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1 toinhibition, promoting its interaction with myosin VI.
2 of coordination between the heads of dimeric myosin VI.
3 ctural plasticity during force generation by myosin VI.
4 o binding normally regulates dimerization of myosin VI.
5 al dimerization sequences within full-length myosin VI.
6 m generates an extension of the lever arm of myosin VI.
7 l or apical cargo, however, does not involve myosin VI.
8 on that hinders binding of both PlexinD1 and myosin VI.
9 e of the presumed poststroke conformation of myosin VI.
10  a testis-specific light chain of Drosophila myosin VI.
11 h differs from Kinesin-1 and is more akin to myosin VI.
12 P hydrolysis mechanism and motor function of myosin VI.
13 s waltzer mutant mice, which fail to express myosin VI.
14 ver dynamics and the monomer/dimer nature of myosin VI.
15  identify the binding partners of Drosophila myosin VI.
16 the extension by altering the strain path in myosin VI.
17 tor of 2,500 for a bipartite binding site on myosin-VI.
18 ated by binding of the coiled-coil domain to myosin-VI.
19 the light-chain domain of individual dimeric myosin VIs.
20             We apply our nanospring to human myosin VI, a mechanosensory motor protein, and demonstra
21                 In this study, we found that myosin VI, a motor protein that regulates border cell mi
22                                              Myosin VI, a ubiquitously expressed unconventional myosi
23 er development, have consistently shown that myosin VI, a unique actin-based motor, is upregulated in
24  abundantly expressed in the testis and like myosin VI, accumulates on these cones.
25        New work shows that the motor protein myosin VI, acting through vinculin, plays a key role in
26 native targeting and activation mechanism of myosin VI, allowing direct inferences on myosin VI funct
27 tein and lipid cargoes cooperate to activate myosin VI, allowing myosin VI to integrate Ca(2+), lipid
28 RF) microscopy during processive motility of myosin VI along actin.
29                                              Myosin VI, an actin-dependent, minus-end directed mechan
30                                     Further, myosin VI and Acam co-immunoprecipitate from the testis
31 ation), as demonstrated by the colabeling of myosin VI and BrdU.
32 her supporting the model demonstrate that 1) myosin VI and GIPC1 interactions do not require a mediat
33 mation is characteristic of the single IQ of myosin VI and is common throughout the myosin superfamil
34           This study examined the changes of myosin VI and myosin VIIa, two unconventional myosins th
35                                 We show that myosin VI and Rab8 colocalize around the Golgi complex a
36 for intracellular interactions of GIPC1 with myosin VI and recruitment of overexpressed myosin VI to
37 artner Dab2 and is identical for full-length myosin VI and the cargo-binding tail region.
38    We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT
39 CFTR co-localized with alpha-AP-2, Dab2, and myosin VI and was identified in a complex with all three
40 o the place where a large insert is found in myosin VI and where several cardiomyopathy mutations hav
41    Single molecule experiments indicate that myosin-VI and myosin-V are processive molecular motors,
42              After 48 h, those SCs expressed myosins VI and VIIA, and by 72 h, they developed hair bu
43 , as a force transducer in the mechanoenzyme myosin VI, and as a flexible spacer in the Kelch-motif-c
44 icrotubule-associated protein Cornetto bound myosin VI, and we demonstrated a role for both in secret
45  alternative clathrin-adaptor Dab2, dynamin, myosin-VI, and actin are involved in the internalization
46 in VEGFR2 intracellular trafficking requires myosin-VI, and myosin-VI knockout in mice or knockdown i
47       We also found that AP-2 interacts with myosin VI, another otoferlin binding partner important f
48  The contractile and enzymatic activities of myosin VI are regulated by calcium binding to associated
49   Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mi
50 ography, the authors identified Munc18-1 and myosin VI as interacting partners for CaBP5.
