ライフサイエンスコーパス: myogenic differentiation

1 rum-derived factors, Mesp1 promotes skeletal myogenic differentiation.

2 ession rescues Map4k4-mediated inhibition of myogenic differentiation.

3 t as a transcriptional repressor and inhibit myogenic differentiation.

4 which nonetheless did not prematurely enter myogenic differentiation.

5 On the other hand, Vps34 is required for myogenic differentiation.

6 roteins has not extensively been explored in myogenic differentiation.

7 oundly impairs MEF2 protein accumulation and myogenic differentiation.

8 2 myoblasts, they have opposing functions in myogenic differentiation.

9 in muscle precursor cells before and during myogenic differentiation.

10 gene expression consistently associated with myogenic differentiation.

11 ons that are yet unknown may be required for myogenic differentiation.

12 ls, but increased during the early stages of myogenic differentiation.

13 re, GPR39 siRNA reduced obestatin action and myogenic differentiation.

14 oss of Notch1 signaling leads to spontaneous myogenic differentiation.

15 miRNA with a previously demonstrated role in myogenic differentiation.

16 ll proliferation and the prevention of early myogenic differentiation.

17 as BRD3 down-regulation resulted in enhanced myogenic differentiation.

18 rves as a regulator for preventing premature myogenic differentiation.

19 x is expressed in skeletal muscle throughout myogenic differentiation.

20 scle progenitor cell proliferation and delay myogenic differentiation.

21 actin, indicative of malignant sarcoma with myogenic differentiation.

22 potential roles of the RSPO proteins during myogenic differentiation.

23 r its function in muscle gene expression and myogenic differentiation.

24 myogenic transcription factors that promote myogenic differentiation.

25 gesting that they are integral components of myogenic differentiation.

26 suggesting a major role for AS regulation in myogenic differentiation.

27 oxylase activity, led to repression of C2C12 myogenic differentiation.

28 blasts, and activating this pathway promoted myogenic differentiation.

29 ins that are involved in distinct aspects of myogenic differentiation.

30 s catalytically inactive mutant, potentiated myogenic differentiation.

31 recently reported to be downregulated during myogenic differentiation.

32 sary for full activation of p38 MAPK, during myogenic differentiation.

33 r205 persists on Pax3-FOXO1 throughout early myogenic differentiation.

34 n of the fusion protein changes during early myogenic differentiation.

35 associated kinase (ROCK1) that occurs during myogenic differentiation.

36 me that both NET25 and MAN1 are required for myogenic differentiation.

37 critical in muscle development and regulates myogenic differentiation.

38 ecific role for mTORC2 signaling in terminal myogenic differentiation.

39 unction of NET37 appears to be important for myogenic differentiation.

40 anscription factor myogenin, which regulates myogenic differentiation.

41 and nucleosome positioning as a function of myogenic differentiation.

42 ing with the rat myocytes that induced their myogenic differentiation.

43 romoter of a key regulatory gene involved in myogenic differentiation.

44 reas siRNA-mediated knockdown of Ret induced myogenic differentiation.

45 tory factors, which plays a critical role in myogenic differentiation.

46 ls (NCSCs) in vivo and is required for their myogenic differentiation.

47 e for SUMO modification in the regulation of myogenic differentiation.

48 to reduce myoblast proliferation and promote myogenic differentiation.

49 ogenic precursor cell expansion but inhibits myogenic differentiation.

50 rmal cell proliferation without induction of myogenic differentiation.

51 atory regions controlling genes regulated by myogenic differentiation.

52 ion protein 1 (MYOD1)-mediated activation of myogenic differentiation.

53 weak inducer of apoptosis (TWEAK) modulates myogenic differentiation.

54 his study suggested their role in preventing myogenic differentiation.

55 y reversed the inhibitory effect of TWEAK on myogenic differentiation.

56 gh different downstream pathways, to promote myogenic differentiation.

57 oss-talk between Notch and MEF2 to influence myogenic differentiation.

58 s sufficient for robust P2 responsiveness to myogenic differentiation.

59 offer a useful resource for others studying myogenic differentiation.

60 hermore, expression of Trim32 was induced in myogenic differentiation.

