ライフサイエンスコーパス: myogenesis

1 efore termed Linc-RAM (Linc-RNA Activator of Myogenesis).

2 uction and is essential for adipogenesis and myogenesis.

3 while inhibiting endogenous miR-431 lowered myogenesis.

4 tors as suitable tools to promote functional myogenesis.

5 equire canonical Wnt signaling during tongue myogenesis.

6 ha is dispensable during embryonic and fetal myogenesis.

7 putative roles in myoblast proliferation and myogenesis.

8 of satellite stem cells and for regenerative myogenesis.

9 egative MLX reduce IGF2 expression and block myogenesis.

10 e gene expression during the early stages of myogenesis.

11 lates many developmental programs, including myogenesis.

12 MyoD-expressing subpopulations during tongue myogenesis.

13 eta-catenin signaling regulates each step of myogenesis.

14 tubule organising factor that is crucial for myogenesis.

15 subpopulations exist during embryonic tongue myogenesis.

16 to skeletal muscle contractility complex and myogenesis.

17 gulates several biological events, including myogenesis.

18 tune the requisite degradation of TBP during myogenesis.

19 n assays of chondrogenesis, osteogenesis and myogenesis.

20 promoting the commitment of muscle cells to myogenesis.

21 the M-ERRalpha(-/-) muscles at the onset of myogenesis.

22 nd reiterate their views on Myf5-independent myogenesis.

23 ciated ribonucleases, is required for proper myogenesis.

24 s in Wnt1-Cre; Alk5(fl/fl) mice during early myogenesis.

25 ctive oxygen species production during fetal myogenesis.

26 h receptor, which plays an essential role in myogenesis.

27 in BAF/Brg1 subunit composition and delayed myogenesis.

28 ERK signaling suppressed both head and trunk myogenesis.

29 paB, a key player in muscle inflammation and myogenesis.

30 le of endogenous hyaluronan synthesis during myogenesis.

31 on defect was rescued, resulting in improved myogenesis.

32 ed in downregulation of myogenin and reduced myogenesis.

33 ntifying genes that play active roles during myogenesis.

34 tellite cell homeostasis during regenerative myogenesis.

35 tellite cells during both neonatal and adult myogenesis.

36 ereas inhibition of Notch signaling restores myogenesis.

37 sting that ERRs may have a role in promoting myogenesis.

38 scle inflammation/injury and improving force/myogenesis.

39 termination gene Myf5 during fetal stages of myogenesis.

40 -1 abrogates Sharp-1-dependent inhibition of myogenesis.

41 gulation, for their potential involvement in myogenesis.

42 latory factor Myf5, whose depletion inhibits myogenesis.

43 ered in their ability to recapitulate normal myogenesis.

44 g fibro-adipogenic lineages while inhibiting myogenesis.

45 esulted in severely delayed ischemia-induced myogenesis.

46 ;-sbsRNA)-triggered SMD regulates C2C12 cell myogenesis.

47 ay facilitate the fusion of myoblasts during myogenesis.

48 r cardiotoxin-injured muscle fail to undergo myogenesis.

49 latory networks fundamental to developmental myogenesis.

50 or efficient MyoD expression during skeletal myogenesis.

51 le of Deltex in the epigenetic regulation of myogenesis.

52 e, highlighting a role for BAI1 in mammalian myogenesis.

53 entiated precursors contributes to localized myogenesis.

54 function of Mef2 genes in other examples of myogenesis.

55 on of PPARbeta/delta in regulating postnatal myogenesis.

56 mension to epigenetic regulation of skeletal myogenesis.

57 at the paralogues have a function in primary myogenesis.

58 ation 1 (MyoD) gene is a master regulator of myogenesis.

59 OD2-mediated neurogenesis with MYOD-mediated myogenesis.

60 a specific role for N-WASp during mammalian myogenesis.

61 rganization of microtubule nucleation during myogenesis.

62 ile ectopically increasing UPF1 levels slows myogenesis.

