ライフサイエンスコーパス: mutate

1 cell lines whether or not JAKs or STATs were mutated.

2 antly altered when the controlling factor is mutated.

3 that is associated with megalencephaly when mutated.

4 erine (Ser) and threonine (Thr) residues are mutated.

5 related receptor response element sites were mutated.

6 quired for ATR-mediated phosphorylation were mutated.

7 MECP2 (methyl CpG-binding protein 2) gene is mutated.

8 f-concept, we used these advances to rapidly mutate 10 high-affinity binding sites for the nucleoid o

9 ranscriptional function was abolished in the mutated 231 G521R ER cells despite appropriate receptor

10 specific mutations in the Il1a gene, we also mutated a long-noncoding (lnc)RNA in the complementary s

11 hose activities are stimulated by AKT, or by mutating a residue in MRE11 that we show is phosphorylat

12 irst independently, and then simultaneously, mutating a transcription factor and the associated promo

13 deno-associated virus (AAV) 1/2-driven human mutated A53T alpha-synuclein (aSyn)-overexpressing PD ra

14 at three of these elements are significantly mutated across multiple cancer types and have mutation d

15 ial ubiquitin ligases and effectors that are mutated across neurodegenerative diseases; accordingly,

16 w genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types,

17 FLT3-mutated acute myeloid leukemia (AML), despite not being

18 patients with FLG wild-type AD (WT/WT), FLG-mutated AD (FLG/WT), IV (FLG/FLG), or FLG WT control ski

19 ns incompletely understood, as, for example, mutating all Tyr1 residues to Phe (Y1F) is lethal in ver

20 terferon and ruxolitinib showed reduction of mutated allele burden, and ruxolitinib might extend surv

21 mized droplet digital PCR to broadly measure mutated alleles of recurrently mutated genes in CR marro

22 tions: p.Phe223Leu in Africans (23.5% of all mutated alleles), p.Gln263X and p.Leu424CysfsX in East A

23 egulated by the C-box YSY motif, which, when mutated, alters species stoichiometry and proteasome-dep

24 single allele knock-in of the most commonly mutated amino acid residue, tyrosine 537, in the estroge

25 n younger patients with newly diagnosed FLT3-mutated AML, but yielded no overall clinical benefit.

26 ppressor genes, beyond those engineered, are mutated, amplified, and deleted.

27 proofreading activity allow FMDV to rapidly mutate and adapt to dynamic environments.

28 They are often found to be mutated and de-regulated in cancers, but how they influe

29 pes of both isocitrate dehydrogenase (IDH-1)-mutated and IDH-1 wild-type glioblastomas.

30 P53 is a major tumor suppressor that is mutated and inactivated in 50% of all human cancers.

31 e report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750

32 nase-like kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related) and by the cycli

33 ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 ki

34 ous chromosome, however, are not recurrently mutated, and the identity of key 8p tumor-suppressor gen

35 Fifty-eight genes were significantly mutated, and the overall mutational load was associated

36 tions identified in IO IBD patients with two mutated ANKZF1 alleles result in dysfunctional ANKZF1, a

37 estation and the specificity of the subunits mutated are incompletely understood.

38 We mutated Arg-84, Arg-88, and Arg-101 in the ATPase-active

39 Conversely, promoter mutated at ARE site did not respond to SFN, validating t

40 EZH2 but not by TRIM28 expression or by EZH2 mutated at the region (pre-SET domain) of TRIM28 interac

41 legans models, expression of alpha-synuclein mutated at the site of interaction with dopamine prevent

42 s transduction with a dominant negative CAV1 mutated at tyrosine 14 reduced the interaction.

43 s revealed in primary T cells expressing CD6 mutated at Y629 and Y662.

44 ele signal through the ataxia telangiectasia mutated (ATM) kinase to feedback-inhibit RAG expression

45 Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well

46 in kinase (DNA-PK) and Ataxia telangiectasia mutated (ATM) signaling.

47 ukemia (CLL) where the ataxia telangiectasia mutated (ATM)-p53 pathway is inactivated with relatively

48 velop several flesh-colored melanocytic BAP1-mutated atypical intradermal tumors (MBAITs).

