ライフサイエンスコーパス: mutant phenotype

1 ecific manner, which may explain the complex mutant phenotype.

2 for two copies of the allele will display a mutant phenotype.

3 Injected human wt ZC4H2 rescued the mutant phenotype.

4 loss of these activities can explain the mwh mutant phenotype.

5 of BASS6 complemented this photorespiration mutant phenotype.

6 oxidase activity partially complemented the mutant phenotype.

7 lains the aetiology of the even-skipped null mutant phenotype.

8 silencing of which partially rescues the stf mutant phenotype.

9 f this approach to the detection of a subtle mutant phenotype.

10 nce in these neurons, recapitulated the FoxP mutant phenotype.

11 and suppresses the gain-of-function bzr1-1D mutant phenotype.

12 W-boxes are essential for rescue of the try mutant phenotype.

13 al region of SS4 alone did not alter the ss4 mutant phenotype.

14 The transgenes completely rescued the cftr mutant phenotype.

15 le TDOR, SdbA, which exhibited a pleiotropic mutant phenotype.

16 Sustained exogenous FGF failed to rescue the mutant phenotype.

17 d protein in strains that suppress the Clock mutant phenotype.

18 ith human EXOC5 mRNA completely reversed the mutant phenotype.

19 v levels significantly suppressed the worniu mutant phenotype.

20 etion of Trm112 results in a bud23Delta-like mutant phenotype.

21 or LUX ARRHYTHMO (LUX) complements the elf4 mutant phenotype.

22 ibition, which molecularly recapitulated the mutant phenotype.

23 he precursor chorismate, also suppressed the mutant phenotype.

24 man SLC16A6 in rmn mutant livers rescues the mutant phenotype.

25 ereas SlGLK2 suppression recapitulated the u mutant phenotype.

26 d transcripts may contribute to the observed mutant phenotype.

27 alloproteinase 13 inhibitor, ameliorated the mutant phenotype.

28 subset of tissues but does not mimic the Gr mutant phenotype.

29 e), and activated AMPKalpha rescued the sgt1 mutant phenotype.

30 rors, but does not further enhance, the idn2 mutant phenotype.

31 BR hyperaccumulation contributes to the lob mutant phenotype.

32 ense mutation in bmp1a, underlies the welded mutant phenotype.

33 tion analysis confirmed correlation with the mutant phenotype.

34 ranscriptionally silenced and confers strong mutant phenotype.

35 d GR24 (a synthetic SL) does not correct the mutant phenotype.

36 2; wild-type slc45a2 mRNA rescued the albino mutant phenotype.

37 erobactin biosynthesis genes, suppressed the mutant phenotype.

38 Edn3 expression rescued the homozygous white mutant phenotype.

39 icient background partially rescues the Sox2-mutant phenotype.

40 pharynx, and its transgene rescues the sms-1 mutant phenotype.

41 sate for actin A167E crowding and rescue the mutant phenotype.

42 a survival advantage conferred by the FAM46C mutant phenotype.

43 H2 O2 ) in myb36-5 significantly rescues the mutant phenotype.

44 th the downstream kinase cascade rescued the mutant phenotype.

45 ORRM6 rescues the orrm6 editing defects and mutant phenotype.

46 tic vesicle TA proteins explains much of the mutant phenotype.

47 ectopic WUS expression as a component of the mutant phenotype.

48 reducing Fgf10 dosage can attenuate the Etv mutant phenotype.

49 n, inhibition of SPT was able to reverse the mutant phenotype.

50 at disrupt Ubx expression, leading to the bx mutant phenotype.

51 haracterised Oakleaf, a novel S locus-linked mutant phenotype.

52 -type mRNAs partially suppresses the rbm25-2 mutant phenotype.

53 monstrating that ZmFNSI-1 can complement the mutant phenotype.

54 networks compared with genes with nonlethal mutant phenotypes.

55 romoter interactions could partially explain mutant phenotypes.

56 ocalization, in combination with analysis of mutant phenotypes.

57 to the outer kinetochore rescues ndc80-NH12-mutant phenotypes.

58 ividual type III LTPs produced no observable mutant phenotypes.

59 reas RAB7L1 overexpression rescued the LRRK2 mutant phenotypes.