61 ic gene expression and sustained or enhanced myogenic differentiation.

62 ion underlies Sharp-1-mediated repression of myogenic differentiation.

63 C2C12 myoblasts and is down-regulated during myogenic differentiation.

64 family of proteins is required for skeletal myogenic differentiation.

65 a molecular mechanism by which 4.1R promotes myogenic differentiation.

66 l in the decision-making process of terminal myogenic differentiation.

67 irst insight into an FSHD-specific defect in myogenic differentiation.

68 was increased, suggesting that Sfrp2 blocks myogenic differentiation.

69 o enhance cellular proliferation and inhibit myogenic differentiation.

70 and/or MKL2 in the requirement for skeletal myogenic differentiation.

71 (BMP), here we examine the role of Smurf1 in myogenic differentiation.

72 ciated intercellular signaling occurs during myogenic differentiation.

73 R controls the rate of myotube fusion during myogenic differentiation.

74 oft tissue cancer characterized by disturbed myogenic differentiation.

75 detrimental effects of cachectic factors on myogenic differentiation.

76 a nanoscale stiffness range known to support myogenic differentiation.

77 inately regulate muscle-related genes during myogenic differentiation.

78 al regulators of muscle-related genes during myogenic differentiation.

79 m-dependent signalling pathways that control myogenic differentiation.

80 re cultured in low-serum medium to stimulate myogenic differentiation.

81 y the role of Wnt-beta-catenin signalling in myogenic differentiation.

82 y, up-regulates Myog expression and promotes myogenic differentiation.

83 nesis, indicating that Mdm2 is necessary for myogenic differentiation.

84 propose that ZBED6 plays a critical role in myogenic differentiation.

85 ted posttranscriptional switch that controls myogenic differentiation.

86 as a key mediator of RSPO-LGR4 signaling in myogenic differentiation.

87 requirement of LGR4 in RSPO signaling during myogenic differentiation.

88 and FGF signaling, thus resulting in reduced myogenic differentiation.

89 ta-catenin and TGF-beta signaling pivotal in myogenic differentiation.

90 a number of miRNAs, thereby contributing to myogenic differentiation.

91 bes under conditions that normally stimulate myogenic differentiation.

92 uration of myogenic microRNAs, thus favoring myogenic differentiation.

93 coma (RMS) and leiomyosarcoma (LMS), feature myogenic differentiation.

94 xpressed at the sarcolemma of myotubes after myogenic differentiation.

95 cilium and cessation of Hh signaling during myogenic differentiation.

96 ore identify miR-186 as a novel regulator of myogenic differentiation.

97 tion and proliferation and promoted terminal myogenic differentiation.

98 ession, functions as a positive regulator of myogenic differentiation.

99 feration, with the cells undergoing enhanced myogenic differentiation.

100 The myogenic differentiation 1 (MyoD) gene is a master regul

101 that quiescent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcript in vivo, wh

102 -specific heterodimeric DNA-binding partner, myogenic differentiation 1 (MYOD).

103 omoting myogenic lineage progression through myogenic differentiation 1 (Myod1) regulation.

104 lls to be positive for desmin, myogenin, and myogenic differentiation 1 (MyoD1).

105 al are integrally involved in the process of myogenic differentiation, acting as nodal regulators of

106 f-6 show a delay of Rac1 inactivation during myogenic differentiation and abnormal myotube formation.

107 rom Deltex2 knockout mice exhibit precocious myogenic differentiation and accelerated regeneration in

108 Pax7(Lo) subpopulation is enriched, enhances myogenic differentiation and accelerates muscle regenera

109 dicate roles for A-type lamins and emerin in myogenic differentiation and also suggest that these eff

110 ion indicates that Mesp-b acts by inhibiting myogenic differentiation and by inducing the dermomyotom

111 us, DUX4-mediated activation of Ret prevents myogenic differentiation and could contribute to FSHD pa

112 um response factor-dependent genes promoting myogenic differentiation and cytoskeletal organization.

