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3 e MEF2Calpha2 isoform in RMS cells increased myogenic activity and promoted differentiation in RMS ce
4 uitously expressed isoform that exhibited no myogenic activity and that MEF2Calpha2, the muscle-speci
6 scles express dystrophin in up to 70% of the myogenic area and increased force generation following i
10 Importantly, elevating miR-431 improved the myogenic capacity of old myoblasts, while inhibiting end
13 nopathy, we investigated in vitro macrophage-myogenic cell interactions and found that Dysf-deficient
15 ast some ARMSs and the PAX3-FOXO1-expressing myogenic cells and demonstrate that fusion RNA profiling
16 e partially reprogrammed from differentiated myogenic cells and display a pluripotent-like state.
17 is transcribed from an intergenic region of myogenic cells and its expression is upregulated during
20 sue; therefore, an unlimited availability of myogenic cells has applications in regenerative medicine
21 e long been recognized as the main source of myogenic cells in adult muscle, most of the knowledge ab
24 minantly expressed by macrophages but not by myogenic cells or capillary endothelia cells in injured
27 Constitutive PKD activation in mouse C2C12 myogenic cells regulated metabolic genes and glucose met
28 n response to muscle injury, and the derived myogenic cells then fuse to repair damaged muscle fibers
30 ICAM-1-ICAM-1 interactions was restricted to myogenic cells, as forced expression of ICAM-1 by fibrob
39 SCs led to increased propensity for terminal myogenic commitment connected to impaired proliferative
40 which encodes a transcriptional regulator of myogenic commitment, via binding to the MyoD mRNA 3' unt
44 determine if AT1 R mechanoactivation affects myogenic constriction in skeletal muscle arterioles and
46 ributes significantly to force generation in myogenic constriction of cerebral resistance arteries.
47 candesartan, indicating that AT1 R-mediated myogenic constriction relies on Ca(2+) -independent down
50 Results also support both neurogenic and myogenic contributions of polyQ AR to several acute aspe
51 e also observed in a model of MYOD1-mediated myogenic conversion of human fibroblasts, and in primary
53 nto the myogenic program also depends on the myogenic determination factor (MyoD) family of genes, bu
54 of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiat
56 that quiescent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcript in vivo, wh
58 rom Deltex2 knockout mice exhibit precocious myogenic differentiation and accelerated regeneration in
59 Pax7(Lo) subpopulation is enriched, enhances myogenic differentiation and accelerates muscle regenera
60 ion indicates that Mesp-b acts by inhibiting myogenic differentiation and by inducing the dermomyotom
61 us, DUX4-mediated activation of Ret prevents myogenic differentiation and could contribute to FSHD pa
62 al lethal, we explored its potential role in myogenic differentiation and development by generating a
63 G translocates to the nucleus in response to myogenic differentiation and sublethal dose of cisplatin
64 ediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of
65 mely paired box 7 (satellite cell) and early myogenic differentiation and terminal differentiation (m
66 ified that LSD1 is the only KDM required for myogenic differentiation and that KDM3B, KDM6A, and KDM8
67 el can help better understand the process of myogenic differentiation and the effects of mechanical c
68 22 was physiologically induced during normal myogenic differentiation and was transcriptionally regul
70 cularly given the lack of drugs that promote myogenic differentiation available for potential clinica
71 These data demonstrate that Ascl2 inhibits myogenic differentiation by targeting MRFs and facilitat
72 on of NKX2-5 or mutant DMPK 3'UTR results in myogenic differentiation defects, which can be rescued b
73 Accordingly, MyoD or Myog expression rescues myogenic differentiation despite Ascl2 overexpression.
74 satellite cells impairs their activation and myogenic differentiation during muscle regeneration.
76 we identified HDAC3 as a major suppressor of myogenic differentiation from a high-efficiency Clustere
77 e identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PF
78 w that myomiR release accompanies periods of myogenic differentiation in cell culture and in vivo.
79 show that cell migration, proliferation, and myogenic differentiation in pre-culture SBB-treated grou
82 transient Myod1 induction efficiently drives myogenic differentiation into multinucleated myotubes.