60 ed their ability to rescue arr1 arr12 double mutant phenotypes.

61 ion in trans partially or fully restored the mutant phenotypes.

62 and ATR kinases in several MRN-dependent E4 mutant phenotypes.

63 o experimental observations of wild type and mutant phenotypes.

64 erally similar to previously reported CaMKII mutant phenotypes.

65 ly and efficiently map genes responsible for mutant phenotypes.

66 urotransmission and does not suppress unc-17 mutant phenotypes.

67 ridis and screened for visible inflorescence mutant phenotypes.

68 aracterized gene with no previously reported mutant phenotypes.

69 TORC1 activity by rapamycin exacerbated the mutant phenotypes.

70 rent arbors and for defining cell-autonomous mutant phenotypes.

71 the majority of which correspond to observed mutant phenotypes.

72 rmline defects similar to a subset of rsks-1 mutant phenotypes.

73 agonistically affect the alpha Aurora double mutant phenotypes.

74 Populus PHYB1 rescued Arabidopsis phyB mutant phenotypes.

75 embryos that develop on maternal plants with mutant phenotypes.

76 tedly, Lid mutations strongly suppress dLsd1 mutant phenotypes.

77 isruptions and created strains with expected mutant phenotypes.

78 ped by their vacuole protein sorting Class E mutant phenotypes.

79 sease associations through the comparison of mutant phenotypes.

80 how that human ADAR2 rescues Drosophila Adar mutant phenotypes.

81 8 gene dosage is sufficient to suppress den1 mutant phenotypes.

82 ere it is now possible to identify genes for mutant phenotypes.

83 e it recapitulates expected loss-of-function mutant phenotypes.

84 ation with DAO1pro:YFP-DAO1 complemented the mutant phenotypes.

85 s was sufficient to rescue their S-dependent mutant phenotypes.

86 17L (GATA17-LIKE), based on loss-of-function mutant phenotypes.

87 henotypes for genes with previously reported mutant phenotypes.

88 confers defects concordant with rec8 phospho-mutant phenotypes.

89 nt suppressors of morc-1(-) and nuclear RNAi mutant phenotypes.

90 ains and investigated the suppression of the mutant phenotypes.

91 s reasonable behaviour of control as well as mutant phenotypes.

92 orrespond to severe loss of function or null mutant phenotypes.

93 roviding a possible mechanism to explain Pvr mutant phenotypes.

94 rexpression is able to rescue several parkin-mutant phenotypes.

95 alances that are not uncovered from deletion-mutant phenotyping.

96 led that resveratrol could ameliorate dnj-14 mutant phenotypes, an effect mimicked by the cAMP phosph

97 using a combination of approaches, including mutant phenotype analyses and chromatin immunoprecipitat

98 Notably, ITK inhibitors mimic the null mutant phenotype and also prevent pancreatic islet infil

99 onal complementation of the non-ripening rin mutant phenotype and caused fruits to ripen.

100 The mutant phenotype and gene identities suggest that NKD co

101 escue the Arabidopsis max1-1 highly branched mutant phenotype and increase the production of the SL,

102 Relationships between mutant phenotype and protein function, genetic redundanc

103 Here we dissected this ridA mutant phenotype and showed it was an indirect consequen

104 This mutant phenotype and the absence of galacturonic acid in

105 nsemble, and selected a model that predicted mutant phenotypes and connections between evening-phased

106 blmp-1 deletion suppressed dre-1 mutant phenotypes and exhibited developmental timing def

107 We use existing mutant phenotypes and fluorescence data to parameterize

108 Typically, it considers single and double mutant phenotypes and for a pair of genes observes wheth

109 lia mutants; however, spatial restriction of mutant phenotypes and lack of left-right patterning defe

110 The mutant phenotypes and localization of him-5 are similar

111 t of the Paf1 complex, Rtf1, causes enhanced mutant phenotypes and loss of histone H3 lysine 36 trime

112 Mutant phenotypes and modeling support an assembly model

113 This proposal is supported by mutant phenotypes and other results indicating that the

114 aspects of Lhx6(-)/(-) cell-fate and laminar mutant phenotypes and provide insight into a neonatal ro

115 efects alter previous interpretations of the mutant phenotypes and provide new insights into the mole

116 his may lead to a better understanding of Rb mutant phenotypes and Rb's roles in oncogenesis.

