1 e sites has been discovered and validated by
mutational analysis.
2 acterize its dinucleotide-binding site using
mutational analysis.
3 ence typing (MLST), and pertactin gene (prn)
mutational analysis.
4 on, P was subjected to mass spectrometry and
mutational analysis.
5 K1 and mapped binding energy hot spots using
mutational analysis.
6 fferent substrates, provides context for the
mutational analysis.
7 ombination of genetics, in vitro assays, and
mutational analysis.
8 sion was demonstrated using lacZ fusions and
mutational analysis.
9 DNA recognition by Spx were examined through
mutational analysis.
10 of this interaction through structure-driven
mutational analysis.
11 ed detail sufficient to guide phenotypic and
mutational analysis.
12 nal miR-214-3p-binding sites as confirmed by
mutational analysis.
13 ed by negative-stain electron microscopy and
mutational analysis.
14 Comprehensive alanine
mutational analysis across 553 residues of E1E2 also res
15 structure with functional and immunological
mutational analysis across E1E2 in order to propose an i
16 Comprehensive
mutational analysis aiming at destabilizing one or the o
17 The power of HCM
mutational analysis,
albeit a more limited role than ini
18 Mutational analysis allowed us to split the mRNA unwindi
19 Thus, random mutagenesis and
mutational analysis allows for the achievement of high s
20 Using
mutational analysis and a minigenome system, we identifi
21 f P(O) and P(C) in viral RNA synthesis using
mutational analysis and a minigenome system.
22 Here, using
mutational analysis and a peptide inhibitor, we show tha
23 eed for a high-resolution structure to guide
mutational analysis and cautions against relying on olde
24 Through
mutational analysis and chemical complementation assays,
25 moter of DNM3os was demonstrated by promoter
mutational analysis and ChIP.
26 A systematic
mutational analysis and competition experiments demonstr
27 In combination with
mutational analysis and electrophoretic mobility shift a
28 Mutational analysis and enzymatic activity assays identi
29 on of skin samples, as well as FLT3 and NPM1
mutational analysis and fluorescence in situ hybridizati
30 suffer from instability, preventing in-depth
mutational analysis and hampering crystallization of key
31 The structural data are supported by
mutational analysis and indicate that Snu17p provides an
32 Mutational analysis and inspection of the 3D structures
33 ogy to previously known cereblon substrates,
mutational analysis and modelling indicate that the cere
34 Using
mutational analysis and NMR, we find that Pru binding in
35 molecular framework for understanding prior
mutational analysis and point to additional residues, lo
36 Further
mutational analysis and quantum chemical calculations pr
37 characterization previously required expert
mutational analysis and specialized NMR or chemical mapp
38 By combining
mutational analysis and super-resolution imaging, we ide
39 ediate the protein interaction with DCTN3 by
mutational analysis and, based on that information, we d
40 ctroscopy, together with molecular modeling,
mutational analysis,
and fluorescent polarization bindin
41 vivo chromatin immunoprecipitation, promoter
mutational analysis,
and real-time quantitative PCR, NRF
42 ere we describe the in vitro reconstitution,
mutational analysis,
and X-ray crystallographic structur
43 The results of the
mutational analysis are highly relevant for the future s
44 Our
mutational analysis,
based on the electron cryomicroscop
45 ng, we employed the complementary methods of
mutational analysis,
binding studies, X-ray crystallogra
46 deficiency subgroups on the basis of tumour
mutational analysis:
BRCA mutant (deleterious germline o
47 address these issues, we performed extensive
mutational analysis by high-throughput sequencing in 215
48 his is the first comprehensive TSC1 and TSC2
mutational analysis carried out in TSC patients in Greec
49 Using
mutational analysis,
circular dichroism, and NMR, we fin
50 Mutational analysis confirmed an essential function for
51 Kinetic and
mutational analysis confirmed several features seen in t
52 Mutational analysis confirmed that changes in modificati
53 Mutational analysis confirmed that the mixed-acid fermen
54 Mutational analysis confirmed that these modifications p
55 Mutational analysis confirmed the critical importance of
56 Mutational analysis confirms an important role for this
57 Finally, structure-guided
mutational analysis confirms the importance of RNA bindi
58 Mutational analysis confirms the importance of several s
59 Structure-guided
mutational analysis converted KATms from a cAMP-regulate
60 Mutational analysis coupled with analytical ultracentrif
61 Mutational analysis coupled with molecular docking and m
62 Mutational analysis coupled with molecular modeling and
63 iquitin-fold domain (UFD) and Cys domain and
mutational analysis,
coupled with thioester transfer ass
64 Mutational analysis defines a chymotrypsin-like serine p
65 Mutational analysis definitively demonstrates that TbPRM
66 Mutational analysis demonstrated an absolute requirement
67 Mutational analysis demonstrates that the Wap super-enha
68 Mutational analysis demonstrates that VP35 interaction i
69 C with bile salt, along with biophysical and
mutational analysis,
demonstrates that the hydrophobic c
70 Mutational analysis determined that only genes in cluste
71 Mutational analysis,
directed by a previously published
72 Mutational analysis established that the C-terminal doma
73 Here, we have performed
mutational analysis followed by a genotype-phenotype cor
74 g of metastatic colorectal cancer (including
mutational analysis for KRAS, NRAS, BRAF, PIK3CA, and ot
75 is determining the clinical utility of KRAS
mutational analysis for predicting benefit of chemothera
76 ata does not support the routine use of KRAS
mutational analysis for predicting chemotherapy benefit.
