ライフサイエンスコーパス: myelinated

1 cytoskeleton organization and are generally myelinated.

2 proximately 1 mum in diameter if they become myelinated.

3 derlying axonal bundles become progressively myelinated.

4 , in which practically all axons are already myelinated.

5 ons (<2 mum), approximately 60% of which are myelinated.

6 onding to fast temporal frequencies are more myelinated.

7 ections of cholera toxin subunit B (CTB) for myelinated A fibers and isolectin B4 (IB4) for unmyelina

8 min) induced bursts of action potentials in myelinated A, but not unmyelinated C-fibers.

9 ompared the intrinsic excitability of single myelinated A- and Adelta-axons from excised cervical vag

10 tle between genotypes, Kv1.1-deficient large myelinated A-axons showed a fivefold increase in suscept

11 ves, unmyelinated C-fibers usually outnumber myelinated A-fibers.

12 ha3 subunit immunoreactivity; terminals from myelinated (Abeta/Adelta) fibers were colabeled in rough

13 hereas sensory modalities conveyed by thinly myelinated Adelta fibers were less sensitive to chemothe

14 cludes both unmyelinated C-fibres and thinly myelinated Adelta nerve fibres.

15 ogeneous group of disorders affecting thinly myelinated Adelta-fibres and unmyelinated C-fibres.

16 PERK activation in oligodendrocytes of fully myelinated adult mice had minimal effects on morphology

17 t but that increases in internodal length of myelinated adult nerve axons do not result in either def

18 able model of motoneurons, interneurons, and myelinated afferent fibers for antagonistic ankle muscle

19 istinct, 200-kD neurofilament-immunopositive myelinated afferent fibers, a subpopulation of which did

20 rans-synaptically through the recruitment of myelinated afferent fibers.

21 minae I-II with normal unmyelinated and thin myelinated afferents labeled with calcitonin gene-relate

22 ciceptors and more sparsely by low-threshold myelinated afferents.

23 unonegative nerves are strikingly similar to myelinated airway afferents, the cough receptor, and smo

24 in relation to neuropathological changes in myelinated and demyelinated hippocampi from postmortem M

25 As (miRNAs), we compared miRNA profiles from myelinated and demyelinated hippocampi from postmortem M

26 pared morphological and molecular changes in myelinated and demyelinated hippocampi from postmortem M

27 pression and C3 activation were increased in myelinated and demyelinated MS hippocampi, mainly in the

28 ly unimodal association cortices are heavily myelinated and higher, multimodal, association cortices

29 Engraftment of human GPCs in normally myelinated and immunodeficient mice resulted in humanize

30 pe resolution, parabrachiothalamic axons are myelinated and make large boutons, forming multiple asym

31 ells is required for proper function of both myelinated and nonmyelinated nerve fibers.

32 rves, ERK1/2 phosphorylation was observed in myelinated and nonmyelinating SCs.

33 The auditory system is heavily myelinated and operates at the upper limits of action po

34 AAVrh10 has higher tropic affinity to large myelinated and small peptidergic sensory neurons that in

35 gical and functional studies to assess large myelinated and small unmyelinated axons in the db/db typ

36 rate that GFRalpha3 expression is similar in myelinated and unmyelinated adult sensory neurons, sugge

37 ch, (3) cowhage activates a subpopulation of myelinated and unmyelinated afferents in monkey, (4) the

38 lectrical and pharmacological stimulation of myelinated and unmyelinated axons, respectively.

39 unmyelinated fibers, despite a loss in both myelinated and unmyelinated axons.

40 erve increased mitochondrial traffic in both myelinated and unmyelinated axons.

41 e of the response to cowhage is different in myelinated and unmyelinated fibers, (5) the time of peak

42 ics of neurofilament transport in contiguous myelinated and unmyelinated segments of axons in long-te

43 long-distance (>25 mm) regeneration of both myelinated and unmyelinated sensory axons with topograph

44 CTb was found in both myelinated and unmyelinated vagal axons and terminals in

45 evaluated at intraorbital (unmyelinated and myelinated) and intracranial sections.

46 The radiate commissural axons are thick and myelinated, and they exit the dorsal acoustic stria of t

47 nections, dense projections from the frontal myelinated area (FM), and moderate projections from S2 a

48 ptide2 antibody showed higher binding to the myelinated areas of treated than untreated EAE mice.