117 as found to cosegregate with a short petiole mutant phenotype, and thus may serve as an example of a

118 Transformation with D1bLIC-GFP rescues the mutant phenotypes, and D1bLIC-GFP assembles into the dyn

119 ion proteins that often mislocalize, exhibit mutant phenotypes, and dramatically knock down wild-type

120 pals-22 mutant phenotypes appear independent of the well-studied

121 Drosophila Adar(5G1) mutant phenotypes are ameliorated by feeding GABA modula

122 Mutant phenotypes are associated with gene information.

123 TF knockout mutant phenotypes are consistent with model predictions.

124 Focusing on r genes whose mutant phenotypes are largely independent of the host ce

125 nthetic lethality in which hlh-1 and unc-120 mutant phenotypes are mutually buffered by joint additiv

126 However, it has long been documented that mutant phenotypes are not a simple result of a single DN

127 on-induced genes with no previously reported mutant phenotypes are required for timely spore maturati

128 Finally, the pcf11-13 and sen1-1 mutant phenotypes are very similar, as both accumulate R

129 1 antitrypsin (AAT) deficiency with the piZZ mutant phenotype as a model system to evaluate the effic

130 ed for male fertility and has the same basic mutant phenotype as spe-45.

131 e that were subject to recurrent screens for mutant phenotypes as the mice aged.

132 on of bba03 as the most likely cause of this mutant phenotype, as previous studies have shown that ex

133 plications for interpreting the cause of any mutant phenotype, assigning gene function, and genetical

134 nsgenes could rescue the loss-of-function er mutant phenotype at both morphological and cellular leve

135 Based on these results, we suggest that mutant phenotypes become the standard metric to define g

136 heart field development not only rescues the mutant phenotype, but also is sufficient for proper func

137 for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss

138 Complementation of the DeltaacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase f

139 Suppression of the rne mutant phenotype by inactivation of deaD was partial, as

140 and pharmaceutical partial rescue of the Sp8 mutant phenotype by reducing Sonic Hedgehog (SHH) signal

141 P deletion partially rescues the bvht(dAGIL) mutant phenotype by restoring differentiation capacity.

142 s based on the rescue of embryonic zebrafish mutant phenotypes by "humanized" zebrafish orthologous m

143 ors (NAMs) has been shown to ameliorate many mutant phenotypes by correcting excessive protein synthe

144 nt approach for producing mice with compound mutant phenotypes, bypassing constraints of conventional

145 Research has demonstrated that mutant phenotypes can be obtained from the disruption of

146 These mutant phenotypes can be rescued by expressing wild-type

147 All edr1 mutant phenotypes can be suppressed by missense mutation

148 These mutant phenotypes cannot be rescued by neuron-specific i

149 The mutant phenotypes closely resemble those associated with

150 encoding a type I Hsp40 protein rescue apm1 mutant phenotypes, conferring sensitivity to the herbici

151 More importantly, our mutant phenotypes confirm that Caf1-mediated silencing i

152 genes were knocked down, also showed the nkd mutant phenotype, confirming the gene identities.

153 den) abolished mRNA rescue of the respective mutant phenotypes, consistent with their known contribut

154 embrane of mitochondria complements the pen2 mutant phenotype, corroborating the functional importanc

155 AHH1) during early seedling development when mutant phenotypes could be clearly observed.

156 In addition, the BDSF(-) mutant phenotypes could be rescued by in trans expressio

157 Its features are joint treatment of the mutant phenotype data with a factorized model and probab

158 n improved quantitative framework to analyze mutant phenotypes, detect symmetry-breaking events in ti

159 The topB mutant phenotype did not result from accumulation of tox

160 ermis development, but lacking a single-gene mutant phenotype due to genetic redundancy.

161 3935 gene leads to complete recovery of dosR mutant phenotypes during hypoxia.