84 Pak1 and Pak2 display delayed expression of myogenic differentiation markers and myotube formation.
86 ycling that plays a nonredundant role in the myogenic differentiation of muscle precursors, limiting
87 ted ERK nuclear translocation induced robust myogenic differentiation of muscle progenitor/stem cells
88 -culturing the dKO-nmMSCs with dKO-MPCs, the myogenic differentiation potential of the dKO-MPCs was r
90 rs for noninvasive in vivo monitoring of the myogenic differentiation process from muscle precursor c
94 We previously showed that RSPO2 promoted myogenic differentiation via activation of WNT/beta-cate
96 immortalized cells retained the capacity for myogenic differentiation when treated with the steroid h
97 urthermore, the model of bexarotene-enhanced myogenic differentiation will provide an important avenu
98 myogenin and a specific Mef2 isoform induced myogenic differentiation without activating endogenous M
99 considered to play an important role during myogenic differentiation, chronological alterations in D
100 he dynamic protein changes that occur during myogenic differentiation, demonstrating the feasibility
101 sults predict the kinetics of the process of myogenic differentiation, including the number of cells
102 rference revealed that BRD4 was required for myogenic differentiation, whereas BRD3 down-regulation r
103 eta superfamily signaling is an inhibitor of myogenic differentiation, with elevated activity in aged
125 to multiple lineages, such as neurogenic and myogenic differentiations; they also display a superior
132 myogenic regulatory factors-muscle-specific myogenic factor 5, myoblast determination 1, and myogeni
133 e characteristic SS18-SSX fusion oncogene in myogenic factor 5-expressing (Myf5-expressing) cells dev
134 rk for studying interactions between general myogenic factors and iTFs in evolutionary diversificatio
138 es a major contribution to the regulation of myogenic function, while E2f2 appears to be less importa
139 m-regulated phosphatase that is required for myogenic gene expression and skeletal muscle differentia
140 yme, which is required for the activation of myogenic gene expression, is a calcineurin substrate.
142 ed more strongly with and recruited HDAC5 to myogenic gene promoters to repress muscle-specific genes
144 nistically, Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn p
146 orm us that Tbx1 is required upstream of key myogenic genes needed for core mesoderm cell survival an
147 s, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate th
148 f knock-in reporter human iPS cell lines for myogenic genes which can be used for disease modeling, d
151 d increasing MT values during the 28 days of myogenic in vivo differentiation and did not reach the v
152 used to noninvasively monitor the process of myogenic in vivo differentiation of hMPCs as a biomarker
153 to a softer blend of PDMS muprinted with FN, myogenic index, myotube width, and myotube length on mum
154 -derived mesenchymal stem cells and promotes myogenic induction of C2C12 mouse myoblasts, whereas dep
158 regulates satellite cell behavior, promoting myogenic lineage progression through myogenic differenti
159 ll muscle progenitor state - a distinct cell myogenic lineage responsible for postnatal growth and re
160 s study characterized a unique population of myogenic lineage stem cells that can be isolated from ad
164 the expression of the cardiac progenitor and myogenic marker Nkx2.5, or that of the myocardial marker
167 es TrxR1 levels and delays the expression of myogenic markers, suggesting the involvement of miR-23 i
169 f the disease can be caused by neurogenic or myogenic mechanisms, we made use of the tet-On and Cre-l
171 lls also demonstrated delayed induction of 3 myogenic microRNAs (miRNAs), miR-1, miR-206, and miR-486
172 was examined in two mouse models of SBMA, a myogenic model that overexpresses wildtype androgen rece
173 ment accumulations were observed only in the myogenic model, even though axonal transport dysfunction
174 g in DMD patients should not only target the myogenic MPCs but should also attempt to prevent the act
175 ence, we termed this population of cells non-myogenic MSCs (nmMSCs); and (ii) a slowly adhering cell
176 ral circuits show that neurons can control a myogenic muscle organ not only by changing the contracti
177 al circuits have long been known to modulate myogenic muscles such as the heart, yet a mechanistic un
178 ing of the Caenorhabditis elegans pharynx, a myogenic muscular pump for feeding, and found three neur
179 e from the STS-131 mission exhibited reduced myogenic (Myf5 and -6) and adipogenic (Pparg, Cebpa, and
181 sal physiological mechanism that may involve myogenic, neural control as well as metabolic regulation
183 pidly adhering cell population, which is non-myogenic, Pax7(-) and express the mesenchymal stem cell
184 selected alveolar rhabdomyosarcoma (ARMS), a myogenic pediatric cancer whose exact cell of origin is
187 ty of the transduced cells, as well as their myogenic phenotype, were determined by flow cytometry an
189 lled labeling and monitoring of lipogenic or myogenic populations of lung fibroblasts during fibrosis
192 compromising each other, which indicates the myogenic potential of this combination of small RNAs.
