ライフサイエンスコーパス: myoepithelial

1 tion of a cell subpopulation from luminal to myoepithelial.

2 original bilaterian mesodermal muscles were myoepithelial.

3 In contrast, Wnt pathway tumors exhibit myoepithelial, acinar, or glandular differentiation, and

4 In human tissue samples, increased myoepithelial alphavbeta6 expression correlated with inc

5 teins, which in turn stimulate AC present on myoepithelial and acinar cells.

6 (EPM), a protein expressed on the surface of myoepithelial and fibroblast cells of the mammary gland,

7 intermediate" cells by lack of expression of myoepithelial and luminal apical membrane markers.

8 AKR1C3 and AKR1C1 were localized on the same myoepithelial and luminal epithelial cell layers.

9 ormal mammary cell types, including luminal, myoepithelial and secretory.

10 from luminal epithelial cells but remain on myoepithelial and stromal cells.

11 T-cadherin delineates endothelial, myoepithelial, and ductal epithelial cells in the normal

12 opment, we find cilia on luminal epithelial, myoepithelial, and stromal cells during early branching

13 transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic

14 of miR-145 and miR-205 was restricted to the myoepithelial/basal cell compartment of normal mammary d

15 Normal human luminal and myoepithelial breast cells separately purified from a se

16 Loss of myoepithelial calponin was specifically associated with

17 Myoepithelial carcinoma (MECA) is an aggressive salivary

18 X-6X) grow very slowly compared to their non-myoepithelial carcinomatous counterparts and accumulate

19 in the breast: luminal (EpCAM(+)) and basal/myoepithelial (CD10(+)).

20 tively support the hypothesis that the human myoepithelial cell (even when transformed) is a natural

21 reas TrkA, TrkB, and TrkC, were localized in myoepithelial cell and ductal cell membranes.

22 Further, we demonstrate a specific defect in myoepithelial cell contractility in Acta2 null mammary g

23 We conclude that Acta2 specifically mediates myoepithelial cell contraction during lactation and that

24 s defects in vascular smooth muscle cell and myoepithelial cell differentiation and function.

25 fic and essential role for MRTF-A in mammary myoepithelial cell differentiation and points to commona

26 Progressive loss of the myoepithelial cell differentiation markers p63, calponin

27 a in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transit

28 portance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identi

29 Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, a

30 lk protein synthesis, whereas others adopted myoepithelial cell fates.

31 ocal disruption of the integrity of both the myoepithelial cell layer and the basement membrane is an

32 l, Forster et al. (2014) show that the basal myoepithelial cell layer directs the final maturation of

33 Immunostaining for p63 demonstrated that the myoepithelial cell layer is disrupted in the p190A defic

34 ls that form ductile tubules surrounded by a myoepithelial cell layer that provides contractility req

35 It is not known how the myoepithelial cell lineage is specified, nor how signals

36 Myoepithelial cell lines (HMS-1-6), derived from diverse

37 These myoepithelial cell lines inhibit endothelial cell chemot

38 These myoepithelial cell lines sense hypoxia, respond to low O

39 By use of bovine mammary epithelial and myoepithelial cell lines, it was found that bovine S. au

40 diagnosed with pure DCIS, a similar loss in myoepithelial cell markers was observed.

41 cell were grown in neuronal, epithelial, and myoepithelial cell media, and examined by light morpholo

42 The protein p75 was expressed only on myoepithelial cell membranes.

43 phological differences of microenvironmental myoepithelial cell nuclei without any direct information

44 rther research is warranted into the role of myoepithelial cell p63 and calponin expression on DCIS p

45 epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal ce

46 structures were closely associated with the myoepithelial cell, as visualized by beta-tubulin antibo

47 que component of the microenvironment is the myoepithelial cell.

48 structures comprising an outer layer of cap/myoepithelial cells (MECs) and an inner layer of luminal

49 alpha-smooth muscle actin (SMA), which marks myoepithelial cells (MECs), by immunofluorescence micros

50 Normal myoepithelial cells act as "natural tumor suppressors";

51 we found that ectopic expression of Cx26 in myoepithelial cells altered the expression of endogenous

52 ll lineages in ACC, cooperating with TP63 in myoepithelial cells and a Notch program in luminal epith

53 lls, aging is associated with a reduction of myoepithelial cells and an increase in luminal cells tha

54 terized by proliferation of both luminal and myoepithelial cells and are rare in human breast cancer,

55 ay, also contain a significant proportion of myoepithelial cells and cells expressing keratin 6.