63 lls and its expression is upregulated during myogenesis.

64 K causes hyper-activation of p38 MAPK during myogenesis.

65 cific transcription factors that orchestrate myogenesis.

66 g the differentiation and miR-143 inhibiting myogenesis.

67 ate, that like PABPN1, MATR3 is critical for myogenesis.

68 Mstn expression in C2C12 cells, and promoted myogenesis.

69 adipogenesis, but is indispensable for their myogenesis.

70 nd 3D organization of gene regulation during myogenesis.

71 tocrine concentrations of IL-15 also support myogenesis.

72 orm cell-specific genome organization during myogenesis.

73 that is fundamentally important in skeletal myogenesis.

74 3) to (2/3) of a gene's normal repression in myogenesis.

75 yoblasts into multinucleated myotubes during myogenesis.

76 whether TBP2 deficiency can compromise adult myogenesis.

77 cells and their function during regenerative myogenesis.

78 hat direct their normal repositioning during myogenesis.

79 biologic and pathologic processes, including myogenesis.

80 fate, whereas higher levels of Pax3 lead to myogenesis.

81 lutionarily conserved role of MUNC lncRNA in myogenesis.

82 pression and mimics the effect of hypoxia on myogenesis.

83 l functionally conserved pathways regulating myogenesis across species and identify chemical compound

84 bility of tumor cells to recapitulate normal myogenesis, altering the tumorigenic capability of these

85 the conclusion that an altered regulation of myogenesis and a downregulated mitochondrial biogenesis

86 bias toward adipogenesis at the detriment of myogenesis and an inhibitory activity on angiogenesis.

87 has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial processes for mus

88 in kinase C beta (PKCbeta) as a repressor of myogenesis and as the enzyme that opposes calcineurin fu

89 that miRNAs regulate key interactions during myogenesis and can act by promoting the switch between q

90 ke A (PTPLa) has been implicated in skeletal myogenesis and cardiogenesis.

91 e findings reveal a role for p110beta during myogenesis and demonstrate that long-term reduction of s

92 l activity, which plays a permissive role in myogenesis and depends on phosphatidylinositol 4,5-bisph

93 c loss of Mkp5 in mice improved regenerative myogenesis and dystrophin-deficient mdx mice lacking Mkp

94 sion of muscle regulatory factors, embryonic myogenesis and formation of skeletal muscle occurred in

95 ursors to maintain COUP-TFII activity during myogenesis and found that elevated COUP-TFII activity re

96 MYF5 is the earliest to be expressed during myogenesis and functions as a transcription factor in mu

97 It was concluded that myogenesis and gene expression patterns during growth ar

98 MP signaling to the HDAC-MEF2 pathway during myogenesis and how this response could specifically occu

99 , restore mitochondrial function and promote myogenesis and hypertrophy.

100 examined the influence of 2,400 chemicals on myogenesis and identified six that expanded muscle proge

101 protein levels are increased during in vitro myogenesis and in conditions that promote skeletal muscl

102 2 blocks the ability of Sox9 to both inhibit myogenesis and induce chondrogenesis, suggesting that Nk

103 sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic.

104 of the splicing transitions observed during myogenesis and is required for the specific step of myob

105 H2Bub levels are oppositely regulated during myogenesis and lung carcinogenesis.

106 in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-medi

107 Da PI3K catalytic subunit beta (p110beta) in myogenesis and metabolism.

108 ese findings support a role for nesprin-1 in myogenesis and muscle disease, and uncover a novel mecha

109 ltipotent stem cells that can participate in myogenesis and muscle regeneration upon transplantation.

110 ucose is a signaling molecule that regulates myogenesis and muscle regeneration via MLX/IGF2/Akt sign

111 uscle wasting in CKD, including proteolysis, myogenesis and muscle regeneration, and expression of pr

112 FGFR4 is involved in myogenesis and muscle regeneration.

113 lpha2, while enhanced AMPK activity promoted myogenesis and myotube formation.

