ライフサイエンスコーパス: myelinate

1 nd adolescence, as fibre bundles develop and myelinate.

2 cytoskeleton organization and are generally myelinated.

3 onding to fast temporal frequencies are more myelinated.

4 ections of cholera toxin subunit B (CTB) for myelinated A fibers and isolectin B4 (IB4) for unmyelina

5 as focused on signaling systems that promote myelinating activity of oligodendrocytes or promote prod

6 hereas sensory modalities conveyed by thinly myelinated Adelta fibers were less sensitive to chemothe

7 ogeneous group of disorders affecting thinly myelinated Adelta-fibres and unmyelinated C-fibres.

8 PERK activation in oligodendrocytes of fully myelinated adult mice had minimal effects on morphology

9 istinct, 200-kD neurofilament-immunopositive myelinated afferent fibers, a subpopulation of which did

10 minae I-II with normal unmyelinated and thin myelinated afferents labeled with calcitonin gene-relate

11 unonegative nerves are strikingly similar to myelinated airway afferents, the cough receptor, and smo

12 ies show that SCs retain their plasticity to myelinate and remodel myelin via mTORC1 throughout life.

13 in relation to neuropathological changes in myelinated and demyelinated hippocampi from postmortem M

14 pression and C3 activation were increased in myelinated and demyelinated MS hippocampi, mainly in the

15 pe resolution, parabrachiothalamic axons are myelinated and make large boutons, forming multiple asym

16 rves, ERK1/2 phosphorylation was observed in myelinated and nonmyelinating SCs.

17 The auditory system is heavily myelinated and operates at the upper limits of action po

18 AAVrh10 has higher tropic affinity to large myelinated and small peptidergic sensory neurons that in

19 gical and functional studies to assess large myelinated and small unmyelinated axons in the db/db typ

20 rate that GFRalpha3 expression is similar in myelinated and unmyelinated adult sensory neurons, sugge

21 unmyelinated fibers, despite a loss in both myelinated and unmyelinated axons.

22 ics of neurofilament transport in contiguous myelinated and unmyelinated segments of axons in long-te

23 long-distance (>25 mm) regeneration of both myelinated and unmyelinated sensory axons with topograph

24 CTb was found in both myelinated and unmyelinated vagal axons and terminals in

25 ssive MS is mainly due to the higher rate of myelinated axon degeneration, coupled to the lower capac

26 Distal myelinated axon outgrowth after 4 weeks was quantified u

27 their myelin sheaths to fully understand how myelinated axon plasticity contributes to neuronal circu

28 fies a mechanism selectively contributing to myelinated axon regeneration, and point out the role of

29 rd, expression of Nogo-A was associated with myelinated axon tracts and upregulated in oligodendrocyt

30 vier is a functionally important site on the myelinated axon where sodium channels are clustered and

31 at GlcNAc6ST-1 modulates PNS myelination and myelinated axonal survival through the GlcNAc-6-O-sulfat

32 Oligodendrocytes myelinate axons in the central nervous system and develo

33 nteract with neurons and the basal lamina to myelinate axons using known receptors, signals and trans

34 duced Ca(2+) influx, some active in normally-myelinated axons (T-type channels, NCX), others active o

35 ronal processes, permitting us to survey all myelinated axons (the projectome).

36 d an important decrease in the percentage of myelinated axons and a substantial increase in the mean

37 a significant decrease in the percentage of myelinated axons and a substantial increase in the mean

38 affecting auditory ganglion cells and their myelinated axons and dendrites; and (iv) central neural

39 al role of the Nfasc gene in the function of myelinated axons and reveals further redundancy in the m

40 Myelinated axons are patterned into discrete and often-r

41 Thus, individual anatomical parameters of myelinated axons can be tuned to optimize pathways invol

42 Myelinated axons can conduct sustained trains of impulse

43 substantial increase in the mean g-ratio of myelinated axons compared with controls.

44 s (Kv1 channels) within the nodal complex of myelinated axons following injury.

45 Oligodendrocytes and myelinated axons have been identified as major targets o

46 relates of this adjacent injury in surviving myelinated axons have not been previously defined.

