ライフサイエンスコーパス: mutation pattern

1 e stringent criteria indicative of an APOBEC mutation pattern.

2 nships between flanking base composition and mutation pattern.

3 f the non-RS transgenes without altering the mutation pattern.

4 selection pressures, which skew the observed mutation patterns.

5 e SHM process and support future analyses of mutation patterns.

6 l tumors, we observed three distinct somatic mutation patterns.

7 (BASELINe) based on the analysis of somatic mutation patterns.

8 d NNRTI-resistance mutations, with divergent mutation patterns.

9 joining and mismatch repair do not influence mutation patterns.

10 tion in specific genomic regions and somatic mutation patterns.

11 ed glycosylation sites, and isolate-specific mutation patterns.

12 ified by germ-line gene usage and junctional mutation patterns.

13 The APOBEC mutation pattern also extended to cancer-associated gene

14 Substantial variability in mutation pattern among loci was found, most of which can

15 The similarity of mutation pattern among triple repeat-related diseases in

16 BRAF V600E and TERT promoter mutation patterns and associated patient deaths caused b

17 s and Measures: BRAF V600E and TERT promoter mutation patterns and associated patient deaths caused b

18 d signaling, that may promote these distinct mutation patterns and differential coupling to specific

19 for efficient and reliable identification of mutation patterns and driver pathways in large-scale can

20 However, certain changes in mutation patterns and frequency of point mutations were

21 lan of key experiments from "Diverse somatic mutation patterns and pathway alterations in human cance

22 the distinct biases inherent in the initial mutation patterns and subsequent evolutionary processes

23 er cytosines or guanines in the same strand, mutation patterns, and genetic controls indicated that s

24 cesses to orphan and newly discovered tumour mutation patterns, and to determine whether avoidable ca

25 d in many tumors, but factors affecting this mutation pattern are not well understood.

26 hen the proper statistical properties of the mutation pattern are used to interpret the readouts.

27 Some mutation patterns are clearly attributable to disruption

28 We further demonstrate that strand-specific mutation patterns arise from some of these POLE-exo* mut

29 I have studied mutation patterns around very short microsatellites, foc

30 We observed a mutation pattern associated with altered CpGs and APOBEC

31 however, is hampered by the large numbers of mutation patterns associated with cross-resistance withi

32 s in Smu- and Sdelta-like (sigma(delta)) nor mutation patterns at Smu-sigma(delta) junctions.

33 Four factors determine the residue type mutation patterns: biases in the germline, accessibility

34 ithin introns are consistent with changes in mutation patterns, but stronger GC elevation at synonymo

35 l selection or CCR5 inhibition have a common mutation pattern characterized by the same two V3 mutati

36 hypotheses tried to explain such significant mutation patterns, conclusive explanations are lacking.

37 In light of the mutation pattern consistent with dCMP insertion observed

38 ells were hypermutated at low frequency with mutation patterns consistent with A3F activity.

39 We observed several mutation patterns consistent with previous studies, such

40 No recurrent mutation pattern correlated with unilineage dysplasia wi

41 ene 2.0 provides thousands of expression and mutation patterns derived from pan-cancer data of The Ca

42 developed a rigorous methodology for cancer mutation pattern discovery based on a new, constrained f

43 We analyzed gene expression data and mutation patterns, distributions and loads for 19 differ

44 Here we report an analysis of the mutation patterns for 5296 Alu elements comprising 20 su

45 Evaluation of intraclonal mutation patterns identified clone-specific punctuated c

46 Mutation patterns implicate replication infidelity as on

47 ly analyzed the mtDNA control region somatic mutation pattern in 2864 single hematopoietic stem cells

48 showed a significant presence of the APOBEC mutation pattern in bladder, cervical, breast, head and

49 The mutation pattern in the nullizygotes was notable for fre

50 f CS, but we also found differences from the mutation pattern in tumorigenesis.