56 els compared to non-malignant epithelial and myoepithelial cells and fibroblasts.

57 OLIN-1 is however highly expressed in breast myoepithelial cells and its expression is retained in tu

58 were strongly TRAF-4 immunopositive whereas myoepithelial cells and most of the mammary epithelial c

59 e varicosities, and leads the contraction of myoepithelial cells and/or of the acinar valve to contro

60 thelial cells advanced collectively, whereas myoepithelial cells appeared to restrain elongating duct

61 l cell type within the gland, that the basal/myoepithelial cells are key regulators of paracrine sign

62 Myoepithelial cells bear a striking resemblance to smoot

63 ell lineage is specified, nor how signals in myoepithelial cells contribute to lactogenesis.

64 The presence of NET in myoepithelial cells did not require sympathetic innervat

65 nance of the differentiated state of mammary myoepithelial cells during lactation, resulting in apopt

66 sitive Leydig, Sertoli, and some peritubular myoepithelial cells express SUMO-1, findings suggesting

67 ransient release of stored Ca(2+) in mammary myoepithelial cells followed by slow, irregular Ca(2+) o

68 is repression of CDKN2A transcript p16 where myoepithelial cells harbour cancer-like gene expression

69 We have shown that myoepithelial cells in a subset of preinvasive ductal ca

70 tions suggested that the activity of typical myoepithelial cells in DCIS was lowered.

71 and both periductal fibroblasts and residual myoepithelial cells in DCIS.

72 ritical role in the maintenance of basal and myoepithelial cells in ectodermally derived tissues and

73 iated with a decrease in keratin 14-positive myoepithelial cells in PyMT(mgko) tumors following LOX i

74 SED1 is expressed by both luminal and myoepithelial cells in the developing epithelial duct, a

75 estinal cells, their impact on human mammary myoepithelial cells in tissue culture was studied.

76 ype that is usually expressed exclusively in myoepithelial cells in women younger than 30 years.

77 bed that fibroblasts promote, whereas normal myoepithelial cells inhibit, the progression of ductal c

78 The absence of mammary myoepithelial cells is associated with invasive mammary

79 and adaptation to matrix rigidity in breast myoepithelial cells is determined by the bond dynamics o

80 and binds to alpha(v) integrin receptors on myoepithelial cells leading to MAPK activation and cell

81 rogenitors to mammary luminal epithelial and myoepithelial cells may be the targets for oncogenesis b

82 The expression of MEPI in myoepithelial cells may prevent breast cancer malignant

83 ations may represent a conserved language in myoepithelial cells of other secretory epithelia, such a

84 ssion signature similar to that of the basal/myoepithelial cells of the breast and is reported to hav

85 e outer root sheath of the hair follicle, in myoepithelial cells of the eccrine gland, and in the bas

86 (c) basal cells of the prostate glands; (d) myoepithelial cells of the mammary glands; (e) distal co

87 norhabditis elegans, specialized contractile myoepithelial cells of the somatic gonad, the gonadal sh

88 has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammar

89 rise), while such shortening was not seen in myoepithelial cells or normal large lactiferous ducts of

90 Myoepithelial cells participated in the hyperplasias but

91 Contractile myoepithelial cells surround the secretory complex to fa

92 P-cadherin expression is localized to the myoepithelial cells surrounding the lumenal epithelial c

93 many more DMRs with adult breast luminal and myoepithelial cells than with melanocytes and fibroblast

94 eas myosin IIB expression is up-regulated in myoepithelial cells that have more mesenchymal character

95 legans spermatheca is a bag-like organ of 24 myoepithelial cells that houses the sperm and is the sit

96 intercellular signaling between luminal and myoepithelial cells that is required for branching morph

97 The metaplasia of myoepithelial cells to chondrocytes appears to require t

98 thelial component, whereas the proliferating myoepithelial cells undergo metaplasia to form chondrocy

99 sue had a distinctive pattern of expression: myoepithelial cells uniformly showed strong PTEN express

100 SMA-positive myoepithelial cells were found in the acini but not in t

101 Human myoepithelial cells which surround ducts and acini of ce

102 lial cells and an outer layer of contractile myoepithelial cells with mesenchymal properties.

