ライフサイエンスコーパス: mutagenicity

1 lead compounds were tested for toxicity and mutagenicity.

2 cranial Doppler ultrasonography, growth, and mutagenicity.

3 ied base pair size, consistent with its high mutagenicity.

4 reated plasmids confirmed a lack of acrolein mutagenicity.

5 P and a significant elevation in DDP-induced mutagenicity.

6 rs, such as DNA adduct levels, toxicity, and mutagenicity.

7 drial damage plays a crucial role in arsenic mutagenicity.

8 g properties of these lesions underlie their mutagenicity.

9 DNA intermediates in regulating AFB1-induced mutagenicity.

10 erocyclic amines (HCAs), benzo[a]pyrene, and mutagenicity.

11 ts and accounted for more than 90% of Cr(VI) mutagenicity.

12 dvantage of the latter for the prediction of mutagenicity.

13 -induced oxidative stress, cytotoxicity, and mutagenicity.

14 tion of structure and context effects define mutagenicity.

15 Overall, the air samples exhibited a weak mutagenicity.

16 ed to quantify directly its genotoxicity and mutagenicity.

17 ain (CTD) was found to be essential for high mutagenicity.

18 stability, GSH adduct formation, and aniline mutagenicity.

19 gested EDB extract inhibited oxidant-induced mutagenicity (26%) in the Salmonella typhimurium TA102 s

20 Derivatives 2g and 2d exhibited maximum anti-mutagenicity against Salmonella typhimurium TA 98 and TA

21 YP selectivity using a panel of CYP enzymes, mutagenicity (Ames screen), and hepatic stability.

22 Mutagenicity analysis showed that riboflavin treatment c

23 ) has received the most attention due to its mutagenicity and because of the possible correlation bet

24 ow that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucos

25 se two detrimental effects contribute to Acr mutagenicity and carcinogenicity.

26 toxicity but also provides a basis for their mutagenicity and carcinogenicity.

27 Ames mutagenicity and CHO-K1 micronucleus assays were applied

28 seven sites, we report the first integrated mutagenicity and comprehensive analytical chemistry of s

29 ransferase (AGT) paradoxically increases the mutagenicity and cytotoxicity of 1,2-dibromoethane (DBE)

30 that Cr(VI) exposure can greatly enhance the mutagenicity and cytotoxicity of PAHs by inhibiting the

31 ity to induce apoptosis as well as for their mutagenicity and cytotoxicity.

32 on location, allowing accurate prediction of mutagenicity and enabling direct genotyping of mutant al

33 ted a modified piggyBac vector with improved mutagenicity and generated insertions in >2000 genes.

34 hat Cr-DNA adducts were responsible for both mutagenicity and genotoxicity of Cr(VI).

35 mprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies

36 recognized by GG-NER, explaining their high mutagenicity and persistence in target tissues.

37 consistent with observed activity as well as mutagenicity and photoaffinity cross-linking studies of

38 Both mutagenicity and pollutant emission factors may be infor

39 Mutagenicity and pollutant emission factors of solid-fue

40 te statistical approach we have examined the mutagenicity and potential consequences of adduct format

41 eference is likely to play a key role in the mutagenicity and repair of IQ-modified oligonucleotides.

42 In the present study, we assessed the mutagenicity and the genotoxicity of complete diesel exh

43 gnificant negative correlation between TALEN mutagenicity and the number of CpG repeats in TALEN targ

44 This coupling between mutagenicity and tolerance for expression variability of

45 ) provides a mechanism for the genotoxicity, mutagenicity, and carcinogenicity of PAHs.

46 ve metabolite of PAHs) induced cytotoxicity, mutagenicity, and DNA adduct formation in Chinese hamste

47 nds were subjected to in vitro cytotoxicity, mutagenicity, and estrogenicity studies.

48 Hepatic DNA adduct formation, in vivo mutagenicity, and hepatocarcinogenicity of MeIQx were ex

49 ng correlation between somatic and germ-line mutagenicity, and identified germ line mutations using Z

50 The mutagenicity/antimutagenicity of proteins and protein hy

51 thods for detecting exhaust genotoxicity and mutagenicity are needed to avoid the widespread applicat

52 mechanisms of nitrous acid cross-linking and mutagenicity, as well as the mechanisms responsible for

53 nd urinary mutagenicity using the Salmonella mutagenicity assay (Ames test).