49 When FveGA20ox4 is mutated, axillary meristems remain dormant or produce se

50 ve selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) ce

51 template strand dictates the addition of the mutated base.

52 eficiency and progressive hepatopathy due to mutated BCS1L, a CIII assembly factor.

53 Restoration of STAG2 expression in a mutated bladder cancer model alleviates the dependency o

54 ally through analyzing the kinetic effect of mutating both interface and solvent exposed residues in

55 lly approved targeted therapies for commonly mutated BRAF(V600E) melanoma.

56 w physical differences between wild type and mutated BRCA1(5382insC) impact the cell's response to ox

57 abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic ca

58 in which the N-linked glycosylation site is mutated by single-amino-acid substitution are highly att

59 balance during embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the

60 APOBEC cytidine deaminases mutate cancer genomes by converting cytidines into uridi

61 e genes involved in OGID and 260 somatically mutated cancer driver genes (p = 1.75 x 10(-14)).

62 TP53-mutated cases had a dismal outcome, with a median OS of

63 A, representing only 10.3% (3 of 29) of BRAF-mutated cases.

64 For this application, we mutated CE7 to create a CL7 tag, which retained the full

65 Desmin-mutated cells required higher forces than wild-type cell

66 transposon integration, and enrich for Cas9-mutated cells.

67 nctional consequences of the most frequently mutated CMGs (KMT2D, CREBBP, and EZH2) and point to a ro

68 Up-regulation of the tRNA cognate to the mutated codon counteracts the effects of the sSNP and re

69 KRAS-mutated colorectal liver metastases (CRLM) are known to

70 host vulnerable to an attack by a virus with mutated corresponding protospacers, while an excessive v

71 Because of the aggressive nature of KRAS-mutated CRLM, more extensive anatomical hepatectomies ma

72 sections and 140 (36.0%) presented with KRAS-mutated CRLM.

73 We find that mutated CSMD3 is associated with better prognosis in Asi

74 ession on ibrutinib, and are associated with mutated CXCR4.

75 nally, we engineered base editors containing mutated cytidine deaminase domains that narrow the width

76 Our data suggest that mutated desmin already markedly impedes myocyte structur

77 We mutated distinguishing active-site residues to generate

78 nctional characterization of the most highly mutated DNase I hypersensitive sites in breast cancer (u

79 We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (H

80 tion, we identified associations between 737 mutated driver genes and site-specific methylation chang

81 rmationally less flexible, target gatekeeper mutated drug-resistant EGFR-L858R/T790M, and covalently

82 nal change that is most prominent around the mutated EF-hand IV, as well as throughout the C-domain.

83 ication of interaction partners that bind to mutated EGFR can help identify novel targets for drug di

84 ), heterogeneous expression of amplified and mutated epidermal growth factor receptor (EGFR) presents

85 y, one of the most frequently altered genes, mutated exclusively by inactivating mutation, was LYST (

86 ormed with a construct in which the uORF was mutated exhibited serrated leaves, compact rosettes, and

87 uced fibrosarcoma cells naturally expressing mutated extracellular signal-regulated kinase (ERK) anti

88 of a single sgRNA was efficient at inducing mutated fetuses, the lack of complete gene inactivation

89 Our findings show that mutated FLT3-ITD and JAK2 augment ROS production and HR,

90 2PPM experiments with non-mutated fluorescently labeled Galphai1 subunits and alph

91 anced whole-cell K(+) currents produced by a mutated form of Kv2.1 mimicking apoptosis in a mammalian

92 ormal levels by wild-type SOS2, but not by a mutated form of SOS2 lacking the T168 residue phosphoryl

93 Furthermore, overexpression of a mutated form of STRAD, underlying the disorder polyhydra

94 Mutated forms of Ras are involved in approximately 30% o

95 Fourteen patients with visual loss and mutated G11778A mitochondrial DNA.

96 To determine whether mutated gene and type of mutation influence age at onset

97 ee RAS oncogenes make up the most frequently mutated gene family in human cancer.

98 p53 is the most frequently mutated gene in human cancer, and over half of human can

99 p53 is the most frequently mutated gene in human cancer.

100 n all the analysed scans irrespective of the mutated gene.