114 nscription factor that is essential for both myogenesis and neural crest development.

115 NF-kappaB and canonical Wnt signaling during myogenesis and promotes skeletal muscle growth and overl

116 ytes, where AUF1 levels rise at the onset of myogenesis and remain elevated throughout myocyte differ

117 ight on PGC-1beta regulation during skeletal myogenesis and reveal a unique function of alternative N

118 g of MEF2C plays an important role in normal myogenesis and RMS development.

119 satellite cell niche and capacity for robust myogenesis and self-regeneration in vitro.

120 tor II (COUP-TFII) has been shown to inhibit myogenesis and skeletal muscle metabolism in vitro.

121 and that MyoD+ progenitors are essential for myogenesis and stem cell development.

122 is rapidly down-regulated upon induction of myogenesis and this is not due to changes in Cebpb mRNA

123 eveal their dynamic expression during embryo myogenesis and uncover the concerted negative regulation

124 A sequencing from various time points during myogenesis and uncovered many chimeric fusion RNAs.

125 ng mechanisms controlling the homeostasis of myogenesis and underline the versatility and context dep

126 r BET proteins in the regulation of skeletal myogenesis, and assign distinct functions to BRD3 and BR

127 dependent effects of Notch activation during myogenesis, and demonstrate that Notch1 activity improve

128 l regulators of actin-dependent processes in myogenesis, and further implicate BAR domain proteins in

129 ive variants BAF60a and BAF60b during embryo myogenesis, and reveals that interactions between tissue

130 chanical cues are known to enhance stem cell myogenesis, and the paper focuses on the stem cell diffe

131 37% of all genes changing expression during myogenesis, and their combined knockdown almost complete

132 a characterize a regulatory role for UPF1 in myogenesis, and they demonstrate that UPF1 provides a me

133 s a platform to identify novel regulators of myogenesis, and uncovered surprising developmental funct

134 oD has been implicated as a key regulator of myogenesis, and yet there is little information regardin

135 ity to restore the contractile apparatus and myogenesis are important, and must be taken into conside

136 ations are established and maintained during myogenesis are not completely understood.

137 has shown that the fundamental mechanisms of myogenesis are remarkably similar in vertebrates and inv

138 The molecular mechanisms of PTPLa in myogenesis are unknown.

139 regions of genes expressed at late times of myogenesis, are in close physical proximity in different

140 Using adipogenesis and myogenesis as model systems, we show that MLL4 exhibits

141 RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low d

142 To investigate SPL's role in myogenesis at the cellular level, we generated and chara

143 sican processing was observed during in vivo myogenesis at the time when myoblasts were fusing to for

144 first model of miRNA:target interactions in myogenesis based on experimental evidence of individual

145 Even if overexpressed, Myf5 does not trigger myogenesis because Notch induces Id3, partially sequeste

146 During early myogenesis, Bin3 promotes migration of differentiated mu

147 GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro.

148 We conclude that ALK4 inhibition increases myogenesis but also regulates the tight balance of prote

149 embryonic depletion of LAP1 does not impair myogenesis but that it is necessary for postnatal skelet

150 The function of Akt/PKB is critical for myogenesis, but less is clear as to the regulation of it

151 y members play important roles in regulating myogenesis, but the functional significance of Smad-depe

152 n fatty acids, and HACD1 has a role in early myogenesis, but the functions of this striated muscle-sp

153 expressing cells results in the cessation of myogenesis by embryonic day 12.5 (E12.5), as assayed by

154 The inhibition of myogenesis by H19 depletion during myoblast differentiat

155 a critical upstream regulator of fast fiber myogenesis by modulating fgf8 signaling during zebrafish

156 This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradati

157 lizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle

158 can control diverse biological processes of myogenesis by regulating step-specific molecules.

