ライフサイエンスコーパス: myelitis

1 nalyzed a cohort of 22 patients with SLE and myelitis.

2 -IgG and its application to acute transverse myelitis.

3 e useful prognostic indicators in transverse myelitis.

4 n evolving understanding of acute transverse myelitis.

5 setting of a paraneoplastic acute transverse myelitis.

6 es in inflammatory non-infectious transverse myelitis.

7 rience with West Nile virus encephalitis and myelitis.

8 therapy of West Nile virus encephalitis and myelitis.

9 aracterized by attacks of optic neuritis and myelitis.

10 diagnosed as NMOSD or idiopathic transverse myelitis.

11 io-like neurological disorder, acute flaccid myelitis.

12 PE/IA may increase recovery in isolated myelitis.

13 me (GBS), meningoencephalitis, or transverse myelitis.

14 sporadically in patients with acute flaccid myelitis.

15 IFN signaling is protective during reovirus myelitis.

16 ), and other sub-acute syndromes (transverse myelitis (1), opsoclonus myoclonus (1)).

17 before we truly understand acute transverse myelitis: (1) What are the various triggers for the infl

18 eminated encephalomyelitis (12%), transverse myelitis (12%), and cerebellar ataxia (10%).

19 ations to be associated with ZIKV, including myelitis (4) , meningoencephalitis (5) and fatal encepha

20 h simultaneous/sequential optic neuritis and myelitis (44% vs 0%; P = .005).

21 tcomes than typical patients with transverse myelitis/acute disseminated encephalomyelitis, and these

22 ovirus D68 (EV-D68)-associated acute flaccid myelitis (AFM) is a devastating neurological disease for

23 /fall 2014, pediatric cases of acute flaccid myelitis (AFM) occurred in the United States, coincident

24 ent ON or recurrent longitudinally extensive myelitis alone are also often positive for AQP4-antibody

25 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p =

26 equency of longitudinal extensive transverse myelitis and a favourable clinical outcome in contrast t

27 One child with acute flaccid myelitis and a sibling with only upper respiratory illne

28 She then presented with recurrent transverse myelitis and a vesicobullous rash over her arms and feet

29 Classically, transverse myelitis and acute disseminated encephalomyelitis are co

30 ching how we classify subtypes of transverse myelitis and acute disseminated encephalomyelitis.

31 Particularly myelitis and bilateral optic neuritis have poor remissio

32 a is a member of the Apicomplexa that causes myelitis and encephalitis in horses but normally cycles

33 assessed for neurologic variables related to myelitis and for clinical and serologic features of SLE.

34 hysterical paraplegia, the second transverse myelitis and its consequences for bladder function.

35 ysis, and was diagnosed as having transverse myelitis and membranous glomerulonephritis secondary to

36 s had initial CNS manifestations: transverse myelitis and meningoencephalitis.

37 uromyelitis optica spectrum disorder (NMOSD) myelitis and myelitis of other cause.

38 r anaphylaxis and death; 0.04 for transverse myelitis and pancreatitis; and 0.009 for motor neuron di

39 unopathogenic mechanisms in acute transverse myelitis and related inflammatory disorders of the spina

40 on between enterovirus D68 and acute flaccid myelitis and the contention that acute flaccid myelitis

41 by disabling relapses of optic neuritis and myelitis and the presence of aquaporin 4 antibodies (AQP

42 %) with encephalitis, 3 (8%) with transverse myelitis, and 1 (3%) with newly diagnosed chronic inflam

43 ute neuromuscular disease), 2 had transverse myelitis, and 1 had chronic inflammatory demyelinating p

44 of encephalopathy, encephalitis, meningitis, myelitis, and seizures have also been reported.

45 l retrograde to produce meningoencephalitis, myelitis, and stroke.

46 oses included multiple sclerosis, transverse myelitis, and unspecified neurodegenerative myelopathy.

47 who had relapsing optic neuritis, transverse myelitis, AQP4-IgG seropositivity, and recurrent myalgia

48 Prognostic factors in pediatric transverse myelitis are reviewed.

49 ders associated with inflammatory transverse myelitis, as well as a greater appreciation of its diver

50 For example, in acute transverse myelitis associated with systemic disease (i.e. systemic

51 To establish if myelitis-associated chronic pain in NMOSD is related to

52 Patients with isolated thoracic cord myelitis at the time of pain onset were significantly mo

53 as follows: (1) AQP4-IgG seropositivity, (2) myelitis attack and (3) MRI spinal cord demonstrating ri

54 with rLETM-onset NMO followed a median of 3 myelitis attacks (range, 2-19).