51  Using expression microarrays, we identified myosin VI as one of the top genes that demonstrated canc
52 , a population of supporting cells expressed myosin VI at 78 hours after gentamicin treatment and myo
53 entified optineurin as a binding partner for myosin VI at the Golgi complex and confirmed this intera
54 e phosphatase receptor Q, normally linked to myosin VI at the tapered base of stereocilia, was maldis
55       Furthermore, we show that knockdown of myosin VI attenuates activation of p53 and impairs Golgi
56 s do not require a mediating protein; 2) the myosin VI binding domain in GIPC1 is necessary for intra
57 s study refines the model by identifying two myosin VI binding domains in the GIPC1 C terminus, assig
58 us, assigning respective oligomerization and myosin VI binding functions to separate N- and C-termina
59              This half-life is shared by the myosin VI-binding partner Dab2 and is identical for full
60 f Disabled-2 (Dab2), a tumour suppressor and myosin VI-binding partner, inhibits recruitment of myosi
61 or protein of myosin VI, optineurin, and the myosin VI-binding segment from a monomeric cargo adaptor
62         This is the first demonstration that myosin VI binds lipid membranes.
63               Our data also demonstrate that myosin VI binds to the cone front using its motor domain
64 stological features continued to overexpress myosin VI but to a lesser extent.
65 f the interactions among PlexinD1, GIPCs and myosin VI by a series of crystal structures of these pro
66 e created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa pho
67                              We propose that myosin VI, by removing key molecules from developing hai
68 erse directionality and large powerstroke of myosin VI can be attributed to unusual properties of a s
69 V2 domain to a peptide from Dab2 (LOVDab), a myosin VI cargo protein.
70 n) minus end-directed unconventional myosin, myosin VI, cause hereditary deafness in mice (Snell's wa
71                                              Myosin VI challenges the prevailing theory of how myosin
72 Dab2 (Disabled 2) is the binding partner for myosin VI, clathrin, and alpha-AP-2 and directs endocyto
73 away from the plasma membrane via a synectin-myosin-VI complex.
74 tion of GIPC1 with such structures; 3) GIPC1/myosin VI complexes coordinately move within cellular ex
75 ay underlies the oligomerization of the GIPC/Myosin VI complexes in solution and cells.
76 large (-)-end-directed stroke of a monomeric myosin VI construct.
77 arm, we have generated a series of truncated myosin VI constructs and characterized the size and dire
78 TP concentration-dependent processivities of myosin VI constructs containing either native or artific
79         In this study we investigate whether myosin VI contributes to mechano-electrical transduction
80                 The underlying motion of the myosin VI converter domain must therefore differ substan
81  an unexpected change in conformation of the myosin VI converter domain, essential for twisting the l
82 d to determine whether the actin-based motor myosin VI coordinately retracts with NHE3 in response to
83 ibed kinetics, this allows us to explain how myosin VI coordinates its heads processively while maint
84 ation of p53, and consequently, knockdown of myosin VI de-sensitizes MCF7 cells to DNA damage-induced
85                                            A myosin VI deafness mutation, D179Y, which is in the tran
86                       In acute hypertension, myosin VI decreased in z1 (from 20.6 +/- 1.9 to 10.5 +/-
87  of myosin VI enhances, whereas knockdown of myosin VI decreases, DNA damage-induced stabilization of
88 impairs Golgi complex integrity, which makes myosin VI-deficient cells susceptible to apoptosis upon
89 The findings support alpha-AP-2 in directing myosin VI-dependent endocytosis of CFTR and a requiremen
90 genes in resting Th1 cells and released in a myosin VI-dependent manner following activation.
91                                              Myosin VI depletion increased the same movement paramete
92       Recent experimental work proposed that myosin VI dimerization triggers the unfolding of the pro
93                          Maternally provided myosin VI does not account for the survival of myosin VI
94 in-coated structures suggests that wild type myosin VI does not function as a stable dimer, but eithe
95 ching (FRAP) to examine the turnover rate of myosin VI during endocytosis.
96    Finally, we showed that overexpression of myosin VI enhances, whereas knockdown of myosin VI decre
97 o function optimally as a dimer, full-length myosin VI exists as a monomer in isolation.
98 l interfering RNA-mediated downregulation of myosin VI expression results in a significant reduction
99                                 Depletion of myosin VI expression was also accompanied by global gene
100 ations uncover a novel mechanism mediated by myosin VI for stabilizing long-lived actin structures in
101 h of which can be co-immunoprecipitated with myosin VI from LNCaP cells.
