ライフサイエンスコーパス: mycobactin

1 cells of the deferri form of the siderophore mycobactin.

2 Mutant strain LUN9 produced no detectable mycobactin.

3 was not known to participate in synthesis of mycobactin.

4 l dimycocerosates, phenolic glycolipids, and mycobactins.

5 nown as MbtA involved in biosynthesis of the mycobactins.

6 btA which is involved in biosynthesis of the mycobactins.

7 ted in the cell wall of M. tuberculosis: the mycobactins.

8 n-binding molecules, and to transfer iron to mycobactins.

9 e termed exochelin (an excreted product) and mycobactin (a cell-associated product).

10 Structurally related mycobactins affect the growth of both mycobacterial and

11 rain produced measurable amounts of excreted mycobactin, although both excreted exochelin (the mycoba

12 l, and the organism imports this metal using mycobactin and carboxymycobactin siderophores.

13 synthesize iron chelating siderophores named mycobactin and carboxymycobactin to extract intracellula

14 t of tuberculosis, produces the siderophores mycobactin and carboxymycobactin.

15 es of MbtG in converting deoxymycobactins to mycobactin and in promoting M. tuberculosis growth.

16 In contrast, although the expression of mycobactin and iron ABC transport operons is highly upre

17 y, we demonstrated the presence of 1 or both mycobactins and/or tuberculosinyladenosine in serum and

18 several biosynthetic pathways (pyrimidines, mycobactin, and polyketides); genes that encode enzymes

19 Mycobactins are small-molecule iron chelators (sideropho

20 for the biosynthesis of the core scaffold of mycobactin based on sequence analysis.

21 tuberculosis and establishes the enzymes of mycobactin biosynthesis as novel targets for the develop

22 osis catalyzes the initial transformation in mycobactin biosynthesis by converting chorismate to sali

23 cyl-AMP ligase (MbtA), the first gene in the mycobactin biosynthesis gene cluster, providing a possib

24 MbtA catalyzes the first committed step of mycobactin biosynthesis in Mycobacterium tuberculosis (M

25 he mbt cluster to evaluate the importance of mycobactin biosynthesis in the growth and virulence of M

26 ting enzyme MbtA catalyzes the first step of mycobactin biosynthesis in two half-reactions: activatio

27 nes for iron scavenging has led to a revised mycobactin biosynthesis model.

28 te synthase MbtI catalyzes the first step of mycobactin biosynthesis through the conversion of the pr

29 which is responsible for the second step of mycobactin biosynthesis, exhibited potent antitubercular

30 erium tuberculosis, which is responsible for mycobactin biosynthesis.

31 orthologue of the Mycobacterium tuberculosis mycobactin biosynthetic gene mbtE.

32 s and order of action of enzymes through the mycobactin biosynthetic pathway.

33 he absence of Esx-3, mycobacteria synthesize mycobactin but are unable to use the bound iron and are

34 synthetic standards to natural mycobacterial mycobactins by nuclear magnetic resonance and mass spect

35 hed on the epsilon-amino group of the lysine mycobactin core, which is transferred by MbtK.

36 luster, providing a possible explanation for mycobactin dependence of Map; and Map-specific sequences

37 tant (MtbDeltambtE) was unable to synthesize mycobactins, displayed an altered colony morphology, and

38 ost and the environment, these organisms use mycobactin, high-affinity iron-binding molecules.

39 fer from each other and from water insoluble mycobactins in polarity, which is dependent primarily up

40 on transferrin, transferred iron to desferri-mycobactins in the cell wall of live bacteria.

41 ing proteins and transferring it to desferri-mycobactins in the cell wall of the bacterium.

42 ns but not iron transferrin transfer iron to mycobactins in the cell wall underscores the importance

43 This study highlights the importance of mycobactins in the growth and virulence of M. tuberculos

44 However, the biological significance of mycobactins in the growth of this pathogen and in diseas

45 of all 109 isolates were confirmed by using mycobactin J dependence and characterization of five wel

46 ented with 1% egg yolk emulsion, 4 microg of mycobactin J, and 0.5% pyruvate (12B/EMP) for use in con

47 in the presence of a panel of siderophores (mycobactin J, deferrioxamine B, acinetoferrin, and nanno

48 sed solid medium was also used that included mycobactin J, pyruvate, and VAN but excluded the egg yol

49 iciency as the more costly, native chelator, mycobactin J.

50 stimulating growth than the native chelator, mycobactin J.

51 7H11 (M7H11) with hemoglobin, and M7H11 with mycobactin J.

52 presenting protein led to the discovery of a mycobactin-like compound, dideoxymycobactin (DDM).

53 ysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide at 2.8 A resolution further revea

54 spectroscopy studies suggested that the LUN8 mycobactin may have an altered fatty acid side chain.

55 osis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelat

56 The production of mycobactin (MBT) by Mycobacterium tuberculosis is essent

57 Here we show that, surprisingly, mycobactin or carboxymycobactin did not rescue the low-i

58 d type when the medium was supplemented with mycobactins or when MtbDeltambtE was genetically complem

59 ther each of nine mbt genes was required for mycobactin production and to examine the conservation of

60 essential nature of each of these genes for mycobactin production has been lacking.

61 Cell-associated mycobactin production in the mutants appeared to be norm

62 ine mbt genes investigated are essential for mycobactin production.

63 olate, and the siderophores enterobactin and mycobactin, respectively.

64 The mycobactin siderophore system is present in many Mycobac

65 mutations lead to altered concentrations of mycobactin siderophores and acylated sulfoglycolipids.

66 s-specific, small molecules as biomarkers: 2 mycobactin siderophores and tuberculosinyladenosine.

67 the incorporation of salicylic acid into the mycobactin siderophores.

68 rium tuberculosis survival in cells requires mycobactin siderophores.

69 tins because of their structural relation to mycobactin siderophores.

70 tion of the iron-dependent regulator (ideR), mycobactin synthase B (mbtB), or mycobactin synthase G (

71 tor (ideR), mycobactin synthase B (mbtB), or mycobactin synthase G (mbtG).

72 o acids with homology to the MbtH protein of mycobactin synthesis in Mycobacteria tuberculosis; no fu

73 hain on the core structure of exochelins and mycobactins, the principal determinant of their polarity

74 ty that the transfer iron from exochelins to mycobactins was influenced by their polarity, we investi

75 riction and that these microvesicles contain mycobactin, which can serve as an iron donor and support

76 the first committed biosynthetic step of the mycobactins, which are important virulence factors assoc