ライフサイエンスコーパス: mutant

1 A-negative or cag pathogenicity island (PAI) mutant.

2 trating C-terminal protonation of H37 in the mutant.

3 henotype of the Arabidopsis mtp11-3 knockout mutant.

4 godendrocytes rescued apoptosis in the abcd1 mutant.

5 region of SS4 and GS in the Arabidopsis ss4 mutant.

6 e crystallographic structure of one such LGK mutant.

7 oximal distal-patterning is abnormal in this mutant.

8 omplement freezing sensitivity in the ice1-2 mutant.

9 plex (BIC) was misregulated in the Deltanmo2 mutant.

10 r mutant but not a vacuolar zinc transporter mutant.

11 ngated bipolar phragmoplast MT arrays in the mutant.

12 etic complementation of the Arabidopsis wri1 mutant.

13 reduction in callose deposition in the adf3 mutant.

14 uidance defects in sax-3/Robo and vab-1/EphR mutants.

15 ransport through several important D-channel mutants.

16 bellar hypoplasia in GCp-specific Chd7 mouse mutants.

17 localization of PINN-1 is altered in dapk-1 mutants.

18 CML38 proteins restored sensitivity in these mutants.

19 mimic acetylated lysines and screened 15 KQ mutants.

20 ion, we analysed the effect of several MjAgo mutants.

21 ior signaling center were preserved in these mutants.

22 ates the airway morphogenesis defects of grh mutants.

23 elta kcs1Delta or ddp1Delta kcs1Delta double mutants.

24 the expression of interferon genes in uhrf1 mutants.

25 clf double mutants compared with clf single mutants.

26 CS active site; thus, we term these "release mutants."

27 ts were obtained with the attenuated lpg2(-) mutant, a convenient model that rapidly enters a persist

28 t cancer cellular invasiveness, this N-TIMP2 mutant acted as a functional inhibitor.

29 ignaling in both types of adenomas, with Apc-mutant adenomas also exhibiting unique changes in pathwa

30 Formation and stability of these mutant aggregates is linked to palmitoylation of the cys

31 nts (sgb10-sgb13) identified, sgb11 is a new mutant allele of ESKIMO1 (ESK1), which encodes a plant-s

32 le, functional tumor suppressor genes by the mutant alleles.

33 Studies on NS1 wild type or mutant alone or in recombinant RSVs demonstrate that str

34 ty and oxidative load in response to chronic mutant alpha-synuclein overexpression.

35 In line with this, Foxp2-null mutants also show a loss of ITCs at postnatal time point

36 Mutant analysis confirms that affinity proteomics is a v

37 Comparison of SPOP-mutant and ERG-fusion organoid models showed evidence of

38 g differential drug susceptibilities of KRAS mutant and wild-type cells, and predict relapse based on

39 In the ABP1-related mutants and Coimbra, no auxin-induced protoplast swellin

40 throughput screens, we identify prion-curing mutants and engineer "anti-prion drives" that reverse th

41 ct is largest when the fitness values of the mutants and wild types are anti-correlated across enviro

42 tructure of vegetative SAMs in ltm sp double mutants, and late flowering was partially suppressed, su

43 The mutant animals displayed increased anxiety-like behavior

44 Both wild-type and mutant ANO5 protein localize to the endoplasmic reticulu

45 The changes in DNA methylation in the pkl mutant are correlated with changes in the non-coding RNA

46 These mutants are a valuable resource to elucidate further how

47 rograde transport defects observed in actr10 mutants are distinct from dynein and dynactin mutant axo

48 vpr-1 null mutants are maternal effect sterile due to arrested gona

49 genes (11 out of the 13 in the collection of mutants) are candidate hypo-competition alleles, and we

50 s formed by the P23T human gammaD-crystallin mutant associated with congenital cataracts.

51 ion and ASC speck formation induced by NALP3 mutants associated with autoinflammatory diseases.

52 nd incubation of a temperature-sensitive ACA mutant at the restrictive temperature prevented c-di-GMP

53 utants are distinct from dynein and dynactin mutant axonal phenotypes.

54 ent species and in the SF3B1 K700E oncogenic mutant background.