102                             Interfering with myosin VI function in PC12 cells reduced the density of
103  of myosin VI, allowing direct inferences on myosin VI function.
104 lmodulin and provide a basis for specialized myosin VI function.
105              The actin-based molecular motor myosin VI functions in the endocytic uptake pathway, bot
106                    Here, we demonstrate that myosin VI gating is achieved instead by blocking ATP bin
107 binds to, and activates, the promoter of the myosin VI gene.
108 about how myosin VI is regulated and whether myosin VI has a function in the DNA damage response.
109                                 In addition, myosin VI has a number of other specialized structural a
110 sence of these adaptor proteins, full-length myosin VI has ATPase properties of a dimer, appears as a
111                                      Because myosin VI has been shown to facilitate secretory traffic
112 protein secretion, but the overexpression of myosin VI has no major impact on clathrin-mediated endoc
113                                     Although myosin VI has properties that would allow it to function
114  lever arm hypothesis needs modification, or myosin VI has some unique form of extension of its lever
115                                              Myosin VI has two light chain binding sites that can bot
116 d-coil sequences, and reports on full-length myosin VI have failed to demonstrate the existence of di
117      We observe force-induced transitions of myosin VI heads from non-adjacent to adjacent binding, w
118  We considered an alternative model in which myosin VI heads sequentially take 60 nm steps whereas th
119                        LOVDab also activates myosin VI in an in vitro gliding filament assay.
120 a p53-dependent manner such that the pool of myosin VI in endocytic vesicles, membrane ruffles, and c
121                               The absence of myosin VI in fibroblasts derived from the Snell's waltze
122 re binding partners for CFTR and the role of myosin VI in localizing endocytic adaptors in the intest
123 nt endocytosis of CFTR and a requirement for myosin VI in membrane invagination and coated pit format
124              Thus, to understand the role of myosin VI in prostate cancer development, we have charac
125 intenance of Golgi complex integrity and for myosin VI in the p53-dependent prosurvival pathway.
126 pected to produce the pre-powerstroke state, myosin VI in their presence was most similar to the trun
127 othesize that it may alter the regulation of myosin VI in this tissue.
128 y in some tumors, differential regulation of myosin VI in various tumor cells by topoisomerase inhibi
129 hich load may regulate the dual functions of myosin VI in vivo.
130  caused by a mutation in MYO6 (which encodes myosin VI) in one and by noise exposure, suggesting that
131 ase inhibitors dictates whether knockdown of myosin VI inhibits, rather than enhances, the susceptibi
132                                    GIPCs and myosin VI interact through two distinct interfaces and f
133 Intracellular targeting seems to involve two myosin VI-interacting proteins, GIPC and LMTK2, both of
134  with these peptides, we cannot detect a CaM/myosin VI interaction in the testis.
135 tural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear.
136 sity of both myosins and a redistribution of myosin VI into the stereocilia bundle, concurrent with e
137                     Our results suggest that myosin VI is a crucial component in the AP-1B-dependent
138                                              Myosin VI is a molecular motor implicated in many proces
139                                              Myosin VI is a molecular motor that is thought to functi
140                                              Myosin VI is a motor protein that moves toward the minus
141                                              Myosin VI is a reverse direction actin-based motor capab
142                                              Myosin VI is an actin motor that moves to the minus end
143                                              Myosin VI is an actin-based motor that has been implicat
144                                 We find that myosin VI is an efficient transporter at loads of up to
145                                              Myosin VI is an unconventional motor protein and functio
146                                              Myosin VI is an unconventional motor protein with unusua
147                                              Myosin VI is an unconventional motor protein, and its mu
148      Herein, we demonstrate that full-length myosin VI is capable of forming stable, processive dimer
149                   These results support that myosin VI is critical in maintaining the malignant prope
150  triggers dimerization, it would appear that myosin VI is designed to function as a dimer in cells.