54 y of the PM (determined using the Salmonella mutagenicity assay with TA98 strain), were measured prio

55 ombinant cytochrome P-450 2E1 Ames bacterial mutagenicity assay, the R597M/W677A protein increased th

56 ed-PAHs (NPAHs) and tested in the Salmonella mutagenicity assay, using Salmonella typhimurium strain

57 Mutagenicity was assessed by the Salmonella mutagenicity assay.

58 Comparative mutagenicity assays (Ames test) were performed on 1 vers

59 The Microscreen mutagenicity assays indicated that certain water column

60 ats but generally tests negative in standard mutagenicity assays.

61 an complete exhaust is used for genotoxicity/mutagenicity assessment, which may reduce the reliabilit

62 Follow-up in vivo mutagenicity assessments will be required to validate th

63 such as in vitro phototoxicity and in vitro mutagenicity associated with compounds 1 and 2 or the in

64 tion and accounts for the surprising lack of mutagenicity associated with this DNA adduct.

65 All HCAs with S9 induced mutagenicity at 10(-10) mol/plate.

66 Without S9, IQ and MeIQ showed mutagenicity at 10(-8) mol/plate, MeIQx and Glu-P-1 at 1

67 The mutagenicity at such sites in many human genes is associ

68 f AZT (as measured by a competitive RIA) and mutagenicity at the HPRT and TK loci (as assessed by cel

69 carcinogen due to its high genotoxicity and mutagenicity attributed to its ability to form DNA-DNA c

70 ity that the enhancement of cytotoxicity and mutagenicity by Cr(VI) is caused by the inhibition of NE

71 a and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metaboli

72 ential biological effects, such as toxicity, mutagenicity, carcinogenicity, and endocrine disrupter a

73 n time prediction and finally toxic effects (mutagenicity caused by aromatic amines).

74 protective effects against the toxicity and mutagenicity caused by quinones.

75 protective effects against the toxicity and mutagenicity caused by quinones.

76 I)-DNA adducts play the dominant role in the mutagenicity caused by the metabolism of Cr(VI) by a bio

77 Bacterial mutagenicity correlated with micronucleus-forming activi

78 Also, rings identified in public domain mutagenicity data sets are compared to rings in drugs da

79 gs in drugs data sets; unfortunately, public mutagenicity data sets do not reflect the types of scaff

80 The distribution of ring systems in public mutagenicity databases is analyzed.

81 A photoproducts linked to skin cancer, whose mutagenicity depends in part on their frequency of forma

82 ing activities; however, the indirect-acting mutagenicity did not decline sharply with distance from

83 s of compounds contributing to surface water mutagenicity due to their widespread occurrence as precu

84 Nevertheless, the mutagenicity emission factor based on fuel energy used (

85 However, mutagenicity emission factors may be especially useful f

86 utagenicity emission factors, correlated the mutagenicity emission factors, and compared them to thos

87 fuel cookstoves for eight pollutant and four mutagenicity emission factors, correlated the mutagenici

88 polyaromatic hydrocarbon (PAH) and indirect mutagenicity emissions were detected with the DISI car.

89 intercalation as a likely mechanism for the mutagenicity-enabled modification of the core scaffold.

90 Cytotoxicity and induced mutagenicity experiments were measured in parallel in UV

91 de of action, specifically DNA adduction and mutagenicity, for aromatic amines, which may account for

92 In an effort to identify compounds with mutagenicity greater than that of ribavirin, we synthesi

93 For decades, mutagenicity has been observed in many surface waters wi

94 indings provide the first evidence of PFOS's mutagenicity in an aquatic model system.

95 in bacteria and mammalian cells and that its mutagenicity in Escherichia coli is dependent on inducti

96 scribed in this report directly examined the mutagenicity in Escherichia coli of both a deoxyadenosin

97 ctive in cisplatin-resistant tumors, but its mutagenicity in humans has not been reported.

98 es for the prediction of carcinogenicity and mutagenicity in methods described in the literature.

99 gnificantly higher level of genotoxicity and mutagenicity in nucleotide excision repair (NER)-deficie

100 , 6-ring positions were tested for bacterial mutagenicity in reverse-mutation assays using Salmonella

101 as similar for genotoxicity in CHO cells and mutagenicity in S. typhimurium, the Salmonella assay was

102 employed quantitative in vitro bioassays for mutagenicity in Salmonella typhimurium, and chronic cyto

103 2.5, levoglucosan (a wood-smoke marker), and mutagenicity in Salmonella.

