paralleled the effects on c

36 The mutagenic effect of low linear energy transfer ionizing

37 in human oral keratinocytes and enhance the mutagenic effect of MNNG.

38 ant role in protecting against the toxic and mutagenic effect of O6 alkylating agents and that a muta

39 d with IFN-alpha alone can be explained by a mutagenic effect of RBV against HCV.

40 However, evidence for a local mutagenic effect of recombination from population sequen

41 Therefore, the mutagenic effect of recombination is far weaker than pre

42 Thus, a mutagenic effect of their repair could constitute a seri

43 The mutagenic effect of TNF-alpha is comparable with that of

44 notype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melan

45 guanine DNA glycosylase involved in reducing mutagenic effects of 7,8-dihydro-8-oxo-guanine (8-oxoG).

46 guanine DNA glycosylase involved in reducing mutagenic effects of 7,8-dihydro-8-oxoguanine (8-oxoG).

47 ine DNA glycosylase involved in reducing the mutagenic effects of 7,8-dihydro-8-oxoguanine (GO).

48 A glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its

49 The mutagenic effects of 8-oxoG in mammalian cells are preve

50 mtMYH can protect mitochondrial DNA from the mutagenic effects of 8-oxoG.

51 we have shown that mitochondria mediate the mutagenic effects of arsenic in mammalian cells, as arse

52 icularly mtDNA, are important targets of the mutagenic effects of arsenic in mammalian cells.

53 DPC lesions contribute to the cytotoxic and mutagenic effects of bis-electrophiles.

54 the possibility that alcohol may enhance the mutagenic effects of cigarette smoke in the lung.

55 n of AGT in protecting against the toxic and mutagenic effects of cyclophosphamide.

56 changes in sensitivity to the cytotoxic and mutagenic effects of DDP.

57 is an important cellular defense against the mutagenic effects of DNA alkylating agents.

58 ordinary ability to withstand the lethal and mutagenic effects of DNA damaging agents-particularly th

59 excision repair pathways that counteract the mutagenic effects of DNA lesions.

60 and induction of DNA repair, to mitigate the mutagenic effects of DNA replication in the presence of

61 In addition to the directly mutagenic effects of energy deposition in DNA, ionizing

62 The cytotoxic and mutagenic effects of H(2)O(2) were compared in four colo

63 phenotype, which has been attributed to the mutagenic effects of imbalanced nucleotide pools and err

64 cts as critical lesions producing lethal and mutagenic effects of ionizing radiation.

65 Nf1 heterozygosity potentiated the mutagenic effects of irradiation, as evidenced by the si

66 ed with point mutations, potentially through mutagenic effects of meiotic crossover.

67 n important role for APNG in attenuating the mutagenic effects of N-alkylpurines in vivo.

68 -type protein against both the cytotoxic and mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidin

69 w clear that, in addition to the known point mutagenic effects of NO(.), it is also important to cons

70 DNA synthesis (TLS) is known to underlie the mutagenic effects of numerous anticancer agents, but lit

71 gate the molecular basis for the synergistic mutagenic effects of nutritional folic acid deficiency a

72 ase (AGT), protects cells from the toxic and mutagenic effects of O6-alkylating agents.

73 ence of DNA protection against the toxic and mutagenic effects of oxidative damage in metabolically a

74 press proteins that confer resistance to the mutagenic effects of oxidative DNA damage.

75 This result suggests that the mutagenic effects of oxidative stress in C. elegans are

76 ates of evolution often invokes the putative mutagenic effects of oxidative stress.

77 acterial system protects the genome from the mutagenic effects of oxidative stress; the role of the m

78 The absence of genotoxic and mutagenic effects of PDT is an important factor for long

79 es defective in MMR to better understand the mutagenic effects of PhIP in MMR-defective individuals a

80 we established that AGT protects against the mutagenic effects of pyridyloxobutylation resulting from

81 ay possess a reduced capacity to counter the mutagenic effects of reactive oxygen species, a deficien

82 The mutagenic effects of replication past these adducts were

83 ty in vivo, in which we have established the mutagenic effects of SHS in transgenic Big Blue mice, an

84 how the B cell genome is protected from the mutagenic effects of somatic hypermutation nor how often

85 r mechanism by which AidB acts to reduce the mutagenic effects of specific DNA alkylators is unknown.

86 mismatch repair pathways are defective, the mutagenic effects of spontaneous cytosine deamination ar

87 e whether there are correlations between the mutagenic effects of such noncanonical DNA structures an

88 cells are highly sensitive to the toxic and mutagenic effects of temozolomide and 1,3-bis(2-chloroet

89 that work together to protect cells from the mutagenic effects of the commonly oxidized guanine produ

90 ntrolling for genetic background and for the mutagenic effects of transgene insertions in studies of

91 Examination of the genotoxic and mutagenic effects of two NRTIs, zidovudine [AZT (3'-azid

92 The mutagenic effects of ultraviolet and solar irradiation a

93 Compared to the relatively moderate mutagenic effects of UVR, acute UV exposure induced subs

94 air is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which

95 t smoking has a transient and dose-dependent mutagenic effect on LOY status.

96 is transposon had a considerable insertional mutagenic effect on past primate genomes.

97 ct on DNA binding and may instead manifest a mutagenic effect on pol beta primarily by distorting nuc

98 s suggest that one way Mn2+ may manifest its mutagenic effect on polymerases is by promoting greater

99 sis, with subsequent characterization of the mutagenic effects on folding (as measured by incorporati

100 d colleagues demonstrated patterned in-vitro mutagenic effects on p53 of benzo[a]pyrene, a carcinogen

101 nesis and subsequent characterization of the mutagenic effects on viral entry and envelope expression

102 s and the subsequent characterization of the mutagenic effects on viral entry, envelope expression, e

103 nesis and subsequent characterization of the mutagenic effects on viral entry; envelope expression, p

104 nt to which these tools may cause off-target mutagenic effects that could potentially confound diseas

105 genic basis of AFB1 has been ascribed to its mutagenic effects, the mutagenic property of the primary

106 icrog/mL MMS and 1.40 microg/mL EMS before a mutagenic effect was detected.

107 without metabolic activation, indicating the mutagenic effect was not secondary to histidine release

108 such functions are associated with moderate mutagenic effects, we observe the evolution of reproduct

109 No significant differences of mutagenic effects were observed among the tested fuels.

110 No mutagenic effects were observed in cells irradiated with

111 The first exons appear more prone to the mutagenic effects, whereas the other exons are more infl

112 MPA, however, could enhance RBV's mutagenic effect, which suggests distinct mechanisms of