55 differences in the frequencies of transverse myelitis, brainstem involvement, cerebellar signs and se

56 nterovirus D68 with those with acute flaccid myelitis but negative for enterovirus D68 using the two-

57 D68 and the recent increase in acute flaccid myelitis cases in the United States.

58 Myelitis causes pain, weakness, and sphincteric deficits

59 ally and geographically linked acute flaccid myelitis clusters at the height of the 2014 outbreak, an

60 ncluding longitudinally extensive transverse myelitis), contributes to an evolving understanding of a

61 initial longitudinally extensive transverse myelitis, delay to diagnosis/treatment was greater when

62 Optic neuritis or transverse myelitis developed after vomiting onset in 11 patients (

63 al fluid from 14 patients with acute flaccid myelitis did not reveal evidence of an alternative infec

64 Short transverse myelitis does not exclude consideration of AQP4-IgG test

65 enterovirus D68 infection and acute flaccid myelitis during the 2014 enterovirus D68 respiratory out

66 Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, w

67 Our findings indicate that SLE myelitis encapsulates 2 distinct and previously unrecogn

68 1996 and 2015 with SCS or NMOSD whose first myelitis episode was accompanied by a spinal cord lesion

69 th an initial STM represented 14% of initial myelitis episodes among patients with NMOSD.

70 g-enhancement accompanies one-third of NMOSD myelitis episodes and distinguishes NMOSD from other cau

71 xial images in 36 of 43 (84%) ring enhancing myelitis episodes and extended a median of two vertebral

72 e clinical characteristics of ring-enhancing myelitis episodes did not differ from non-ring-enhancing

73 -enhancement was detected in 50 of 156 (32%) myelitis episodes in 41 patients (83% single; 17% multip

74 In AQP4-IgG-positive STM cases, subsequent myelitis episodes were longitudinally extensive in 92%.

75 nge, 1-12); in 21 of 48 (44%) ring enhancing myelitis episodes, the ring extended greater than or equ

76 erintensity in 44 of 50 (88%) ring enhancing myelitis episodes.

77 D68 sequences associated with acute flaccid myelitis grouped into a clade B1 strain that emerged in

78 biomarkers associated with acute transverse myelitis has led to a better understanding of the spectr

79 Radiation myelitis has long been recognised as a sinister conseque

80 For the last century, descriptions of SLE myelitis have been primarily limited to case reports.

81 Acute transverse myelitis in children, in contrast to adults, is more lik

82 neurologic toxicity consisting of transverse myelitis in five patients, CNS toxicity in three, and se

83 he central nervous system; necrotizing focal myelitis in the cervical spinal cord; radiculitis; neuri

84 ive myelopathy of other cause (n=66) and (2) myelitis in the context of a concurrent or subsequent di

85 stigate innate immune responses during viral myelitis, including the activation of glia (microglia an

86 Acute transverse myelitis is a group of disorders characterized by focal

87 Acute transverse myelitis is a pathogenetically heterogeneous inflammator

88 elitis and the contention that acute flaccid myelitis is a rare yet severe clinical manifestation of

89 Short transverse myelitis is not uncommon in NMOSD and, when it is presen

90 nts with longitudinally extensive transverse myelitis (LETM) behave differently from those with AQP4-

91 Longitudinally extensive transverse myelitis (LETM) is a frequently devastating clinical syn

92 ation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or developm

93 a (NMO), longitudinally extensive transverse myelitis (LETM), multiple sclerosis with a history of op

94 Acute transverse myelitis may be an isolated entity or may occur in the c

95 ay be complicated by postherpetic neuralgia, myelitis, meningoencephalitis, and VZV vasculopathy.

96 uded radiation recall (n = 2) and transverse myelitis (n = 1).

97 (NMOSD, n=10), idiopathic AQP4-IgG-negative myelitis (n=4), idiopathic AQP4-IgG-negative optic neuri

98 4), and other subacute syndromes (transverse myelitis [n = 1], opsoclonus myoclonus [n = 1]).

99 In many recurrent cases who also have myelitis (neuromyelitis optica) a serum antibody to aqua

100 nded fever, seizure, meningitis/encephalitis/myelitis, nonanaphylactic serious allergic reaction, ana

101 e flaccid paralysis associated with anterior myelitis noted in the United States from 2012 to 2015.