104 Conversely, mixture mutagenicity in site-of-contact tissues (e.g., small int

105 Mechanistic analyses support a key role for mutagenicity in TCE-induced kidney carcinogenicity.

106 g of an advanced compound revealed bacterial mutagenicity in the Ames test using TA97a Salmonella str

107 he particles and characterized the bacterial mutagenicity in the gas phase and the particles of the e

108 - and UVB-induced DNA lesions in relation to mutagenicity in transgenic mouse fibroblasts irradiated

109 the first comprehensive investigation of SHS mutagenicity in vivo, in which we have established the m

110 l ZFN and TALEN target sites did not predict mutagenicity in vivo.

111 be a large-scale comparison of ZFN and TALEN mutagenicity in zebrafish.

112 The direct-acting mutagenicity increased the most after NO3/N2O5 exposure,

113 of estrogenic effects, whereas the in vitro mutagenicity increased.

114 ariations and sequence context also affected mutagenicity, indicating that a combination of structure

115 ffectively prevents BG-enhanced toxicity and mutagenicity induced by these agents.

116 angerous than nuclear traversal, because the mutagenicity is accomplished by little or no killing of

117 The mutagenicity is attributed to the C8- and N2-G adducts,

118 results strongly suggest that surface water mutagenicity is highly complex and driven by synergistic

119 co-expressed with the methyltransferase its mutagenicity is kept in check.

120 re, our data indicate that the nature of the mutagenicity may not be identical for complete exhaust a

121 While such mutagenicity might undermine functionality of these elem

122 ibute to the much higher carcinogenicity and mutagenicity of (+)-BPDE-2 compared with its (-)-enantio

123 Our data indicate that DD suppresses the mutagenicity of (+/-)-anti-BPDE by producing BPQ, but in

124 at the C9 position led to elimination of the mutagenicity of 1, while a crucial hydrogen bond interac

125 ylguanine-DNA alkyltransferase increases the mutagenicity of 1,2-dibromoethane by reacting with it at

126 The results show that WLT inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

127 ML in the range of 1-5mg/plate inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

128 The results showed that WFI inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mu

129 Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE(2)), an oxidat

130 00 mumol/l, the five compounds inhibited the mutagenicity of 4-nitroquinoline-N-oxide, a direct mutag

131 etic damage, as illustrated by the increased mutagenicity of 5-methylcytosine and the silencing of th

132 c studies provided a molecular basis for the mutagenicity of 5ClC; a snapshot of human polymerase bet

133 The mutagenicity of a prominent tobacco carcinogen, benzo[a]

134 ith chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cel

135 ecific sites in DNA and the cytotoxicity and mutagenicity of alkylating agents.

136 The mutagenicity of aromatic amines (AAs) and HCAs, measured

137 r current knowledge on the DNA adduction and mutagenicity of aromatic amines in relation to smoking-a

138 he radical scavenger DMSO, which reduced the mutagenicity of arsenic in these cells, and provide conv

139 dimethyl sulfoxide significantly reduces the mutagenicity of arsenite.

140 Lower toxicity and high mutagenicity of ascorbate-Cr(III)-DNA adducts in human c

141 ium-modified plasmids demonstrated increased mutagenicity of binary Cr(III)-DNA and ternary cysteine-

142 It is known that the cytotoxicity and mutagenicity of BPDE are mainly caused by the formation

143 ome resistance to DNA damage and much of the mutagenicity of bulky DNA adducts in dividing cells.

144 r differences in the efficacy, toxicity, and mutagenicity of CP and OX.

145 The observed mutagenicity of Cr(III)-induced phosphotriesters demonst

146 rent forms of DNA damage in genotoxicity and mutagenicity of Cr(VI) activated by physiological concen

147 vestigated the effect of nitric oxide on the mutagenicity of crocidolite in G12 cells.

148 intracellular glutathione indicated that the mutagenicity of cytoplasmic irradiation depends on gener

149 an REV1 (hREV1) affects the cytotoxicity and mutagenicity of DDP.