151    In the sensory hair cells of the cochlea, myosin VI is expressed in the cell bodies and along the
152                                              Myosin VI is found in distinct intracellular locations a
153                                              Myosin VI is found to play a key role in the protein tra
154                    In the Drosophila testis, myosin VI is important for maintenance of moving actin s
155                   Specifically, we show that myosin VI is induced by p53 and DNA damage in a p53-depe
156  depleted from cells using RNA interference, myosin VI is lost from the Golgi complex, the Golgi is f
157 the leading edge of the actin cones and that myosin VI is necessary for this Acam localization.
158           We show here that complete loss of myosin VI is not lethal in flies and that the previously
159                                              Myosin VI is proposed to act as both a molecular transpo
160      However, very little is known about how myosin VI is regulated and whether myosin VI has a funct
161                          Here, we found that myosin VI is regulated by DNA damage in a p53-dependent
162  show that the intracellular localization of myosin VI is substantially altered by p53 and DNA damage
163                                              Myosin VI is the only type of myosin motor known to move
164                                              Myosin VI is thought to function as both a transporter a
165 e, but the endocytic adaptor linking CFTR to myosin VI is unknown.
166                    Previously, we found that myosin VI is up-regulated in RKO, LS174T, and H1299 cell
167                                              Myosin-VI is a dimeric isoform of unconventional myosins
168                     Our results suggest that myosin VI kinetics are tuned such that the motor maintai
169 asts derived from the Snell's waltzer mouse (myosin VI knock-out) gives rise to defective clathrin-me
170              Small interference RNA-mediated myosin VI knockdown in the LNCaP human prostate cancer c
171                                              Myosin VI knockdown selectively impaired a late phase of
172 ificantly recovers arterial morphogenesis in myosin-VI(-/-) knockdown zebrafish and synectin(-/-) mic
173 cellular trafficking requires myosin-VI, and myosin-VI knockout in mice or knockdown in zebrafish phe
174             Using both dimeric myosin V- and myosin VI-labelled nanotubes, we find that neither myosi
175 ing cone movement, whereas overexpression of myosin VI leads to bigger cones with more F-actin.
176 placing calmodulin at Insert 2 will increase myosin VI lever arm flexibility, which may favor the com
177                        Swapping the flexible myosin VI lever arm for the relatively rigid myosin V le
178 ecifically, intramolecular strain causes the myosin VI lever arm of the lead head to uncouple from th
179 th high affinity to peptide versions of both myosin VI light chain binding sites.
180  We conclude that Acam and not CaM acts as a myosin VI light chain in the Drosophila testis and hypot
181 cam replaces calmodulin as a tissue-specific myosin VI light chain on the actin cones that mediate D.
182                       However in Drosophila, myosin VI loss of function has been thought to be lethal
183                                              Myosin VI (M6) is specialized for processive motion towa
184  VI redistribution and support the idea that myosin VI may serve as the molecular motor for NHE3 retr
185       We propose that homologous pairing and myosin VI-mediated transcriptional pause release account
186  and simulation to demonstrate that multiple myosin VI molecules can coordinate to efficiently transp
187                         However, all dimeric myosin VI molecules so far examined have included non-na
188 rs and initiates dimerization of full-length myosin VI molecules.
189 asure the interhead distance of nearly rigor myosin VI molecules.
190                      Based on the ability of myosin VI monomers to dimerize when held in close proxim
191 this bundle unfolds upon dimerization of two myosin VI monomers.
192 he Ca(2)(+)- and CaM-dependent regulation of myosin VI motility and ATP utilization.
193                     This supports a model of myosin VI motility in which the lever arm is either mech
194 a and the lamellar edge in S2 cells, whereas myosin VI motility is excluded from the same regions.
195  structures of the unique minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-ADP (5.5
196 docytosis by tethering cargo proteins to the myosin VI motor.
197 m Spudich, on the mechanism of the enigmatic myosin VI motor; and Joe Goldstein, on the function of t
198  alters the conformation and activity of the myosin-VI motor implicated in pivotal steps of these pro
199            We report that tethering multiple myosin VI motors, but not myosin V motors, modifies thei
200                       In contrast, tethering myosin VI motors, but not myosin V motors, progressively
201 function to couple vesicle-bound proteins to myosin VI movement.