55 EM structure of the 860-A-diameter isometric mutant bacteriophage T4 capsid has been determined.

56 n the structurally destabilized Miz1-4(A86K) mutant bound to the DNA consensus with a 30-fold increas

57 T2 also complemented a manganese transporter mutant but not a vacuolar zinc transporter mutant.

58 tol pyrophosphatase), or kcs1Delta vip1Delta mutants but not in ipk1Delta kcs1Delta or ddp1Delta kcs1

59 nescence in zebrafish embryos overexpressing mutant, but not wild-type, PDGFRA, suggesting a mechanis

60 ffected in seipin2 seipin3 and triple seipin mutants, but there is a striking increase in seed dorman

61 rescue of this ostensibly dead general base mutant by a synthetic substrate, 3beta-hydroperoxycholes

62 We identified Arabidopsis pex6 and pex26 mutants by screening for inefficient seedling beta-oxida

63 ein the P-body assembly phenotype of a given mutant can be predicted from the number of currently kno

64 Loss of ClpC repression in MD mutants causes constitutive activation and severe cellul

65 s are required for the active elimination of mutant cells from the tissue, while utilizing both endog

66 w wild-type cells limit the proliferation of mutant cells to maintain proper tissue homeostasis.

67 ietic stem cells, which give an advantage to mutant cells, driving their clonal expansion and potenti

68 phenotypic consequences in sudemycin-treated mutant cells.

69 adenosine diphosphoribose insensitive TRPM2 mutant channel (C1008-->A) in ECs suppressed the Ca(2+)

70 enes was strongly reduced in eol1 clf double mutants compared with clf single mutants.

71 Moreover, loss of SEP4 severely impaired mutant conidiation, melanin and chitin accumulation in h

72 We demonstrate that Hoxb8 mutants contain corticostriatal circuit defects.

73 r, nor did it influence the incorporation of mutant-containing heterodimers into microtubule polymers

74 Remarkably, fertility of heterochromatin mutants could be partially restored by inhibiting cep-1/

75 Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) selectively aff

76 trations in combination with chemical double-mutant cycles (DMCs) have been used to study the competi

77 ctopic expression of the 2 identified SAMD9L mutants decreased cell proliferation relative to wild-ty

78 hetic ligands modulated signaling of a GPR56 mutant defective in autoproteolysis and hence, in Stache

79 approach, we identified two Lotus japonicus mutants defective in AM-specific paralogs of lipid biosy

80 ALK2 mutants defective in binding FKBP12 increase hepcidin ex

81 lysis of hypocotyl cell growth in the nek6-1 mutant demonstrated that NEK6 suppresses ectopic outgrow

82 or interneurons partially phenocopies Satb1 mutants, demonstrating that Satb1-dependent Cntn5 expres

83 Nearly 50% of newborns with the S187A mutant died in the first week due to failure to undergo

84 t-negative C-terminus-truncated human DISC1 (mutant DISC1) in astrocytes would affect adult hippocamp

85 e, cells expressing a phospho-mimicking Atf1 mutant display enhanced stress resistance, and although

86 Zebrafish pontin mutants display phenotypes tightly associated with cilia

87 Conversely, apc15Delta mutants display reduced association between the MCC and

88 We also showed that TBPH mutants displayed reduced motor neuron bursting and coor

89 CREBBP-mutant DLBCL clones exhibited reduced histone H3 acetyla

90 The opal5 mutant does not close in response to darkness but exhibi

91 an amyotrophic lateral sclerosis-associated mutant, E478G, induced cell death selectively in 661W ce

92 the structure of the Na(+)-selective AtTPC1 mutant elucidates the structural basis for Na(+) selecti

93 bed and analyzed a similar phenotype in POMT mutant embryos that shows left-handed body torsion.

94 Phenotypic and genetic analyses of TF mutants enable the organization of these four TFs and PH

95 parison, the zinc binding region of the P73G mutant, even under native conditions, was markedly disor

96 We show that although ugt80A2 mutants exhibit significantly lower levels of total SGs

97 Cs for BDQ and clofazimine, whereas one atpE mutant exhibited a 50-fold increase in MIC for BDQ.

98 iated genome editing efficiently excised the mutant exon 23 in dystrophic mice, and immunofluorescenc

99 uses a complete absence of liver invasion as mutants fail to attach to host cells.

100 as this relationship was not observed in the mutant FANCD2 (K561R)-carrying cells.

101 TS) for two engineered beta-solenoid protein mutant fibril structures (spruce budworm and Rhagium inq

102 d with the weak vip3-6 allele and in vip6, a mutant for another Paf1c subunit.