150 ession and BER activity results in increased mutagenicity of dimethyl sulfate as evidenced by a 2-fol

151 However, there are no previous studies on mutagenicity of disinfected spa (hot tub) waters or comp

152 Neither toxicity nor mutagenicity of DSMZ16671 was detected.

153 This work explores lesion bypass and mutagenicity of EA replicated in vivo and demonstrates t

154 To take advantage of the mutagenicity of ENU and its ability to create allelic se

155 Standard tests of toxicity and mutagenicity of heat-killed DSMZ16671 were performed.

156 Furthermore, the mutagenicity of KP1212 was found to increase dramaticall

157 lly, a model is proposed that correlates the mutagenicity of KP1212 with its tautomeric distribution

158 ed the molecular mechanism(s) underlying the mutagenicity of KP1212, and specifically whether tautome

159 We investigated the in vivo mutagenicity of long-term thiopurine treatment by determ

160 The mutagenicity of M(1)dG in Escherichia coli is dependent

161 The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may a

162 In contrast, the mutagenicity of m1G and m3T in AlkB(-) cells dropped sli

163 indicated that the SOS response enhances the mutagenicity of M1G and that M1G is a substrate for repa

164 ne technology, preliminary toxicology tests, mutagenicity of medicinal compounds, and other chemical

165 esculins were more efficient in reducing the mutagenicity of methyl methanesulphonate, by, respective

166 ly resistant to the cytotoxicity but not the mutagenicity of MNNG, presumably as a result of inactiva

167 tionary adaptation, which allows reconciling mutagenicity of non-B DNA structures with their location

168 ansgenic rodent mutation assay to assess the mutagenicity of nonpolar neutral and semipolar aromatic

169 lowered both the direct and indirect acting mutagenicity of NPAHs and may result in an underestimati

170 dTTP opposite O6mG and may contribute to the mutagenicity of O6mG.

171 ed model, yOgg2 activity should increase the mutagenicity of OG lesions.

172 This work reports the mutagenicity of oxanine as well as oxanine DNA glycosyla

173 The results suggest that much of the mutagenicity of oxopurines arises from their shapes in t

174 Mutagenicity of particle extracts was less efficiently d

175 transgenic medaka, to evaluate the potential mutagenicity of PFOS in vivo following a subchronic expo

176 nerating stable thioureas, may also decrease mutagenicity of processed meat.

177 To study the mechanism of mutagenicity of psoralens in humans, we examined the eff

178 The mutagenicity of ribavirin results from the incorporation

179 rong protection against sodium azide induced mutagenicity of Salmonella typhimurium strains TA 98 and

180 To determine sequence preferences and mutagenicity of SB-mediated transposition, we cloned and

181 The organ-specific mutagenicity of SHS is most pronounced in the lung and r

182 target site methylation may explain the poor mutagenicity of some TALENs in vivo.

183 To determine the mutagenicity of TA* in Escherichia coli, we constructed

184 ene expression are discussed in light of the mutagenicity of TA*.

185 We investigated DNA adduct-targeted mutagenicity of tamoxifen as a function of its genotoxic

186 Non-targeted mutations may enhance overall mutagenicity of the 10S-BPDE-dG lesion and contribute to

187 isomers accounted between 4.2 and 86% of the mutagenicity of the blue rayon extracts and may be bypro

188 Mutagenicity of the exhaust was low compared to previous

189 s well as nonregulated emissions such as the mutagenicity of the exhaust.

190 PAH emissions and mutagenicity of the exhausts were generally low, with HV

191 aromatic hydrocarbons (PAHs), and bacterial mutagenicity of the exhausts.

192 s may play a role in the carcinogenicity and mutagenicity of the parent hydrocarbons.

193 adducts can affect both the cytotoxicity and mutagenicity of the platinum adducts.

194 s, as well as the direct and indirect-acting mutagenicity of the PM (determined using the Salmonella

195 The potential mutagenicity of the primary guanine oxidation product 8-

196 rain designed to bioactivate MeIQ and detect mutagenicity of the products.

197 We studied the mutagenicity of the proximate bladder carcinogen, N-hydr

198 suggests that this could greatly affect the mutagenicity of these lesions in vivo.

199 ng differences in the efficacy, toxicity and mutagenicity of these platinum anticancer agents.

