ライフサイエンスコーパス: mutation frequency

1 tations into the C. difficile genome (20-50% mutation frequency).

2 mutation efficiency on HBV DNA and total HBV mutation frequency.

3 ng parent-of-origin-dependent effects on the mutation frequency.

4 ave been suggested, one of them being simple mutation frequency.

5 er the last 12 years has revealed a 25% PTEN mutation frequency.

6 nes, which leads to DNA damage and increased mutation frequency.

7 C activity of VH1 antibodies correlated with mutation frequency.

8 henotype may arise from the resulting higher mutation frequency.

9 temperature while maintaining an increase in mutation frequency.

10 onstruct may have been responsible for lower mutation frequency.

11 d with enhanced MMR efficiency and decreased mutation frequency.

12 of reactive nitrogen species or reduction in mutation frequency.

13 species, and possesses an endogenously high mutation frequency.

14 ent use; HCDR3 length or positive charge; or mutation frequency.

15 utation frequency and a minority with a high mutation frequency.

16 they arose in a subpopulation with a higher mutation frequency.

17 ype, and disease site were not predictive of mutation frequency.

18 les per tumour type, depending on background mutation frequency.

19 nce contributes to genome-wide variations in mutation frequency.

20 utators, which exhibit increased spontaneous-mutation frequencies.

21 mapping of polymorphisms and measurement of mutation frequencies.

22 viruses including alphaviruses exhibit high mutation frequencies.

23 identified that significantly altered virus mutation frequencies.

24 port to show that NNRTIs can influence virus mutation frequencies.

25 sed in antiviral drug therapy increase virus mutation frequencies.

26 sistant RT can significantly influence virus mutation frequencies.

27 ighly drug resistant RT led to altered virus mutation frequencies.

28 on the analysis of HIV strains, rather than mutation frequencies.

29 ity that conditions on per-event, per-sample mutation frequencies.

30 two orders of magnitude higher than somatic mutation frequencies.

31 r, it is unknown if filoviruses exhibit high mutation frequencies.

32 are preferential targets for altered somatic mutation frequencies.

33 utation frequencies comparable to background mutation frequencies.

34 target regions in which nucleotides have low mutation frequencies.

35 In kidney, an elevated mutation frequency above controls of approximately 2.5-f

36 ant activity correlates imperfectly with its mutation frequency across breast cancer populations.

37 onal processes and disease aetiology, and in mutation frequency across the genome, which is strongly

38 RAF; 15% NRAS), a nonsignificant increase in mutation frequency after progression from primary melano

39 AP site with nuclear extract and an elevated mutation frequency after transformation into wild-type o

40 Mouse models that harbor elevated mtDNA mutation frequencies age prematurely; these findings wer

41 Mutation frequencies among clear cell RCCs were as follo

42 icularly useful for doped selections such as mutation frequency analysis, information content calcula

43 ubmitted to whole-genome sequencing prior to mutation frequency analysis.

44 t a mutant of the beta clamp causes elevated mutation frequencies and is reduced for MutS-GFP focus f

45 hology and ethnic occurrence, accompanied by mutation frequencies and references.

46 uals studied (19 and 23 years old) had lower mutation frequencies and smaller foci at both mutation s

47 ere are no good assays for comparing somatic mutation frequencies and spectra between different verte

48 We determined non-B DNA-induced mutation frequencies and spectra in human U2OS osteosarc

49 equencing assay for the determination of HIV mutation frequencies and spectra using the Illumina sequ

50 but not subtype significantly affects viral mutation frequencies and spectra.

51 and other steps for analyzing damage-induced mutation frequencies and spectra.

52 The differential mutation frequencies and structural variation patterns i

53 populations comprising a majority with a low mutation frequency and a minority with a high mutation f

54 ity coincided with a significant increase in mutation frequency and a shift in the HIV mutation spect

55 Modeling of the relationship of mutation frequency and drug concentration showed an asym

56 fections reveal a strong correlation between mutation frequency and fitness.

57 a 6- to 14-fold increase in the MMS-induced mutation frequency and in a significant increase in AT-t

58 notably from that of MZ B cells by a higher mutation frequency and lower VH4 and higher JH6 gene usa

59 elationship among evolutionary conservation, mutation frequency and mutation distribution.