113 al lethal, we explored its potential role in myogenic differentiation and development by generating a

114 GEFT is transcriptionally upregulated during myogenic differentiation and downregulated during adipog

115 -mfa-domain-containing) proteins function in myogenic differentiation and embryonic development by pa

116 Mirk is induced within the initial 24 h of myogenic differentiation and enables MEF2 to transcribe

117 role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk

118 ) stimulates myoblast proliferation, induces myogenic differentiation and generates myocyte hypertrop

119 bnl3 expression is required for normal C2C12 myogenic differentiation and high-throughput sequencing

120 ating that Map4k4 is a negative regulator of myogenic differentiation and hypertrophy.

121 RSPOs also promoted myogenic differentiation and induced hypertrophic myotub

122 and Sirt1 cross-talk each other to regulate myogenic differentiation and mediate EPO activity during

123 at the cell cortex is a crucial step during myogenic differentiation and might be a general mechanis

124 tant increase in Pax3-mediated inhibition of myogenic differentiation and myoblast migration.

125 important extracellular cue in regulation of myogenic differentiation and myofiber size.

126 ts identify Stac3 as a new gene required for myogenic differentiation and myofibrillar protein assemb

127 as MSulf double mutant mice exhibit delayed myogenic differentiation and prolonged Pax7 expression a

128 pathway may contribute to the inhibition of myogenic differentiation and resistance to apoptosis in

129 easing Tmod in the nucleus severely hampered myogenic differentiation and selectively suppressed musc

130 etion of the LGR4 receptor severely disrupts myogenic differentiation and significantly diminishes th

131 TNFalpha inhibits myogenic differentiation and skeletal muscle regeneratio

132 G translocates to the nucleus in response to myogenic differentiation and sublethal dose of cisplatin

133 hly significant manner, many are involved in myogenic differentiation and suggest a partial block in

134 ediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of

135 mely paired box 7 (satellite cell) and early myogenic differentiation and terminal differentiation (m

136 ified that LSD1 is the only KDM required for myogenic differentiation and that KDM3B, KDM6A, and KDM8

137 hat EB3 [6] is specifically upregulated upon myogenic differentiation and that knockdown of EB3, but

138 el can help better understand the process of myogenic differentiation and the effects of mechanical c

139 e limb mesoderm that determines the sites of myogenic differentiation and thus establishes the basic

140 22 was physiologically induced during normal myogenic differentiation and was transcriptionally regul

141 s not interfere with the program of skeletal myogenic differentiation, and does not affect myoblast m

142 FR1 gene expression is down-regulated during myogenic differentiation, and FGFR1 promoter activity is

143 s of dermomyotomal markers and activation of myogenic differentiation, and higher levels induce loss

144 ative form of TCF4 reversed MYF5 expression, myogenic differentiation, and hypertrophic myotube forma

145 e significantly compromised MYF5 expression, myogenic differentiation, and myotube formation.

146 or other E2F family members, is required for myogenic differentiation, and that this requirement for

147 1 expression, impaired EPO effect on delayed myogenic differentiation, and the Sirt1 knockdown effect

148 leavage of the alpha7 chain is elevated upon myogenic differentiation, and this cleavage may be media

149 sed alpha7 mRNA and protein levels following myogenic differentiation are inversely correlated with c

150 Akt substrates required for myogenic differentiation are unknown.

151 molecule involved in the cellular control of myogenic differentiation, are increased by MIBP.

152 We used human myogenic differentiation as a model system to statistica

153 Using myogenic differentiation as a model, we found that reduc

154 hat although mTOR knockdown severely impairs myogenic differentiation as expected, the knockdown of r

155 wering Xhes6 expression levels blocks normal myogenic differentiation at tail bud stage.

