ライフサイエンスコーパス: myelin proteolipid protein

1 y different encephalitogenic determinants of myelin proteolipid protein.

2 n the X chromosome which codes for the major myelin proteolipid protein.

3 ncoding a mutant form of the DM20 isoform of myelin proteolipid protein.

4 cell hybridoma stimulated by a set of three myelin proteolipid protein 139-151 altered peptide ligan

5 tide (Q144) from an autoantigenic peptide of myelin proteolipid protein 139-151 by a single amino aci

6 on in the frequency and effector function of myelin proteolipid proteins 139-151/I-A(s)-tetramer(+) c

7 ases in the amounts of myelin basic protein, myelin proteolipid protein, and 2',3'-cyclic nucleotide

8 ted proteins including myelin basic protein, myelin proteolipid protein, and 2'3'-cyclic nucleotide 3

9 ity, associates with myelin proteins such as myelin proteolipid protein, and assembles lipid-rich mic

10 patients and are specific for two different myelin proteolipid protein-derived peptides presented by

11 that T-cell responses to the immunodominant myelin proteolipid protein epitope (PLP139-151) did not

12 mimic (HI574-586) of an immunodominant self-myelin proteolipid protein epitope (PLP139-151) induced

13 Th1 cells reactive to myelin proteolipid protein expressed more H1R and less H

14 Although the myelin proteolipid protein gene (Plp1) is highly express

15 t with axons, and subsequently expressed the myelin proteolipid protein gene, initiating remyelinatio

16 ing regulates cell surface expression of the myelin proteolipid protein in cultured oligodendrocytes

17 The major intrinsic membrane protein of myelin, proteolipid protein, interacts with rafts in oli

18 We have found that the myelin proteolipid protein is critical to regulating OPC

19 entrations of myelin-specific proteins (MBP, myelin proteolipid protein, MAG, and 2',3'-cyclic nucleo

20 immunized for disease with encephalitogenic myelin proteolipid protein peptide 139 to 151, and analy

21 Collectively, these results indicate that myelin proteolipid protein peptide-specific CD8+ CTL may

22 A protein complex containing the myelin proteolipid protein (PLP) and alphav integrin mod

23 Mutated HSP proteins include myelin proteolipid protein (PLP) and axon-enriched prote

24 a systematic epitope mapping of responses to myelin proteolipid protein (PLP) as well as assaying res

25 ope-mapping series of 265 12-mer peptides of myelin proteolipid protein (PLP) by patients with isolat

26 The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM2

27 meric genes containing portions of the mouse myelin proteolipid protein (PLP) gene fused to the lacZ

28 uorescent protein (EGFP) driven by the mouse myelin proteolipid protein (PLP) gene promoter have been

29 specific for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139-151 (HSLGKW

30 We used myelin proteolipid protein (PLP) peptide 139-151 and its

31 In B10.S mice immunized with myelin proteolipid protein (PLP) peptide 139-151, both P

32 TCR) (5B6) specific for the encephalitogenic myelin proteolipid protein (PLP) peptide 139-151, on the

33 oimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, wherea

34 gnize peptides derived from sequences of the myelin proteolipid protein (PLP) presented by HLA class

35 oimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) residues 139-151 (HSLGK

36 e immunized with the p139-151 determinant of myelin proteolipid protein (PLP) were transfected with a

37 gies to intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epito

38 g a conundrum with regard to the function of myelin proteolipid protein (PLP), one of the major prote

39 ar change when a tetraspan membrane protein, myelin proteolipid protein (PLP), replaced the type I in

40 A new role for the myelin proteolipid protein (PLP), the most abundant prot

41 -2(s)) mice, which are highly susceptible to myelin proteolipid protein (PLP)-induced experimental au

42 ntal autoimmune encephalomyelitis (EAE) with myelin proteolipid protein (PLP).

43 ium-binding proteins, and, surprisingly, the myelin proteolipid protein (PLP).

44 ive CD4+CD25-Foxp3- T cells specific for the myelin proteolipid protein (PLP)139-151 peptide can be c

45 modified multitransmembrane domain proteins, myelin proteolipid protein (PLP, 30 kDa) and DM-20 (26 k

46 We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in

47 combined with an autoantigenic peptide from myelin proteolipid protein (PLP; PLP(139-151)) and used

48 6b, bore significant homology with the major myelin proteolipid protein, PLP/DM20.

49 mpassing the immunodominant encephalitogenic myelin proteolipid protein (PLP139-151) epitope.

50 encoding a minigene for residues 139-151 of myelin proteolipid protein (PLP139-151), a pathogenic se

51 treatment of oligomerized T cell epitope of myelin proteolipid protein (PLP139-151).

52 Finally, we show that myelin proteolipid protein-specific autoreactive T cells

53 ences were remarkably similar to that of the myelin proteolipid protein were previously isolated.