ライフサイエンスコーパス: mutation accumulation

1 with purely deleterious late-life effects ("mutation accumulation").

2 neutral (or nearly neutral) mutations (i.e., mutation accumulation).

3 degrade over time as a result of spontaneous mutation accumulation.

4 an average of 370 generations of spontaneous mutation accumulation.

5 he Sia-recognition domain, suggesting biased mutation accumulation.

6 trols was assayed after 27-33 generations of mutation accumulation.

7 cell death as an important defense to avoid mutation accumulation.

8 ce of meiosis and sex is expected to lead to mutation accumulation.

9 the parameter space in which models predict mutation accumulation.

10 nvironments, and thus the tradeoff is due to mutation accumulation.

11 gated ER Ca2+ replenishment may be linked to mutation accumulation.

12 d demographic models to represent effects of mutation accumulation and antagonistic pleiotropy on ran

13 jor theories of the evolution of senescence (mutation accumulation and antagonistic pleiotropy) make

14 cesses can produce ecological specialization-mutation accumulation and antagonistic pleiotropy.

15 rrent mutation, population structure, and/or mutation accumulation and drift.

16 ttle is known about the relationship between mutation accumulation and gene reassortment for rotaviru

17 icula to mitigate the effects of deleterious mutation accumulation and increase potentially adaptive

18 ng that most metabolic erosion was driven by mutation accumulation and not by physiological tradeoffs

19 DNA repair pathways in preventing C. elegans mutation accumulation and provides evidence for the pres

20 xual diploid species is not only a matter of mutation accumulation and reduced efficiency of selectio

21 is based upon a population dynamics model of mutation accumulation and selection in colorectal tissue

22 This leads to mutation accumulation and somatic cell mosaicism in mult

23 mote repair or apoptosis, thereby preventing mutation accumulation and suppressing tumor development.

24 gene-drug interactions and extend the use of mutation accumulation and whole-genome sequencing analys

25 Two recent reports combine mutation accumulation and whole-genome sequencing to mea

26 ed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neu

27 ing to its rapid proliferation, high rate of mutation accumulation, and genetic tractability.

28 linked genes is an accidental by-product of mutation accumulation, and not driven by selection to ei

29 general evolutionary theory, along with the mutation accumulation, antagonistic pleiotropy, and disp

30 Drosophila melanogaster by using a modified mutation accumulation approach.

31 Alternatives to the mutation-accumulation approach have been developed to ch

32 or mortality in Drosophila, and they support mutation accumulation as a viable mechanism for the evol

33 teaus, with both antagonistic pleiotropy and mutation accumulation as driving population genetic mech

34 s predictions for senescent mortality due to mutation accumulation, at the price of reliance on a lin

35 portunity for recombination to slow down the mutation accumulation, but always at a cost of increased

36 The polyploid state reduces spontaneous mutation accumulation by gene conversion, the freshly mu

37 on-Ig loci, many of which are protected from mutation accumulation by high-fidelity DNA repair.

38 inally, we show that the rates of endogenous mutation accumulation by intrinsic processes are not suf

39 eory suggests that the risk of extinction by mutation accumulation can be comparable to that by envir

40 arent decline in viability under spontaneous mutation accumulation could have been nonmutational, per

41 Subsequent workers have suggested that mutation accumulation could produce an age-related incre

42 spite the increasing availability of QTL and mutation accumulation data, such data have not yet been

43 ate of viral suppression and drug-resistance-mutation accumulation derived from patients receiving pr

44 Mutation accumulation diminishes the degree of adaptatio

45 once fitness reached a maximum, the rate of mutation accumulation dropped.

46 ve trait and have implications regarding the mutation-accumulation evolutionary explanation of senesc

47 "treatment" alleles on one chromosome during mutation accumulation experience an elevated mutation ra

48 We conducted a mutation accumulation experiment for approximately 350 g

49 Here, we report the results of a mutation accumulation experiment performed on panmictic

50 estructive cheaters to spread, as shown by a mutation accumulation experiment.

51 Here we present the results of a mutation-accumulation experiment designed to assess the

52 We sequenced eight genomes produced by a mutation-accumulation experiment in Drosophila melanogas

53 We have performed a mutation-accumulation experiment similar to those of Muk

54 s estimated as 2 x 10(-4) in a 10-generation mutation-accumulation experiment.