200 he differences in tumor range, toxicity, and mutagenicity of these two important chemotherapeutic age

201 ion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytos

202 s further suggest that asbestos enhances the mutagenicity of tobacco carcinogens and that it acts, at

203 Site-specific mutagenicity of trans-opened adducts at the exocyclic N(

204 In this study, we have investigated the mutagenicity of two model reactive intermediates of tamo

205 ere, we present data on general toxicity and mutagenicity of upper water column waters and, to a less

206 We investigated the mutagenicity of UVA alone and in combination with delta-

207 Here, we investigated the mutagenicity of UVA in relation to its DNA damaging effe

208 Notably, the 8-oxo-dG-mediated mutagenicity of UVA plus delta-ALA is similar to that es

209 idely used to study the biological activity (mutagenicity) of C(8)-arylamine-dG adducts with adduct c

210 ndent pathways for 1,2-dibromoethane-induced mutagenicity, one involving Gua N7-alkylation by alkyltr

211 he identification of signatures that predict mutagenicity or carcinogenicity.

212 herefore, the previously reported increasing mutagenicity per dimer with increasing wavelengths canno

213 (4-HNE-dG) adducts, but its genotoxicity and mutagenicity remain elusive.

214 icant inhibitory effect of 2-aminoanthracene mutagenicity (respectively 82.4% and 79.3% in the presen

215 and models in DNA allowed resolution of the mutagenicity risk, affording molecules with favorable po

216 plore the application of in vitro assays for mutagenicity (Salmonella mutation assays) and cytotoxici

217 Average post-event levels of urinary mutagenicity showed a significant, event-related 4.3-fol

218 rmining their selectivity and also performed mutagenicity studies.

219 s, such a nitro groups, for the outcome of a mutagenicity study.

220 Its relatively low contribution to mutagenicity suggests that other newly discovered DNA po

221 m TA100 and Chinese hamster V79) of standard mutagenicity tests treated with 1-MIM glucosinolate/myro

222 eatment leads to a positive response in Ames mutagenicity tests, which is then removed after granulat

223 uration mostly being associated with greater mutagenicity than the R configuration.

224 ously developed linear regression models for mutagenicity that include log(k(az)/k(s)) as an independ

225 mechanisms for combating DNA damage, and the mutagenicity that ultimately may lead to liver cancer.

226 their relative contribution to the acrolein mutagenicity, the genotoxic properties of alpha-OH-PdG a

227 entified were not responsible for the sample mutagenicity, the structure-generation-based identificat

228 d be refined to reduce the potential risk of mutagenicity to consumers.

229 known DNA-damaging effects of acrolein, its mutagenicity to mammalian cells remains uncertain.

230 problems of classification and prediction of mutagenicity, toxicity and anti-cancer activity on three

231 wipes and personal air samples, and urinary mutagenicity using the Salmonella mutagenicity assay (Am

232 Mutagenicity was abrogated for m1A, m3C, and e3C in wild

233 Moreover, their potential mutagenicity was also assessed.

234 Remarkably, m1G mutagenicity was also eliminated in AlkB(+) cells, estab

235 Mutagenicity was assessed at the thymidine kinase (TK) l

236 Mutagenicity was assessed by the Salmonella mutagenicity

237 Mutagenicity was determined by the standard plate incorp

238 In general, mutagenicity was higher with S9 hepatic microsomal activ

239 ning techniques based on these results, Mos1 mutagenicity was increased to within an order of magnitu

240 In bone marrow, mixture mutagenicity was less than dose-additive and the PEF-met

241 Moreover, MeIQx mutagenicity was lowered in the presence of ITCs, as wel

242 Cisplatin mutagenicity was most pronounced in xpf-1 mutants, sugge

243 The rank order of mutagenicity was N-nitrosodimethylamine (NDMA)>N-nitroso

244 The highest indirect-acting mutagenicity was observed for sites closest to mining ac

245 Mutagenicity was observed in Salmonella typhimurium TA98

246 3C in wild-type (AlkB(+)) cells, whereas m3T mutagenicity was only partially reduced.

247 The reduction of mutagenicity was particularly observed in the condensate

248 and subsequent study demonstrated that this mutagenicity was pervasive throughout the series.

249 No mutagenicity was seen in S. typhimurium TA100 or Escheri

250 Indirect-acting mutagenicity was strongly correlated with levels of tota

251 Radiation-induced toxicity and mutagenicity was then compared among p53-null cells, TK6

252 containing compounds also contributed to the mutagenicity when aromatic amines were present.

253 e of attached side chains appeared to induce mutagenicity with these agents, although other studies h