60 position, protein structure, tRNA abundance, mutation frequency and patterns, and GC compositions.

61 To further define the mutation frequency and phenotypes associated with mutati

62 We will present how this may affect the mutation frequency and population dynamics.

63 This retrospective study reports the mutation frequency and spectrum of BRCA1 and BRCA2 mutat

64 A descriptive analysis of mutation frequency and spectrum was performed for Hispan

65 airs and discover extraordinary variation in mutation frequency and spectrum within cancer types, whi

66 Taken together, the extremely high mutation frequency and strand specificity of mutations p

67 muNeil3 greatly reduced both the spontaneous mutation frequency and the level of FapyG in the DNA, su

68 h age, which would contribute to an enhanced mutation frequency and tumorigenesis in the aging proces

69 a and hemiplegic migraine to investigate the mutation frequency and type and the genetic and phenotyp

70 ine the phenotype spectrum and establish the mutation frequency and variants.

71 quencing (RNA-seq) to investigate the genome mutation frequency and viral mRNA accumulation in HRSV-i

72 ncreased levels of genomic uracil, increased mutation frequencies, and C-to-T transitions.

73 n D270A/D271A mutations, exhibited increased mutation frequencies, and mutants containing the Q282R m

74 Complete sequence identity, somatic mutation frequencies, and V(H) gene usage was determined

75 and C-->T transversion mutations, increased mutation frequency, and a shift of the nucleotide profil

76 This change was reflected in the overall mutation frequency, and it was associated with an increa

77 results in rapid mtDNA depletion, increased mutation frequency, and mitochondrial dysfunction.

78 g revealed that NHEJ at 5' DSBs had a higher mutation frequency, and validated the differential requi

79 Fpg, MutY or Smn showed elevated spontaneous mutation frequencies; and, these mutator phenotypes corr

80 Instead, we find foci where C758G mutation frequencies are 3-4 orders of magnitude greater

81 w that propionaldehyde is a mutagen and that mutation frequencies are increased in MCP-minus mutants

82 Variants with the highest mutation frequencies are less fit in vivo and fail to pr

83 However, mutation frequencies are not reduced in a mutY mutator b

84 FLT3-ITD demonstrated a relative increase in mutation frequency as detected by thymidine kinase (TK)

85 Mutation frequencies at the site of the lesions in the o

86 The background mutation frequencies at the TK locus of siRNA-transfecte

87 Here, we have analysed the mutation frequency at an expanded simple tandem repeat (

88 ites and to a lesser extent by elevating the mutation frequency at existing sites even before the pre

89 ol zeta-deficient B cells had a reduction in mutation frequency at Ig loci in the spleen and in Peyer

90 a particular gene, simultaneous analysis of mutation frequency at multiple genetic loci is feasible.

91 BLM in the WRN- ALT+ cell line increased the mutation frequency at telomeres and at the MS32 minisate

92 ' against DSB formation but does enhance the mutation frequency at the site of 8-oxoG relative to tha

93 and IgG3, which was associated with reduced mutation frequency at the switch regions and a bias towa

94 ariants, we used deep sequencing to quantify mutation frequencies before and after selection.

95 itiate corresponds to the zone where the AID mutation frequency begins to rise, despite a constant de

96 Less-responsive cells exhibit increased mutation frequencies but resume wild-type behavior.

97 train-dependent increases in the spontaneous-mutation frequency but also shifts in mutational type an

98 no growth defects or changes in spontaneous mutation frequency but had increased sensitivity to UV i

99 Enhanced pS38 elevated Myc translocation and mutation frequency but not CSR or Ig switch region mutat

100 Some non-coding regions exhibited high mutation frequencies, but most have distinctive structur

101 e radiosensitization nor did it increase the mutation frequency, but after short hairpin RNA-directed

102 -2'-deoxycytidine were found to increase the mutation frequency by 3.1- and 3.4-fold, respectively.

103 cultured, cellular movement altered observed mutation frequency by up to 18.5%.

104 t 49 degrees C, and they show an increase in mutation frequency caused by a partial defect in MMR at

105 nstability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-deficient cell

106 treated with RNA-guided nucleases that have mutation frequencies close to 100% at targeted sites.