47 nerve fibres and significant degeneration of myelinated axons in both the distal sural nerve and nerv

48 duction of mature oligodendrocyte number and myelinated axons in gpr56 zebrafish mutants.

49 ccess to the nanostructural dynamics of live myelinated axons in health and disease.

50 diameter of the axon plus myelin sheath) of myelinated axons in regions subject to significant NPC-d

51 nique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and periphera

52 struction, and failure to produce adequately myelinated axons in the central nervous system (CNS).

53 ure oligodendrocytes and a reduced number of myelinated axons in the corpus callosum and optic nerves

54 elin basic protein, and decreased numbers of myelinated axons in the corpus callosum.

55 also established the feasibility of imaging myelinated axons in the human cerebral cortex.

56 particularly from the brainstem, and more SC-myelinated axons in the implants and improvement in hind

57 otein and a reduction in the total number of myelinated axons in the lesion.

58 domains (the paranode and juxtaparanode) of myelinated axons in the pathology of acquired, inflammat

59 not lose unmyelinated fibres in the skin or myelinated axons in the sural nerve and toe after vincri

60 ice displayed abnormal myelination and fewer myelinated axons in the white matter despite elevated OP

61 flected light, enabling nanoscale imaging of myelinated axons in their natural living state.

62 onal activity regulates oligodendrocytes and myelinated axons in vivo, with a focus on the timing of

63 Conduction in myelinated axons involves substantial ion movements that

64 cise fine-tuning of conduction along already-myelinated axons may also be mediated by alterations to

65 In peripheral myelinated axons of mammalian spinal motor neurons, Ca(2

66 ury, when nerve repair is normally advanced, myelinated axons of MEK1DD mutants demonstrated higher r

67 we quantitatively examined K(v)7 channels in myelinated axons of rat neocortical pyramidal neurons us

68 sm in humans to test whether alcohol damages myelinated axons of the prefrontal cortex.

69 We previously reported that pain and myelinated axons regenerating through a Y-shaped nerve g

70 tion potential initiation and propagation in myelinated axons require ion channel clustering at axon

71 es of Ranvier are the myelin-free gaps along myelinated axons that allow fast communication between n

72 Herceptin also increased the number of myelinated axons that regenerated 4 weeks after immediat

73 Finally, oligodendrocytes and myelinated axons were analyzed using stereology and cohe

74 eduction in major myelin proteins, 30% fewer myelinated axons, a 33% decrease in myelin thickness, an

75 icient mice of both sexes and found that, in myelinated axons, alphaII spectrin forms a periodic cyto

76 y describe the organization of myelin and of myelinated axons, as well as the functions of myelin in

77 own that white matter, primarily composed of myelinated axons, can also be dynamically regulated by a

78 In myelinated axons, it also enhances myelin thickness thro

79 ence of cerebral oedema, loss of neurons and myelinated axons, microglial proliferation and reactive

80 found at greater densities in large-diameter myelinated axons, suggesting that nodes are particularly

81 d filaments that extend longitudinally along myelinated axons.

82 substantial increase in the mean g-ratio of myelinated axons.

83 med in one case revealed subtotal absence of myelinated axons.

84 a general marker of damage to large-caliber myelinated axons.

85 preferential degeneration of large-diameter myelinated axons.

86 mechanism of current flux minimization along myelinated axons.

87 astructurally, and occurred in virtually all myelinated axons.

88 ction algorithm to identify and characterize myelinated axons.

89 apid propagation of the nerve impulses along myelinated axons.

90 establish functional membrane domains along myelinated axons.

91 nd efficient action potential propagation in myelinated axons.

92 preferential degeneration of large-diameter myelinated axons.

93 anges were accompanied by reduced numbers of myelinated axons.