101 However, the impact of non-significantly mutated genes (non-SMGs), which may also play important

102 orts had been made to identify significantly mutated genes (SMGs) in ECs and use them as biomarkers f

103 altered pathways, with associations between mutated genes and pathways, and stage or subtype of T-AL

104 d the identification of a set of recurrently mutated genes central to the pathogenesis of MDS, which

105 oadly measure mutated alleles of recurrently mutated genes in CR marrows of AML patients at levels as

106 TP53 is one of the most commonly mutated genes in human cancers.

107 K- and H-Ras are the most commonly mutated genes in human tumors and are critical for confe

108 FAM46C is one of the most recurrently mutated genes in multiple myeloma; however its role in d

109 1 (LKB1/STK11) is one of the most frequently mutated genes in non-small cell lung cancer (NSCLC) and

110 TP53 are two of the most commonly deleted or mutated genes in prostate cancer, the compound loss of w

111 4 T2 and 225 T8 genes, including four highly mutated genes that are functionally related to the targe

112 river genes and identifies new significantly mutated genes with highly plausible biological functions

113 Within specific mutated genes, frequency, mutation hotspot residues, in

114 by low mutational burden and few recurrently mutated genes.

115 profiles were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendrogl

116 lic response (P < 0.001) and non-KIT exon 11-mutated GISTs (P < 0.001).

117 Conclusion IDH-mutated glioblastomas have a less invasive phenotype com

118 A repair pathway extensively sensitized IDH1-mutated glioma cells to TMZ.

119 n-binding protein C), is the most frequently mutated HCM gene.

120 Mutating HISTONE DEACETYLASE 6 (HDA6), or the cytosine m

121 During CMV-CTL monitoring using mutated HLA/CMV tetramers selectively detecting high-avi

122 cells were found in the SDT group, while p53-mutated HSC-3 cells did not show such increase.

123 reased (P = .037) in low-grade glioma with a mutated IDH gene, and MTI was significantly increased in

124 ducible chemokines, including CXCL10, in IDH-mutated (IDH-MUT) tumors compared with IDH-WT tumors.

125 Anaplastic astrocytoma samples with mutated IDH1 display lower levels of Mcl-1 than IDH1 wil

126 s (Activity-on-Target cytokines), optimized (mutated) immunocytokines that are up to 1,000-fold more

127 s including KMT2C/MLL3 and ARID1B, which are mutated in >50% of hepatocellular carcinomas, were also

128 The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leuk

129 BRAF was mutated in 7.6% (484 of 6353) of colorectal cancer and 9

130 e encoding the RUNX1 transcription factor is mutated in a subset of T-cell acute lymphoblastic leukem

131 and IDH2) are key metabolic enzymes that are mutated in a variety of cancers to confer a gain-of-func

132 It was recurrently mutated in advanced human cancers and significantly co-o

133 ded on specific surface residues on profilin mutated in ALS patients.

134 a core component of the Ras pathway that is mutated in both RASopathies and cancers in humans.

135 eiotropic functions and has been found to be mutated in cancer cells, ciliopathies such as the polycy

136 As p53 is frequently mutated in cancer, our findings provide a mechanism by w

137 es that target signalling molecules that are mutated in cancers can often have substantial short-term

138 oteins implicated in membrane remodeling and mutated in centronuclear myopathies (CNMs).

139 r, contains six tandem BDs and is frequently mutated in clear cell renal cell carcinoma (ccRCC).

140 contain mutations in multiple genes that are mutated in cutaneous squamous cell cancers.

141 re threshold 2), a metazoan-specific protein mutated in epilepsy, recruits a fraction of mammalian GA

142 es (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR.

143 are critical mediators of signalling and are mutated in familial exudative vitreoretinopathy.

144 Because these residues are mutated in genetic disease, lid displacement was hypothe

145 ent transcription factor that is recurrently mutated in hematopoietic and solid tumors.

146 of a virus library targeting genes commonly mutated in human cancers into the brains of conditional-

147 Protein kinases are frequently mutated in human cancers, which leads to altered signali

148 tch1 and Mll2, which are recurrently deleted/mutated in human haematological malignancies.