49 first quantitatively characterize the highly myelinated auditory core in terms of shape, area, cortic

50 A reduction in the number of myelinated auditory nerve fibers leads to a reduced maxi

51 ls, and exclusively supports large-diameter, myelinated axon conduction during aglycemia.

52 ssive MS is mainly due to the higher rate of myelinated axon degeneration, coupled to the lower capac

53 omprises the paranodal barriers required for myelinated axon domain organization.

54 In this study, we quantified myelinated axon fiber length density and the expression

55 ipheral nerve development, each segment of a myelinated axon is matched with a single Schwann cell.

56 Distal myelinated axon outgrowth after 4 weeks was quantified u

57 their myelin sheaths to fully understand how myelinated axon plasticity contributes to neuronal circu

58 fies a mechanism selectively contributing to myelinated axon regeneration, and point out the role of

59 rd, expression of Nogo-A was associated with myelinated axon tracts and upregulated in oligodendrocyt

60 vier is a functionally important site on the myelinated axon where sodium channels are clustered and

61 d an inhibitory effect on OPCs and decreased myelinated axonal segments in cocultures with neurons fr

62 at GlcNAc6ST-1 modulates PNS myelination and myelinated axonal survival through the GlcNAc-6-O-sulfat

63 uring aglycemia, conduction failure in large myelinated axons (A fibers) mirrored the time course of

64 duced Ca(2+) influx, some active in normally-myelinated axons (T-type channels, NCX), others active o

65 ronal processes, permitting us to survey all myelinated axons (the projectome).

66 a significant decrease in the percentage of myelinated axons and a substantial increase in the mean

67 d an important decrease in the percentage of myelinated axons and a substantial increase in the mean

68 affecting auditory ganglion cells and their myelinated axons and dendrites; and (iv) central neural

69 al role of the Nfasc gene in the function of myelinated axons and reveals further redundancy in the m

70 opy showed a reduction in both the number of myelinated axons and the average diameter of myelin surr

71 Myelinated axons are patterned into discrete and often-r

72 rmittent fasting increased the proportion of myelinated axons as well as myelin sheath thickness in l

73 ry both in the nerve size and the density of myelinated axons at 7 months in almost half of the optic

74 n serves to compartmentalize the membrane of myelinated axons at specific locations that are determin

75 Thus, individual anatomical parameters of myelinated axons can be tuned to optimize pathways invol

76 Myelinated axons can conduct sustained trains of impulse

77 substantial increase in the mean g-ratio of myelinated axons compared with controls.

78 otypic improvement in transplanted shi/shis, myelinated axons exhibited faster conduction, lower acti

79 s (Kv1 channels) within the nodal complex of myelinated axons following injury.

80 return to the levels in nondemyelinated and myelinated axons following remyelination.

81 In DRG neurons and peripheral myelinated axons from Scn8a(med/med) mice, which lack fu

82 Oligodendrocytes and myelinated axons have been identified as major targets o

83 to the distance between nodes of Ranvier in myelinated axons have implications for nervous system fu

84 relates of this adjacent injury in surviving myelinated axons have not been previously defined.

85 Myelinated axons histologically measured using BLFB were

86 nerve fibres and significant degeneration of myelinated axons in both the distal sural nerve and nerv

87 duction of mature oligodendrocyte number and myelinated axons in gpr56 zebrafish mutants.

88 ccess to the nanostructural dynamics of live myelinated axons in health and disease.

89 ondria within demyelinated, remyelinated and myelinated axons in post-mortem tissue from patients wit

90 diameter of the axon plus myelin sheath) of myelinated axons in regions subject to significant NPC-d

91 nique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and periphera

92 struction, and failure to produce adequately myelinated axons in the central nervous system (CNS).

93 ure oligodendrocytes and a reduced number of myelinated axons in the corpus callosum and optic nerves

94 elin basic protein, and decreased numbers of myelinated axons in the corpus callosum.

95 also established the feasibility of imaging myelinated axons in the human cerebral cortex.

96 particularly from the brainstem, and more SC-myelinated axons in the implants and improvement in hind

97 otein and a reduction in the total number of myelinated axons in the lesion.