103 ethods Mutation analyses (wild-type [WT] and mutant) for TP53, KRAS, and EGFR were determined in blin

104 signal transduction was downregulated in the mutant forebrain, consistent with a role for Vax1 in med

105 e elasticity of mouse myoblasts expressing a mutant form of the gene encoding for desmin intermediate

106 myloids, whereas their strongly destabilized mutants form both amyloids and nonamyloid aggregates.

107 cted genes with their drugs in wild type and mutant forms.

108 is the first functional characterization of mutant FOS proteins found in tumors.

109 Whereas lambda somatic mutants from the depleted sample displayed evidence of p

110 ent wild-type SOD1 (wt SOD1YFP) or monomeric mutant G85R SOD1YFP had no effect on net ionic currents

111 g properties of G protein complexes carrying mutant Gbeta1 subunits were further analyzed by their ab

112 CML38-knockout mutants generated via T-DNA insertion were insensitive t

113 Increased expression of the mutant GlyR alpha1(Q177K) subunit in vivo was not suffic

114 an aberrant extracellular binding partner of mutant GlyRS.

115 to fluorescence in a set of virally encoded mutant green fluorescent proteins, which allowed us to m

116 The mutant has no growth defect, arguing against ongoing res

117 Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several features for an ideal vaccine candida

118 We show that tan1 air9 double mutants have a synthetic phenotype consisting of short,

119 Legume mutants have shown the requirement for receptor-mediated

120 pathological cross-seeding between DISC1 and mutant HTT aggregates in the brains of HD patients as we

121 eterioration (all p < 0.001), independent of mutant HTT CAG repeat size.

122 tically inhibited the growth of multiple RAS-mutant human cancer cell lines of diverse tissue origin

123 We show that mutant huntingtin markedly accelerates all of these cell

124 ne (polyQ) sequences in the exon-1 region of mutant huntingtin plays a central role in the pathogenes

125 Ceftazidime/inhibitor resistant mutants hyperproduce L1, but retain aztreonam/inhibitor

126 Mutant IDH1 establishes a CD24(+) population with a prol

127 reversed by IDH-C35, a specific inhibitor of mutant IDH1.

128 ical activity of enasidenib in patients with mutant-IDH2 advanced myeloid malignancies.

129 r evidence suggests a thymic origin of these mutant ILC2s.

130 Neto2 S409A, the Neto2 S409D phosphomimetic mutant impeded GluK1 trafficking to synapses.

131 n of wild-type human SOD1 and the ALS-linked mutant in human cells also require the diacidic residues

132 Mice that were doubly mutant in prostate tissue for Pten and Erk5 (prostate DK

133 We then made substitution mutants in DnaK residues suggested by the model to inter

134 ular interest is the absence of gL syncytial mutants in other herpesviruses.

135 To address this, we expressed human CFH mutants in Pichia pastoris We found that recombinant I62

136 Using zebrafish mutants in which OPCs migrate out of the spinal cord and

137 Mutants in which TF is not palmitoylated display drastic

138 on at near-cognate UUG start codons in yeast mutants in which UUG selection is abnormally high.

139 We engineered alphaS mutants incapable of multimerization, leading to excess

140 expression of the GluA1 ubiquitin-deficient mutants inhibited the adverse effects of Abeta on the su

141 Remarkably, introduction of T150D K5 mutants into KtyII-lacking (KtyII(-/-)) keratinocytes pr

142 Expression of this histone mutant is accompanied by a reduction in the levels of po

143 w that the autoinflammation-associated H443P mutant is altered in interaction with SUG1 and ubiquitin

144 We further found that the DeltaMoglo3 mutant is defective in endocytosis, scavenging of the re

145 dimers and larger oligomers, while the K101E mutant is predominantly monomeric and K101C/E107C is dom

146 role in the post-translational regulation of mutant KRAS activity.

147 K inhibitors induces a deleterious effect on mutant KRAS cells.

148 lore biophysical properties of wild-type and mutant KV 3.1 channels.