94 ning the segregation of axonal domains along myelinated axons; however, the proteins required to orga

95 erved across the brain, particularly in late myelinating brain regions such as frontal white matter a

96 Not all axons are myelinated, but mechanisms directing myelination of spec

97 ma-immunoreactive interneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical

98 electrically active axons are preferentially myelinated by glial cells, and if so, whether axo-glial

99 ndicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

100 studies demonstrate that BiP is critical for myelinating cell survival and contributes to the protect

101 Dedicated adhesion molecules on myelinating cells and axons govern node organization.

102 for their timely differentiation to mature, myelinating cells and plays a crucial role in radial axo

103 Thus we propose that myelinating cells can regulate the neurofilament content

104 study, we constitutively overexpress CHOP in myelinating cells during development and into adulthood

105 Myelinating cells of the CNS [oligodendrocytes (OLs)] ar

106 ng development, oligodendrocytes (OLGs), the myelinating cells of the CNS, undergo a stepwise progres

107 Schwann cells (SCs) are myelinating cells of the PNS.

108 egenerated preOLs fail to normally mature to myelinating cells required for white matter growth.

109 Myelinating cells synthesize large amounts of membrane p

110 the effect of modulating ERK1/2 activity in myelinating cells using transgenic mouse lines in which

111 emarkably, when repair cells transit back to myelinating cells, they shorten approximately 7-fold to

112 o examine the potential importance of BiP to myelinating cells, we used a conditional knock-out appro

113 al progenitors that generate both classes of myelinating cells.

114 could, in fact, have detrimental effects on myelinating cells.

115 In the CNS, oligodendrocytes act as the myelinating cells.

116 oligodendrocyte progenitor cells (OPCs) into myelinating cells.

117 and proliferate before differentiating into myelinating cells.

118 on markedly amplified mechanical currents in myelinated, CGRP-negative neurons projecting to muscle.

119 Following inflammation of the hindpaw, myelinated, CGRP-positive neurons projecting to the paw

120 purified spinal cord neuron-oligodendrocyte myelinating co-culture system, we demonstrate that disru

121 Myelinating co-cultures using human induced pluripotent

122 uced for the first time long-term and stable myelinating co-cultures with human neurons.

123 a computational model of a single mammalian myelinated cochlear nerve fiber coupled to a stimulator-

124 unmyelinated segments of axons in long-term myelinating cocultures established from the dorsal root

125 Using purified SCs and myelinating cocultures, we demonstrate that localization

126 Evoked action potentials in the myelinated corpus callosum projections of Msh2-null mice

127 nificantly differed between demyelinated and myelinated cortex (p < 0.001).

128 tors activated during myelination by probing myelinating cultures and developing nerves with an antib

129 , in the strong coupling regime, relevant to myelinated dendritic trees, the spike train statistics c

130 Unmyelinated epidermal nerve fiber and myelinated dermal nerve fiber densities were quantified

131 Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated ne

132 and the pathobiology of various de- and dys-myelinating disorders.

133 on in certain sensory neurons, which possess myelinated distal dendritic tree-like arbors with excita

134 ires that oligodendrocytes and Schwann cells myelinate distinct central and peripheral nervous system

135 system that oligodendrocytes preferentially myelinate electrically active axons, but synapses from a

136 These cells myelinate fewer axons than in wild-type mice and, in cor

137 titative stereologic analysis showed reduced myelinated fiber length and density.

138 ignificantly reduced the ratio of abnormally myelinated fibers (p = 0.00148) and secondary inflammati

139 aPOZ mice are impaired in the maintenance of myelinated fibers and are a promising model for studying

140 ly large myelinated fibers, bortezomib small myelinated fibers and cisplatin damaged all types of mye

141 portance of sensory input in the building of myelinated fibers and suggest that this activity-depende

142 Sensory modalities that involved large Abeta myelinated fibers and unmyelinated C fibers were most af

143 Striking color patterns unique to individual myelinated fibers are generated that facilitate their tr

144 osarcoma, and irregularity and disruption of myelinated fibers in areas infiltrated by oligodendrogli

145 f IQCJ-SCHIP1 in vivo by studying peripheral myelinated fibers in Schip1 knock-out mutant mice.

146 The contribution of injury to myelinated fibers that was observed at P18 is probably a

147 ed fibers and cisplatin damaged all types of myelinated fibers to a similar degree.

148 We found evidence for two classes of myelinated fibers within the pinniped optic nerve, those

149 ect on neurite outgrowth and regeneration of myelinated fibers without affecting unmyelinated DRG neu

150 itaxel and vincristine affected mostly large myelinated fibers, bortezomib small myelinated fibers an

151 eous observation of neuronal cell bodies and myelinated fibers, we were able to correlate subnuclear

152 out affecting other structural properties of myelinated fibers.