77 Mutational analysis found that residues R329 and G330 in
78 Mutational analysis has identified EcRppH residues cruci
79 uctures, molecular dynamics simulations, and
mutational analysis have previously indicated that an ex
80 Subsequent
mutational analysis identified 3 additional variants wit
81 Furthermore,
mutational analysis identified a high-risk group of pati
82 Site-directed
mutational analysis identified a TQ motif at amino acid
83 Mutational analysis identified an extended RNA-binding s
84 Molecular modeling and
mutational analysis identified residues for glucosinolat
85 1 (CK1) activity, and mass spectrometry and
mutational analysis identified serine 334 as an importan
86 of signal intensity in the 2:1 complex, and
mutational analysis implicated the distal surface away f
87 trans relieved translational inhibition, and
mutational analysis implied a mechanism in which the clo
88 s of the psaL, psaJ, chlN, and cpcA mRNAs by
mutational analysis in a heterologous reporter system.
89 We performed GNA11
mutational analysis in a kindred with familial hypocalci
90 to date followed by N/KRAS, PIK3CA, and AKT1
mutational analysis in BRAF wild-type patients.
91 Here we use
mutational analysis in combination with measurements of
92 VIPER-inferred protein activity outperformed
mutational analysis in predicting sensitivity to targete
93 Mutational analysis in the putative RNA1-contacting resi
94 e docking, molecular dynamics and systematic
mutational analysis in three Fur transporters with disti
95 etic resonance studies in lipid bicelles and
mutational analysis indicate differences in structure ex
96 Pulse chase and
mutational analysis indicated that HRD1 inhibits STT3B-d
97 Mutational analysis indicated that human TPP1 does not r
98 Mutational analysis indicated that multiple regions of t
99 imolecular fluorescence complementation, and
mutational analysis indicated that SR-BI associates with
100 Mutational analysis indicated that the active site for b
101 Mutational analysis indicated that the kinase and the tr
102 Mutational analysis indicated that while the phosphoryla
103 Mutational analysis indicates that at least six distinct
104 negatively charged alpha-Fe2O3 surface, and
mutational analysis indicates that electrostatic interac
105 Furthermore,
mutational analysis indicates that IKKalpha-dependent ph
106 Mutational analysis indicates that the degree of binding
107 Our kinetic and
mutational analysis indicates that the two double stand
108 s most commonly a clinical diagnosis because
mutational analysis is challenging in mosaic conditions.