98 domains (the paranode and juxtaparanode) of myelinated axons in the pathology of acquired, inflammat

99 not lose unmyelinated fibres in the skin or myelinated axons in the sural nerve and toe after vincri

100 Kv1.1 channels cluster at juxtaparanodes of myelinated axons in the vagus nerve, the primary conduit

101 ice displayed abnormal myelination and fewer myelinated axons in the white matter despite elevated OP

102 flected light, enabling nanoscale imaging of myelinated axons in their natural living state.

103 causes intrinsic hyperexcitability in large myelinated axons in vagus nerve which could contribute t

104 onal activity regulates oligodendrocytes and myelinated axons in vivo, with a focus on the timing of

105 In chimpanzees, the density of myelinated axons increased steadily until adult-like lev

106 The precise and remarkable subdivision of myelinated axons into molecularly and functionally disti

107 Conduction in myelinated axons involves substantial ion movements that

108 rgeting and maintenance of axonal domains in myelinated axons is essential for saltatory conduction.

109 cise fine-tuning of conduction along already-myelinated axons may also be mediated by alterations to

110 In peripheral myelinated axons of mammalian spinal motor neurons, Ca(2

111 ury, when nerve repair is normally advanced, myelinated axons of MEK1DD mutants demonstrated higher r

112 we quantitatively examined K(v)7 channels in myelinated axons of rat neocortical pyramidal neurons us

113 sm in humans to test whether alcohol damages myelinated axons of the prefrontal cortex.

114 We previously reported that pain and myelinated axons regenerating through a Y-shaped nerve g

115 tion potential initiation and propagation in myelinated axons require ion channel clustering at axon

116 Rapid action potential propagation in myelinated axons requires Na(+) channel clustering at no

117 es of Ranvier are the myelin-free gaps along myelinated axons that allow fast communication between n

118 Herceptin also increased the number of myelinated axons that regenerated 4 weeks after immediat

119 etylcholinesterase (AChE) and the density of myelinated axons throughout postnatal development in the

120 ankyrin-spectrin protein complexes exist in myelinated axons to cluster Na(+) channels at nodes of R

121 cemia and is passed, probably as lactate, to myelinated axons to support function.

122 Finally, oligodendrocytes and myelinated axons were analyzed using stereology and cohe

123 Myelinated axons were fewer, and g-ratios of those that

124 In myelinated axons within the central nervous system, over

125 eduction in major myelin proteins, 30% fewer myelinated axons, a 33% decrease in myelin thickness, an

126 icient mice of both sexes and found that, in myelinated axons, alphaII spectrin forms a periodic cyto

127 y describe the organization of myelin and of myelinated axons, as well as the functions of myelin in

128 own that white matter, primarily composed of myelinated axons, can also be dynamically regulated by a

129 where CASPR2 organizes nodal microdomains of myelinated axons, CASPR2 performs an earlier organizatio

130 In myelinated axons, it also enhances myelin thickness thro

131 In myelinated axons, Kv1 (Shaker) voltage-gated potassium (

132 ence of cerebral oedema, loss of neurons and myelinated axons, microglial proliferation and reactive

133 as more sensitive to injury than neighboring myelinated axons, smaller axons yet to initiate radial e

134 found at greater densities in large-diameter myelinated axons, suggesting that nodes are particularly

135 astructurally, and occurred in virtually all myelinated axons.

136 ction algorithm to identify and characterize myelinated axons.

137 apid propagation of the nerve impulses along myelinated axons.

138 establish functional membrane domains along myelinated axons.

139 e morphological features of unmyelinated and myelinated axons.

140 f unmyelinated sensory axons and a subset of myelinated axons.

141 ural activity in endogenous unmyelinated and myelinated axons.

142 ebral cortex contains significant amounts of myelinated axons.

143 the number of surviving oligodendrocytes and myelinated axons.

144 for energy production and glucose supply in myelinated axons.

145 nd efficient action potential propagation in myelinated axons.

146 se cells appear to be engulfing degenerating myelinated axons.

147 demyelinated axons but more numerous than in myelinated axons.

148 r long-term maintenance of axonal domains in myelinated axons.

149 organization and saltatory conduction along myelinated axons.