107 that cancer susceptibility regions have gene mutation frequencies comparable to background mutation f

108 RTs led to significant changes in the virus mutation frequencies compared to virus replication of dr

109 Primary XP-C cells had increased UV-induced mutation frequencies compared with normal cells, consist

110 ximately 10% of normal) of WRN have elevated mutation frequencies compared with wild-type cells.

111 kewed CDR3 length distribution and increased mutation frequency compared with naive B cells.

112 A structural model that explains the mutation frequency data is discussed.

113 is 100-1,000 times more common than genomic mutation frequency data predict.

114 ervations support a model in which increased mutation frequency decreases infectivity through lethal

115 with significant increases in break-induced mutation frequencies, deletion lengths and the annealing

116 RB inversely correlated with mutation frequency, demonstrating a key difference betwe

117 We find that BRAF mutation frequencies depend on the equilibrium between t

118 not increase mitochondrial point or deletion mutation frequencies, despite evidence both compounds in

119 Mutation frequencies did not differ according to whether

120 l population reached a threshold after which mutation frequency did not correlate with a dose-depende

121 DNA glycation is associated with increased mutation frequency, DNA strand breaks, and cytotoxicity.

122 This mutation frequency dropped to 5% when analysis was restr

123 a resulted in significant decreases in T-->C mutation frequencies for all the O(4)-alkyldT lesions ex

124 id not lead to any detectable alterations in mutation frequencies for any of the O(2)-alkyldT lesions

125 t was not accompanied by marked increases in mutation frequencies for several traits tested.

126 The mutation frequencies for the purified enzyme in vitro va

127 resulting in a damage-dependent increase in mutation frequency for alpha-acetoxytamoxifen; 4-OHtamQM

128 r subtypes (eg, CMT1, CMT2) and the observed mutation frequency for CMT genes.

129 Ultradeep sequencing revealed that the mutation frequency for EBOV was high and similar to thos

130 We analyzed mutation frequencies from the liver tissue of animals wi

131 ed phenotype (>12 mutations/megabase); 6 had mutation frequencies >200/megabase, and 5 of these had s

132 xposed skin, we determined the BRAF and NRAS mutation frequencies in 32 truly congenital nevi.

133 We determined complete sequences and somatic mutation frequencies in all isolated variable light chai

134 pathways may play a wider role in modulating mutation frequencies in different parts of the genome th

135 C and/or OC were compared with the FANCM LoF mutation frequencies in geographically matched controls

136 oups based on high, low, or background-level mutation frequencies in human melanomas, and we further

137 The mutation frequencies in mice correlated with those in tw

138 Mutation frequencies in OC were compared with the Nation

139 FANCM LoF mutation frequencies in patients with BC and/or OC were

140 Mutation frequencies in SMRs demonstrate that distinct p

141 Tet2(-/-) Lin(-)c-Kit(+) cells shows higher mutation frequencies in Tet2(-/-) cells.

142 Our genetic screening revealed varying mutation frequencies in the FZD4 (8.0 %), TSPAN12 (5.4 %

143 icients to find the expected distribution of mutation frequencies in the population.

144 Hence, we measured APOBEC3B-induced CAN1 mutation frequencies in yeast deficient in BER endonucle

145 Importantly, we found 41.9% NOTCH1 mutation frequency in aggressive trisomy 12 CLL cases.

146 tric oxide (NO), significantly decreased the mutation frequency in both bystander rho(o) and rho(+) c

147 nd blood correlate with lower regional CpG>T mutation frequency in cancers originating in the respect

148 opy number, which may be favored by a higher mutation frequency in cells expressing the oncoprotein.

149 d to disease or is coincidental, because the mutation frequency in control subjects is unknown.

150 unctional nucleotide insertions and a higher mutation frequency in D and J segments than normal.

151 new members, we determined mSWI/SNF subunit mutation frequency in exome and whole-genome sequencing

152 revealed a ribavirin-associated elevation in mutation frequency in HTNV vRNA similar to that previous

153 nome of primary cells significantly reflects mutation frequency in malignant melanoma.