162 type C. elegans, uncovers previously unknown mutant phenotypes, efficiently tracks changes in aging p

163 The mutant phenotypes exhibit dominant inheritance, but inco

164 cur due to proliferation of cells exhibiting mutant phenotypes, experiments that would not be possibl

165 mtbri1 mutants displayed characteristic bri1 mutant phenotypes: extreme dwarfness, dark green curled

166 as assessed by its ability to suppress yeast mutant phenotypes for both metals.

167 e mutation in lines selected on the basis of mutant phenotypes from FN-mutagenized A. thaliana popula

168 in improving the ability to detect putative mutant phenotypes from post-hoc analysis of large data s

169 king general cytological surveys to classify mutant phenotypes, Golubovskaya focused her efforts on c

170 OGTs that did not fully rescue the deletion mutant phenotypes had reduced or no activity.

171 Our Drosophila sff mutant phenotype has features in common with SAD kinase

172 Distinct expression patterns and mutant phenotypes, however, reveal that Sox11 and Sox4 a

173 The ron3-1 and ron3-2 mutant phenotypes [i.e., reduced apical dominance, prima

174 n tan1 air9 significantly rescued the double mutant phenotype in all three respects.

175 taset of 2,400 genes with a loss-of-function mutant phenotype in Arabidopsis.

176 ty and enhances the supernumerary neuroblast mutant phenotype in brat mutant brains.

177 The severity of the Pol-gamma mutant phenotype in heterozygous diploid humanized yeast

178 types are opposite to the known class II TCP mutant phenotype in JAW plants.

179 TAN1-DeltaII-YFP, significantly rescued the mutant phenotype in terms of root growth and division pl

180 STF also complements the lfl mutant phenotype in the flower if expressed under the LF

181 a reporter fusion and complementation of the mutant phenotype in vivo.

182 ion, analysis of individual and combined hox mutant phenotypes in a single strain background provides

183 we observed complete correspondence between mutant phenotypes in assays for cell fusion and plaque f

184 ld potentially be limited by modification of mutant phenotypes in different accessions and/or by the

185 we show that MUL1 suppresses PINK1 or parkin mutant phenotypes in Drosophila.

186 mev-1::miniSOG transgene complemented mev-1 mutant phenotypes in kn1 missense and tm1081(lf) deletio

187 Here we show that the yki mutant phenotypes in multiple developmental contexts are

188 consistent with the observation that B3GLCT mutant phenotypes in PPS patients are less severe than e

189 rinsic sources of noise in the penetrance of mutant phenotypes in signaling hypomorphs and explains a

190 splice site morphants showed various ciliary mutant phenotypes in these organs.

191 otype has features in common with SAD kinase mutant phenotypes in these other organisms, but we detec

192 xpression of SLP-2 transgenes rescued parkin mutant phenotypes, in particular loss of dopaminergic ne

193 The nakr1-1 mutant phenotype includes high Na(+), K(+), Rb(+), and s

194 icate a significant functional rescue of the mutant phenotype (including re-assembly of Complex V) fo

195 uncover the underlying genes for 44 of these mutant phenotypes, including 12 late-onset phenotypes.

196 Here, we show that all of the taa mutant phenotypes, including defects in shade avoidance,

197 nd glycosylphosphatidylinositol anchors, the mutant phenotypes indicate that GlcNAc metabolism is not

198 rison of Efnb2 and Notch signaling-deficient mutant phenotypes indicated that these two signaling sys

199 S1 was not able to complement the tomato rin mutant phenotype, indicating AcMADS1 may not be a functi

200 s1 mutants, and application of B rescues the mutant phenotype, indicating that the TLS1 protein facil

201 The mutant phenotype is also temperature-sensitive.

202 and transgenic experiment, we show that the mutant phenotype is caused by a dominant-negative mutati

203 lino oligonucleotides confirmed that the ecl mutant phenotype is caused by down-regulation of sp8.

204 This dysbindin mutant phenotype is fully rescued by presynaptic express

205 We further show that the UB(mdm2-/-) mutant phenotype is mediated by aberrant p53 activity be

206 similar to PEX11 in other organisms but the mutant phenotype is more extreme and environmentally det

207 This Hox9 mutant phenotype is restricted to the forelimbs; mutant

208 Indeed, the cmpy mutant phenotype is strongly suppressed by RNAi-mediated

209 The uox mutant phenotype is suppressed in a xanthine dehydrogena

210 We show that the induction of the zim17 mutant phenotype leads to strong import defects for Ssc1

211 The collection of mutant-phenotype mapping provides a framework for engine

212 ir potential to aid in the discrimination of mutant phenotypes masked by alterations in growth.

