ライフサイエンスコーパス: mycobacteriophage

1 eric hosts and the phage L5-related group of mycobacteriophages.

2 Mycobacteriophages accomplish this by producing two lysi

3 ation of PA6 resembled that of the temperate mycobacteriophages, although the genome was much smaller

4 luster M further expand the diversity of the mycobacteriophages and introduce novel features.

5 ntifiable recombination proteins are rare in mycobacteriophages, and only 1 of 30 genomically charact

6 Mycobacteriophage are viruses that infect mycobacteria.

7 hat have plagued their genetic manipulation, mycobacteriophages are especially appealing subjects for

8 Mycobacteriophages are viruses that infect mycobacterial

9 Mycobacteriophages are viruses that infect mycobacterial

10 on vector can be easily adapted to different mycobacteriophage attachment sites (attB) due to its mod

11 Mycobacteriophage-based approaches to tuberculosis diagn

12 This study analyzes one of these, the mycobacteriophage Bethlehem DnaB intein, which we descri

13 ill facilitate postgenomic explorations into mycobacteriophage biology.

14 Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, and Rey, constitute a

15 nstrates a high degree of similarity to many mycobacteriophages both morphologically and genetically.

16 The PR promoter of mycobacteriophage BPs directs early lytic gene expressio

17 Mycobacteriophage Brujita is an unusual temperate phage

18 ore than 60% of the genes unrelated to other mycobacteriophages, but offers novel insights into how m

19 Integration of the mycobacteriophage Bxb1 genome into its host chromosome i

20 Here we report that mycobacteriophage Bxb1 integrase also mediates targeted

21 This is mediated by mycobacteriophage Bxb1 integrase, which catalyzes recomb

22 ite-specific integration was mediated by the mycobacteriophage Bxb1 integrase-catalyzed recombination

23 Mycobacteriophage Bxb1 is a temperate phage of Mycobacte

24 Mycobacteriophage Bxb1 is a temperate phage of Mycobacte

25 cribe a pair of serine integrases encoded by mycobacteriophages Bxz2 and Peaches with unusual and unp

26 and Cjw1, which are distinguished from other mycobacteriophages by their possession of a Pnkp enzyme,

27 This study determined which class the mycobacteriophage Catera Gp206 and Nocardioides sp. JS61

28 The mycobacteriophage Catera Gp206 intein (starting with Ser

29 The mycobacteriophage Catera Gp206, Nocardioides sp. strain

30 , and only 1 of 30 genomically characterized mycobacteriophages (Che9c) encodes homologs of both RecE

31 Genomic comparison of these mycobacteriophages contributes to our understanding of t

32 ese challenges by utilizing real-time PCR of mycobacteriophage D29 DNA to evaluate the drug resistanc

33 struction of luciferase reporter phages from mycobacteriophage D29 DNA.

34 Mycobacteriophage D29 is a lytic phage that infects both

35 Mycobacteriophage D29 is a lytic phage that infects both

36 dissection of the function and regulation of mycobacteriophage D29 Lysin A.

37 ction of Mycobacterium tuberculosis by using mycobacteriophage D29.

38 onally replicating shuttle phasmids from the mycobacteriophages D29 and TM4 that enable efficient del

39 of the phams have sequence similarity to non-mycobacteriophage database entries, and fewer than 10% o

40 rived single-stranded DNA recombineering and mycobacteriophage-encoded proteins.

41 e system by identification and expression of mycobacteriophage-encoded recombination proteins, adapti

42 Mycobacteriophages encounter a unique problem among phag

43 lowed by incubation with 10(3) PFU/ml of D29 mycobacteriophage for 24 h and then real-time PCR.

44 Although mycobacteriophage genes exhibit a smaller average size t

45 hermosensitive mutations were created in the mycobacteriophage genome that allow replication at 30 de

46 More than 1,400 mycobacteriophage genomes have been sequenced, coding fo

47 Ten new mycobacteriophage genomes presented by show that most ph

48 eplete with novel genes not present in other mycobacteriophage genomes, and although most are of unkn

49 literature estimates, extrapolating from 14 mycobacteriophage genomes, suggesting that two billion p

50 Analysis of the novel mycobacteriophage Giles genome not only extends our curr

51 describe a functional genomic dissection of mycobacteriophage Giles, in which the virion proteins ar