51 Here we determine genome-wide mutation patterns in ASCs of the small intestine, colon

52 The ability to detect selection by analyzing mutation patterns in experimentally derived immunoglobul

53 res have been associated with characteristic mutation patterns in genes, the factors that lead to pro

54 We demonstrate that mutation patterns in immortalised cell lines derived fro

55 Differential mutation patterns in known resistance alleles indicated

56 developed a method that analyzes correlated mutation patterns in multiple sequence alignments in ord

57 Analyses of mutation patterns in noncoding DNA suggest that the exte

58 The mutation patterns in one case suggest that the intestina

59 TIgGER analyzes mutation patterns in Rep-Seq data to identify novel V se

60 ne sequences, we have thoroughly studied DNA mutation patterns in the human genome.

61 The mutation patterns in these unexpressed genes are unselec

62 n is secondary to the gastric tumor, and the mutation patterns in two cases indicate that the gastric

63 , and we also report potentially interesting mutation patterns in world populations estimated by mStr

64 Mutation patterns (including clearance of leukemia-assoc

65 e switch process can create numerous complex mutation patterns, including hairpin loop structures, an

66 Complex mutation patterns, including thymidine-analog mutations,

67 The mutation pattern is defined by a dominant prevalence of

68 The aetiology of this differing mutation pattern is still unknown.

69 HM in a non-B cell context was compared with mutation patterns observed for SHM in vivo.

70 However, there is discordance between the mutation patterns observed in HIV-infected patients fail

71 The conservation of the c-kit mutation pattern, observed in consecutive lesions from t

72 membrane compartments, and reflective of the mutation pattern of HIV-1.

73 using a novel typing method to monitor fimH mutation patterns of fecal isolates from adenoma patient

74 inhibitors in combination or in succession, mutation patterns of protease isolates from these person

75 Here we analyzed the mutation patterns of the PPI interfaces from 10,028 prot

76 The predominant mutation patterns of these tumors also suggest differenc

77 Analyses of Drosophila spontaneous mutations, patterns of segregating variation and covaria

78 Furthermore, we find that change in mutation pattern or in tDNA copy number changed codon-us

79 el with hidden states representing different mutation patterns; PSSV can thus differentiate heterozyg

80 ily be adapted to analyze other types of DNA mutation patterns resulting from a mutator that displays

81 In addition, they demonstrate that the mutation pattern seen previously in mismatch repair defe

82 den retrievers, show little overlap in their mutation pattern, sharing only one of their 15 most recu

83 roduced an elevated mutation frequency and a mutation pattern similar to that seen in the tumors.

84 ex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53.

85 Mutation patterns strongly implicate ultraviolet radiati

86 clearly enriched for tumors with the APOBEC mutation pattern, suggesting that this type of mutagenes

87 To identify mutation patterns that affect disease phenotype and clin

88 ive power and can be used to predict complex mutation patterns, that have not yet been observed due t

89 By studying virus migration and mutation patterns, the field of phylogeography provides

90 o the generation of specific antibodies with mutation patterns typical of affinity maturation, showin

91 cesses and the extent to which MMR-deficient mutation patterns vary among species.

92 n the group that secreted both isotypes, the mutation pattern was identical, indicating either synthe

93 tected in 2 (8.3%) neonatal samples, but the mutation pattern was not identical to the mother's.

94 The mutation pattern was similar to that of Ig genes.

95 The mutation pattern was similar to that previously reported

96 ually high mutation frequency and an altered mutation pattern were seen in xeroderma pigmentosum vari

97 Interestingly, similar mutation patterns were also observed in minor quasispeci

98 tures, DNA copy number patterns, and somatic mutation patterns were highly similar across each primar

99 Few differences in mutation patterns were observed before and after treatme

100 Readily interpreted mutation patterns were observed, such as small inversion

101 gene in that it showed a mutually exclusive mutation pattern when compared with mutations in the Trr

102 ximately 25% of AML, with a distinct genetic mutation pattern where >98% of cells are CD34(-), there

103 rmline could inform risk for specific tumour mutation patterns, which could have important translatio

104 story of presence at birth showed an inverse mutation pattern with common BRAF mutations (20/28 or 71

105 Thus, comparing complex mutation patterns with viral fitness may help to elucida

106 ructural and functional significance of this mutation pattern within the context of the complex relat