213 ults prompted us to ask whether neuroligin-3 mutant phenotypes may be reshaped by developmental plast

214 Creating and analyzing mutant phenotypes may therefore become rate-limiting in

215 inal mutation and by determining whether the mutant phenotype might be due to a polar effect of the t

216 several DELLA proteins suppressed the det1-1 mutant phenotype more obviously than GA treatment, indic

217 report a novel aspect of the documented Tbx6 mutant phenotype, namely an increase from two to four ec

218 Many of the mutant phenotypes observed were contingent upon the pres

219 The flhE mutant phenotype of Escherichia coli is similar overall

220 mothorax (hth) as a strong enhancer of the L mutant phenotype of loss of ventral eye.

221 This phenotype is complementary to the L mutant phenotype of loss-of-ventral eye.

222 ing Rac1 in SH-SY5Y cells rescues the G2019S mutant phenotype of neurite retraction.

223 90BRhoGAP impairs RhoB inactivation, and the mutant phenotype of patient-derived ECs is replicated by

224 Attenuation of glycolysis rescued the mutant phenotype of premature cartilage maturation, ther

225 st this possibility further, we analyzed the mutant phenotype of the zebrafish kif3a gene, which enco

226 kcross into the maize inbred line PH09B, the mutant phenotype of vyl lasted much longer in the greenh

227 bon1-1, while overexpression of CPR1 rescues mutant phenotypes of both bon1-1 and snc1-1.

228 The loss of SNC1 function suppresses the mutant phenotypes of cpr1-2 and cpr1-2 bon1-1, while ove

229 Our experiments demonstrated that mutant phenotypes of CSAS are similar to those of DSiaT,

230 Finally, the mutant phenotypes of DeltaPpXLG and DeltaPpGbeta2 can be

231 Mutant phenotypes of hypersensitivity to drought and few

232 ools will facilitate the rapid evaluation of mutant phenotypes of specific genes and the precise modi

233 In support of this, many mutant phenotypes of the pil1 lsp1 cells were rescued by

234 their role in ciliogenesis, we investigated mutant phenotypes of zebrafish crumbs genes.

235 ementary dataset of 401 genes that exhibit a mutant phenotype only when disrupted in combination with

236 al classes of genes have been associated, by mutant phenotypes or cell biology, with the formation of

237 ermore, transcription patterns together with mutant phenotypes pointed to the involvement of GLV4 and

238 zed by analyzing expression patterns, double mutant phenotypes, promoter-GUS fusions and expression o

239 Mutant phenotypes provide strong clues to the functions

240 d-type gene product, however, can also cause mutant phenotypes, providing geneticists with an alterna

241 sted repressive role is a result of specific mutant phenotypes, rather than a reflection of the norma

242 dentifying the genetic changes that underlie mutant phenotypes remains a significant bottleneck in th

243 a curated dataset of Arabidopsis genes with mutant phenotypes remains to be established.

244 We establish that the mutant phenotype represents a gain of function and can b

245 Hinge mutant phenotypes resemble loss of Pds5p, which binds op

246 The trr mutant phenotype resembles that of Utx, which encodes a

247 he inability of LAX sequences to rescue aux1 mutant phenotypes, respectively.

248 Analysis of CSN1b mutant phenotypes revealed a requirement for the COP9 si

249 te how our system confirms causality through mutant phenotype reversion.