149 Chromatin-modifying genes are frequently mutated in human lung adenocarcinoma, but the functional

150 rs of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number of ciliopathies

151 genitors of the human embryonic brain and is mutated in individuals with autosomal recessive primary

152 Targeted-NGS on genes commonly mutated in IPMN and PDAC was performed on tumors from (1

153 phosphatase INPP5E localizes to cilia and is mutated in JBTS.

154 >50% of hepatocellular carcinomas, were also mutated in liver metastases.

155 t-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new

156 PARK2 is the most common gene mutated in monogenic recessive familial cases of Parkins

157 While in human solid tumors TP53 is mutated in more than half of cases, TP53 mutations occur

158 We then constructed two RBDs mutated in multiple key residues in the receptor-binding

159 ted in leukemic transformations and commonly mutated in other tumors.

160 uman brain synapses is highly complex and is mutated in over 130 diseases.

161 The p53 gene is mutated in over half of all cancers, reflecting its crit

162 has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML).

163 ific residues on human profilin-1 (PFN1) are mutated in patients with amyotrophic lateral sclerosis (

164 ate of mutation than that observed for genes mutated in PIDs where revertants have not been identifie

165 Analyses of other genes mutated in primary immunodeficiency diseases (PIDs) wher

166 MCPH1 gene, mutated in primary microcephaly, regulates cell progress

167 Only VP24, GP and NP were consistently found mutated in rodent-adapted Ebola virus strains.

168 g protein (CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal center

169 , and R291Q is orthologous to R294, which is mutated in the BXH2 IRF8-deficient mouse.

170 ential role in development and is frequently mutated in the context of human disease.

171 inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM

172 a temperature-sensitive fission yeast strain mutated in the exocyst subunit Sec3 (sec3-913).

173 ed in congenital mirror movements when it is mutated in the heterozygous state but whose biallelic lo

174 Ras, a high value therapeutic target that is mutated in up to a third of human cancers.

175 and seven other essential proteins that are mutated in various FA subtypes.

176 In vivo, mutating Indian Hedgehog results in a sex ratio bias aga

177 Mutating individual residues implicated in G4 binding ha

178 09) or a hydrophobic (Ile-305) amino acid is mutated instead.

179 ER stress signalling results in loss of Apc mutated intestinal epithelial stem cells by interference

180 nity defense mechanisms, often deleteriously mutating invading retroviruses or retrotransposons and,

181 within the terminals of mice expressing the mutated isoform.

182 f an alanine, A(186), within the CX3C motif, mutating it to CX4C ((182)CWAIAC(187)), known to block b

183 e osteoclastogenesis in cells expressing the mutated IVVY motif.

184 regulatory autophosphorylation, and that the mutated kinase acts in a dominant-negative manner to red

185 meostasis and represents the most frequently mutated kinase in tumors.

186 omimetic and phosphorylation-dead mutants by mutating known conserved regulatory serine (S) residues

187 y increases Spo11-oligonucleotide levels but mutating known Tel1 phosphotargets on Hop1 and Rec114 do

188 complishing the selective targeting of point-mutated KRAS in vitro and in vivo.

189 Specifically, mutated KRAS is a documented driver for malignant transf

190 The heavily mutated landscape of coding and non-coding mutations in

191 lving phylogenic relationships, we uncovered mutated LCP1 and WNK1 as novel CLL drivers, supported by

192 VGF silencing resensitized EGFR-mutated lung adenocarcinoma cells to TKI.

193 KRAS-mutated lung cancer cell clones were stably silenced for

194 Here we report that RP-mutated lymphoblastoid cell lines (LCLs) established fro

195 re, we sought to characterize the effects of mutating Lys-300 of NhaA to amino acid residues containi

196 ted rVSVs (wild-type and attenuated VSV with mutated matrix protein [VSVm] versions) that express eit

197 onstrated the proliferative kinetics of BRAF-mutated melanoma cells treated with the BRAF inhibitor P

198 Given many BRAF-mutated melanoma patients experience disease progression

199 re available for patients with advanced BRAF-mutated melanoma.