159 last differentiation and plays a key role in myogenesis by regulating the cytosolic activation of ERK

160 HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRN

161 Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the De

162 vide evidence that Mdm2 regulates entry into myogenesis by targeting C/EBPbeta for degradation by the

163 expression, suggesting that Ripply1 promotes myogenesis by terminating Tbx6-dependent inhibition of m

164 ent transcription and relieves repression of myogenesis by the deacetylases.

165 Robust myogenesis can be achieved in vitro within 1 month by pe

166 We show that primary and secondary skeletal myogenesis can be recapitulated in vitro from the PSM-li

167 ion and senescence of MPCs, and restored the myogenesis capacity while reducing inflammation and fibr

168 ocyte growth factor, known to be involved in myogenesis, cell migration, and immunoregulation.

169 tion but disappear as cells progress through myogenesis, concomitant with the destruction of proteins

170 as emerged as a master regulator of skeletal myogenesis, controlling multiple stages of the myofiber

171 or the first time that dyW-/- mice exhibit a myogenesis defect already in utero.

172 nt with a non-phosphorylatable mutant allows myogenesis despite inhibition of calcineurin signalling,

173 During myogenesis, downregulation of PTB and miR-221 robustly i

174 tial for adipogenesis and less potential for myogenesis, driven by differences in beta-catenin, a reg

175 Most importantly, it implies that myogenesis drives angiogenesis in the setting of skeleta

176 signalling is essential for skeletal muscle myogenesis during development, but its role in adult hum

177 T signaling plays multiple roles in skeletal myogenesis during gestation and postnatal stages.

178 iR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it

179 h energy requirements of muscle contraction, myogenesis entails an increase in mitochondrial (mt) mas

180 (2015) identified key regulators of skeletal myogenesis from mouse and human pluripotent stem cells.

181 provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stag

182 xpression of Myf5 during embryonic and fetal myogenesis has been extensively studied, its expression

183 Although myogenesis has been studied extensively, changes in dNTP

184 factors and signalling proteins involved in myogenesis have been identified, upstream regulators are

185 While many of the molecular details of myogenesis have been investigated extensively, the funct

186 , the expression and function of 4.1R during myogenesis have not been characterized.

187 otemporal expression and play vital roles in myogenesis; however, it is still largely unknown how WNT

188 BAF60c is essential for myogenesis; however, the mechanisms regulating the subun

189 ellite cells, but its function in late-stage myogenesis, i.e. post-differentiation myocytes and post-

190 ble pathway to target for the improvement of myogenesis in a plethora of diseases including cancer ca

191 in regulating satellite cell function during myogenesis in adult.

192 3 in the cross-talk between angiogenesis and myogenesis in adults.

193 We postulated that AMPK promotes myogenesis in an isoform-specific manner.

194 We found that compound 53 improves delayed myogenesis in CDM1 myoblasts, while compounds 1 and 53 h

195 ith substantial conservation of MRF-directed myogenesis in chordates and demonstrate for the first ti

196 studies showed that MyoD+ progenitors rescue myogenesis in embryos in which Myf-5-expressing cells we

197 the loss of OTX2 expression is linked to the myogenesis in medullomyoblastoma.

198 rotein, Bridging integrator 3 (Bin3), during myogenesis in mice.

199 pressed by muscle cells during developmental myogenesis in mouse.

200 As a result, both inhibitors rescued myogenesis in myoblasts treated with GDF8.

201 key regulator of stem cell self-renewal and myogenesis in normal skeletal muscle; however, little is

202 We propose that MYF5 enhances early myogenesis in part by coordinately elevating Ccnd1 trans

203 cting Hdac3 to the nuclear periphery rescues myogenesis in progenitors otherwise lacking Hdac3.

204 h the Myf5 and MyoD genes drives the de novo myogenesis in satellite cells even in aged muscle.

205 mined how PAX3/FOXO1A and PAX7/FOXO1A affect myogenesis in satellite cells.

206 crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cell

207 nction and expression of MyoD protein during myogenesis in stem cells.