52 Here we investigate mycobacteriophage Giles-host protein-protein interaction

53 tic determination of the genome sequences of mycobacteriophages has revealed the presence of several

54 70 complete genome sequences available, the mycobacteriophages have provided a wealth of information

55 Mycobacteriophages have provided key tools for tuberculo

56 The cluster M mycobacteriophages have siphoviral morphologies with unu

57 of a Pnkp enzyme, are also unique among the mycobacteriophages in their specification of putative RN

58 f features not previously described in other mycobacteriophages, including noncanonical genome archit

59 Mycobacteriophages infect and replicate in viable bacter

60 eight-gene cluster has strong similarity to mycobacteriophage integrase sequences.

61 ycobacterial lysis, a Giles DeltalysB mutant mycobacteriophage is viable, but defective in the normal

62 Mycobacteriophage L5 accomplishes this by an atypical ph

63 The well-characterized mycobacteriophage L5 forms stable lysogens in Mycobacter

64 ning the phage attachment site attP from the mycobacteriophage L5 genome and additionally containing

65 The genome of temperate mycobacteriophage L5 integrates into the chromosomes of

66 Mycobacteriophage L5 integrates into the genome of Mycob

67 The temperate mycobacteriophage L5 integrates site specifically into t

68 Lysogenization of mycobacteriophage L5 involves integration of the phage g

69 Mycobacteriophage L5 is a temperate phage that forms lys

70 Mycobacteriophage L5 is a well-characterized temperate p

71 Integration of mycobacteriophage L5 is catalyzed by a phage-encoded int

72 Integration of mycobacteriophage L5 requires the mycobacterial integrat

73 that shares a similar genome organization to mycobacteriophage L5, although the two phages are hetero

74 that it is a close relative of the temperate mycobacteriophage L5, and is presumably a non-temperate

75 that it is a close relative of the temperate mycobacteriophage L5, whose sequence has been described

76 tuberculosis that stimulates integration of mycobacteriophage L5.

77 megmatis whose product confers resistance to mycobacteriophages L5 and D29 when overproduced.

78 logy of Bxb1 particles is similar to that of mycobacteriophages L5 and D29, although Bxb1 differs fro

79 element phiRv2, and compare them to those of mycobacteriophages L5 and D29.

80 cterium smegmatis that confers resistance to mycobacteriophages L5 and D29.

81 e previously described a luciferase reporter mycobacteriophage (LRP) assay that can detect Mycobacter

82 The utility of luciferase reporter mycobacteriophages (LRPs) for detection, identification,

83 Tmp's of mycobacteriophages may thus have acquired these motifs i

84 u homologs in Corndog and Omega, two related mycobacteriophages of Mycobacterium smegmatis.

85 Here we show that mycobacteriophages Omega and Cjw1 and vibriophage KVP40

86 P protocol is the ability of the recombinant mycobacteriophage phAE40 to infect a variety of Mycobact

87 We developed a more powerful mycobacteriophage (Phi(2)GFP10) with a fluorescent repor

88 hermore, rarefaction analysis shows that the mycobacteriophage population is not closed, and there is

89 cobacteriophages, which-together with the 83 mycobacteriophages previously reported-represent the lar

90 Upon infection, mycobacteriophages produce lysins that catalyze cell wal

91 Although the attachment site DNA of mycobacteriophage Pukovnik is likely to contain four sit

92 , and new methods for simple construction of mycobacteriophage recombinants will facilitate postgenom

93 Mycobacteriophages represent a genetically diverse group

94 Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct proph

95 The genomic sequences of ten newly isolated mycobacteriophages suggest that the bacteriophage popula

96 Mycobacteriophages-the viruses of mycobacterial hosts-pr

97 Here we focussed on the WhiB-like protein of mycobacteriophage TM4, WhiBTM4.

98 Many of these mycobacteriophage Tmp's contain small motifs with sequen

99 Thirdly, it is the first mycobacteriophage to be described that forms a large pro

100 quirements responsible for the attachment of mycobacteriophage to the host cell wall.

101 The predominant morphotype of mycobacteriophage virions has a DNA-containing capsid at

102 TM4 is a lytic mycobacteriophage which infects mycobacteria of clinical

103 ere the complete genome sequences of 138 new mycobacteriophages, which-together with the 83 mycobacte