200 d extrinsic components of resistance in BRAF-mutated melanoma; the model describes tumor-stroma dynam

201 termination codon and the degradation of the mutated messenger RNA by nonsense-mediated messenger RNA

202 n was explored by stratifying the results by mutated MMR gene, sex, and a history of CRTs.

203 Stratification by mutated MMR gene, sex, and CRT history did not show sign

204 GroES(7) variants with two or three mutated modules collaborated with GroEL(SR) to perform c

205 Using mutated MYD88 as a tumor marker, BTK(Cys481) mutations w

206 ation of HSV-1-induced membrane fusion since mutating N58 to alanine (N58A) caused extensive virus-in

207 Importantly, the mutated NDK5 that appeared fully functional in ndk5 cell

208 nt T cell reactivities were directed against mutated neoantigens or a cancer germline antigen, rather

209 ively, these findings validate GPC2 as a non-mutated neuroblastoma oncoprotein and candidate immunoth

210 nhibition of gene expression mediated by the mutated NS1 protein.

211 KRAS is the most frequently mutated oncogene in cancer and KRAS mutation is commonly

212 KRAS is the most frequently mutated oncogene in human cancer and plays a central, al

213 The detection of significantly mutated (or undermutated) genes is completely confounded

214 exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, whic

215 pletion of KDM3A was capable of reactivating mutated p53 to induce the expression of pro-apoptotic ge

216 ( approximately 2-fold) when associated with mutated p85alpha.

217 pe normal pancreas cells, as well as in KRAS mutated pancreatic cancer cells and was essential for ER

218 in design of vaccine strategies against fast mutating pathogens.

219 phenotypic and functional analysis of STAT1-mutated patient cells.

220 marker, phosphorylated ataxia telangiectasia mutated (pATM), were quantified in circulating lymphocyt

221 e we present the crystal structures of these mutated peptides bound to mouse IA(g7) and human HLA-DQ8

222 n of neoantigens, which are tumour-specific, mutated peptides presented on the surface of cancer cell

223 rface, allowing T cells to detect foreign or mutated peptides.

224 This His is involved in UFM1 binding and if mutated perturbs activation of UFM1.

225 The p190A/eIF3A interaction is unaffected by mutating phosphorylated p190A-Tyr(308), but disrupted by

226 Activation of FoxO3 by mutating phosphorylation sites to enhance its nuclear ex

227 omplementation of the disrupted locus with a mutated PIMMS2 allele reveals that amino acid residues c

228 ymmetry is the opposite between cancers with mutated polymerases delta and epsilon, consistent with t

229 Moreover, by using mutated promoter constructs, we identified a NF-kappaB s

230 in response to high VPD, whereas plants with mutated protein kinase OST1 showed stunted VPD-induced r

231 randed DNA as it translocates through charge-mutated protein nanopores.

232 ased by 8-10 folds for wild-type but not INS-mutated pvLAAD, indicating that the INS-membrane interac

233 Mutated pyrin prohibits this colocalization, leading to

234 Influenza viruses mutate rapidly, necessitating annual vaccine reformulati

235 ound to have profoundly differing effects on mutated receptors compared with TBS-516 and TQS, a findi

236 se salt bridges activated binding unless the mutated residue also formed a salt bridge with GpIbalpha

237 cognized by germline-encoded and somatically mutated residues on the Ab heavy chain.

238 can improve the stability of SAT2 viruses by mutating residues at the capsid interface through predic

239 By mutating residues in ABD1, we find that this activity is

240 Two new provisional entities, AML with mutated RUNX1 and AML with BCR- ABL1, have been included

241 Progressive loss of mutated SAMD9 through the development of monosomy 7 (-7)

242 L mutation, 3 developed MDS upon loss of the mutated SAMD9L allele following intracellular infections

243 Only 2 RAS mutated samples (6.5%) were identified.

244 ent tumors, and shared specificity for a non-mutated self-antigen derived from U2AF2.

245 Three of the TIL TCRs were specific for non-mutated self-antigens, two of which were present in sepa

246 The nucleic acid alignment of the mutated sequences against the wild-type sequence reveale

247 UNC-18 variants, created by mutating Ser(311) or Ser(322), disrupt thermotaxis and s

248 We identified 39 genes that were mutated significantly above background mutation rates.

249 shed by deletion of the CENPC-k motif and by mutating single conserved amino acids, but can be restor

250 This Cel7A variant contains 18 mutated sites and is active under application conditions

251 ed for the stabilizing effect at many of the mutated sites.

