ライフサイエンスコーパス: mutationally

1 gh shear stress, and verified its importance mutationally.

2 We examined mutationally a two-hairpin structure (nucleotides 57 to

3 of prsA2 mutant strains in the presence of a mutationally activated allele of the virulence regulator

4 However, a mutationally activated alpha s (alpha sR201C) is diffuse

5 rmal growth factor receptor (EGFR), which is mutationally activated and/or overexpressed in a wide va

6 tion, confirming that the three FAD-APPs are mutationally activated APP695.

7 these malignancies, the PI3K pathway is not mutationally activated as in many other cancers, but it

8 -Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61.

9 Mutationally activated BRAF(V600E) (BRAF(VE)) is detecte

10 In contrast, mutationally activated BRAF(V600E), a KRAS effector, fai

11 th elevated tumoural PBF/PTTG expression and mutationally activated BRAF.

12 inhibitor, sodium vanadate, or expression of mutationally activated c-Src resulted in enhanced curren

13 ion by the same Galpha proteins; conversely, mutationally activated Cdc42 stimulates the JNK pathway

14 g activities that determine addiction to the mutationally activated EGFR in human lung cancer cells.

15 es in relation to aberrant overexpression of mutationally activated erbB-2/neu.

16 endogenous patterning: ectopic expression of mutationally activated FAST-1, ectopic expression of dom

17 Together, our results demonstrate that mutationally activated FGFR4 acts as an oncogene, and th

18 y proteins that specifically interact with a mutationally activated form of Galpha(z).

19 identify proteins that could interact with a mutationally activated form of Gzalpha.

20 The presence of a mutationally activated form of PrfA, known as PrfA*, inc

21 increased secretion by strains containing a mutationally activated form of prfA, the key regulator o

22 naling defects, even in strains expressing a mutationally activated G alpha-subunit, which activates

23 The introduction of mutationally activated G12 proteins into K562 cells expr

24 t described activation of Akt in response to mutationally activated Galpha(q) and Galpha(i) transfect

25 Moreover, the mutationally activated Galpha12 and Galpha13 stimulated

26 lls stably expressing specific NHE isoforms, mutationally activated Galpha12 inhibited NHE1 activity

27 Transient expression of mutationally activated Galpha12 inhibited serum- and Gal

28 for beta-catenin degradation, expression of mutationally activated Galpha12 or Galpha13 causes an in

29 In contrast, mutationally activated Galpha13, another member of the G

30 assa, we examined properties of strains with mutationally activated gna-1 alleles (R178C or Q204L) as

31 that just such dysregulation resulting from mutationally activated GRK4 contributes to the heritable

32 e that is stimulated by Mg2+, forskolin, and mutationally activated Gsalpha.

33 ia coli extract that can efficiently convert mutationally activated GTP-bound Ras to the inactive GDP

34 d Akt activation resulting from betagamma or mutationally activated H-Ras co-transfection in these ce

35 Expression of mutationally activated H-Ras fails to activate Rin in no

36 Ras proteins are mutationally activated in a variety of human cancers.

37 s are critical regulators of mitosis and are mutationally activated in many human tumors.

38 erexpressed in numerous human cancers and is mutationally activated in N-ethyl-N-nitrosourea (ENU)-in

39 hway is highlighted in the fact that EGFR is mutationally activated in over 50% of GBM tumors.

40 is a key regulator of the ERK pathway and is mutationally activated in two-thirds of human melanomas.

41 Mutationally activated kinases define a clinically valid

42 Mutationally activated kinases play an important role in

43 Similarly to Ha-Ras, expression of mutationally activated M-Ras in NIH 3T3 mouse fibroblast

44 We describe a knockin mouse with mutationally activated Met (Met(mut)) that develops a hi

45 ity of Met and that NIH 3T3 cells expressing mutationally activated Met are transformed in vitro and

46 e also report that transgenic mice harboring mutationally activated Met develop metastatic mammary ca

47 suggest that signaling via wild type Met and mutationally activated Met may proceed through distinct

48 portance of these residues for signaling via mutationally activated Met.

49 trifolii, a fungal pathogen of alfalfa, the mutationally activated oncogenic fungal Ras (DARas) elev

50 rt here the first example of an alternative, mutationally activated pathway for meiotic recombination

51 the wild-type catalytic subunit of PIK3CA to mutationally activated PIK3CA(H1047R).