156 cularly given the lack of drugs that promote myogenic differentiation available for potential clinica

157 that these myoblasts are unable to complete myogenic differentiation because of an inability to up-r

158 R-210 was induced in normoxic myoblasts upon myogenic differentiation both in vitro and in vivo.

159 a are assembled during the initial stages of myogenic differentiation but disappear as cells progress

160 rct, which did not express Nkx2.5 or undergo myogenic differentiation, but adopted a vascular fate wi

161 cAMP signaling can both promote and inhibit myogenic differentiation, but little is known about the

162 mTOR is a master regulator of myogenic differentiation, but the pathways mediating ami

163 posed that netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as co

164 on of skeletal muscle gene expression during myogenic differentiation by facilitating the transition

165 ta suggest that inhibition of MSC suppresses myogenic differentiation by inhibiting the caspase-3 act

166 factor receptor in RMS cells, which promotes myogenic differentiation by inhibiting the Notch and the

167 uggest that MIBP functions in the control of myogenic differentiation by regulating alpha7beta1 integ

168 heb-mTOR/raptor pathway negatively regulates myogenic differentiation by suppressing IRS1-PI3K-Akt si

169 These data demonstrate that Ascl2 inhibits myogenic differentiation by targeting MRFs and facilitat

170 tions of BCL9/9-2 inhibited the promotion of myogenic differentiation by Wnt and the normal regenerat

171 inhibitory mechanisms can be suppressed and myogenic differentiation can be induced in the RD rhabdo

172 We first show that cell cycle exit and myogenic differentiation can be uncoupled.

173 considered to play an important role during myogenic differentiation, chronological alterations in D

174 ion of genes involved in neuroectodermal and myogenic differentiation, closely simulating the develop

175 ur data suggest that the role of Fn14 during myogenic differentiation could be independent of TWEAK c

176 strated that cells lacking c6orf32 exhibit a myogenic differentiation defect, characterized by a decr

177 in other inflammatory myopathies, display a myogenic differentiation defect.

178 on of NKX2-5 or mutant DMPK 3'UTR results in myogenic differentiation defects, which can be rescued b

179 n of the master regulator MyoD, resulting in myogenic differentiation defects.

180 tained expression of Pax3 proteins inhibited myogenic differentiation, demonstrating that Pax3 degrad

181 he dynamic protein changes that occur during myogenic differentiation, demonstrating the feasibility

182 Accordingly, MyoD or Myog expression rescues myogenic differentiation despite Ascl2 overexpression.

183 satellite cells impairs their activation and myogenic differentiation during muscle regeneration.

184 longed activation of MAPK/ERK pathway during myogenic differentiation, expression of myogenin does no

185 Here, we show that myogenic differentiation factors regulate miR-182 levels

186 we identified HDAC3 as a major suppressor of myogenic differentiation from a high-efficiency Clustere

187 c fibroblasts failed to undergo MyoD-induced myogenic differentiation, further suggesting that Maml1

188 12 myoblasts markedly enhances expression of myogenic differentiation genes, myoblast fusion, and myo

189 diated H3-K9 methylation on the promoters of myogenic differentiation genes.

190 in embryonic development, bone formation and myogenic differentiation; however, its role in human can

191 ported that the tyrosine kinase Abl promotes myogenic differentiation in a manner dependent on its cy

192 e show that MyoD up-regulates miR-378 during myogenic differentiation in C2C12 cells.

193 e identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PF

194 w that myomiR release accompanies periods of myogenic differentiation in cell culture and in vivo.

195 Furthermore, myogenic differentiation in Mef2a-deficient myoblasts is

196 show that cell migration, proliferation, and myogenic differentiation in pre-culture SBB-treated grou

197 but not constitutive active Akt restored the myogenic differentiation in TAK1-deficient mouse embryon

198 vestigated the role of Wnt signalling during myogenic differentiation in the developing chick wing bu

199 ed that distinct regulatory cascades control myogenic differentiation in the head and the trunk.

200 signaling rescues CNC cell proliferation and myogenic differentiation in these mutant mice.

201 ons impairs MyoD function, thereby arresting myogenic differentiation in these tumor cells.

202 ppaBalphaDeltaN) significantly increased the myogenic differentiation in TWEAK-treated C2C12 cultures

203 superfamily member that positively regulates myogenic differentiation in vitro and in vivo and signal

204 We found that Deltex2 inhibits myogenic differentiation in vitro, and that skeletal mus

205 During myogenic differentiation in vitro, Has2 was the most hig

206 ive-CD45 negative epCSCs and increased their myogenic differentiation in vitro.

207 he requirement of most of these microRNAs in myogenic differentiation in vivo.

208 d in reduced cell proliferation coupled with myogenic differentiation, including increased expression

209 eveloping mouse embryo that is important for myogenic differentiation, including notably, the differe

210 sults predict the kinetics of the process of myogenic differentiation, including the number of cells

211 Thus, the myogenic differentiation-induced microRNAs miR-1 and -20

212 Conversely, myogenic differentiation into multinucleated myotubes wa

213 transient Myod1 induction efficiently drives myogenic differentiation into multinucleated myotubes.

214 The process of stem cell myogenic differentiation is interpreted as the interplay

215 However, the role of those components in myogenic differentiation is not entirely clear.

216 of E2F proteins, and in particular E2f3, in myogenic differentiation is not well understood.

217 pleted from proliferating myoblasts by RNAi, myogenic differentiation is significantly impaired, and

218 molecular mechanism by which RSPO2 regulates myogenic differentiation is unknown.

219 Pak1 and Pak2 display delayed expression of myogenic differentiation markers and myotube formation.

220 Results showed that relaxin promoted myogenic differentiation, migration, and activation of m

221 tion and onset time relative to the stage of myogenic differentiation, miniagrin was found to induce

222 At genes expressed throughout the program of myogenic differentiation, Myod can bind and recruit hist

223 show that in addition to inhibiting MyoD and myogenic differentiation, NICD(OE) upregulates Pax7 and

224 O1 or PAX7-FOXO1 fusions that block terminal myogenic differentiation, no functionally comparable gen

225 Transplantation and myogenic differentiation of bone marrow-derived progenit

226 that increased expression of Smurf1 promotes myogenic differentiation of C2C12 cells and blocks the B

227 demonstrate that Smurf1 is required for the myogenic differentiation of C2C12 cells and plays an imp

228 transmembrane protein NET37 is required for myogenic differentiation of C2C12 cells.

229 During myogenesis, Sfmbt1 represses myogenic differentiation of cultured and primary myoblas

230 Immunohistology at 4 weeks revealed myogenic differentiation of donor cells at the site of c

231 -Fc chimera or short interfering RNA induced myogenic differentiation of IBM mesoangioblasts.

232 atin to the differentiation medium increased myogenic differentiation of L6E9 cells.

233 s repression of the Runx2 P1 promoter during myogenic differentiation of mesenchymal cells.

234 se (TERT) enhanced the survival, growth, and myogenic differentiation of mesenchymal stromal cells (M

235 Moreover, TWEAK inhibited myogenic differentiation of mesoangioblasts.

236 Myogenic differentiation of MSCs in culture was induced

237 ycling that plays a nonredundant role in the myogenic differentiation of muscle precursors, limiting

238 D2 (CCND2) was shown to dramatically enhance myogenic differentiation of muscle progenitor cells and

239 ted ERK nuclear translocation induced robust myogenic differentiation of muscle progenitor/stem cells

240 Ebp1 was expressed in the dermomyotome, and myogenic differentiation of muscle progenitors was inhib

241 genes in the regulation of chondrogenic and myogenic differentiation of paraxial mesoderm.

242 unostaining showed extensive engraftment and myogenic differentiation of preconditioned Sca-1+ cells.

243 Myogenic differentiation of retinal cells prior to their

244 In vitro, CDCs showed the greatest myogenic differentiation potency, highest angiogenic pot

245 ogenic potential in myoblasts, the augmented myogenic differentiation potential observed is likely th

246 -culturing the dKO-nmMSCs with dKO-MPCs, the myogenic differentiation potential of the dKO-MPCs was r

247 g high levels of endoglin (NCSC(CD105+)) had myogenic differentiation potential.

248 pansion during regeneration, but compromised myogenic differentiation prevented the contribution of t

249 Myogenic differentiation proceeds through a highly coord

250 rs for noninvasive in vivo monitoring of the myogenic differentiation process from muscle precursor c

251 rogenitor cells followed by the execution of myogenic differentiation, processes that are coordinated

252 e from which these tumors arise, restore the myogenic differentiation program and block the tumorigen

253 th IP3R and RYR, is expressed as part of the myogenic differentiation program and enhances NFAT-depen

254 ssemble a regulatory network controlling the myogenic differentiation program in mammalian cells.