149 yonic 293 cell lines, while the PF-deficient mutants lacked the ability to stimulate, and the complem

150 An APP mutant lacking all C-terminal lysines underwent the most

151 We found that isogenic mutants lacking SPN, SLO, and both toxins are equally im

152 Pathological Tau mutants lacking the vesicle binding domain still localiz

153 The Axin mutant larvae are transparent and have severe adipocyte

154 idermal cells in a TAS3 ta-siRNA-insensitive mutant led to the formation of supernumerary megaspore m

155 ion of cathepsin B and cathepsin B-resistant mutant LFABP in McA-RH7777 cells resulted in an increase

156 ic interactions, which involves comparing Tn mutant libraries generated in different genetic backgrou

157 Exposing a saturating transposon insertion mutant library of S Typhimurium to immune serum identifi

158 is study, we established another Arabidopsis mutant line harbouring a different allele of gene GRIK1

159 We have analyzed a panel of 17 KRAS mutant lung cancer cell lines classified as K-Ras-depend

160 ic signaling and triggered apoptosis in KRAS-mutant lung cancer cells and inhibited tumor growth in m

161 Importantly, the Delta346 mutant maintains similar antigenicity to wild-type virus

162 the stomatal VPD regulation of ABA-deficient mutants may be conditional on the initial pretreatment s

163 eping inflorescence phenotype of atlazy1,2,4 mutants may be due at least in part to a reversal in the

164 ning energy metabolism, particularly in BRAF-mutant melanoma, and represent a promising lead for the

165 his combination therapy in patients with NF1 mutant melanoma.

166 ired and sufficient to activate MAPK in GNAQ mutant melanomas.

167 ical functions of DGCR8, we complemented the mutant mESCs with a phosphomutant DGCR8, which restored

168 here Cre-recombinase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cel

169 Nisch-mutant mice also exhibited increased rates of glucose ox

170 Scx-mutant mice demonstrated disrupted callus healing and as

171 We screened 36,530 third-generation germline mutant mice derived from N-ethyl-N-nitrosourea-mutageniz

172 Mutant mice developed a Bartter syndrome phenotype, char

173 We found that heterozygote GALC mutant mice have reduced myelin debris clearance and dim

174 Biochemically mutant mice showed impaired electron transport chain act

175 and proliferation compared with control Pten-mutant mice, the latter of which exhibited increased Erk

176 vascular defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly rescues the

177 ucing ends, which is present at birth in the mutant mice.

178 Viruses containing wild-type and mutant MN/10 or BJ/92 hemagglutinins (HAs) were construc

179 telet-derived growth factor receptor (PDGFR)-mutant models with mean 66.9% (range, 42.0%-87.6%) reduc

180 cytokine receptor-like factor 2 (CRLF2)/JAK-mutant models with mean 92.2% (range, 86.0%-99.4%) reduc

181 We generated a novel mutant mouse (Dclre1c(leaky)) that develops a LS phenoty

182 Anti-hypoallergenic Cyp c 1 mutant mouse and rabbit sera were tested for their abili

183 E12.5) and E13.5 Osr2(RFP/+) and Osr2(RFP/-) mutant mouse embryos and performed whole transcriptome R

184 Using mutant mouse models for the most common form of congenit

185 and C) remain unknown, we generated a novel mutant mouse, dys-1A(-/-), with selective loss of dysbin

186 Here we constructed a mutant murine P-gp with a shortened linker to facilitate

187 se, unlike WT Neto2 and the phosphodeficient mutant Neto2 S409A, the Neto2 S409D phosphomimetic mutan

188 observed in the postsynaptic compartment of mutant NMJs include reduced glutamate receptor field siz

189 Mutant nrx1 plants displayed reduced catalase activity a

190 f the excited state ensemble of a stabilized mutant of an extensively studied flavodoxin fold protein

191 Using a constitutively open mutant of ENaC, we demonstrate that the augmentation of

192 To address this question, we engineered a mutant of MYO6, MYO6+, which undergoes plus-end-directed

193 length PTEN but a membrane-binding defective mutant of the C2 domain abrogated these properties.

194 By using the C35S mutant of TRX, which formed a metastable mixed disulfide

195 Here, we show that dominant-negative mutants of ATL1 in PC-12 cells inhibit nerve growth fact

196 Mutants of gamma-ECS and PCS1 were hypersensitive to As

197 Two glaucoma-associated mutants of OPTN, E50K and M98K, but not an amyotrophic l

198 hic structures of two catalytically inactive mutants of protein-tyrosine phosphatase-like myo-inosito

199 estored plaque formation for lysis-defective mutants of Rz and Rz1 were selected.

200 Mutants of the fusome, an organelle that is known to fac

201 No mutants of these genes exist in a large database of para

202 l and molecularly defined strategy to target mutant p53 in pancreatic cancer.