208 echanisms activate Ci-Mrf Here, we show that myogenesis in the atrial siphon muscles (ASMs) and oral

209 osteoblast differentiation RUNX2 to promote myogenesis in the C2C12 model system.

210 Skeletal myogenesis in the embryo is regulated by the coordinated

211 regulatory network (GRN) model that promotes myogenesis in the sea urchin embryo, an early branching

212 Myogenesis in the tail of the simple chordate Ciona exhi

213 rovide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs).

214 ility (hypoxia) impedes progenitor-dependent myogenesis in vitro through multiple mechanisms, includi

215 , and differentiation, ultimately inhibiting myogenesis in vitro.

216 t evidence that HIF1alpha regulates skeletal myogenesis in vivo and establish a novel link between HI

217 owever, whether HIF1alpha regulates skeletal myogenesis in vivo is not known.

218 the necessity of the AMPKalpha1 subunit for myogenesis in vivo, we prepared both DsRed AMPKalpha1 kn

219 uggesting a detrimental role for elastase on myogenesis in vivo.

220 spatial and temporal regulation to skeletal myogenesis in zebrafish.

221 nin signaling can regulate multiple steps of myogenesis, including cell proliferation, myoblast fusio

222 s as a transcriptional co-factor to activate myogenesis, independently of WNT ligand.

223 d in high C/EBPbeta levels and a blockade of myogenesis, indicating that Mdm2 is necessary for myogen

224 Flox/Flox) mice, demonstrating that impaired myogenesis indirectly affects ischemia-induced angiogene

225 Upregulation of Huwe1 expression during myogenesis induces TBP degradation and myotube different

226 Skeletal myogenesis involves sequential activation, proliferation

227 Myogenesis involves the stable commitment of progenitor

228 Myogenesis is a tightly regulated differentiation proces

229 lls expressing MyoD activate Notch, skeletal myogenesis is abolished and pericyte genes are activated

230 tochondrial biogenesis normally accompanying myogenesis is associated with nuclear translocation of n

231 we show that TrxR1 decrease occurring during myogenesis is functionally involved in the coordination

232 on of skeletal muscle gene expression during myogenesis is mediated by lineage-specific transcription

233 the first time that Gli3-regulated postnatal myogenesis is necessary for muscle repair-associated ang

234 trol of chicken FGFR1 gene regulation during myogenesis is presented.

235 Skeletal myogenesis is regulated by signal transduction, but the

236 tems, a general mechanistic understanding of myogenesis is still lacking.

237 Map4k4 regulation of myogenesis is unlikely to be mediated by classic mitogen

238 In contrast, neurons appeared 2 days after myogenesis, just before the hatching of fully formed cyd

239 beta/delta has been implicated in regulating myogenesis, little is presently known about the role and

240 dramatically reduced levels of PAX7 and late myogenesis markers.

241 During myogenesis, muscle genes are activated, lose MLL3 occupa

242 During myogenesis, myoblasts fuse into multinucleated myotubes

243 ensive occupancy of transcription factors of myogenesis (MyoD and Myogenin) at extragenic enhancer re

244 MLX promotes myogenesis not via an adjustment of glucose metabolism b

245 BMPs can induce osteogenesis and inhibit myogenesis of mesenchymal stem cells.

246 strate a central role of Ptpn11 in postnatal myogenesis of mice.

247 nisolone treatment was unable to improve the myogenesis of stem cells and reduce fibrosis in dKO musc

248 osin therefore dictates fundamental steps of myogenesis prior to regulating contraction in the sarcom

249 We find that myotomal and primary myogenesis proceed normally in homozygous dyW-/- embryos

250 propose that MEF2C is a key effector of the myogenesis program promoted by AUF1.

251 -ratio (1:1 and 10:1) yeast and mouse embryo myogenesis proteomes.

252 ent miRNAs with important roles in adulthood myogenesis (regeneration) and myofibre hypertrophy and a

253 d, cultured, and evaluated for expression of myogenesis regulator PAX7.

