ライフサイエンスコーパス: myb gene

1 is estimated to contain more than a hundred MYB genes).

2 phila melanogaster, which possesses a single myb gene.

3 lymphoma by insertional activation of the c-myb gene.

4 in the chromosomal region that includes the myb gene.

5 ng 2 cases with gain of an apparently intact MYB gene.

6 e rhomboid protease gene and a SHAQKY family Myb gene.

7 isruptions are now in clinical trial, is the myb gene.

8 nscription in the 3' ends of the pim-1 and c-myb genes.

9 ted a comprehensive phylogenetic analysis of Myb genes.

10 recently expanded P-to-A group of maize R2R3 Myb genes.

11 Vertebrates have three related Myb genes.

12 es examined thus far contain three different Myb genes (A-Myb, B-Myb, and c-Myb).

13 p107 has a significant role in regulating B-myb gene activity.

14 The protein products of the myb genes all bind the Myb-binding site (MBS) [YG(A/G)C(

15 lencing efficacy assays on seven Arabidopsis MYB genes, all of which contain conserved miR159-binding

16 i1, which maps 30 to 40 kb downstream of the Myb gene and appears to be the most common site of somat

17 ise of mice with targeted deletions of the c-myb gene and incomplete of knowledge about c-myb's expre

18 The avian retroviral v-myb gene and its cellular homologues throughout the anim

19 ution of MIR828 from an ancestral gymnosperm MYB gene and subsequent formation of TAS4 by duplication

20 ntrast, the Chlamydomonas genome has only 38 MYB genes and eight bHLH genes.

21 s in the 5'-flanking sequence of the human c-myb gene, and we found that the positive regulators diff

22 ined that maize expresses >80 different R2R3 Myb genes, and evolutionary distances among maize Myb(BR

23 The A-myb and B-myb genes are both expressed in a cell- and stage-specif

24 iological phenotypes produced by A-myb and c-myb genes are mediated by their COOH-terminal domains.

25 However, while the functions of some plant MYB genes are relatively well understood they are, at pr

26 R2R3 Myb genes are widely distributed in the higher plants an

27 1380, which encodes a small R3 single repeat MYB gene, as a negative regulator of trichome initiation

28 is thaliana line that is mutant for the R2R3 MYB gene, AtMYB4, shows enhanced levels of sinapate este

29 deficient mutant (dn-CDK9) also represses B-myb gene autoregulation.

30 e frequently up-regulate expression of the c-myb gene, but it is unclear whether this is a cause or a

31 The Arabidopsis genome harbors >100 R2R3 Myb genes, but few have been found in monocots, animals,

32 that R1R2R3 Myb genes were derived from R2R3 Myb genes by gain of the R1 repeat through an ancient in

33 on recently duplicated maize (Zea mays) R2R3 Myb genes (C1/Pl1 and P1/P2) by cloning and characterizi

34 ide evidence that the product of the human B-myb gene can be activated in vivo by coexpression with c

35 transcription and splicing to the downstream myb gene, causing overexpression of a slightly truncated

36 evidence also suggests that R2R3 and R1R2R3 Myb genes co-existed in eukaryotes before the divergence

37 utant embryos that carry a deletion of the c-myb gene demonstrates that c-myb is not required for pri

38 To date, v-myb is the only myb gene directly implicated in tumorigenesis, a propert

39 ypic analysis of mutations in the Drosophila myb gene, Dm myb, has revealed a previously undiscovered

40 adult transgenic mice expressing the human B-myb gene, driven by the basal cytomegalovirus promoter,

41 routes of sequence divergence that followed Myb gene duplication, we supplemented the information av

42 eful for determining the precise role of the MYB genes during stress responses with crop improvement.

43 Thus, the v-myb gene encoded by the Avian Myeloblastosis Virus, is t

44 The results suggest that the human c-myb gene encodes a family of related proteins with diffe

45 The c-myb gene encodes a sequence specific transactivator that

46 The c-Myb gene encodes a transcription factor required for pro

47 The c-myb gene encodes a transcription factor required for pro

48 The human B-myb gene encodes a transcriptional regulator that plays

49 AP2, Myb113 and Myb114) showed downregulated Myb gene expression and obvious anthocyanin deficiencies

50 revealed an increase in endogenous NmU and c-myb gene expression at day 8 and a 16% expansion of earl

51 Microarray analysis showed that KLF13 and MYB gene expression changes were significantly greater i

52 E and phosphorothioate (PS) ODNs to target c-myb gene expression.

53 This review focuses on the evolution of the myb gene family and the role of these genes in developme

54 The myb gene family consists of three members, named A, B an

55 The myb gene family consists of three members, named A-, B-,

56 The myb gene family consists of three members, named A-, B-,

57 The Myb gene family currently consists of three members, nam

58 Members of the myb gene family exhibit different temporal and spatial e

59 ovide new insights into the evolution of the MYB gene family in Arabidopsis, and, more generally, the

60 f evidence for the amplification of the R2R3 Myb gene family in the early history of land plants and

61 The molecular evolution of the R2R3-MYB gene family is of great interest because it is one o

62 e that most of the amplification of the R2R3 Myb gene family occurred after the origin of land plants

63 Transactivation by myb gene family varies considerably depending on cell ty

64 is of the five members of a single-repeat R3 MYB gene family, including CAPRICE (CPC), TRIPTYCHON (TR

65 MYB98 is a member of the R2R3-MYB gene family, the members of which likely encode tran

66 ort a new model for the ordered evolution of Myb gene family.

67 The MYB-gene family encodes sequence-specific DNA-binding tr

68 a neomorphic origin of an ancestral A-Myb/c-Myb gene from a duplicated B-Myb-like gene.