109 Genetic
mutational analysis is vital for ruling in and out hered
110 f local mechanical elasticity, combined with
mutational analysis,
may be used to identify and study c
111 The model of the active state built by
mutational analysis,
molecular modeling, and small-angle
112 We performed a
mutational analysis of 18 genes in 398 patients younger
113 We performed targeted
mutational analysis of 194 patients with rigorously defi
114 cancer metastatic process, we performed deep
mutational analysis of 676 genes in 107 stages II to IV
115 Mutational analysis of a cyclin F-specific amino acid mo
116 Mutational analysis of a rhomboid enhancer reveals at le
117 Mutational analysis of AD-5 identified tyrosine 280 in c
118 Through a detailed
mutational analysis of all interface residues, we identi
119 Mutational analysis of amino acids in the binding interf
120 We also performed targeted
mutational analysis of an additional 24 such tumors and
121 Mutational analysis of bicistronic minigenomes and recom
122 By
mutational analysis of both cluster-binding sites, we we
123 Genome-wide
mutational analysis of breast and lung cancer cohorts (n
124 A recent molecular and
mutational analysis of breast cancers revealed that inac
125 atography, and DNA sequencing, comprehensive
mutational analysis of BrS1- through BrS12-susceptibilit
126 Mutational analysis of c-kit demonstrated kinase-indepen
127 We performed
mutational analysis of CALM1, CALM2, and CALM3 gene-codi
128 Mutational analysis of candidate genes in an 11.9-Mb lin
129 Mutational analysis of celR demonstrated that the cyclas
130 Mutational analysis of conserved active site residues su
131 Comprehensive
mutational analysis of conserved MafA Region 3 revealed
132 Structure-activity studies and
mutational analysis of contact residues define the optim
133 Mutational analysis of cysteine residues in CNPYb identi
134 Mutational analysis of eIF1A and eIF5B revealed distinct
135 Mutational analysis of exon 12 of CACNA1C was completed
136 Detailed
mutational analysis of four CRP binding sites upstream o
137 Moreover,
mutational analysis of GluVI:-06 in TM-VI and the neighb
138 Mutational analysis of GNB3 in a cohort of 58 subjects w
139 XS data for the binary complex together with
mutational analysis of gp59 protein, is presented in the
140 Here we report a
mutational analysis of HA stability utilizing a panel of
141 Mutational analysis of HDAC4 suggests that the peptide i
142 Complementing this with
mutational analysis of HDAC7, we show that HDAC7, via it
143 We performed a
mutational analysis of highly conserved serine residues
144 s, Vif/A3G degradation assays and a detailed
mutational analysis of human A3G.
145 rates the power of mouse reverse genetics in
mutational analysis of human genetic disorders and attes
146 EET in plant and mammalian cells, as well as
mutational analysis of its cluster binding domain.
147 and 24 depressed tumors, were subjected for
mutational analysis of KRAS (exon 2), BRAF (exon 11 and
148 However,
mutational analysis of MC159 failed to reveal a correlat
149 Mutational analysis of N protein supports a correlation
150 aralog in Saccharomyces cerevisiae Extensive
mutational analysis of Nap1 has revealed that Nap1 affin
151 Subsequent high-resolution
mutational analysis of NS5B (nt 7787 to 9289) using appr
152 Mutational analysis of nuclear and plastid isoforms demo
153 Mutational analysis of p53 and EGFR was performed on DNA
154 and describe a comprehensive structure-based
mutational analysis of potential catalytic and recogniti
155 Using mass spectrometry and
mutational analysis of purified proteins, we found that
156 However,
mutational analysis of R1-7 reveals differences in bindi
157 Mutational analysis of residues in CDR1 and CDR2 of the
158 hich NS2 may impact this process, a detailed
mutational analysis of residues spanning amino acids (aa
159 Mutational analysis of residues within the CBM65 of Ra18
160 We also performed
mutational analysis of samples from members of five othe
161 Comprehensive
mutational analysis of SEMA3A was performed on 198 unrel
162 Mutational analysis of several residues in a highly cons
163 The
mutational analysis of swapping the residues at the +2 a
164 and without IDH mutations, and on subsequent
mutational analysis of the 13 IDH wild-type samples with
165 Here we report comprehensive
mutational analysis of the ACKR3 interaction with its ch
166 Structural analysis, molecular modeling, and
mutational analysis of the ARD identified two adjacent s
167 Subsequent
mutational analysis of the candidate gene was performed
168 Mutational analysis of the cas6 gene reveals three amino
169 Mutational analysis of the Clk1 phosphorylation sites on
170 Extensive
mutational analysis of the DBP7 promoter revealed a comp
171 Mutational analysis of the ectopic VSG 3'UTR demonstrate
172 Alanine-scanning
mutational analysis of the first 62 amino acids of Vif2
173 Mutational analysis of the i-motif DNA revealed that bin