254 educes myoblasts growth by inducing an early myogenesis -related gene expression pattern which includ

255 this association between Has2 expression and myogenesis relates to a role for Has2 in myoblast differ

256 oles of LncRNAs in stem cell maintenance and myogenesis remain largely unexamined.

257 pathways underlying its positive effects on myogenesis remain unclear.

258 ween AMP-activated protein kinase (AMPK) and myogenesis remains poorly defined.

259 nalysis of alternative splicing during human myogenesis reveals that CDM-relevant exons undergo prena

260 abundance partially rescued the decrease in myogenesis seen after MYF5 silencing.

261 n levels partially rescued the impairment of myogenesis seen after reducing AUF1 levels.

262 During myogenesis, Sfmbt1 represses myogenic differentiation of

263 molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and abil

264 Unlike the well-studied events of myogenesis, such as myoblast specification and myoblast

265 We discuss the upstream regulators of myogenesis that lead to the activation of myogenic deter

266 regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders

267 PAX7 is a master regulator of myogenesis that rescues DUX4-mediated apoptosis.

268 precursor is the nascent myotube, and during myogenesis the myotube completes guided elongation to re

269 f tissue degradation and subsequent enhanced myogenesis, thereby accelerating muscle repair and funct

270 Beyond the study of myogenesis, this differentiation method offers an attrac

271 Given the conserved features of IFM myogenesis, this sequence of cell interactions and membr

272 results indicate that AMPK activity promotes myogenesis through a mechanism mediated by AMPKalpha1.

273 odel, that PPARbeta/delta enhances postnatal myogenesis through increasing both myoblast proliferatio

274 ors further suggest that HIF1alpha represses myogenesis through inhibition of canonical Wnt signaling

275 strate that Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity.

276 0, an ARMS cell line, is most similar to the myogenesis time point when PAX3-FOXO1 is expressed.

277 sults intimately associate the initiation of myogenesis to a change in cell adhesion and may reveal a

278 rogenitor cells, but is required during late myogenesis to directly control the expression of a set o

279 They can either undergo myogenesis to promote muscle regeneration or differentia

280 The process of stem cell myogenesis (transformation into skeletal muscle cells) i

281 unced dysregulation of molecules involved in myogenesis, vascularization, hypertension, hypertrophy (

282 ers, suggesting the involvement of miR-23 in myogenesis via TrxR1 repression.

283 The AMPKalpha1-specific effect on myogenesis was likely due to the dominant expression of

284 n for genes required for myoblast fusion and myogenesis, we discovered an 84-amino acid muscle-specif

285 To explore this facet of myogenesis, we performed a genetic screen for regulators

286 Myogenin expression and myogenesis were nearly abolished in the absence of both

287 els in RD cells than muscle cells and rescue myogenesis when expressed in RD cells.

288 mimetic mutant in primary myoblasts inhibits myogenesis, whereas replacement with a non-phosphorylata

289 naling network underlying mTOR regulation of myogenesis, which contrasts with the well established me

290 a is a positive regulator of skeletal muscle myogenesis, which functions through negatively modulatin

291 etic deletion of MyoD, a master regulator of myogenesis, which is down-regulated in the absence of MA

292 ng promotes proliferation of FAPs to support myogenesis while inhibiting their differentiation into a

293 Suppressing UPF1 accelerates myogenesis, while ectopically increasing UPF1 levels slo

294 Moreover, MYF5 silencing reduced myogenesis, while ectopically restoring CCND1 abundance

295 Importantly, lowering AUF1 delayed myogenesis, while ectopically restoring MEF2C expression

296 A, increases NPM protein levels and inhibits myogenesis, while its overexpression elicits the opposit

297 ription factor that is a master regulator of myogenesis, while leaving MYOD mRNA stability unaffected

298 Uncoupling fusion from preceding stages of myogenesis will help in the analysis of the interplay be

299 c injury, implying that it coordinates adult myogenesis with nutrient availability in vivo.

300 Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell grou