153 l regions for action potential conduction in myelinated fibers.

154 ls because the organization and abundance of myelinated fibres in this region make the RVM a challeng

155 ce-labelling of paranodal proteins of dermal myelinated fibres revealed disruption of paranodal archi

156 Loss of large-myelinated fibres was a uniform feature in a total of 21

157 Studies of myelinated fibres, however, show that voltage-gated sodi

158 ed by immunofluorescence labelling of dermal myelinated fibres.

159 ation of MEP glia resulted in the absence of myelinating glia along spinal motor root axons and an im

160 -specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infection.

161 at mediate interactions between the axon and myelinating glia at the nodal gap (i.e., NF186) and the

162 ory networks and mechanisms in both types of myelinating glia but that the exact mode of action and t

163 re, we reveal a novel and important role for myelinating glia in regulating synapse elimination at th

164 Schwann cells are myelinating glia in the peripheral nervous system that f

165 drocytes (OLs) and Schwann cells (SWCs), the myelinating glia of central and peripheral nervous syste

166 uring CNS development, oligodendrocytes, the myelinating glia of the CNS, progress through multiple t

167 Schwann cells, the myelinating glia of the peripheral nervous system (PNS),

168 Schwann cells are the myelinating glia of the peripheral nervous system and dy

169 xpression is conditionally eliminated in the myelinating glia of transgenic mice, myelin initiation i

170 Myelinating glia play a fundamental role in promoting th

171 Schwann cells, the peripheral nervous system myelinating glia, are found remyelinating demyelinated r

172 nsic, cytoskeletal mechanisms and extrinsic, myelinating glia-dependent mechanisms.

173 ls at the nodes of Ranvier is coordinated by myelinating glia.

174 which forms a novel pathway to control AS in myelinating glia.

175 rocyte progenitor cells (OPCs), the resident myelinating glial cell of the CNS, into the periphery.

176 a prodeath protein, and we demonstrate that myelinating glial cells function normally in the presenc

177 Following perturbations to peripheral myelinating glial cells, centrally derived oligodendrocy

178 Although large, myelinated group A fibers, in particular Abeta-fibers, h

179 a-afferent neurons, or in Schwann cells that myelinate Ia-afferent axons remains unresolved.

180 ascending (CoPA) neurons are among the first myelinated in the zebrafish CNS.

181 uctural plasticity has come to light for the myelinated infrastructure of the nervous system.

182 st sort and ensheathe a single axon and then myelinate it.

183 d that Ube3a is expressed monoallelically in myelinated large-diameter neurons and biallelically in u

184 ssed from the maternally inherited allele in myelinated large-diameter sensory neurons and biallelica

185 d with the appearance of multi-branched 'pre-myelinating' MBP+ / PLP+ oligodendrocytes that interact

186 The Ca(2+) that enters myelinated motor axons during normal activity is likely

187 sin-positive synapses or mtHSP70 was seen in myelinated MS hippocampi, further pointing toward a link

188 tional ordering of membrane compounds in the myelinated nerve fiber by means of polarized Raman micro

189 ermal nerve fiber density, as well as dermal myelinated nerve fiber density, which persisted througho

190 erest because the global effects of aging on myelinated nerve fibers are more complex and profound th

191 Although the development of myelinated nerve fibers was not impaired, Miz1DeltaPOZ m

192 sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic featu

193 ction, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic n

194 sent a new method to quantify differences in myelinated nerve fibers.

195 adhesion molecules, such as MAG, present in myelinated nerve fibers.

196 14 cutaneous nerve biopsies revealed loss of myelinated nerve fibres (86%), increased regenerative cl

197 o myelinate developing nerve and to maintain myelinated nerve in adulthood.

198 Rapid nerve conduction in myelinated nerves requires the clustering of voltage-gat

199 Fast, saltatory conduction in myelinated nerves requires the clustering of voltage-gat

200 response protein 2) transcription factors in myelinated nerves.

201 e significantly impaired in their ability to myelinate neurites in vitro To our knowledge, this is th

202 induced alteration of paranodal junctions in myelinated neuronal culture.