174 ncoded receptor-ligand complex, coupled with
mutational analysis of the interface, establishes a dock
175 Mutational analysis of the lysines in the calmodulin-bin
176 A
mutational analysis of the major long-QT syndrome-suscep
177 Finally,
mutational analysis of the metal ligands of AdcR caused
178 Truncation and
mutational analysis of the miR-155 promoter confirmed th
179 We carried out
mutational analysis of the N-terminal 62 amino acids of
180 Cytogenetic array and
mutational analysis of the parental tumors and the corre
181 Mutational analysis of the pigmented lesions did not ide
182 Mutational analysis of the Pink1 sequence revealed that
183 Mutational analysis of the potential farnesyl-binding si
184 biochemical and genetic approaches including
mutational analysis of the promoter, Fe(2+) cleavage ass
185 Here, we performed a large-scale
mutational analysis of the RBS of A/WSN/33 (H1N1) and A/
186 Subsequent NMR structure-based
mutational analysis of the region highlighted the critic
187 Mutational analysis of the regulatory site showed that t
188 odel was tested in the current study using a
mutational analysis of the Sac7d region of the chromodom
189 y, we conducted an extensive and family-wide
mutational analysis of the serine recombinase DNA-bindin
190 We performed a comprehensive
mutational analysis of the three extracellular loops of
191 Mutational analysis of the trailer HSPA8 binding motif r
192 Here, we present a
mutational analysis of the U1 snRNA, which shows that al
193 Mutational analysis of these stem loops supports a model
194 Mutational analysis of this atypical dileucine-like moti
195 e performed an alanine- and glycine-scanning
mutational analysis of this pore-loop segment to systema
196 Mutational analysis of this region identified four disti
197 a striking example of convergent evolution,
mutational analysis of this terpene synthase revealed an
198 Subsequent
mutational analysis of TRDN revealed either homozygous o
199 particularly appropriate for high-throughput
mutational analysis of two-state reversible binding proc
200 Mutational analysis of Vps1 in a helix of the stalk doma
201 Mutational analysis of wild-type B. pseudomallei demonst
202 Here, we conducted a
mutational analysis of Yhc1, guided by the U1C NMR struc
203 We performed targeted
mutational analysis on samples obtained before transplan
204 Previously, computer modeling and
mutational analysis predicted two pyrethroid receptors,
205 Using
mutational analysis,
real-time RT-PCR, transcriptional f
206 cleotide-conversion strategy for large-scale
mutational analysis (
RESA-bisulfite).
207 Structural modeling combined with
mutational analysis revealed a highly conserved catalyti
208 Mutational analysis revealed a ribavirin-associated elev
209 Computer modeling and further
mutational analysis revealed a surprising finding: Altho
210 Mutational analysis revealed an alpha-helical region of
211 This high-throughput
mutational analysis revealed dominant characteristics fo
212 Mutational analysis revealed specific epistatic interact
213 Mutational analysis revealed that a single amino acid (T
214 Our
mutational analysis revealed that a tripeptide motif ((2
215 Mutational analysis revealed that a truncated XTUT7 enzy
216 Mutational analysis revealed that KIR residues involved
217 A systematic
mutational analysis revealed that Tfp biogenesis in S. s
218 Moreover, competition experiments and
mutational analysis revealed that the helicase activity
219 Mutational analysis revealed that the patient achieving
220 showed that their interaction is direct, and
mutational analysis revealed that the pleckstrin homolog
221 Mutational analysis revealed that the VEGFR2-epsin inter
222 Mutational analysis revealed that Thr-1007 dephosphoryla
223 Computational modeling and cellular
mutational analysis revealed the hydrophobic face of two
224 Mutational analysis revealed the remarkable importance o
225 Mutational analysis revealed three methionines that are
226 Mutational analysis revealed Tyr747, located in the firs
227 demonstrate the presence of oligomers; (ii)
mutational analysis reveals a trans-arginine finger, R15
228 Structure-based
mutational analysis reveals how this enzyme recognizes t
229 Mutational analysis reveals that Asn191 is essential for
230 Mutational analysis reveals that proline residues are re
231 Using
mutational analysis,
S1 nuclease mapping, quantitative R
232 Mutational analysis showed a role for TET13 in primary r
233 Mutational analysis showed that induction of hyphae in a
234 Mutational analysis showed that its efficient splicing r
235 Although docking and
mutational analysis showed that LDK1229 forms similar in
236 Our
mutational analysis showed that loop-1 of A3A is respons
237 Mutational analysis showed that mutations in prrB impart
238 Further
mutational analysis showed that N(1575)Y could also syne
239 Site-specific
mutational analysis showed that PMA increased serine pho