203 rdingly, we focus not only on the effects of mutant p53 oncogenic gain of function but also on the me

204 Knockdown of Myc, but not the mutant p53, significantly inhibited tumor cell prolifera

205 of pro-apoptotic genes in breast cancer with mutant p53.

206 Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display sp

207 apparent dominant ZSD in whom a heterozygous mutant PEX6 allele (c.2578C>T [p.Arg860Trp]) was overrep

208 The mutant phenotype is also temperature-sensitive.

209 ith human EXOC5 mRNA completely reversed the mutant phenotype.

210 xpression of SLP-2 transgenes rescued parkin mutant phenotypes, in particular loss of dopaminergic ne

211 Gene expression and mutant phenotypic analysis of SWIB5 and SWIB family memb

212 he wild-type virus revealed that some escape mutants possessing an amino acid substitution other than

213 We tested several candidate miRNA-deletion mutants post gamma-irradiation and identified cel-mir-23

214 ease ER stress by inducing misfolding of the mutant protein and subsequently disrupting hypertrophic

215 The level of IFNAR1*557Gluext*46 mutant protein expressed in patient fibroblasts was comp

216 ls with pyrin and wild-type and mutated WDR1 Mutant protein formed aggregates that appeared to accumu

217 (/+)) (and thus expresses both wild-type and mutant protein).

218 Although such mutant proteins are prone to aggregation, toxicity is al

219 ne-string domain, however the regions of the mutant proteins that drive aggregation have not been det

220 y site-directed mutagenesis that encode PORB mutant proteins with defined Cys-->Ala exchanges.

221 Cdc42 interface on ACK, creating a panel of mutant proteins with which we can now describe the compl

222 ranscriptome profiling of overexpressors and mutants, provided insights into their regulatory role in

223 ield is experiencing renewed excitement that mutant RAS may finally be conquered.

224 through which the oncogenic activity of the mutant receptor is tempered by the activation of prematu

225 Drosophila CaMKII-null mutants remain viable throughout development, enabling m

226 2 (MECP2-KO), congenic pair of wild-type and mutant RTT patient-specific induced pluripotent stem cel

227 rectly kill Staphylococcus aureus Further, a mutant S. aureus that is more sensitive to antimicrobial

228 Hypocotyls of SOB3 mutant seedlings grown in white light with a higher flue

229 highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alternative therapeuti

230 Out of the four sgb mutants (sgb10-sgb13) identified, sgb11 is a new mutant

231 Specifically, structurally stable mutants show low aggregation propensity and moderately d

232 A mot1.3-1 knockout mutant showed impaired growth concomitant with a reducti

233 In turn, ann1 mutants showed elevated chitin-induced rapid responses.

234 transporter pin1 and influx transporter lax2 mutants showed reduced vein numbers.

235 ALS mutant SOD1 induced reductions in Miro1 levels were Park

236 eated animals involves an increase in mature mutant SOD1 protein in the disease-affected spinal cord,

237 on of the NES consensus sequence relocalizes mutant SOD1 to the nucleus, resulting in higher toxicity

238 93A) mice is instigated by expression of the mutant SOD1, we show the improved phenotype of the Cu(II

239 amide peaks, partial NMR assignments, and JM mutants (ST(296)AA or T(304)A) investigated, confirm tha

240 troso-guanidine mutagenesis and selection, a mutant strain Apmu4 was derived, in which the rate of lo

241 cytogenes infection, a reduced number of the mutant strain compared to the parental strain was observ

242 he hypothesis that vaccination with the batA mutant strain elicits protective immunity against subseq

243 on of LipA from Xac306 and verified that the mutant strain lost most of its lipase and esterase activ

244 egulated by RpoE, and surprisingly, the rseA mutant strain where RpoE activity was elevated expressed

245 Here we show that mutant strains of S. praecaptivus that lack genetic comp

246 genetic interactions in single and multiple mutant strains, (2) can identify drug targets, (3) detec

247 a four-step mechanism for HCCS, whereby HCCS mutants such as E159A are enhanced in release (step 4) o

248 Four of these mutants target the components of the Bone Morphogenetic

249 native agarose gel electrophoresis from A36V mutant than from the wild-type core protein.