150 preferential degeneration of large-diameter myelinated axons.

151 anges were accompanied by reduced numbers of myelinated axons.

152 d filaments that extend longitudinally along myelinated axons.

153 substantial increase in the mean g-ratio of myelinated axons.

154 med in one case revealed subtotal absence of myelinated axons.

155 preferential degeneration of large-diameter myelinated axons.

156 a general marker of damage to large-caliber myelinated axons.

157 mechanism of current flux minimization along myelinated axons.

158 ature oligodendrocytes and normal numbers of myelinated axons; however, myelin thickness was signific

159 ning the segregation of axonal domains along myelinated axons; however, the proteins required to orga

160 l content within remyelinated, compared with myelinated, axons was due to an increase in density of p

161 ny large- and intermediate-caliber axons are myelinated but show structural defects at nodes of Ranvi

162 Not all axons are myelinated, but mechanisms directing myelination of spec

163 ma-immunoreactive interneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical

164 modal, association cortices are more lightly myelinated, but there are notable exceptions in the lite

165 electrically active axons are preferentially myelinated by glial cells, and if so, whether axo-glial

166 reidentifiable fibers also became partially myelinated by the third naupliar stage.

167 on markedly amplified mechanical currents in myelinated, CGRP-negative neurons projecting to muscle.

168 Following inflammation of the hindpaw, myelinated, CGRP-positive neurons projecting to the paw

169 a computational model of a single mammalian myelinated cochlear nerve fiber coupled to a stimulator-

170 Evoked action potentials in the myelinated corpus callosum projections of Msh2-null mice

171 nificantly differed between demyelinated and myelinated cortex (p < 0.001).

172 , in the strong coupling regime, relevant to myelinated dendritic trees, the spike train statistics c

173 Unmyelinated epidermal nerve fiber and myelinated dermal nerve fiber densities were quantified

174 on in certain sensory neurons, which possess myelinated distal dendritic tree-like arbors with excita

175 n a subset of nonpeptidergic nociceptors and myelinated dorsal root ganglia neurons.

176 Visualization of myelinated fiber arrangements, cytoarchitecture, and pro

177 betic mice, resulted in significantly higher myelinated fiber densities and conduction velocities con

178 ld be determined along an extended length of myelinated fiber in the physiological condition.

179 titative stereologic analysis showed reduced myelinated fiber length and density.

180 that the IC and MGC exhibit relatively high myelinated fiber length density (MFLD) values at birth a

181 ignificantly reduced the ratio of abnormally myelinated fibers (p = 0.00148) and secondary inflammati

182 aPOZ mice are impaired in the maintenance of myelinated fibers and are a promising model for studying

183 ly large myelinated fibers, bortezomib small myelinated fibers and cisplatin damaged all types of mye

184 portance of sensory input in the building of myelinated fibers and suggest that this activity-depende

185 Sensory modalities that involved large Abeta myelinated fibers and unmyelinated C fibers were most af

186 Striking color patterns unique to individual myelinated fibers are generated that facilitate their tr

187 osarcoma, and irregularity and disruption of myelinated fibers in areas infiltrated by oligodendrogli

188 l lines of evidence for an important role of myelinated fibers in cowhage-induced itch: (1) a selecti

189 icroscopic comparison of the organization of myelinated fibers in lateral olfactory tract in the ante

190 f IQCJ-SCHIP1 in vivo by studying peripheral myelinated fibers in Schip1 knock-out mutant mice.

191 In addition, most of the fine myelinated fibers projecting from the corpus callosum in

192 ed itch: (1) a selective conduction block in myelinated fibers substantially reduces itch in a subgro

193 The contribution of injury to myelinated fibers that was observed at P18 is probably a

194 ed fibers and cisplatin damaged all types of myelinated fibers to a similar degree.

195 We found evidence for two classes of myelinated fibers within the pinniped optic nerve, those

196 ect on neurite outgrowth and regeneration of myelinated fibers without affecting unmyelinated DRG neu

197 d itch matches the time for peak response in myelinated fibers, and (6) the time for peak itch sensat

198 itaxel and vincristine affected mostly large myelinated fibers, bortezomib small myelinated fibers an

199 ous and evoked neuronal hyperexcitability in myelinated fibers, coupled with development of neuropath

200 eous observation of neuronal cell bodies and myelinated fibers, we were able to correlate subnuclear

201 se novel connective tissues are comprised of myelinated fibers, with reduced myelin basic protein lev

202 morphometric changes in distal tibial nerve myelinated fibers.