55 his purpose using (1) de novo mutations from mutation accumulation experiments and (2) extremely rare

56 Recently, the coupling of mutation accumulation experiments and next-generation se

57 Mutation accumulation experiments have shown that hyperm

58 tness, but most information comes from a few mutation accumulation experiments in Drosophila in which

59 e model is based on mutation parameters from mutation accumulation experiments involving balancer chr

60 Mutation accumulation experiments were performed by sequ

61 of high mutation rates with weak selection (mutation accumulation experiments) and low mutation rate

62 the distribution of mutational effects from mutation accumulation experiments.

63 Mutation-accumulation experiments are widely used to est

64 Mutation-accumulation experiments have been used to stud

65 crepancy between the present s and that from mutation-accumulation experiments in Drosophila (approxi

66 fects of deleterious mutations by performing mutation-accumulation experiments on five viral genotype

67 measure such rates and patterns directly in mutation-accumulation experiments or tries to infer them

68 We confirmed our hypothesis in mutation-accumulation experiments that showed a normaliz

69 Mutation-accumulation experiments, in which mutations ar

70 Genomic data from mutation-accumulation experiments, parent-offspring trio

71 intensive, relying on long-term, laboratory mutation-accumulation experiments.

72 enic aquatic microcrustacean, using parallel mutation-accumulation experiments.

73 s that are consistent with observations from mutation-accumulation experiments.

74 iews the three strands and, concentrating on mutation accumulation, extends a mathematical result wit

75 Using mutation accumulation followed by whole-genome sequencin

76 istic pleiotropy appears more important than mutation accumulation for the decay of unused catabolic

77 Somatic mutation accumulation has been implicated as a major cau

78 rom the same patient, it helps to reveal the mutation accumulation history, track cancer progression,

79 of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of se

80 ate-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the ant

81 The mutation-accumulation hypothesis attributes senescence t

82 es may be exceptionally prone to deleterious-mutation accumulation in both nuclear and organelle gene

83 d a hybrid stochastic-deterministic model of mutation accumulation in both stem cells and progenitors

84 ve a greater ability of delaying the rate of mutation accumulation in colonic stem cells compared to

85 The accelerated mutation accumulation in liver was accompanied by an inc

86 from our data that age-related mtDNA somatic mutation accumulation in mouse HSCs is influenced by the

87 We found that mutation accumulation in organoids deficient in the mism

88 nvestigate the dynamics of proliferation and mutation accumulation in spatially arranged tissues.

89 To compare mutation accumulation in the transcribed genomic regions

90 To study the impact of NER deficiency on mutation accumulation in vivo, mutant frequencies have b

91 We show that, under mutation accumulation, inbreeding decline and three majo

92 If mutation accumulation is important, their unused functio

93 ral observations, including that the rate of mutation accumulation is maximal during ontogeny, oncoge

94 es of current human behavior for deleterious-mutation accumulation leads to the conclusion that a sub

95 gnificant heterogeneity in u among the three mutation-accumulation-line genotypes.

96 We performed mutation accumulation lines and genome-wide mutational p

97 Analysis of genomic data of yeast mutation accumulation lines and human neutral polymorphi

98 This contrasts with results derived from mutation accumulation lines and suggests that mutation s

99 ed in a large collection of Escherichia coli mutation accumulation lines by analysis of whole genome

100 g 20 million bases of DNA from three sets of mutation accumulation lines by using denaturing high-per

101 s mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natu

102 An analysis of long-term mutation accumulation lines of Caenorhabditis elegans fo

103 We applied this procedure to mutation accumulation lines of Drosophila melanogaster e

104 d elimination of old elements in the Harwich mutation accumulation lines of Drosophila melanogaster,

105 mutation rates of 24 microsatellite loci in mutation accumulation lines of Drosophila melanogaster.

106 The mutation accumulation lines were studied in three enviro

107 tes of the gene conversion rate from Daphnia mutation accumulation lines, we are able to age each ase

108 a long-term series of Caenorhabditis elegans mutation accumulation lines, we performed a wide-scale s

109 iances (VM) for these traits, estimated from mutation accumulation lines, were 4.75 and 1.97 x 10(-4)

110 Here, we used mutation accumulation lines, whole-genome sequencing, an

111 direct genotyping of 96 Arabidopsis thaliana mutation accumulation lines.

112 patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to

113 Comparison of the mutation-accumulation lines at generations 19 and 47 wit

114 Here, we show in mutation-accumulation lines of asexual Daphnia that the

115 eliminations have been scored in the Harwich mutation-accumulation lines of Drosophila melanogaster.