252 ignificantly elevated in cells harboring the mutated SLC25A24.

253 , isolated from a Forrest M2 population (EMS-mutated soybean) were studied.

254 e A-, B- and/or C-helices within each of the mutated spectrin repeats.

255 the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids.

256 the strongest elements were most frequently mutated, suggesting a selective advantage.

257 Analysis of mutated target sequences and human genomic DNA reveal th

258 he almost complete loss of expression of the mutated TBK1 allele is due to loss-of-function mutations

259 In viruses with the N-terminal Cys residues mutated, TF is much less efficiently localized to the pl

260 due to the activity of cellular enzymes that mutate the viral genome.

261 We modularly mutated the five Cys residues in the identical N termini

262 e significance of the latter correlation, we mutated the splice sites in an affected intron to consen

263 A3G mutates the HIV genome by deamination of dC to dU, leadi

264 nerates highly negatively charged pectin and mutates the physiochemical properties of the plant cell

265 Mutating the bulge sequence to 5'-ACCCC-3' ablates base

266 lycosylation sites in Env typically involved mutating the glycosylated asparagine residues to structu

267 Of note, mutating the phosphorylation sites in the MAD1(CTD), inc

268 istent with mimicking substrate interaction, mutating the putative substrate-binding site in a consti

269 oth congenital and age related cataract when mutated, the extended promoter region of EPHA2 was scree

270 Mutant lysenin still can form pores, but mutating these glutamic acids to glutamines rendered the

271 oultry from wild birds have the potential to mutate to highly pathogenic avian influenza (HPAI) virus

272 Oral poliovirus vaccine can mutate to regain neurovirulence.

273 When Glu(73) was mutated to a glutamine, KK174 no longer photolabeled thi

274 pared to wild-type Nav1.5, Nav1.5 with K1479 mutated to a nonacetylatable residue increases peak INa

275 m that arose when an ancestral threonine was mutated to alanine, greatly increasing resistance to DCV

276 tes is strongly altered when this residue is mutated to alanine.

277 Stem cell-derived cardiomyocytes mutated to carry the effect allele had diminished contra

278 which encodes a chromatin remodeling protein mutated to cause human epilepsies.

279 the canonical nucleotide binding site 2 was mutated to glutamine.

280 ya virus in which the cleavage site has been mutated to inhibit proteolysis.

281 egulated by Sirt1, whereas Nav1.5 with K1479 mutated to mimic acetylation decreases INa.

282 with the proprotein convertase cleavage site mutated to mimic the structure of the TGF-beta1 proprote

283 Here, human Msh3 was mutated to selectively inactivate MutSbeta.

284 nce will increase substantially if the virus mutates to increase human-to-human transmissibility.

285 ancer cell lines examined and upregulated by mutated TP53, a gene commonly altered in ovarian cancer.

286 iscriminate targeting of wild-type and point-mutated transcripts represents an important limitation.

287 Either TNKS1 inhibition or TBM mutated TRF1 expression markedly sensitizes cells to tel

288 Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitop

289 ould be the major connecting hub between SDH-mutated tumors and the (18)F-FDG uptake profile.

290 hat are captured in PET images, whereas KRAS-mutated tumors do not.

291 PIK3CA mutated tumors expressed higher p-AKT/AKT protein levels

292 KRAS mutated tumours represent a large fraction of human canc

293 We needed to mutate two lysine residues to abolish trypsin inhibition

294 Mutating two G4-interacting residues (T1024G and T1086G)

295 established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective r

296 r, we found that hippocampal expression of a mutated version of TRIP8b further impaired HCN-channel t

297 del(17p) or TP53 mutation, or both, and IGHV mutated versus unmutated.

298 d HEK293T cells with pyrin and wild-type and mutated WDR1 Mutant protein formed aggregates that appea

299 when gamma subunit palmitoylation sites were mutated, whereas DHHCs 1, 2, and 14 still activated ENaC

300 Unsurprisingly, mutated Wnt pathway components are causative to multiple