203 y enters the brain and specifically binds to myelinated fibers.

204 l regions for action potential conduction in myelinated fibers.

205 out affecting other structural properties of myelinated fibers.

206 ls because the organization and abundance of myelinated fibres in this region make the RVM a challeng

207 ce-labelling of paranodal proteins of dermal myelinated fibres revealed disruption of paranodal archi

208 Loss of large-myelinated fibres was a uniform feature in a total of 21

209 Studies of myelinated fibres, however, show that voltage-gated sodi

210 ed by immunofluorescence labelling of dermal myelinated fibres.

211 Although large, myelinated group A fibers, in particular Abeta-fibers, h

212 In contrast, myelinated hair mechanoreceptive afferents proportionall

213 d approximately 47% of large fiber axons are myelinated in les spinal cord.

214 ascending (CoPA) neurons are among the first myelinated in the zebrafish CNS.

215 uctural plasticity has come to light for the myelinated infrastructure of the nervous system.

216 d that Ube3a is expressed monoallelically in myelinated large-diameter neurons and biallelically in u

217 ssed from the maternally inherited allele in myelinated large-diameter sensory neurons and biallelica

218 Axons of various hippocampal neurons are myelinated mainly postnatally, which is important for th

219 t DOR activation at the central terminals of myelinated mechanoreceptors depresses synaptic input to

220 opioid receptor (DOR), which is expressed by myelinated mechanoreceptors that form Meissner corpuscle

221 nsient neurons are large- or medium-diameter myelinated mechanoreceptors that form the Merkel cell-ne

222 The Ca(2+) that enters myelinated motor axons during normal activity is likely

223 sin-positive synapses or mtHSP70 was seen in myelinated MS hippocampi, further pointing toward a link

224 tional ordering of membrane compounds in the myelinated nerve fiber by means of polarized Raman micro

225 ermal nerve fiber density, as well as dermal myelinated nerve fiber density, which persisted througho

226 erest because the global effects of aging on myelinated nerve fibers are more complex and profound th

227 Although the development of myelinated nerve fibers was not impaired, Miz1DeltaPOZ m

228 sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic featu

229 ction, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic n

230 sent a new method to quantify differences in myelinated nerve fibers.

231 adhesion molecules, such as MAG, present in myelinated nerve fibers.

232 14 cutaneous nerve biopsies revealed loss of myelinated nerve fibres (86%), increased regenerative cl

233 o myelinate developing nerve and to maintain myelinated nerve in adulthood.

234 Fast, saltatory conduction in myelinated nerves requires the clustering of voltage-gat

235 Rapid nerve conduction in myelinated nerves requires the clustering of voltage-gat

236 in the spinal cord and peripherally in large myelinated nerves.

237 response protein 2) transcription factors in myelinated nerves.

238 induced alteration of paranodal junctions in myelinated neuronal culture.

239 t that mechanical sensitization can occur in myelinated neurons after inflammation.

240 the slowing of conduction velocity in large myelinated neurons and a lack of understanding of the ba

241 Nodes of Ranvier in the axons of myelinated neurons are exemplars of the specialized cell

242 tral nervous system, predominantly involving myelinated neurons of the brain, spinal cord, and optic

243 A second channel found in larger myelinated neurons, Nav1.6, subsequently evolved resista

244 nclude a small population of CGRP-expressing myelinated nociceptors that we now identify as the somat

245 d particularly the morphologically distinct, myelinated, nodose-derived mechanoreceptors described in

246 in gene-related peptide and substance P) and myelinated non-nociceptive fibers (positive for neurofil

247 When myelinated optic nerves from conditional NMDA receptor m

248 sis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small

249 In myelinated peripheral axons, Kv1 potassium channels are

250 12 status displayed improved conductivity in myelinated peripheral nerves after vitamin B-12 treatmen

251 ced consistent improvements in conduction in myelinated peripheral nerves; the sensory latency of bot

252 d partly by early-born neurons destined to a myelinated phenotype participate in fating late-born RUN

253 myelinated retinal nerve fiber layer and the myelinated post-laminar axons, as well as olygodendrocyt

254 preparation for detailed investigation and a myelinated preparation for validation, we report that it

255 e interneurons appear to receive exclusively myelinated primary afferents in type II synaptic glomeru

256 That only myelinated primary afferents were found to contact PKCga

257 reflecting a glial response to pathology in myelinated projection fibers.