154 ied- and UVC-irradiated DNAs induce a higher mutation frequency in MCs than in NHSFs; and, XP complem

155 uding the BRAF oncogene that has the highest mutation frequency in melanoma.

156 r level in mice, and we demonstrate that the mutation frequency in mouse mitochondria is more than te

157 capture (RMC) assay to measure nuclear point mutation frequency in mouse tissue is described.

158 Increased mutation frequency in mtDNA of CSB-deficient cells demon

159 We evaluated 100 probands to determine the mutation frequency in MYH11, ACTA2, TGFbetaRI, and TGFbe

160 strains but a slight increase in T:A to C:G mutation frequency in NER-proficient strains.

161 Rp22 showed a significantly lower (P< 0.001) mutation frequency in nsp2, which is one of the most var

162 enic Pol zeta displayed a marked increase in mutation frequency in Peyer's patches, revealing a patte

163 Our study had 80% power to detect a 4.9% mutation frequency in POAG patients.

164 fidelity than other retroviruses and shows a mutation frequency in the 10(-5) range.

165 gements and demonstrated a low somatic point mutation frequency in the absence of tobacco mutagens.

166 tumor also showed a substantially increased mutation frequency in the Aid gene itself as well as in

167 layed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the colon than p27(+/+) littermate

168 e report a significant increase in the mtDNA mutation frequency in the hippocampus of early stage AD,

169 At 2 months of age, the lacZ mutation frequency in the liver of the hybrid animals wa

170 f ubiquitylated PCNA and significantly lower mutation frequency in the tailless H2A/H3 mutant, indica

171 The mutation frequency in this group was 1.6-fold higher tha

172 ession, and suggest that elevation of random mutation frequency in tumors might serve as a novel prog

173 of poleta significantly elevates spontaneous mutation frequency in various organs and tissues of the

174 The effect of the L561A replacement on the mutation frequency in vivo was determined by infecting E

175 ding at promoter elements, and increases the mutation frequency in vivo.

176 A significantly reduced mutation frequency in WA motifs compared with normal don

177 cient in ODD repair and ODD induces a higher mutation frequency in XPA cells than in NHSFs.

178 Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN1

179 wed that the HUWE1 expression is altered and mutation frequency increased in three different XLID ind

180 This difference in mutation frequency increased to >3-fold at 6 months of a

181 DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of AP sites in D

182 The most effective BNAbs have very high mutation frequencies, indicative of the long periods of

183 ncer genomics and precision medicine, as the mutation frequency is low, and targeted therapies are le

184 it can affect clinical outcome, because the mutation frequency is rare, genetic testing is not stand

185 Moreover, this mutation frequency is sufficient for pushing a viral pop

186 BnAbs exhibit high somatic mutation frequencies, long third heavy-chain complementa

187 Mutation frequencies measured in vivo equal those measur

188 Mutation frequency (MF) of dG-C8-IQ was reduced by 38-67

189 dels in the coding sequence, with an average mutation frequency more than 10-fold higher in smokers t

190 ( approximately 0.08% in both cases) and the mutation frequencies observed with a number of DNA polym

191 We then show that the increased CpG mutation frequency observed in some cancers primarily oc

192 inimal off-target mutagenesis and with indel mutation frequencies of 40-50% and homology-directed rep

193 press the ADH1 or TT4 ZFNs exhibited somatic mutation frequencies of 7% or 16%, respectively.

194 PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes.

195 Spontaneous mutation frequencies of JP26 mutY mutants, assessed by r

196 air GAP-assisted GTP --> GDP hydrolysis, the mutation frequencies of K-Ras4B in human cancers vary.

197 Current approaches are primarily based on mutation frequencies of single-genes, which lack the pow

198 The mutation frequencies of siRNA-transfected TK6 cells afte

199 polymerases does not result in alteration of mutation frequencies of these two lesions.

200 AID silencing did not decrease the mutation frequencies of tumor Ag gene P1A.

201 BRCA1 or BRCA2 mutation, was designed using mutation frequencies of white and Ashkenazi Jewish popul

202 Transformed cells exhibited lower rare mutation frequencies of whole mtDNA than did normal stem

203 Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and n

204 of 2.05 (95% CI, 0.94-4.54; P = .049) and a mutation frequency of 1.03% in index cases.