202                                              Myosin VI moves processively along actin with a larger s
203                                      Dimeric myosin VI moves processively hand-over-hand along actin
204               Unusual for this motor family, myosin VI moves toward the minus (pointed) end of actin
205                  The molecular motor protein myosin VI moves toward the minus-end of actin filaments
206                                              Myosin VI moves toward the pointed (minus) end of actin
207                                         In a myosin VI mutant, the cones do not accumulate F-actin du
208 oacetamide-labeled actin with strongly bound myosin VI (MVI) and to evaluate the effect of MVI-bound
209                                              Myosin VI (MVI) has been found to be overexpressed in ov
210                                              Myosin VI (MVI) is the only known member of the myosin s
211 f network components revealed a key role for myosin VI (MYO6) in Salmonella invasion.
212                                              Myosin VI (Myo6) is a minus end-directed actin-based mot
213                                              Myosin VI (Myo6) is an actin-based motor protein implica
214                                              Myosin VI (myo6) is the only actin-based molecular motor
215                                              Myosin VI (MYO6) is the only myosin known to move toward
216 acting partners: vimentin, actin, myosin Va, myosin VI, myosin X, myosin XIV, kinesin 1, Als2cr4, and
217                         Myosin Va (myoV) and myosin VI (myoVI) are processive molecular motors that t
218    In this article the effect of the loss of myosin VI no insert isoform (NoI) on endocytosis in nonp
219 osin VI does not account for the survival of myosin VI null animals.
220 e common to both the large insert isoform of myosin VI on clathrin-coated structures and the no-inser
221 fe of an artificially dimerized construct of myosin VI on clathrin-coated structures suggests that wi
222 light and electron microscopy, we identified myosin VI on Rab5-positive early endosomes, as well as o
223  of constitutively active Rab8-Q67L recruits myosin VI onto Rab8-positive structures.
224 ates that a functional complex consisting of myosin VI, optineurin, and probably the GTPase Rab8 play
225 ing a known dimeric cargo adaptor protein of myosin VI, optineurin, and the myosin VI-binding segment
226 d 4) blocking either GIPC1 interactions with myosin VI or GLUT1 interactions with GIPC1 disrupts norm
227 xpected Mendelian frequency, suggesting that myosin VI participates in processes which contribute to
228                                          The myosin VI PDZ (postsynaptic density 95, Disk large, Zona
229                                              Myosin VI plays a role in the maintenance of Golgi morph
230                        We find that Acam and myosin VI precisely colocalize at the leading edge of th
231           Additionally, we found that on the myosin VI promoter, the level of acetylated histone H3 w
232                          We hypothesize that myosin VI protects the actin cone structure either by cr
233                                              Myosin VI protein expression in cell lines positively co
234 nstrated the most consistent cancer-specific myosin VI protein overexpression, whereas prostate cance
235           Here, we showed that the levels of myosin VI protein were markedly inhibited in MCF7 and LN
236             We also found that the levels of myosin VI protein were markedly inhibited in MCF7 cells
237                   During acute hypertension, myosin VI redistributed from low density apical MV-enric
238 t observation that acute hypertension causes myosin VI redistribution and support the idea that myosi
239                              The actin motor myosin VI regulates endocytosis of cystic fibrosis trans
240 sults suggest that in prostate cancer cells, myosin VI regulates protein secretion, but the overexpre
241  fluorescent protein-myosin VI revealed that myosin VI remains bound to F-actin for minutes, suggesti
242  experiments using green fluorescent protein-myosin VI revealed that myosin VI remains bound to F-act
243                                Single-headed myosin VI S1 constructs take nonprocessive 12 nm steps,
244                                              Myosin VI SI thus recruits SGs to the cortical actin net
245                                        These myosin VI SI-specific effects were prevented by deletion
246      However, this mechanism cannot work for myosin VI, since its lever arm positions are reversed.
247 was selectively rescued by expression of the myosin VI small insert (SI) isoform, which efficiently t
248           Thus, it may be possible to create myosin VI-specific drugs that rescue the function of dea
249                                 We find that myosin VI stabilizes a branched actin network in actin s
250 ly provide the source of the highly variable myosin VI step size.