258 ytes ensures that all relevant CNS axons are myelinated properly.

259 esulted in higher density and larger size of myelinated radial nerve fibers, sprouting of fibers into

260 found to distribute preferentially in highly myelinated regions and was able to detect regions of foc

261 found that MASS1 protein is enriched in the myelinated regions of the superior and inferior collicul

262 tra-axonal diffusion microenvironment; while myelinated regions showed no changes.

263 De, perpendicular in both premyelination and myelinated regions, indicative of both intra- and extra-

264 etermines whether an individual axon becomes myelinated remains unknown.

265 hich reveal remarkable bilateral symmetry in myelinated reticulospinal and lateral line afferent axon

266 driving axonal wrapping by unmyelinated and myelinated Schwann cells and enhancing myelin protein sy

267 tion of an inducible Raf-kinase transgene in myelinated Schwann cells is sufficient to control this p

268 Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated anim

269 fied profiles, including a new pattern where myelinated segments are interspersed with long, unmyelin

270 The myelinated segments contained more neurofilaments and ha

271 ARTN promotes robust regeneration of large, myelinated sensory afferents.

272 between db/db and db/+ mice studies of large myelinated sensory and motor nerves.

273 morphology of small unmyelinated as well as myelinated sensory axons and relate such changes to soma

274 chanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury.

275 nly stimulates robust regeneration of large, myelinated sensory axons to the brainstem, but also prom

276 ment-200, which is commonly used to identify myelinated sensory axons within organs.

277 cells of C3 nerves serves to prevent loss of myelinated sensory axons, particularly in distal nerves,

278 associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over

279 modalities mediated by both unmyelinated and myelinated sensory axons.

280 efects of the JAM-C SC KO animals, on finely myelinated sensory nerve fibers.

281 Diminished Kv9.1 function also augmented myelinated sensory neuron excitability, manifested as sp

282 P), peptidergic nociceptors (PEP), and large myelinated sensory neurons (LM) under both control and i

283 assium channel subunit Kv9.1 is expressed in myelinated sensory neurons, but is absent from small unm

284 rge caliber Mauthner axon is the first to be myelinated (shortly before axons of smaller caliber) and

285 low morphological and Ca(2+) changes in live myelinated spinal axons acutely following injury.

286 de novo ensheathment of approximately 30% of myelinated spinal axons at injury epicenter 3 months aft

287 ), primarily localized by Perls' staining to myelinated structures.

288 ctional recovery are usually worse for large myelinated than for small sensory axons.

289 ciation cortical areas were thicker and less myelinated than primary cortical areas at 14 y.

290 Neonatally engrafted hiPSC OPCs robustly myelinated the brains of myelin-deficient shiverer mice

291 (+) cells were highly migratory and robustly myelinated the hypomyelinated shiverer mouse brain more

292 likely to be partially, and then completely, myelinated, the latter having a lower ratio of axon core

293 Conversely, the distribution of myelinated tracts along the length of axons has been ass

294 hus, microglia and low-grade inflammation of myelinated tracts emerged as the trigger of a previously

295 t the white matter, most markedly in heavily myelinated tracts.

296 ain by the predominant (95%) large-diameter, myelinated type I afferents, each of which is postsynapt

297 ate to activate AMPA-type receptors on these myelinated type-I neurons, which carry the neuronal sign

298 naptically modulate afferent transmission by myelinated, unmyelinated, and peptidergic afferents in t

299 were fewer, and g-ratios of those that were myelinated were increased in erbin(-/-) mice, which were

300 l recovery is accompanied by preservation of myelinated white matter and motor neurons and an increas

301 Myelinated white matter supports the speed of electrical

302 mouse optic nerve, which is a pure and fully myelinated WM tract, aging axons are larger, have thicke