205 itional VEFS domain mutant, yielding a total mutation frequency of 1.4% (2 of 148).

206 er family with DA1, accounting for an MYBPC1 mutation frequency of 13% (two of 15).

207 CH98 had a mutation frequency of 25% and 15% nt somatic mutations i

208 y mutated gene in PTNFL was TNFRSF14, with a mutation frequency of 29%, similar to that seen in limit

209 primary tumours, corresponding to an overall mutation frequency of 4.5%.

210 e in PTNFL was MAP2K1, encoding MEK1, with a mutation frequency of 43%.

211 following replication in COS-7 cells, with a mutation frequency of 45%.

212 ty-purified CCCs and CCC cell lines showed a mutation frequency of 46%.

213 g(K164R) mice a significant reduction in the mutation frequency of A:T residues in WA motifs preferre

214 The Ig mutation frequency of all V(H) genes from AICDA(-/-) pat

215 Our reanalysis supports a mutation frequency of approximately 0.2 events per cell,

216 ncer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independen

217 the cross-linked dG component occurred at a mutation frequency of approximately 8%.

218 Besides the high mutation frequency of CDH1 in 65% of tumors, alterations

219 We determined the spontaneous mutation frequency of EBOV, which is relevant to underst

220 otein were used to determine the spontaneous mutation frequency of EBOV.

221 This implies that the mutation frequency of foci increases as adults age, and

222 Poleta), and a strand-biased increase in the mutation frequency of G residues, preferentially in the

223 At a postconceptional age of 60 wk, somatic mutation frequency of IgA H chain transcripts reached 25

224 less than that of normal donors, whereas the mutation frequency of mutated V(H) sequences from AICDA(

225 es double-strand DNA breaks and enhances the mutation frequency of proto-oncogenes and tumor suppress

226 provide a mechanistic basis for the elevated mutation frequency of RNA phage relative to animal RNA v

227 We found that the mutation frequency of the inserted Sgamma1 region was dr

228 The mutation frequency of the ovarian cancer cell line A2780

229 While the mutation frequency of the STK11/LKB1 gene in HNSCC remai

230 The polyclonality and low mutation frequency of these VH1 antibodies reveal fundam

231 Thus, we aimed at identifying the mutation frequency of TP53, its association with cytogen

232 and infectious virus, only RBV increased the mutation frequency of viral RNA (vRNA).

233 n the vicinity of the lesion, with a maximum mutation frequency of ~1%.

234 Measures: Clinical categorization of somatic mutations; frequencies of deleterious germline mutations

235 CT-->TAT and TCG-->TTG mutations and overall mutation frequencies often exceeding 100 mutations/Mb.

236 ficiency had no additional effect on the DNA mutation frequency or spectrum in Ung(-/-) or wild-type

237 ion, we made a comprehensive analysis of the mutation frequency over several RBV concentrations.

238 le therapeutic target as the result of ahigh mutation frequency, PIK3CA mutations do not seem to affe

239 OxodG mutation frequencies ranged from 3.1% to 9.8%, whereas t

240 apping revealed that the control elements of mutation frequency reside within the first 596 amino aci

241 s resulted in a 12- and 160-fold increase in mutation frequency, respectively, and gave rise to varia

242 everal methods, we show that the increase in mutation frequency resulting from each dnaN allele is li

243 ults demonstrate that EBOV has a spontaneous mutation frequency similar to those of other RNA viruses

244 nt age is positively correlated with somatic mutation frequency, suggesting that some poly-G variants

245 , stavudine, and zalcitabine increased HIV-1 mutation frequencies, supporting the general hypothesis

246 and MMC/uvrD double mutants exhibited higher mutation frequencies than any single mutant.

247 These mice exhibited significantly higher mutation frequencies than did wild-type animals.

248 ple sclerosis (RRMS) have higher replacement mutation frequencies than observed in healthy controls o

249 with regulator-encoding genes having higher mutation frequencies than the genome average.

250 These mutator strains generate higher mutation frequencies than WT virus and are more sensitiv

251 were targeted by SHM and displayed a higher mutation frequency than functional sequences.