103 cts, blood vessels, acini, nerve fibers, and myoepithelial cells within the gland.

104 demonstrate that Cav-3 is also expressed in myoepithelial cells within the mammary gland.

105 ) and alpha-smooth muscle actin (a marker of myoepithelial cells).

106 cluding keratinocytes and breast luminal and myoepithelial cells, against neural crest-derived melano

107 le (SM22) alpha protein were detected in the myoepithelial cells, and a large number of cytokeratin s

108 , Gli2 and Gli3 are expressed in stromal and myoepithelial cells, and Gli3 is also found within the l

109 differentiated luminal epithelial and basal myoepithelial cells, as well as undifferentiated stem ce

110 hey proliferated to produce both luminal and myoepithelial cells, comprised both lobule-limited and d

111 eal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal ret

112 trans-dominant negative for Cx43 function in myoepithelial cells, highlighting the importance of cell

113 Progenitor cell markers and myoepithelial cells, however, are lacking in mammary tum

114 rogenitors and their differentiated progeny, myoepithelial cells, in epithelial basal and suprabasal

115 A whole transcriptome analysis of basal/myoepithelial cells, luminal estrogen receptor negative

116 populations including mammary epithelial and myoepithelial cells, progenitors, and multi-lineage stem

117 s are distinct from the K14-expressing basal/myoepithelial cells, proliferate at a significantly high

118 ne interacting factors showed that the basal/myoepithelial cells, remarkably, expressed over twice as

119 eolar pneumocytes, kidney glomeruli, mammary myoepithelial cells, Schwann cells, and most types of br

120 l population located between the luminal and myoepithelial cells, similar to the unpolarized body cel

121 aryotyping, and applied it to epithelial and myoepithelial cells, stromal fibroblasts from normal bre

122 tissue, both TrkC and Bcl2 were expressed in myoepithelial cells, suggesting a principal role for thi

123 stem/progenitor cells or are associated with myoepithelial cells, suggestive of an epithelial-mesench

124 ex carcinomas offer an ideal system to study myoepithelial cells, the second major cell lineage of th

125 , which in normal breast is localized to the myoepithelial cells, tracks with malignant phenotype in

126 Epithelial cells, especially myoepithelial cells, were determined to be a rich source

127 nd activin type II receptor are expressed by myoepithelial cells, whereas no expression was detected

128 ession of Srf-dependent genes in the mammary myoepithelial cells, which control milk ejection followi

129 that Numb and Numbl are enriched in mammary myoepithelial cells, with their expression peaking durin

130 contractile cells, such as smooth muscle and myoepithelial cells.

131 from the active motility of both luminal and myoepithelial cells.

132 control differentiation of smooth muscle and myoepithelial cells.

133 ression of markers expressed in normal basal/myoepithelial cells.

134 ithelial cells but absent from either cap or myoepithelial cells.

135 , NET simultaneously appeared in sweat gland myoepithelial cells.

136 Tag-induced proliferation of epithelial and myoepithelial cells.

137 membranes of acinar and ductal cells and on myoepithelial cells.

138 , while HGF is produced by stromal and basal myoepithelial cells.

139 pomethylated enhancer elements compared with myoepithelial cells.

140 l epithelial cells or the basally positioned myoepithelial cells.

141 organized as a bilayer of luminal and basal/myoepithelial cells.

142 ithelial cells and Cx43 is expressed only in myoepithelial cells.

143 terminally differentiated acinar, ductal and myoepithelial cells.

144 nohistochemical evidence for the presence of myoepithelial cells.

145 se to incompletely differentiated luminal or myoepithelial cells.

146 ations are observed in the tumor-stromal and myoepithelial cells.

147 The AC II was found exclusively on myoepithelial cells; AC IV was located intracellularly i

148 e composed of luminal (secretory) and basal (myoepithelial) cells, which are descendants of a common

149 ing of the ductal tree, lumen formation, and myoepithelial compartmentalization in the postnatal MG.

150 e resistant to viral transduction than their myoepithelial counterparts.

151 gesterone or MPA increased expression of the myoepithelial cytokeratins (CK) 5 and 6 in a subpopulati

152 sis in the mammary gland is likely driven by myoepithelial-derived VEGF-C and/or VEGF-D.

