ライフサイエンスコーパス: mutational pattern

1 anscriptomic anomalies and a hitherto unseen mutational pattern.

2 evolution is not a consequence of underlying mutational patterns.

3 s combined to Cmu or Cgamma showed identical mutational patterns.

4 Tumor mitochondrial genomes show distinct mutational patterns and are disproportionately enriched

5 The framework explores DNA context-dependent mutational patterns and underlying somatic cancer mutage

6 In lung cancers, the p53 mutational patterns are different between smokers and no

7 ous recombination pathway; (ii) dominant T>G mutational pattern associated with a high mutational loa

8 Kataegis, a further mutational pattern associated with APOBEC deregulation,

9 of cloned env sequences revealed no specific mutational pattern associated with reduced susceptibilit

10 y analysing human cancer genomes we identify mutational patterns associated with aging.

11 des an unprecedented opportunity to identify mutational patterns associated with smoking.

12 To analyze and compare K-ras mutational patterns between colorectal tissues at differ

13 human populations and have characterized the mutational patterns by direct observation of 731 meioses

14 genic processes often produce characteristic mutational patterns called mutational signatures.

15 with Ks, suggesting that methylation-induced mutational patterns can explain some of the variation in

16 We found significant differences in mutational patterns, chromosomal instability, and gene e

17 BeWith in providing novel information about mutational patterns, driver genes, and pathways.

18 interfaces with high confidence using solely mutational patterns extracted from prokaryotic genomes.

19 uggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further sugg

20 The mutational pattern for the TP53 tumour suppressor gene i

21 ns (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have t

22 Significantly, the mutational pattern found overlaps oxidative damage hot s

23 increased mutability 10-fold and changed the mutational pattern from predominantly insertions to main

24 that accounts for local variation in neutral mutational patterns further improves our predictions.

25 Furthermore, the mutational pattern giving rise to diversification in the

26 cr-DNA binding pattern is similar to the p53 mutational pattern in human lung cancer.

27 ation and dN/dS analyses suggest that unique mutational patterns in alpha2 and insertions in the V1-t

28 Investigations of VH gene mutational patterns in B-cell tumors are often performed

29 es in esophageal adenocarcinomas and complex mutational patterns in liver cancer.

30 ences using probabilistic models of expected mutational patterns in pairwise sequence alignments.

31 Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of

32 sequences of these antibodies show clustered mutational patterns in the complementarity determining r

33 es may influence HBeAg seroconversion rates, mutational patterns in the precore (PC) and core promote

34 ognition by Rlm7 is governed by more complex mutational patterns, including gene loss or drastic modi

35 Mutational patterns indicative of rapid viral population

36 There was apparent clustering of mutational patterns into either an IgMD/IgG3/IgA set or

37 The mutational pattern is consistent with dG to dT transvers

38 Notably, neither mutational patterns nor gene expression profiles differ

39 e imposed bias of Ag-mediated selection, the mutational pattern of 37 nonproductively rearranged VH g

40 To address this, the mutational patterns of a large panel of productive V(H)D

41 The mutational patterns of cancer genomes allow conclusions

42 quencing studies are beginning to reveal the mutational patterns of genes in various cancers, identif

43 Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance

44 e further show major differences between the mutational patterns of the mitochondrial and nuclear gen

45 type and HLA-B* 57/5801 epitope-specific Gag mutational patterns of the transmitted virus and not to

46 due to molecular drivers associated with the mutational patterns of these polyC/G repeats, rather tha

47 These combinatorial mutational patterns provide guiding information for the

48 l clusters provides insight into the complex mutational patterns required for HIV-1 protease inhibito

49 The observed mutational pattern resembles the deamination signature o

50 Complex mutational patterns resulted in convergent PNG shifts in

51 The mutational patterns revealed recurrent evolution of biof

52 DNA methylation also may explain the unusual mutational patterns seen in A. mellifera that lead to AT

53 In addition, the observed mutational patterns suggest candidates of new cosequenci

54 y mutated gene in our cohort, IGLL5, shows a mutational pattern suggestive of activation-induced cyti

55 rriers are mosaic for repeat size, but these mutational patterns tend to be well conserved when compa

56 tingly, some spontaneous mutants exhibited a mutational pattern that is characteristic of oxidative m

57 We have addressed this question by comparing mutational patterns that are linked to the manifestation

58 C repeat instability describing two types of mutational patterns that can be partitioned by transcrip

59 Understanding the mutational patterns that define the maturation pathways

60 Tumor-derived IgG V genes exhibited mutational patterns that were consistent with antigenic

61 Despite extensive investigation, the mutational pattern they provoke in eukaryotic cells rema

62 However, certain combinatorial mutational patterns violate these simple rules and demon

63 Unlike the Tm clones where the replacement mutational pattern was similar to that seen for synonymo

64 The mutational pattern was strikingly nonrandom, with somati

65 Two distinct zidovudine-resistance mutational patterns were noted.

66 Clear mutational patterns were observed that both pointed to k

67 ans- and (+)-cis-adducts also show a similar mutational pattern with a more even mixture of G --> T,

68 load and neoantigen burden; and (iii) C>A/T mutational pattern with evidence of an aging imprint.

69 nd (-)-cis-adducts show a remarkably similar mutational pattern with G --> A mutations predominating

70 EC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types.

71 ty, HLA concordance, race and ethnicity, and mutational patterns within the clustering and noncluster