203 t that mechanical sensitization can occur in myelinated neurons after inflammation.

204 Nodes of Ranvier in the axons of myelinated neurons are exemplars of the specialized cell

205 A second channel found in larger myelinated neurons, Nav1.6, subsequently evolved resista

206 nclude a small population of CGRP-expressing myelinated nociceptors that we now identify as the somat

207 d particularly the morphologically distinct, myelinated, nodose-derived mechanoreceptors described in

208 lls with the potential to differentiate into myelinating OLGs.

209 nitor cells, differentiate into fully mature myelinating OLGs.

210 programs governing myelination, and acts on myelinating oligodendrocyte (OL) cells across the human

211 1/5/8 and inhibits OPC differentiation into myelinating oligodendrocytes (OLs) while promoting an as

212 ied by an important decline in the number of myelinating oligodendrocytes and in the rate of OPC prol

213 ied by an important decline in the number of myelinating oligodendrocytes and in the rate of OPC prol

214 isms regulate expression of zebrafish mpz in myelinating oligodendrocytes and its induction following

215 In the vertebrate central nervous system, myelinating oligodendrocytes are postmitotic and derive

216 Hence, we developed a protocol to generate myelinating oligodendrocytes from mouse embryonic stem c

217 development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem r

218 lyzed the role of Brg1 during development of myelinating oligodendrocytes in the CNS of the mouse.

219 te precursor cells are the primary source of myelinating oligodendrocytes in the neonatal CNS.

220 utonomous role of impaired eIF2B activity in myelinating oligodendrocytes in the pathogenesis of VWMD

221 The differentiation of these cells into myelinating oligodendrocytes is characterized by tempora

222 mate instruct OPCs to differentiate into new myelinating oligodendrocytes that recover lost function.

223 o, we selectively eliminated DCC from mature myelinating oligodendrocytes using an inducible cre regu

224 cursor cells, newly formed oligodendrocytes, myelinating oligodendrocytes, microglia, endothelial cel

225 In addition to serving as progenitors of myelinating oligodendrocytes, NG2 glia might also fulfil

226 areas or OPCs in lesions may not mature into myelinating oligodendrocytes.

227 rocyte development, but are downregulated in myelinating oligodendrocytes.

228 l nervous system and the principal source of myelinating oligodendrocytes.

229 PCs, resulting in their differentiation into myelinating oligodendrocytes.

230 ytes and found in a subset of presumably new myelinating oligodendrocytes.

231 cells but also in terminally differentiated, myelinating oligodendrocytes.

232 e progenitor cells from differentiating into myelinating oligodendrocytes.

233 A subpopulation of pre-myelinating OLs (pre-OLs) can generate Nav1.2-driven act

234 n OPs prevents their development into mature myelinating OLs, leading to SCWM hypomyelination in mice

235 is selectively expressed in differentiating/myelinating OLs.

236 When myelinated optic nerves from conditional NMDA receptor m

237 injured spinal cord; invasion of peripheral myelinating (P0+) Schwann cells made only a limited cont

238 hich OPCs migrate out of the spinal cord and myelinate peripheral motor axons, we assayed perineurial

239 (OPCs) ectopically exit the spinal cord and myelinate peripheral nerves in myelin with CNS character

240 poorly, sort axons inefficiently, and cannot myelinate peripheral nerves.

241 12 status displayed improved conductivity in myelinated peripheral nerves after vitamin B-12 treatmen

242 ced consistent improvements in conduction in myelinated peripheral nerves; the sensory latency of bot

243 While oligodendrocytes are capable of myelinating permissive structures in the absence of mole

244 myelinated retinal nerve fiber layer and the myelinated post-laminar axons, as well as olygodendrocyt

245 e interneurons appear to receive exclusively myelinated primary afferents in type II synaptic glomeru

246 That only myelinated primary afferents were found to contact PKCga

247 f active enhancers, to identify enhancers in myelinating rat peripheral nerve and their dynamics afte

248 lasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show

249 tra-axonal diffusion microenvironment; while myelinated regions showed no changes.