153 e observed expression of genes indicative of myoepithelial differentiation, as expected, including th

154 d cystic carcinoma (ACC), is notable for its myoepithelial differentiation, proclivity for hematogeno

155 anism for the underlying phenotype is due to myoepithelial dysfunction postpartum resulting in precoc

156 RK1/2) effector RSK prevents the EGF-induced myoepithelial expansion.

157 is ovulated by increasing contraction of the myoepithelial gonadal sheath and relaxation of the dista

158 pressing markers associated with luminal and myoepithelial HMEC lineages in vivo in contrast to the b

159 ed with the same genes: basal-like BPLER and myoepithelial HMLER.

160 Keratin K17, the myoepithelial keratin, is expressed in psoriasis but is

161 ration of the existence of a layer of normal myoepithelial KRT14 expressing cells that separate HER2+

162 rate that loss of Numb/Numbl compromised the myoepithelial layer and expanded the luminal layer, led

163 cells, which are normally restricted to the myoepithelial layer, are found within the luminal compar

164 g1 expression is primarily restricted to the myoepithelial layer.

165 61 and HMS-1, an immortalized 'benign' human myoepithelial line which produced an abundant extracellu

166 Little is known about the myoepithelial lineage or about growth factor effects on

167 ctor (EGF) causes a massive expansion of the myoepithelial lineage.

168 ts in both a shift in the balance of luminal/myoepithelial lineages and to changes in the functional

169 genitor cell expansion along the luminal and myoepithelial lineages.

170 gel which included cells of both luminal and myoepithelial lineages.

171 sed of three cell lineages, namely the basal/myoepithelial, luminal epithelial estrogen receptor posi

172 Stem cell markers ESRRB and CK5, myoepithelial marker CK14, and lactocyte marker alpha-la

173 CF10A cells and a variant that expresses the myoepithelial marker p63 stably overexpressing the const

174 This suggests that the stromal and myoepithelial microenvironment of preinvasive breast can

175 (BK5) promoter and is directed to either the myoepithelial or basal cells in a variety of organs, inc

176 have an effect on the cell cycle of primary myoepithelial or luminal cells.

177 hway tumors also have scanty stroma and lack myoepithelial or squamous differentiation.

178 orphogenesis relies on the preservation of a myoepithelial phenotype.

179 y epithelial stem cell (MaSC) enriched basal/myoepithelial population and an increase in in vitro ste

180 ng cell (BCIC) population, and a decrease in myoepithelial progenitor cells in the DCIS lesions in vi

181 2 and HER3 signaling pathways and fewer DCIS myoepithelial progenitor cells in vivo.

182 ast in part, originates from region-specific myoepithelial progenitors.

183 the gonad arm by contraction of the proximal myoepithelial sheath and dilation of the distal spermath

184 Myoepithelial sheath cells of the proximal ovary are smo

185 pled via gap junctions to smooth muscle-like myoepithelial sheath cells.

186 Here we report that the myoepithelial sheath has a distinct myosin population co

187 Therefore, although the myoepithelial sheath has smooth muscle-like contractile

188 The myoepithelial sheath in the somatic gonad of the nematod

189 PL-1 and Ce-CPZ-1 enzymes are present in the myoepithelial sheath surrounding germ cells, oocytes, an

190 tive for function of the nonstriated oviduct myoepithelial sheath, and defective for epidermal morpho

191 were associated with actin filaments in the myoepithelial sheath, and the association of troponin C

192 Two myosin heavy chains are expressed in the myoepithelial sheath, which are also expressed in the bo

193 nately regulate ovulatory contraction of the myoepithelial sheath.

194 Myoepithelial sialadenitis (MESA) is the reactive saliva

195 rated that many lesions formerly regarded as myoepithelial sialadentis or benign lymphoepithelial les

196 and remain unipotent when healing epidermal, myoepithelial-specific, and lumenal-specific injuries.

197 In contrast, both luminal and myoepithelial subpopulations of normal breast tissues ex

198 e markers and contain luminal epithelial and myoepithelial tumor cells that share a secondary mutatio

199 lines (HMS-1-6), derived from diverse benign myoepithelial tumors, all constitutively express high le

200 xtensive necrosis in comparison to their non-myoepithelial xenograft counterparts.

201 These myoepithelial xenografts exhibit only minimal hypoxia bu