116 Using long-term mutation-accumulation lines of the nematode Caenorhabdit

117 lymer mutation assays in a set of C. elegans mutation-accumulation lines reveal an approximately 20-f

118 by mapping QTL that cause divergence between mutation-accumulation lines that have been established f

119 molecular spectrum with a set of C. elegans mutation-accumulation lines that reveal a mutation rate

120 revisiae, we measured the growth rate of 151 mutation-accumulation lines to estimate parameters of mu

121 Using long-term series of mutation-accumulation lines, we have obtained direct est

122 e new predictions to distinguish between the mutation accumulation (MA) and antagonistic pleiotropy (

123 effect of spontaneous mutations generated by mutation accumulation (MA) experiments.

124 , smaller than typical direct estimates from mutation accumulation (MA) experiments.

125 (changes in cytosine methylation status) in mutation accumulation (MA) lineages of Arabidopsis thali

126 We used two Arabidopsis thaliana mutation accumulation (MA) lines and determined that ove

127 The first, mutation accumulation (MA) lines are the product of main

128 over five generations in eight MMR-deficient mutation accumulation (MA) lines of the model plant spec

129 wo sets of nematode (Caenorhabditis elegans) mutation accumulation (MA) lines that differ by threefol

130 hod of studying spontaneous mutations is via mutation accumulation (MA) lines.

131 We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Sacc

132 average homozygous mutation effects (s) from mutation-accumulation (MA) experiments in which phenotyp

133 in two Daphnia pulex genotypes via separate mutation-accumulation (MA) experiments.

134 very lines were initiated from a low-fitness mutation-accumulation (MA) line progenitor and allowed t

135 air-deficient (xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of th

136 ent (msh-2 and msh-6) Caenorhabditis elegans mutation-accumulation (MA) lines and compared our observ

137 Egg-to-adult viability of 72 nonlethal mutation-accumulation (MA) lines and the controls was as

138 The inbred lines but not the mutation-accumulation (MA) lines showed heterosis for pr

139 rols for assessing viability declines of the mutation-accumulation (MA) lines.

140 ution mutations in 10 Caenorhabditis elegans mutation-accumulation (MA)-line nuclear genomes.

141 After approximately 644 generations of mutation accumulation, MA lines had accumulated an avera

142 The data suggest that mutation accumulation may be a major source of standing

143 Reduced fitness from deleterious-mutation accumulation may be important in the evolution

144 Under the mutation accumulation model of senescence, it was predic

145 In contrast to predictions of the mutation accumulation model of senescence, the age-speci

146 d how rearing conditions affect tests of the mutation accumulation model of senescence.

147 The results are consistent with the mutation accumulation model, but can only be explained b

148 ber of replication cycles leading to a rapid mutation accumulation model.

149 population noninfectious - known as the slow mutation accumulation model.

150 However, contrary to the predictions of mutation-accumulation models, inbreeding load for loci a

151 In mutation accumulation, mutations become fixed by genetic

152 After 60 generations of mutation accumulation, negligible changes in mean reprod

153 ll for mutation rather than in the extent of mutation accumulation once targeted.

154 embed genetic theories of senescence (either mutation accumulation or antagonistic pleiotropy) in the

155 lved via many diverse genetic mechanisms and mutation-accumulation patterns support this inference.

156 ing the full nonlinear demographic model for mutation accumulation recently developed by Evans, Stein

157 ographic theory includes three main strands--mutation accumulation, stochastic vitality, and optimal

158 magnitude lower than those that are based on mutation accumulation studies.

159 We used a mutation accumulation study to see if unusually high mic

160 This result provides support for the mutation accumulation theory of aging.

161 These results indicate that a modified mutation-accumulation theory can both explain the origin

162 ss all age classes, consistent with modified mutation-accumulation theory.

163 support a prediction derived from MEDAWAR's "mutation accumulation" theory for the evolution of senes

164 Because of mutation accumulation, viable metapopulations may need t

165 These data suggest that mutation accumulation was an important evolutionary forc

166 M, and G proteins showed that the pattern of mutation accumulation was coherent with fitness changes

167 No increased mutation accumulation was observed in brain or spleen.

168 such mice is due to accelerated spontaneous mutation accumulation, we crossed these mutants with mic

169 se specialists by the relentless pressure of mutation accumulation, which has taken 25 years to detec

170 ution of a given variant of a strain through mutation accumulation within an individual, sequential r