195 se model ectopically expressing COUP-TFII in myogenic precursors to maintain COUP-TFII activity durin
196 ssion of TrxR1 during differentiation delays myogenic process, by negatively affecting the expression
198 rium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated
201 nse to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs) within the extracellula
202 of Pask in promoting the differentiation of myogenic progenitor cells, embryonic stem cells and adip
203 that cytoglobin is up-regulated in activated myogenic progenitor cells, where it localizes to the nuc
206 tem cells (satellite cells, SCs) and derived myogenic progenitors (MPs); however, the factors respons
207 n be subcultured to produce large amounts of myogenic progenitors amenable to numerous downstream app
208 n in the fusion and differentiation of human myogenic progenitors and that dominant negative inhibiti
214 man primary CD56(Pos) satellite cell-derived myogenic progenitors obtained from healthy individuals t
221 of genes, but Pax3 is not expressed in these myogenic progenitors, where different gene regulatory ne
223 Instead, the later emergence of a competing myogenic program and variable transgene dynamics over ti
224 ifferentiation led to an anticipation of the myogenic program because of an alteration of PcG protein
226 cle fate both by promoting an MRF-associated myogenic program in myoblasts and by maintaining an undi
227 -1 inhibition activates an miR-206-dependent myogenic program in RMS, offering a novel therapeutic st
230 vior of these cells and their entry into the myogenic program is controlled by gene regulatory networ
231 porting a pivotal role for Shox2 in the core myogenic program orchestrating venous pole and pacemaker
232 pression that promotes the activation of the myogenic program, and is therefore termed Linc-RAM (Linc
238 nduced pluripotent stem cells (iPSCs) with a myogenic propensity are able to engraft into both cardia
242 urthermore, methods to enhance the intrinsic myogenic properties of MiPs are likely needed, given the
251 ignificantly improved the gene expression of myogenic regulatory factors in vitro, suggesting myogeni
252 r cells express in a coordinated fashion the myogenic regulatory factors, while down-regulating the s
253 Conversely, the levels of expression of 3 myogenic regulatory factors-muscle-specific myogenic fac
254 the expression and functional activation of myogenic regulatory transcription factors (MRFs) are wel
255 RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5
256 plays an active role in both the arteriolar myogenic response and during changes in vascular tone in
258 sis, reduced KV current density and restored myogenic responses in PAs from TgNotch3(R169C) mice, whe
259 in TgNotch3(R169C) and TgBAC-TIMP3 mice, and myogenic responses of brain arteries were likewise atten
262 etion of p66Shc from these rats restored the myogenic responsiveness of renal preglomerular arteriole
263 lts demonstrate that the pharynx generates a myogenic rhythm in the presence of tonically released ac
264 y reprograms gene expression in BAT toward a myogenic signature, including increased expression of my
265 er human iPS cell line for MYF5, as an early myogenic specification gene, to allow prospective identi
272 cell cycle withdrawal in fetal and postnatal myogenic stem cells, and assign to Ptpn11 signaling a ke
274 estigated the relationship between different myogenic subpopulations and the function of canonical Wn
275 We found that Myf5- and MyoD-expressing myogenic subpopulations exist during embryonic tongue my
278 e that a combinatorial anti-fibrotic and pro-myogenic therapy could be the foundation of future thera
281 he AT1 R blocker losartan (1 mum) diminished myogenic tone and blocked stretch-induced cation current
282 HFD/STZ treatment induced a progressive myogenic tone augmentation in mesenteric and olfactory c
283 n-dependent inhibition of pressure-dependent myogenic tone consistent with previous reports of mechan
284 ilatory responses to an NO donor and loss of myogenic tone in KW animals were also rescued with Nox1
285 ooth muscle cell TNF drives the elevation of myogenic tone via enhanced sphingosine-1-phosphate (S1P)
288 depolarization and constriction to pressure (myogenic tone) were blunted in PAs from TgNotch3(R169C)
289 d from patients with diabetes have augmented myogenic tone, despite reasonable blood glucose control.
292 genes contributes to temporal regulation of myogenic transcription by restricting late gene expressi
295 man skin fibroblasts by forced expression of myogenic transcription factor MyoD, we performed quantit
296 and fusion associated with dysregulation of myogenic transcription factors and disruption of the nes
297 R-182 and provide insight into the role that myogenic transcription factors have in sarcoma progressi
299 h muscle cell TNF augments resistance artery myogenic vasoconstriction in a diabetes model that induc
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