52 These experiments revealed that mutationally activated PIK3CAH1047R cooperates with BRAF

53 ty measured in vitro, as it is enhanced by a mutationally activated Plk, T210D, but is not observed w

54 The use of mutationally activated prfA alleles therefore provides a

55 s(12V, 37G), cooperates synergistically with mutationally activated Raf to induce foci of growth and

56 Introduction of a mutationally activated Raf-1 kinase domain reversed tumo

57 The well-validated role of mutationally activated RAS genes in driving cancer devel

58 Expression of mutationally activated RAS is a feature common to the va

59 Although only two of the lines harbor mutationally activated ras, we found that five of nine b

60 ly transfected to constitutively overexpress mutationally activated rat neu oncogene.

61 wild-type H-Ras but failed to interact with mutationally activated soluble H-Ras (G12V).

62 Src) but does not form a stable complex with mutationally activated Src (v-Src).

63 an cells, TRAP-1 was co-precipitated only by mutationally activated TbetaR-I and ligand-activated Tbe

64 ), that interacts in yeast specifically with mutationally activated TbetaR-I, but not wild-type Tbeta

65 constitutively dimerized form of Met, and a mutationally activated version of Met corresponding to t

66 nd/autocrine stimulation, Met which has been mutationally activated, and Tpr-Met (a constitutively ac

67 that Ras may only affect PI3K signaling when mutationally activated, such as in Ras(V12)-transformed

68 n induce tumorigenesis when overexpressed or mutationally activated.

69 s independent of MEKK, and microinjection of mutationally active Galpha 13 results in a Rho phenotype

70 In contrast, expression of mutationally active MAP kinase kinase causes activation

71 Furthermore, mutationally active p160ROCK phosphorylated an NHE1 C-te

72 HE1 activity was stimulated by expression of mutationally active p160ROCK, but not by mutationally ac

73 of mutationally active p160ROCK, but not by mutationally active protein kinase N, another RhoA targe

74 ormation driven by a strong oncogenic insult-mutationally active Ras.

75 Our results uncover a mutationally adjustable, caliper-like mechanism that gen

76 evidence for the same genomic position being mutationally affected multiple times in individual tumor

77 Here, we mutationally alter a hydrophobic patch on the third comp

78 Here we describe a method for directing a mutationally altered activator to either one or the othe

79 We propose that the side chains of these mutationally altered amino acids are in direct contact w

80 re involved in transcription activation by a mutationally altered CRP derivative, FNR and AraC.

81 Several mutationally altered forms of TyrR were deficient in the

82 specifically targeting the kinases that are mutationally altered in individual melanomas.

83 The V(max) of the mutationally altered protein was only 4% that of the unm

84 TRAP-1 protein that specifically binds these mutationally and ligand-activated forms of TbetaR-I can

85 re the fitness effects of genotypes that are mutationally available to the two populations.

86 arnesyl transferase inhibitor rac-R115777 or mutationally by alteration of the CaaX motif dramaticall

87 complex provides general insights into how a mutationally challenged enzyme, i.e., an enzyme whose ev

88 niversally conserved aspartic acid that were mutationally characterized.

89 in several cell lines, especially those with mutationally compromised p53.

90 NA in which the UUUU loop of stem-loop I was mutationally configured into a single-stranded RNA by re

91 r the formation of large neutral networks of mutationally connected genotypes which enhance the capac

92 Mutationally converting this His to either Tyr or Trp re

93 length that may be intact and 167 apparently mutationally damaged and/or unexpressed genes (pseudogen

94 Aside from the mutationally defined CHE-1-binding site, cog-1 contains

95 al techniques, this is the first report of a mutationally defined prolyl-4-hydroxylase in any animal.

96 This function is dependent on the mutationally defined Rev activation domain, which also f

97 This action depends on the mutationally defined Rev activation domain, which both b

98 Of the mutationally defined rhythm genes in Drosophila melanoga

99 n the limited sequence identity observed for mutationally defined Tas or Bel-1 response elements and

100 he human and simian foamy viruses, have been mutationally defined, they show little evident sequence

101 Donors mutationally derepressed for blcC yielded transconjugant

102 he stability of the protein by comparing two mutationally destabilized variants of the protein.

103 Putative magnesium transporter genes were mutationally disrupted, singly and in combination, in or

104 Thus, we show that mutationally disrupting the hydrophobic network in vario

105 previous studies, this packaging domain was mutationally dissected into at least seven functional el

106 Sequential immunization with mutationally distant variants is shown to robustly induc

107 One idea is that all excess DNA is mutationally hazardous, but weakly enough so that genome

108 becomes promiscuous when these proteins are mutationally impaired, thus promoting templated mutation

109 We used mutationally imposed adaptational modification states an

110 perativities of Tsr receptors with different mutationally imposed modifications at sites 1 to 4 and/o

111 r of mutations best predicted the ability to mutationally inactivate HIV.