240 Mutational analysis showed that these differences result
241 Mutational analysis showed that three ABA RESPONSE ELEME
242 Furthermore,
mutational analysis shows p21 repression requires intera
243 Mutational analysis shows that Ca(2+) binding is necessa
244 Our
mutational analysis shows that differences between NtA a
245 Mutational analysis shows that key residues important fo
246 Mutational analysis shows that residues forming the Ash2
247 The resolved structure, as well as
mutational analysis,
shows that the interaction is prima
248 ays with monoclonal antibody (MAb) C179, and
mutational analysis suggest that the compounds bind in t
249 an N-terminal mutation in the Tyr motif and
mutational analysis suggest that transmembrane alpha-hel
250 Mutational analysis suggested that Cys(609) in GC1 is in
251 Mutational analysis suggested that differences in the N-
252 confer high Rca activity to rice Rca Further
mutational analysis suggested that Glu-217 restricts the
253 B complexes bound up to two LIS1 dimers, and
mutational analysis suggested that LIS1 binds directly t
254 Mutational analysis suggests that multisite ubiquitinati
255 Broadly, our
mutational analysis suggests that there are key genes an
256 Mutational analysis suggests the involvement of an N-ter
257 sed on recent crystal structures, along with
mutational analysis,
suggests that each subunit within a
258 Extensive
mutational analysis supports a previously unrecognized f
259 Mutational analysis supports the bifunctional PH domain
260 We also show by
mutational analysis that both of these motifs are requir
261 ctroscopic analysis and performed a thorough
mutational analysis that gave insight into their biosynt
262 minal sequencing, pharmacologic studies, and
mutational analysis that proprotein convertases (PCs) pr
263 ription start site, and demonstrated through
mutational analysis that this sequence is crucial for C/
264 ble electron microscopy data, we validate by
mutational analysis the mechanism of Cdc45 association w
265 By means of
mutational analysis,
the critical role of both the upstr
266 Through
mutational analysis this novel proline hydroxylation mot
267 Cryoelectron tomography and
mutational analysis thus combine synergistically to prov
268 involving the SLC1 gene, which we found via
mutational analysis to be required for yeast filamentous
269 We performed
mutational analysis to define a PML interaction motif wi
270 We used a
mutational analysis to demonstrate that the EUO binding
271 In this study, we used a
mutational analysis to establish the importance of this
272 Here we used confocal microscopy and
mutational analysis to identify the residues within the
273 We also performed structure-guided
mutational analysis to survey the functions of 36 residu
274 g both gain-of-function and loss-of-function
mutational analysis together with NMR structural analysi
275 Based on
mutational analysis using bacteria found resistant to on
276 Mutational analysis verified consensus sequence nucleoti
277 Comprehensive
mutational analysis was performed on I(to)-encoding KCNA
278 Mutational analysis was performed with polymerase chain
279 GJA1 open reading frame
mutational analysis was performed with polymerase chain
280 apping in 2 families with HIES from Tunisia,
mutational analysis was performed with selector-based, h
281 SLC6A3
mutational analysis was undertaken in all patients.
282 By
mutational analysis we establish a high-resolution map o
283 n with homologous HPr kinases and subsequent
mutational analysis,
we confirmed the essential catalyti
284 Through
mutational analysis,
we demonstrate that PagPBPa is requ
285 By in vitro assays and
mutational analysis,
we demonstrate that protein arginin
286 Here, using
mutational analysis,
we determine the significance of ea
287 Using
mutational analysis,
we elucidate the mechanism of this
288 compartment-specific chemical labeling, and
mutational analysis,
we found that activated integral me
289 wn assays, luciferase expression assays, and
mutational analysis,
we identified Mpl as a direct targe
290 the viral 3C-like proteinase NS6(Pro) Using
mutational analysis,
we identified the FCV-induced cleav
291 Through
mutational analysis,
we identified two glutamine residue
292 On the basis of sequence and
mutational analysis,
we identify a small hydrophobic reg
293 Using molecular docking and
mutational analysis,
we mapped the gedunin-binding site
294 80) and an LR deletion mutant, combined with
mutational analysis,
we show here that these full-length
295 Performing biochemical and
mutational analysis,
we show that Bacillus subtilis delt
296 Through
mutational analysis,
we show that disrupting the N-termi
297 Using
mutational analysis,
we show that domains of Vpr involve
298 Using
mutational analysis,
we show that Nck sequesters WTIP an
299 Using
mutational analysis,
we show that the accessory subunits
300 Through
mutational analysis,
we validated the RPN2-binding inter