250 De, perpendicular in both premyelination and myelinated regions, indicative of both intra- and extra-

251 Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy.

252 hich reveal remarkable bilateral symmetry in myelinated reticulospinal and lateral line afferent axon

253 driving axonal wrapping by unmyelinated and myelinated Schwann cells and enhancing myelin protein sy

254 While DRG neurons express MCT1, myelinating Schwann cells (SCs) coexpress MCT1 and MCT4

255 g SMA mice selectively overexpressing SMN in myelinating Schwann cells (Smn(-/-);SMN2(tg/0);SMN1(SC))

256 Autophagy was up-regulated by myelinating Schwann cells after nerve injury, myelin deb

257 which correlated with a reduced presence of myelinating Schwann cells and increased numbers of nonmy

258 which correlated with diminished numbers of myelinating Schwann cells and severe PNS hypomyelination

259 microscopy (THGM) for label-free imaging of myelinating Schwann cells in live culture and ex vivo an

260 itionally deleted the MHC-II beta-chain from myelinating Schwann cells in mice and investigated how t

261 OPCs also produced the majority of myelinating Schwann cells in the injured spinal cord; in

262 tes in the central nervous system (CNS), non-myelinating Schwann cells in the peripheral nervous syst

263 Myelinating Schwann cells in the vertebrate peripheral n

264 We demonstrate that deletion of MHC-II in myelinating Schwann cells reduces thermal hyperalgesia a

265 To develop a gene therapy approach targeting myelinating Schwann cells that can be translatable, we d

266 We report for the first time, defects in myelinating Schwann cells, enteric neurons and pigment c

267 ed domains formed by axonal interaction with myelinating Schwann cells, such as clustered voltage-gat

268 ls and enhancing myelin protein synthesis in myelinating Schwann cells.

269 Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated anim

270 t led to abnormalities in nonmyelinating and myelinating SCs in the later phases of nerve repair, res

271 nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in sev

272 The myelinated segments contained more neurofilaments and ha

273 ARTN promotes robust regeneration of large, myelinated sensory afferents.

274 between db/db and db/+ mice studies of large myelinated sensory and motor nerves.

275 morphology of small unmyelinated as well as myelinated sensory axons and relate such changes to soma

276 chanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury.

277 nly stimulates robust regeneration of large, myelinated sensory axons to the brainstem, but also prom

278 cells of C3 nerves serves to prevent loss of myelinated sensory axons, particularly in distal nerves,

279 associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over

280 modalities mediated by both unmyelinated and myelinated sensory axons.

281 P), peptidergic nociceptors (PEP), and large myelinated sensory neurons (LM) under both control and i

282 low morphological and Ca(2+) changes in live myelinated spinal axons acutely following injury.

283 de novo ensheathment of approximately 30% of myelinated spinal axons at injury epicenter 3 months aft

284 xcitability in relation to maturation to the myelinating stage are controversial, although oligodendr

285 ), primarily localized by Perls' staining to myelinated structures.

286 larly vulnerable brain compartment, the late myelinating superficial white matter.

287 ctional recovery are usually worse for large myelinated than for small sensory axons.

288 ciation cortical areas were thicker and less myelinated than primary cortical areas at 14 y.

289 emonstrate that iPSC-derived OL disperse and myelinate the CNS of Mbp(shi/shi)Rag(-/-) mice during de

290 progenitor cells (hGPCs) densely engraft and myelinate the hypomyelinated shiverer mouse.

291 We further show that, when SCs become myelinating, they downregulate functional AMPARs.

292 Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the rema

293 hus, microglia and low-grade inflammation of myelinated tracts emerged as the trigger of a previously

294 ain by the predominant (95%) large-diameter, myelinated type I afferents, each of which is postsynapt

295 ate to activate AMPA-type receptors on these myelinated type-I neurons, which carry the neuronal sign

296 l recovery is accompanied by preservation of myelinated white matter and motor neurons and an increas

297 Myelinated white matter supports the speed of electrical

298 Late-myelinating white matter is more susceptible to age-rela

299 susceptible to age-related change than early-myelinating white matter, consistent with the retrogenes

300 mouse optic nerve, which is a pure and fully myelinated WM tract, aging axons are larger, have thicke