102 rger-scale cohort studies have revealed that myelitis occurring in the idiopathic demyelinating disea

103 ptica spectrum disorder (NMOSD) myelitis and myelitis of other cause.

104 ansverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis.

105 No transverse myelitis or late toxicities of grade 4 or greater have b

106 lomyelitis (ADEM), one episode of transverse myelitis or optic neuritis, multiple sclerosis (MS), ant

107 weakness and sensory loss due to transverse myelitis or peripheral nerve disease.

108 s ratio [OR] = 0.97, p = 0.011), presence of myelitis (OR = 0.38, p = 0.002), CR from previous attack

109 event (optic neuritis, incomplete transverse myelitis, or brain-stem or cerebellar syndrome) and evid

110 ation (optic neuritis, incomplete transverse myelitis, or brain-stem/cerebellar syndrome) and at leas

111 in the diagnosis of any acute encephalitis, myelitis, or encephalomyelitis.

112 syndromes such as optic neuritis, transverse myelitis, or isolated brainstem syndromes in whom multif

113 m 12 (48%) of 25 patients with acute flaccid myelitis overall.

114 for isolated optic neuritis versus isolated myelitis (p < 0.001), and for unilateral versus bilatera

115 sed by a longitudinally extensive transverse myelitis (p=0.003), more often a complete resolution of

116 NMOSD myelitis patients were more commonly women, had concurre

117 cephalopathy, optic papillitis, inflammatory myelitis, postural tremor, and cerebellar ataxia.

118 ratory illness in children and acute flaccid myelitis, raising concerns about its potential impact on

119 Acute flaccid myelitis refers to acute flaccid limb weakness with spin

120 total lesion burden and number of transverse myelitis relapses did not correlate with pain.

121 ronic pain scores, irrespective of number of myelitis relapses, lesion length and lesion burden.

122 1.4 per month, and admissions for transverse myelitis remained constant at 0.6 per month.

123 itis and longitudinally extensive transverse myelitis [reported on at least 1 magnetic resonance imag

124 Isolated myelitis responded better to PE/IA than to HD-S as first

125 f a spinal cord biopsy during ring-enhancing myelitis revealed tissue vacuolation and loss of AQP4 im

126 ecurrent longitudinally extensive transverse myelitis (rLETM) are lacking.

127 ially presented with 2 attacks of transverse myelitis (rLETM-onset NMO).

128 tudy was undertaken to determine whether SLE myelitis similarly encapsulates distinct syndromes.

129 Short transverse myelitis (STM; <3 vertebral segments) is considered nonc

130 cidated about the causes of acute transverse myelitis, tantalizing clues as to the potential immunopa

131 rteriovenous fistula is a very rare cause of myelitis that can only be treated interventionally or su

132 recognized cause of longitudinally extensive myelitis that commonly mimics NMOSD.

133 In idiopathic acute transverse myelitis, there is an intraparenchymal or perivascular c

134 tis (ADEM), two with ON, one with transverse myelitis (TM) and two with clinically isolated syndrome

135 sent with optic neuritis (ON) and transverse myelitis (TM) are diagnosed with NMO and those who show

136 Transverse myelitis (TM) is an immune-mediated spinal cord disorder

137 ggested that vaccines may trigger transverse myelitis (TM) or acute disseminated encephalomyelitis (A

138 syndromes (CIS), 27 patients with transverse myelitis (TM), 50 patients with human immunodeficiency v

139 by severe optic neuritis (ON) and transverse myelitis (TM).

140 ritis (ON); 20% bilateral ON; 15% transverse myelitis (TM); 15% simultaneous TM&ON; 10% Acute dissemi

141 atients were included: 25 with acute flaccid myelitis, two with enterovirus-associated encephalitis,

142 Myelitis usually is known to respond well to immunosuppr

143 Reovirus myelitis was associated with the pronounced activation o

144 Transverse myelitis was the initial diagnosis.

145 initial longitudinally extensive transverse myelitis were excluded (n = 151).

146 Patients with acute flaccid myelitis who presented to two hospitals in Colorado and

147 We compared patients with acute flaccid myelitis who were positive for enterovirus D68 with thos

148 on-multiple sclerosis optic neuritis without myelitis will be shown to be associated with this autoan

149 uromyelitis optica spectrum disorder (NMOSD) myelitis, with no satisfactory treatment; few studies ha