69 were classified into 13 groups with the R2R3-MYB genes from Arabidopsis and rice.

70 hese two tomato myb clones are compared with myb genes from other plant species and organisms.

71 xplain the origin of the plant-specific R2R3 Myb genes from widely distributed R1R2R3 Myb genes, thro

72 to resolve previous discrepancies regarding myb gene function in Drosophila and vertebrates.

73 l activation domain in the ancestral A-Myb/c-Myb gene generated from the initial duplication of an an

74 The myb gene has been shown to be an important regulator of

75 The vertebrate Myb genes have been specifically implicated in regulatin

76 parative and bioinformatics analyses on R2R3-MYB genes identified from the rice (Oryza sativa subsp.

77 , primarily, to the ever-expanding number of MYB genes identified in higher plants (Arabidopsis thali

78 have previously established that the single myb gene in Drosophila melanogaster, Dm myb, which is re

79 e transcriptional regulation of the WEREWOLF MYB gene in epidermal cells at the H position.

80 Looking for mutations of the B-MYB gene in human cell lines and primary cancer samples,

81 hus, these findings strongly implicate the A-myb gene in the regulation of B-cell survival and confir

82 MADS-box genes in 9 clades and 42 Iris R2R3 MYB genes in 19 clades were identified.

83 The results revealed that the MYB genes in cotton were differentially expressed under

84 ere is great diversity in the number of R2R3-MYB genes in different plants.

85 nt duplication of particular classes of R2R3 Myb genes in the grasses.

86 Activation of the myb gene into an oncogenic form has involved structural

87 The A-myb gene is a transcription factor that shares structura

88 Transcription of the B-Myb gene is cell cycle regulated by an E2F-dependent mec

89 The ubiquitously expressed B-Myb gene is essential for early embryonic development in

90 The c-myb gene is implicated in the differentiation and prolif

91 evidence indicates that the product of the B-myb gene is necessary for the growth and survival of sev

92 The c-myb gene is primarily expressed in hematopoietic cells,

93 Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting

94 The A-Myb gene is required for spermatogenesis and mammary gla

95 The Myb gene is upregulated during oxidative stress and deve

96 examine the hypothesis that the expansion of Myb genes is associated with the regulation of novel pla

97 ralogs prior to the amplification of current Myb genes is identified.

98 sitional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cel

99 l assays demonstrated that deletion of the c-myb gene leads to a slightly reduced proliferative capac

100 oid pathway; therefore, we hypothesized that MYB genes might be involved in the regulation of the bio

101 Drosophila has a single Myb gene most closely related to B-Myb.

102 A R2R3-MYB gene MYB112 was also identified as being directly si

103 Similar experiments with a distantly related MYB gene (MYB2) showed that its product cannot functiona

104 The expression of the MIXTA-like MYB gene NOK was elevated.

105 Poplar has 192 annotated R2R3 MYB genes, of which only three have been shown to play a

106 lyses indicate that some recently duplicated Myb gene pairs display substantial differences in the nu

107 he entire corolla of M. lewisii and two R2R3-MYB genes, PELAN and NEGAN, controlling anthocyanin prod

108 and miR858 can collectively target up to 81 MYB genes potentially involved in diverse aspects of pla

109 the molecular evolutionary properties of six MYB genes previously shown to be expressed in cotton fib

110 lead to increased production of a truncated myb gene product from an ALV-myb readthrough RNA.

111 with retroviral vectors expressing different myb gene products.

112 lasias, we sought to determine whether the A-myb gene promoted proliferation and survival of B lympho

113 all four full-size members activate a common MYB gene (PtrMYB021).

114 re merely analogous structures, and that the myb genes regulating their differentiation are specific

115 GLABROUS 1, a myb gene required for trichome development in Arabidopsi

116 Targeted disruption of the c-myb gene resulted in a critical depletion of the HSC poo

117 Loss of the c-myb gene results in embryonic lethality because mature b

118 analysis of the 5' flanking region of the c-myb gene revealed a consensus PU box at position +16 to

119 will be pigmented or white, corresponds to a myb gene segregating in southeastern U.S. populations fo

120 protein-coding regions of each single-repeat MYB gene suggest that all five proteins are functionally

121 A total of 105 potential Myb gene targets were identified.

122 c experiments and identify a MIXTA-like R2R3 MYB gene that controls nectar guide formation in M. lewi

123 2R3 Myb genes from widely distributed R1R2R3 Myb genes, through a series of well-established steps.

124 conserved and divergent sequence features of MYB genes to initiate distinct regulatory networks targe

125 Changes in the rate of B-myb gene transcription could account for part of the obs

126 growth-suppressive activity by regulating B-myb gene transcription.

127 To explore the evolutionary origin of Myb genes, we cloned and sequenced Myb domains from maiz

128 monious than the previous proposal that R2R3 Myb genes were derived from R1R2R3 Mybs by loss of the R

129 Based on our results, we propose that R1R2R3 Myb genes were derived from R2R3 Myb genes by gain of th

130 Expression patterns for the MYB genes were examined in several organs to determine i

131 present study, a total of 205 putative R2R3-MYB genes were identified in cotton D genome (Gossypium

132 amily because invertebrates possess a single Myb gene, whereas all vertebrate genomes examined thus f

133 CotMYBA, a myb gene which is expressed in Gossypium hirsutum ovules

134 H3T3 fibroblasts that transcription of the B-myb gene, which encodes a transcription factor required

135 le amebic genes, including an E. histolytica Myb gene, which is upregulated during oxidative stress r

136 closely related to the vertebrate family of Myb genes, which encode transcription factors that are i

137 divergence for some recently duplicated R2R3 Myb genes, yielding important information on general pat