250 ticles isolated from an Arabidopsis thaliana mutant that accumulates zeaxanthin constitutively, have

251 ld-type Pdcd4 and Pdcd4(157-469), a deletion mutant that binds to translation initiation factor 4A (e

252 By contrast, Pdcd4(157-469)(D253A,D418A), a mutant that does not bind to eIF4A, failed to inhibit Si

253 bioenergy crop poplar, we have identified a mutant that overcomes the block of lateral root (LR) for

254 t in human cells, we demonstrate that CENP-A mutants that cannot be phosphorylated at Ser68 or ubiqui

255 ctivity, whereas the other Ser5 isoforms and mutants that do not have the 10th transmembrane domain s

256 Pathogenic LRRK2 R1441G/C and Y1699C mutants that promote GTP binding are more readily recrui

257 Among the Asn(297) mutants that result in lack of glycosylation and thus lo

258 ies, here we examined 13 disease-causing DAT mutants that were retained in the endoplasmic reticulum

259 is constitutively phosphorylated in the misS mutant, the data suggest that controlled but not constit

260 turation-deficient biofilms of a DeltagroEL1 mutant, thereby differentiating the process of aggregati

261 tflow tract, but in the Nkx2-5(+/-)/Sspn(KO) mutant they commonly deviate into the septum even in the

262 rate synthesis of large libraries of desired mutants through design and efficient organization of pri

263 The ubiquitin proteasome mutants tir1-1 and axr1-12, which show enhanced resistan

264 e constant of the binding of the S339D/S340D mutant to the FERM domain of Ezrin is sensitive to buffe

265 Using catalytic site mutants to create Rad50 dimers with only one functional

266 rial IDH2), we used lysine-to-glutamine (KQ) mutants to mimic acetylated lysines and screened 15 KQ m

267 n forks, and sensitivity of the double rnhAB mutants to translation inhibition points to R-loops as p

268 ce carrying human wild-type torsinA (hWT) or mutant torsinA (hMT).

269 on results in nonsense-mediated decay of the mutant transcripts.

270 quantify the effect of 4-PBA on human ABCC6 mutants transiently expressed in the liver.

271 was amplified in osimertinib-resistant EGFR-mutant tumor cells, the effects of which were overcome b

272 exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in genetically engine

273 on in 5/23 (22%) tumours, and that KRAS/BRAF mutant tumours were particularly sensitive to the anti-p

274 SCRAMBLED (SCM), is mislocalized in ugt80B1 mutants, underscoring the aberrant root epidermal cell p

275 Moreover, an analysis of ahk double mutants using CycB1;1:GUS/ahk introgressed lines reveale

276 Expression of miss-regulated mutant variants of RabA2 resulted in an increased number

277 In addition, we show that a mutant version of a protein involved in lipopolysacchari

278 that prevent reproduction and spread of the mutant viruses in human cells.

279 Competitive growth of the escape mutant viruses with the wild-type virus revealed that so

280 This mutant was found to harbor another mutation in AG and wa

281 the peroxynitrite response, because the ohr mutant was more sensitive than wild type to 3-morpholino

282 creased lysozyme resistance of the DeltagpsB mutant was PgdA-dependent and OatA-independent.

283 sensitivity to glucose, the grik1-2 grik2-1 mutant was sensitive to high salt, indicating that GRIKs

284 Each of the 852 mutants was expressed in human cells and screened for an

285 Using a zebrafish ncx1 mutant, we explored the impacts of impaired Ca(2+) homeo

286 Through analysis of multiple mutants, we conclude that curvature sensitivity is intri

287 Using Caenorhabditis elegans mutants, we identify DNA repair factors that protect aga

288 wn inactive GDP- and active GTP-bound RAB11B mutants, we modeled the variants on the three-dimensiona

289 Two EspP mutants were also gradually degraded by DegP but were to

290 Two mutants were created with blue-shifted (E254D, lambdamax

291 were created in the xylanase by PCR, and the mutants were expressed in Pichia pastoris.

292 ained unidentified since the 1960s when madC mutants were first isolated.

293 ch, one nonsense and four missense Gmsacpd-c mutants were identified to have high levels of seed, nod

294 gement in both wild-type cells and DeltamamJ mutants, which exhibit differing magnetosome organizatio

295 In E1R/R4E KCNQ1, a mutant with constitutively activated voltage sensors, F5

296 Mutants with reduced enzymatic activity had slower repli

297 information can be used to engineer allergen mutants with reduced IgE Ab binding for immunotherapy.

298 We identified an N-TIMP2 mutant, with five mutations in its interface, that has a

299 exoc5 mutant zebrafish rescue with human EXOC5 mRNA completely

300 Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant p