ライフサイエンスコーパス: myometrial

1 A switch from myometrial quiescence to myometrial activation is required to establish uterine c

2 ation between the onset of preterm labor and myometrial activation of the inflammatory transcription

3 fect only myometrial quiescence, can promote myometrial activation over time by increasing the expres

4 oteins and connexin 43 is a critical step in myometrial activation, allowing for a maximal contractil

5 oteins and connexin 43 is a critical step in myometrial activation, allowing for a maximal contractil

6 During myometrial activation, proteins that prime the smooth mu

7 ed in the premature occurrence of labor-type myometrial activity and increases in maternal plasma est

8 dly, peripheral estrogen infusions increased myometrial activity but did not produce preterm delivery

9 hanism by which Hsp20 acetylation can affect myometrial activity by liberating cofilin is described a

10 aternal endocrinology, a nocturnal switch in myometrial activity from low amplitude, infrequent contr

11 brane biochemical changes, and alteration of myometrial activity patterns.

12 slational modification that can affect human myometrial activity.

13 aglandins that could significantly influence myometrial activity.

14 ivate proinflammatory pathways in both human myometrial and amnion cells, which suggests that the pro

15 NF-kappaB and p38 kinase activation in both myometrial and amnion cells.

16 isoform (mK44) is expressed predominantly in myometrial and aortic smooth muscle and forms a function

17 Data for the imaging evaluation of myometrial and cervical invasion were abstracted indepen

18 by the downregulation of Fabp4 and Fatp4 in myometrial and decidual tissues, respectively; this supp

19 Using matched pairs of human myometrial and leiomyoma smooth muscle cells from the sa

20 Only Thy-1(+) human myometrial and orbital fibroblasts were capable of myofi

21 Immunohistochemistry localized Cav3.1 to myometrial and vascular smooth muscle cells whilst Cav3.

22 , neutrophils, and mature dendritic cells to myometrial and/or decidual tissues.

23 ly activates AP-1 but not NFkB, we show that myometrial AP-1 activation drives production of cytokine

24 Chorionic plate and myometrial artery relaxation was increased compared to c

25 tein expression using immunohistochemstry in myometrial biopsies from pregnant women.

26 s of these findings for the co-ordination of myometrial [Ca2+]i signalling and contractility are disc

27 Lactate is increased in myometrial capillary blood from women in slow or non-pro

28 We previously identified myometrial caspase-3 (CASP3) as a potential regulator of

29 Polymerase chain reaction of mouse myometrial cDNA identified four alternatively spliced si

30 The pregnant human myometrial cell line PHM1-41 and primary cultured uterin

31 overexpression of miR-200a in cultured human myometrial cells (hTERT-HM) suppressed STAT5b and increa

32 n nuclear factor-kappaB (NF-kappaB) in human myometrial cells are time-dependent.

33 Cytokine stimulation of cultured myometrial cells did not induce iNOS expression or nitri

34 on of the proquiescent Galphas gene in human myometrial cells following stimulation with the proinfla

35 Here we report that myometrial cells from human and mouse express bitter tas

36 nd survive when directly mixed with unsorted myometrial cells in monolayer culture.

37 Gap junctions between myometrial cells increase dramatically during the final

38 Estrogen/progesterone treatment of mature myometrial cells induced expression of WNT11 and WNT16,

39 ng revealed that CGRP-Rs are abundant in the myometrial cells of pregnant women who are not in labor,

40 n of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometr

41 bour contractions require synchronization of myometrial cells through gap junctions (GJs).

42 In primary myometrial cells treated with phorbol ester, transient i

43 In isolated single mouse myometrial cells, a phenotypical bitter tastant (chloroq

44 ated agonist activity in estrogen-responsive myometrial cells, as determined by induction of prolifer

45 In LMSP cells cocultured with mature myometrial cells, estrogen-progesterone selectively indu

46 In human myometrial cells, knockdown of TAS2R14 but not TAS2R10 i

47 K1 and IK2 were unevenly distributed between myometrial cells, most cells possessing either IK1 (30 c

48 lock oxytocin-induced contractility in human myometrial cells.

49 zyme in in vitro cultures of amnion-WISH and myometrial cells.

50 8%, respectively, in amnion-derived WISH and myometrial cells.

51 ly expressed in the submyometrial stroma and myometrial connective tissues during this period.

52 Myometrial connexin-43 gap junctions are scarce througho

53 onists to determine the relationship between myometrial contractility (spontaneous and oxytocin-induc

54 he myometrium suggests that CRH may modulate myometrial contractility and hence parturition.

55 reveal new roles for Kir7.1 in regulation of myometrial contractility and melanocortin signaling.

56 n the physiological range potently decreases myometrial contractility as a result of its inhibition o

57 our initial expectations, TNF did not induce myometrial contractility but did inhibit the relaxation

58 Spontaneous myometrial contractility declined after 24 h but was les

59 e concentrations, plays a role in regulating myometrial contractility during labour.

60 en proposed to play a role in the control of myometrial contractility in pregnancy.

61 ose-response curves showed that 5-HT-induced myometrial contractility is drastically increased in lat

62 and the ability of cAMP agonists to repress myometrial contractility is lost with prolonged exposure

63 athogen-derived ligands may directly promote myometrial contractility via Rho/ROCK signaling, thus co

64 patterns, (2) relationships between ECoG and myometrial contractility, and (3) 24 h ECoG patterns at

65 Acute cAMP elevation inhibits myometrial contractility, but the mechanisms responsible

66 nd the impact of prolonged cAMP elevation on myometrial contractility.

67 efined the functional consequence of this on myometrial contractility.

68 Myometrial contraction is a central feature of labor.

69 racellular acid pH transients that accompany myometrial contraction.

70 re frequent but shorter duration spontaneous myometrial contractions (P < 0.05) and an attenuated con

71 ulation of extracellular lactate will reduce myometrial contractions and could therefore contribute t

72 of tissues, but the effects of CGRP on human myometrial contractions and the changes in CGRP receptor

73 and maintenance therapy, as it inhibits both myometrial contractions and the proinflammatory effects

74 us research has suggested that cAMP inhibits myometrial contractions via protein kinase A (PKA) activ

75 cyclic adenosine monophosphate which favours myometrial contractions.

76 nd that prolonged cAMP elevation can prevent myometrial contractions.

77 lationship was found between ECoG cycles and myometrial contracture cycles.

78 rs involved in controlling the expression of myometrial CREM splice variants.

79 meostasis and in pathogenesis of orbital and myometrial diseases characterized by persistent myofibro

80 Electrocorticogram (ECoG) and myometrial electromyogram (EMG) were recorded continuous

81 eous onset of labour was determined from the myometrial EMG.

82 placental contrast material enhancement with myometrial enhancement as a reference.

83 postcontrast images and precedes substantial myometrial enhancement.

84 hich is a likely mechanism for modulation of myometrial excitability during pregnancy.

85 Myometrial excitability is governed by ion channels, and

86 te the effect of stretch on human myometrium.Myometrial explants, prepared from biopsies obtained at

87 the presence of active ARF6 and ARF1 in all myometrial extracts.

88 d fluorescence-activated cell sorting, human myometrial fibroblasts were successfully separated into

89 l causes remain uncertain, although impaired myometrial function has been implicated.

90 a production has the potential for modifying myometrial function in pathological settings, particular

91 delayed progesterone withdrawal and impaired myometrial function.

92 -layer cell pairs, the voltage dependence of myometrial gap junction conductance is more apparent at

93 etrium and may thus be useful in achieving a myometrial gene expression profile that favors uterine q

94 e events allowed for a premature increase in myometrial GJA1 levels, elevated contractile responsiven

95 Using immortalized human myometrial (hTERT-HM) cells stably expressing wild-type

96 essing human GPR10 in the myometrium develop myometrial hyperplasia with excessive extracellular matr

97 There were no instances of myometrial infarction.

98 m of mouse parturition is thought to involve myometrial infiltration by amniotic fluid (AF) macrophag

99 ient for both SRC-1 and SRC-2 had suppressed myometrial inflammation, increased serum progesterone, a

100 These data suggest that changes in myometrial iNOS expression may participate in the regula

101 , 0.5 cm) and enhancement of the endometrial-myometrial interface and a signal void in the lumen on g

102 1.8 cm) with enhancement of the endometrial-myometrial interface and latticelike enhancement travers

103 Optimal cutoffs for MTV in predicting deep myometrial invasion (20 mL) and the presence of lymph no

104 15 for all) and independently predicted deep myometrial invasion (P < 0.015) and lymph node metastase

105 lying MTV cutoffs for the prediction of deep myometrial invasion and lymph node metastases may increa

106 nerated, and MTV cutoffs for predicting deep myometrial invasion and lymph node metastases were calcu

107 acteristic curves for identification of deep myometrial invasion and lymph node metastases were gener

108 ly in endometrial polyps than in carcinomas; myometrial invasion and necrosis showed high predictive

109 Myometrial invasion and overall stage were compared by u

110 ior diagnostic accuracy in the assessment of myometrial invasion and significantly higher staging acc

111 association between inaccurate assessment of myometrial invasion and standard pitfalls with DW MR ima

112 more sensitive than US for the detection of myometrial invasion and the type of abnormal placentatio

113 lls associated with inaccurate assessment of myometrial invasion at T1- and T2-weighted imaging, DW M

114 P = .001), and the proportion of tumors with myometrial invasion compared with those with none (92% v

115 Posttest probabilities of deep myometrial invasion for grades 1, 2, or 3 increased to 6

116 tly affects the posttest probability of deep myometrial invasion in patients with all grades of endom

117 mean weighted pretest probabilities of deep myometrial invasion in patients with tumor grades 1, 2,

118 all female mice as early as age 1 month with myometrial invasion occurring by 3 months.

119 Patients with grade 3 cancer and >/= 50% myometrial invasion or cervical stroma invasion may bene

120 r women with grade 1 or 2 cancer and >/= 50% myometrial invasion or grade 3 cancer and < 50% myometri

121 The threshold of TVR associated with myometrial invasion was assessed by using receiver opera

122 pathology reports, pretest probabilities for myometrial invasion were correlated with tumor grade.

123 The mean pretest probabilities of deep myometrial invasion were derived from seven articles (1,

124 LRs for the prediction of myometrial invasion with contrast-enhanced MR imaging we

125 n or equal to 25% allowed prediction of deep myometrial invasion with sensitivity of 100% and specifi

126 phovascular space), disease stage (including myometrial invasion), patients' characteristics (age and

127 For assessing the depth of myometrial invasion, diagnostic accuracy, sensitivity, a

128 for women with grade 1 or 2 cancer and < 50% myometrial invasion, especially when no other high-risk

129 In the assessment of myometrial invasion, however, contrast-enhanced MR imagi

130 For myometrial invasion, kappa values were 0.75 with DW MR i

131 gists independently interpreted the depth of myometrial invasion, overall stage, and presence of pitf

132 , and TLG were significantly related to deep myometrial invasion, presence of lymph node metastases,

133 metrial invasion or grade 3 cancer and < 50% myometrial invasion, vaginal brachytherapy is as effecti

134 d endometrial adenocarcinoma as evidenced by myometrial invasion.

135 grade, lymphovascular invasion, and depth of myometrial invasion.

136 rast, IGFBP-5 hybridization occurs over both myometrial layers before implantation, but decreases in

137 Gland formation and myometrial layers were significantly reduced, and the st

138 of NF-kappaB, TNF, and IL-10 in decidual and myometrial macrophages in C57BL/6J mice.

139 trophysiological recordings demonstrate that myometrial maxi-K current is suppressed in term-pregnant

140 Myometrial mitochondrial copy number was reduced in olde

141 a a stretch-initiated contraction mechanism (myometrial myogenic response).

142 These mothers exhibited decreased myometrial NF-kappaB activation, PGF2alpha, and expressi

143 WNT/beta-catenin pathway that enables mature myometrial or leiomyoma cells to send mitogenic signals

144 gen/progesterone receptor levels than mature myometrial or leiomyoma cells.

145 rigenesis, involving LMSP and differentiated myometrial or leiomyoma cells.

146 image was also evaluated for the presence of myometrial perfusion defects and new fibroids.

147 At 1 and 4 months, myometrial perfusion returned to normal, but leiomyoma p

148 Intriguingly, the predominant myometrial PG produced just prior to labor is prostacycl

149 Intriguingly, the predominant myometrial PG produced just prior to labor is prostacycl

150 We measured serum levels of lipoxin A(4) and myometrial protein release using ELISA, quantified lipox

151 relevance of uterine UPR-ERSR in maintaining myometrial quiescence and regulating the timing of partu

152 A switch from myometrial quiescence to myometrial activation is requir

153 that were previously thought to affect only myometrial quiescence, can promote myometrial activation

154 t time are thought to include maintenance of myometrial quiescence, regulation of plasma volume, and

155 ar microenvironment to maintain the required myometrial quiescence.

156 PKA is not the sole mediator of cAMP-induced myometrial relaxation and that prolonged prophylactic el

157 These data suggest that cAMP-induced myometrial relaxation is not solely dependent on PKA act

158 t PKA activity is necessary for cAMP-induced myometrial relaxation, and that prolonged cAMP elevation

159 role of PKA in mediating cAMP-induced human myometrial relaxation, and the impact of prolonged cAMP

160 (1 h) application of cAMP agonists promoted myometrial relaxation, but this was weakly related to PK

161 versus vehicle; P = 0.0313) without inducing myometrial relaxation.

162 This work is the first to describe the myometrial S-nitrosylproteome in both pregnant and nonpr

163 Elucidation of the myometrial S-nitrosylproteome provides a list of mechani

164 nvitro contractility were performed on human myometrial samples from term, preterm, labour and not in

165 We also analysed myometrial samples from women with spontaneous preterm l

166 The myometrial segments of the uteroplacental arteries have

167 the period of invasion, particularly in the myometrial segments where the key failure occurs.

168 GRP-Rs in myometrium, and resulting enhanced myometrial sensitivity to CGRP, may play a role in maint

169 lcium are essential for contraction of human myometrial smooth muscle (HMSM) and hence parturition.

170 ndothelin-1 as both a constrictor of uterine myometrial smooth muscle and a proinflammatory mediator.

171 and in decidualizing uterine endometrium and myometrial smooth muscle at even earlier postimplantatio

172 ctivated K+ (maxi-K) channels modulate human myometrial smooth muscle cell (hMSMC) excitability; howe

173 qually effective at inhibiting leiomyoma and myometrial smooth muscle cell proliferation.

174 e serotonin-mediated gene regulations in the myometrial smooth muscle cell.

175 onal tumor arising from a single transformed myometrial smooth muscle cell; however, it is not known

176 Human myometrial smooth muscle cells (HMSMCs) in culture were

177 protein 1 (LRP1), in cultured primary human myometrial smooth muscle cells (hMSMCs).

178 Employing transient transfection of human myometrial smooth muscle cells and HeLa cells, as well a

179 NOS isoforms were not detectable in human myometrial smooth muscle cells cultured from term non-la

180 l patch clamp technique, in freshly isolated myometrial smooth muscle cells from pregnant women at te

181 y, xenografts comprised of LMSP and unsorted myometrial smooth muscle cells grew into relatively larg

182 Serotonin treatment of rat uterine myometrial smooth muscle cells induced inositol phosphat

183 of the gene for interstitial collagenase in myometrial smooth muscle cells is absolutely dependent u

184 as xenografts comprised of LMMP and unsorted myometrial smooth muscle cells produced smaller tumors (

185 human pregnant myometrium and cultured human myometrial smooth muscle cells, by immunoblotting, immun

186 L-1beta-stimulated COX-2 expression in human myometrial smooth muscle cells.

187 al vasculature, with no staining detected in myometrial smooth muscle cells.

188 e and our understanding of the regulation of myometrial smooth muscle contraction-relaxation is incom

189 nalling system in modulating the response of myometrial smooth muscle in complicated pregnancies.

190 ma is thought to arise from a single mutated myometrial smooth muscle stem cell.

191 potent vasoconstrictor capable of increasing myometrial smooth muscle tone, has been shown to be up-r

192 inflammatory cytokines and that it increases myometrial smooth muscle tone.

193 nce that nitric oxide-mediated relaxation of myometrial smooth muscle, unlike vascular or gastrointes

194 gated its effects and mechanism of action on myometrial strips from term pregnant rats.

195 tions acutely when added to freshly obtained myometrial strips in 2 out of 9 cases, but Western blot

196 d oocytes, and found ratio of endometrial to myometrial thicknesses in abdominal ultrasonic transvers

197 d not detect message for ERG2 and 3 in whole myometrial tissue extracts.

198 nexin 43 through cAMP/PKA signaling in human myometrial tissue in organ and cell culture.

199 nexin 43 through cAMP/PKA signaling in human myometrial tissue in organ and cell culture.

200 ctile response to oxytocin in pregnant human myometrial tissue strips, which was inhibited by the IP

201 ocin-augmented contractions of ex vivo human myometrial tissue strips.

202 noblotting of extracts from freshly isolated myometrial tissue, affinity-enriched for NOS proteins by

203 tically as compared with the matching normal myometrial tissue.

204 coordinately expressed with labour onset in myometrial tissue.

205 ls in UL-affected tissue compared to matched myometrial tissue.

206 likely to be due to TREK channels, in murine myometrial tissues and myocytes using PCR, Western blots

207 activation of conventional CD4(+) T cells in myometrial tissues and the infiltration of activated mac

208 Myometrial tissues obtained from term, pre-labour electi

209 estigated 94 leiomyomas and 60 corresponding myometrial tissues using exon arrays, whole genome seque

210 in leiomyoma tissues compared with adjacent myometrial tissues.

211 ability to mimic estrogen action in uterine myometrial tissues.

212 aberrations but not in any of the 9 matching myometrial tissues.

213 oduced NO is not likely to be a modulator of myometrial tone during human pregnancy.

214 ng of the molecular events that regulate the myometrial transition from the quiescent pregnant state

215 In six patients thought to have myometrial tumor invasion at MR imaging, five tumors wer

216 maging appears accurate in the prediction of myometrial tumor involvement and in showing the relation

217 sed (P <.001), with no significant change in myometrial vascularity.

218 ein was restricted to the endothelium of the myometrial vasculature, with no staining detected in myo