252 MNNG displayed approximately 15-fold higher mutation frequency than parental counterparts and predom

253 fected hybridomas had a significantly higher mutation frequency than those in the uninfected hybridom

254 train of Rev1 exhibits a lower 4-NQO-induced mutation frequency than wild type.

255 rmal and CS-B cells had increased background mutation frequencies that decreased upon irradiation, pu

256 assified into these subgroups do not display mutation frequencies that deviate from those expected.

257 non-B DNA and WRN-KD served to increase the mutation frequency, the increase afforded by WRN-KD was

258 ributed to its ability to increase the HIV-1 mutation frequency through viral-DNA incorporation durin

259 The MP2 sequence significantly reduces the mutation frequency throughout the nucleosome, and especi

260 cate that, although RNA viruses have extreme mutation frequencies to maximize adaptability, nature ha

261 of the JP26 mutY mutant restored spontaneous mutation frequencies to wild-type levels.

262 hogenicity led to a further reduction of the mutation frequency to 0.024.

263 Efflux-pump blockage reduced the mutation frequency to ethambutol 64-fold.

264 leles showed a dominant negative increase in mutation frequency to wild-type mutL.

265 We illustrate the distributions of mutation frequencies, types and contexts across tumour t

266 Mutation frequencies varied from 1/1000- to 1000-fold gr

267 onstrate that target DNA sequences influence mutation frequency via regulating AID recruitment.

268 nt RT mutants from CRF01_AE viruses on HIV-1 mutation frequencies was analyzed and it was found that

269 Mutation frequency was >10%: SF3B1 (74.5%), TET2 (45.7%)

270 mal shuttle vector, the psoralen-PNA-induced mutation frequency was 0.13%, 3.5-fold higher than the b

271 EGFR mutation frequency was 22.1% in NSCLC, and erlotinib ach

272 KRAS mutation frequency was 24.9% in NSCLC, and selumetinib f

273 in which an approximately 3-fold increase in mutation frequency was found compared with the normal le

274 The mutation frequency was lower than found in germinal cent

275 BV, GTP levels, specific infectivity, and/or mutation frequency was measured in the presence of RBV,

276 In contrast, ESTR mutation frequency was only slightly elevated in the off

277 c potential of the beta-anomer in vitro, the mutation frequency was significantly reduced when condit

278 evealed that ERBB2/HER2 amplification and/or mutation frequency was unchanged between local disease a

279 Resistance to rifampin, an indicator for mutation frequency, was found to increase approximately

280 , can influence AID targeting efficiency and mutation frequency, we established a knock-in mouse mode

281 ypoxanthine phosphoribosyltransferase (HPRT) mutation frequencies were approximately 5-fold higher in

282 MS2, EPCAM, POLE, and POLD1 with ColoSeq and mutation frequencies were established.

283 Increased mutation frequencies were observed in samples from treat

284 e three drugs, expanded simple tandem repeat mutation frequencies were significantly elevated in the

285 In contrast to OxodG bypass, Fapy.dG mutation frequencies were unaffected by carrying out exp

286 Antiviral activity and increased mutation frequency were also associated with the late ph

287 of nonsynonymous (K(a)) to synonymous (K(s)) mutation frequency were calculated for codons in the sia

288 tional frequency over the background somatic mutation frequency were calculated for each tumor type b

289 esults also demonstrated that 100% and 98.8% mutation frequency were occurred on GhMYB25-like-sgRNA1

290 creased DNA double-strand breaks, and higher mutation frequencies when compared with HPV-negative cel

291 lta results in a similar 30-fold increase in mutation frequency when copying gapped DNA templates.

292 es and did not have an appreciable effect on mutation frequency when separated from G73R.

293 esistance can act together to increase HIV-1 mutation frequencies, which would have important implica

294 ons in the exonuclease domain result in high mutation frequencies with a preference for C-->A mutatio

295 nvestigated the association of T790M and its mutation frequencies with clinical outcome.

296 Although there is only a mild increase in mutation frequency with sequential TKI treatment, novel

297 ancer genomes exhibited substantially higher mutation frequencies, with 2,000-4,000 novel coding vari

298 correlated with elongation rates and in vivo mutation frequencies, with faster polymerases having low

299 However, the mutation frequencies within the two publically available

300 Measuring mutation frequency within an intron of a transcribed gen