255 d a critical role for eRNAs in regulation of myogenic differentiation program through increasing chro

256 ng cell cycle progression and initiating the myogenic differentiation program.

257 of SRF have been identified in the skeletal myogenic differentiation program.

258 context, EWS/FLI-1 profoundly inhibited the myogenic differentiation program.

259 leads to Pax7 cleavage and initiation of the myogenic differentiation program.

260 form essential for normal progression of the myogenic differentiation programme.

261 Expression of early myogenic differentiation proteins Myf-5 and MyoD increas

262 c function, the highest cell engraftment and myogenic differentiation rates, and the least-abnormal h

263 alpha7 integrin is tightly regulated during myogenic differentiation, reflecting required functions

264 However, its role in regulation of myogenic differentiation remains unknown.

265 tion of immunoproteasomes (i-proteasomes) in myogenic differentiation remains unknown.

266 ion of MyoD and its target genes, diminished myogenic differentiation, repression of glutathione redo

267 The block in C2C12 myogenic differentiation required the nuclear localizati

268 iated E2A protein degradation depends on the myogenic differentiation state (t 1/2 approximately 2 h

269 MyoD and Id1 degradation are independent of myogenic differentiation state.

270 id not inhibit other biochemical measures of myogenic differentiation, suggesting a specific role of

271 to multiple lineages, such as neurogenic and myogenic differentiations; they also display a superior

272 of beta-catenin-recovered their capacity for myogenic differentiation through myocyte enhancer factor

273 ate the ubiquitin-proteasome system (UPS) in myogenic differentiation through regulating cell cycle p

274 apidly divide, and are capable of undergoing myogenic differentiation to form myotubes.

275 Importantly, Bhlhe40 knockdown rescues myogenic differentiation under hypoxia.

276 We have dissected the role of the UPS in myogenic differentiation using an in vitro muscle differ

277 We previously showed that RSPO2 promoted myogenic differentiation via activation of WNT/beta-cate

278 t PAX3/FOXO1A and PAX7/FOXO1A act to prevent myogenic differentiation via suppression of the transcri

279 Insulin growth factor 1-induced myogenic differentiation was also found to involve TAK1.

280 Induced myogenic differentiation was associated with a decrease

281 The inhibitory effect of DMOG on myogenic differentiation was markedly impaired in C2C12

282 The inhibitory effect of gadolinium ions on myogenic differentiation was reversible and independent

283 ermine the role of these factors in skeletal myogenic differentiation we used a dominant negative MKL

284 ur understanding on how microtubules support myogenic differentiation, we analyzed the role of EB1-re

285 um of distal regulatory elements that govern myogenic differentiation, we generated chromatin state m

286 Remarkably, during the course of myogenic differentiation, we observed retention and acqu

287 immortalized cells retained the capacity for myogenic differentiation when treated with the steroid h

288 F-II, IGFBP-5 restores IGF-II expression and myogenic differentiation, whereas an IGF binding-deficie

289 rference revealed that BRD4 was required for myogenic differentiation, whereas BRD3 down-regulation r

290 ed that blockage of this pathway accelerated myogenic differentiation, whereas its activation diminis

291 ly, composed of miR-1 and miR-206, promoting myogenic differentiation, whereas miR-133 maintains the

292 least partially overlapping functions during myogenic differentiation, which are distinct from those

293 nd suggests that it is involved in mediating myogenic differentiation, which is HIF-independent.

294 alities in cell-cycle parameters and delayed myogenic differentiation, which were associated with per

295 y cilia strongly suppresses Hh signaling and myogenic differentiation while enhancing proliferation.

296 ntigen family protein, promotes neuronal and myogenic differentiation while inhibiting adipogenesis.

297 urthermore, the model of bexarotene-enhanced myogenic differentiation will provide an important avenu

298 ferentiation and mediate EPO activity during myogenic differentiation with Sirt1 playing a role upstr

299 eta superfamily signaling is an inhibitor of myogenic differentiation, with elevated activity in aged

300 myogenin and a specific Mef2 isoform induced myogenic differentiation without activating endogenous M