112 A T4 whose gene 43 has been mutationally inactivated can be replicated by a cognate

113 LKB1 (also called STK11) tumor suppressor is mutationally inactivated in approximately 20% of non-sma

114 The CDC73 gene is mutationally inactivated in hereditary and sporadic para

115 The CDC73 tumor suppressor gene is mutationally inactivated in hereditary and sporadic para

116 Although Pdcd4 is not mutationally inactivated in human cancer, the mechanisms

117 pha-1,3-galactosyltransferase (alpha3GT), is mutationally inactivated in humans, leading to the prese

118 TP53 is mutationally inactivated in most types of cancer and is

119 Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and i

120 The Tsc2 gene, which is mutationally inactivated in the germ line of some famili

121 In contrast, transgenic mice bearing a mutationally inactivated NF-IL-6 site showed no increase

122 Comparison to a mutationally inactivated precursor structure revealed se

123 When the hMSH6 is mutationally inactivated, hMSH3 increases by both transc

124 or Rb and p16, suggesting that they were not mutationally inactivated.

125 reported KSHV miRNA, miR-K9, was found to be mutationally inactivated.

126 plex in which the low affinity site had been mutationally inactivated.

127 nd in enzyme forms where C2 and T3 have been mutationally inactivated.

128 d if either the cyclin D1 or Cdk2 domain was mutationally inactivated.

129 Mutationally-inactivated ARSs that co-reside with 3'-end

130 1 is not activated in fibroblasts expressing mutationally inactive Cdc42-N17.

131 y, loss of endogenous RBBP9 or expression of mutationally inactive RBBP9 leads to elevated Smad2/3 ph

132 Mutationally induced changes at site II of cTnC alter ca

133 A clear correlation is observed between mutationally induced conformational differences in one o

134 may have greater evolutionary potential than mutationally induced ones.

135 However, natural, altered, and mutationally interconverted editing sites reveal that U-

136 The highly conserved and mutationally intolerant retroviral zinc finger motif of

137 Thus, DIBAs chemically modified the mutationally intolerant retroviral zinc fingers in infec

138 terface increases ligand-binding affinity by mutationally introducing an N-glycosylation site into it

139 The alpha(L) I domain can be mutationally locked with disulfide bonds into two distin

140 Using purified rAAV containing a mutationally marked globin gene (A(gamma)*) and sites 2,

141 These findings suggest that mutationally modified PTEN can actively contribute to we

142 eir key roles in viral replication and their mutationally nonpermissive nature.

143 Many TKs are mutationally or autocrine activated and/or often overexp

144 Using modified substrates to either mutationally or chemically block the second step, we fou

145 this interaction is more pronounced with the mutationally or functionally activated form of Galpha(13

146 this interaction is more pronounced with the mutationally or functionally activated form of Galpha13

147 lomerase-specific T motif of human TERT were mutationally probed, leading to variant telomerases with

148 ts are in turn composed of subsets which are mutationally related, suggesting a high degree of flexib

149 n though the prototype sequence that is most mutationally robust is preferred by evolution, the prefe

150 er group had earlier shown that pre-miRNA is mutationally robust, even controlling for compositional

151 lower fitness peak also exists that is more mutationally robust.

152 , Finb, as the protein binding to one of the mutationally sensitive elements.

153 onnecting the strands were largely devoid of mutationally sensitive positions.

154 It is therefore worth noting that the mutationally sensitive residues lie along one face of a

155 Region 4 of Taf1p is mutationally sensitive, can assemble several Tafps into

156 is of aminoacylation, and editing, have been mutationally separated.

157 By mutationally separating early and late requirements for

158 s residues Trp-342, Trp-430, and Trp-472 are mutationally silent when analyzed individually.

159 In contrast, when the alphaL I domain was mutationally stabilized in the open conformation with a

160 e transformation, we transduced wild-type or mutationally stabilized murine N-myc(T58A) into neural s

161 However, when the mutationally tagged telomere is considerably longer than

162 When a mutationally tagged telomere is of normal length, its se

163 leotide changes continues to favor MKK4 as a mutationally targeted tumor suppressor gene.

164 the results support the prior designation of mutationally tolerant spacer regions of LacI as well as

165 Expression of a mutationally truncated form of the protein (C-Sst2) coul

166 We identified nine mutationally verified interaction sites between sigma(70

167 We were able to separate the AroK activities mutationally with an aroK mutant allele lacking shikimat