250 Genetic analysis indicated that the mutant phenotype segregates as a single recessive Mendel

251 in a subdomain of the shoot apical meristem, mutant phenotype showing defect in polar leaf and/or mer

252 trait locus, microarray, RNA-sequencing and mutant phenotyping studies to identify gene-function ass

253 mponent system ChvG-ChvI, and the suppressor mutant phenotypes suggest that all or most of the charac

254 era of human Hook3 and Hok1 rescues the hok1 mutant phenotype, suggesting functional conservation bet

255 e raptor knockdown did not phenocopy the TSC mutant phenotype, suggesting that a novel role exists fo

256 factors and RNAi genes failed to revert the mutant phenotype, suggesting the involvement of a distin

257 e find that human Leptin can rescue the upd2 mutant phenotypes, suggesting that Upd2 is the functiona

258 Genetic analysis of mutant phenotypes suggests that RecG is needed to dissip

259 e 14-kb eps cluster resulted in an acapsular mutant phenotype that was not able to produce either EPS

260 of individual miRNAs often induces specific mutant phenotypes that can guide their functional study.

261 with a causal role for elevated IS in dfmr1 mutant phenotypes, the expression of dfmr1 specifically

262 GA signaling is sufficient to suppress arf2 mutant phenotypes through repression of GNC and GNL.

263 encoding gene, bba66, and characterizing the mutant phenotype throughout the natural mouse-tick-mouse

264 cient met7 yeast is able to rescue the yeast mutant phenotype, thus demonstrating that bm4 encodes a

265 Expressing OsRZFP34 in atrzfp34 reverted the mutant phenotype to normal, which indicates a conserved

266 tumor xenografts through reconversion of the mutant phenotype to wild-type p53.

267 miR165-mediated cleavage reversed the stp-2d mutant phenotype to wild-type, indicating that AtHB15 re

268 egrated S-linked genes, marker sequences and mutant phenotypes to create a map of the P. vulgaris S l

269 We used these expression patterns and mutant phenotypes to develop a margin-patterning model t

270 complementation mostly restored the observed mutant phenotypes to WT levels, leading to the postulati

271 two groups of transcripts connected to dek1 mutant phenotypes: transcripts related to cell wall remo

272 ype cells and highlights the need to examine mutant phenotypes under a range of conditions.

273 LR9 knock-out (KO) mice resemble the UNC93B1 mutant phenotype upon infection with L. major.

274 The OpBR mutant phenotype variably includes bone expansion and fu

275 al area of control mice, and a rescue of the mutant phenotype via pharmacological potentiation of AMP

276 sequencing revealed that, in both cases, the mutant phenotype was associated with mutations in the CY

277 The mutant phenotype was characterized using cell and molecu

278 The mutant phenotype was completely rescued by transgenic ex

279 The PBC mutant phenotype was evaluated in assays using monolayer

280 The gene responsible for the mutant phenotype was found to encode a putative protein

281 The mutant phenotype was partially rescued by retinoic acid

282 The deletion mutant phenotype was reproduced by using transformants w

283 y of Vps35 variants to rescue multiple vps35-mutant phenotypes, we found that the D620N mutation conf

284 Gsx overexpression contributes to the Dlx1/2 mutant phenotypes, we made compound loss-of-function mut

285 The xyl1 mutant phenotypes were associated with modifications to

286 The mutant phenotypes were complemented by transformation wi

287 However, after these first two miRNA mutant phenotypes were described, progress on the identi

288 Among the genes with robust mutant phenotypes were gdpP, which encodes a phosphodies

289 Mutant phenotypes were morphologically and molecularly e

290 Two distinct mutant phenotypes were observed: an excess of buds on th

291 Remarkably, most of these mutant phenotypes were rescued by supplying sucrose to t

292 -GFP was broadly expressed in seedlings, but mutant phenotypes were restricted to root hairs, indicat

293 ormant for each line, clones associated with mutant phenotypes were tested for repeatability and co-s

294 that either Robo1 or Robo2 rescues the robo3 mutant phenotype when each is knocked into the endogenou

295 the M2 proton channel, suppressed the UAS-M2 mutant phenotype when fed to larvae.

296 ly, knockdown of Sox6 fully rescued the Trbp-mutant phenotype, whereas mice overexpressing Sox6 pheno

297 s were selected for further analysis through mutant phenotyping, which revealed combinations of trans

298 TAN1-DeltaI-YFP, failed to rescue the double mutant phenotype, while TAN1 missing a conserved middle

299 Functional complementation of the mutant phenotype with the addition of tryptophan suggest

300 ning procedure predicted known knockdown and mutant phenotypes with high precision.

301 Comparison of the mutant phenotypes with those of the wild-type strain ind