251 ackbone that may account for the behavior of myosin VI stepping along actin.
252 he androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) ligh
253 lish a Ca(2+)-regulated, calmodulin-mediated myosin VI structural change.
254                                          The myosin VI structure demonstrates that a unique insert at
255          Recent experiments suggest that the myosin VI structure has an unfolded and flexible region
256                                              Myosin VI supports movement toward the (-) end of actin
257                              We propose that myosin VI supports the acquisition of adaptation by remo
258 d in expansion of the terminal web region in myosin VI((sv/sv)) enterocytes.
259 umulated in this location in Snell's Waltzer myosin VI((sv/sv)) intestine.
260 ing induces a large structural change in the myosin VI tail (31% increase in helicity) and when assoc
261                                 However, the myosin VI tail fragment had no effect on the recycling o
262 omains, and defining a central region in the myosin VI tail that binds GIPC1.
263 the 36-nm step-size observed in myosin V and myosin VI that corresponds to the actin pseudohelical re
264 hich may favor the compact monomeric form of myosin VI that functions on the actin cones by facilitat
265              We found that in the absence of myosin VI the MET current fails to acquire its character
266                 We have studied the shape of myosin VI, the actin minus-end directed motor, by negati
267 n the motor domain and lever arm that allows myosin VI to accommodate the helical position of binding
268         In vivo targeting and recruitment of myosin VI to clathrin-coated structures (CCSs) at the pl
269 nstead, we propose that for the two heads of myosin VI to coordinate their processive movement, the l
270  VI-binding partner, inhibits recruitment of myosin VI to endocytic structures at the plasma membrane
271 o the lead head, which makes it possible for myosin VI to function as a processive transporter as wel
272 es cooperate to activate myosin VI, allowing myosin VI to integrate Ca(2+), lipid, and protein cargo
273 h myosin VI and recruitment of overexpressed myosin VI to membrane structures, but not for the associ
274     These results show that optineurin links myosin VI to the Golgi complex and plays a central role
275   LOVDab robustly recruits human full-length myosin VI to various organelles in vivo and hinders pero
276          U2OS cells allow for 1 motor class, myosin VI, to move along stress fiber bundles, while mot
277     Surprisingly, we found that the level of myosin VI transcript was slightly increased instead of d
278                       However, the levels of myosin VI transcript were decreased only by topoisomeras
279                 The results demonstrate that myosin VI turns over dynamically on endocytic structures
280 shows that CaBP5 interacts with Munc18-1 and myosin VI, two proteins involved in the synaptic vesicle
281 mine force generation by single molecules of myosin VI under physiological nucleotide concentrations.
282       Here, we demonstrate a new function of myosin VI using observations of Drosophila spermatid ind
283                                              Myosin VI walks in a hand-over-hand fashion with an aver
284                      By confocal microscopy, myosin VI was detected over the whole length of the MV i
285                                 In controls, myosin VI was evenly distributed through the five MV zon
286 n assay and mass spectrometry, we found that myosin VI was recruited to SGs in a Ca(2+)-dependent man
287                        Protein expression of myosin VI was subsequently analyzed in arrayed prostate
288                   The shape of truncated apo myosin VI was very similar to the apo crystal structure,
289 ral model for the redirected power stroke of myosin VI, we have constructed bidirectional myosins thr
290  Furthermore, several molecules of monomeric myosin VI, which are nonprocessive in single molecule as
291  the gene encoding an unconventional myosin, myosin VI, which is present in the hair bundles.
292   Allelic pairing required a nuclear myosin, myosin VI, which is rapidly recruited to the LT/TNF locu
293                                        Using myosin VI, which moves toward the pointed end of actin f
294  characterization of their interactions with myosin VI will advance our understanding of the roles of
295 ures, understanding the design principles of myosin VI will help guide the study of the functions of
296 e observed that a specific splice isoform of myosin VI with no insert in the tail domain is required
297                                   To control myosin VI with this specificity, we created an optogenet
298 tin, we compare and contrast the motility of myosin-VI with myosin-V.
299           Combining the measured kinetics of myosin-VI with the elasticity of the light chains, and t
300  core, we attached the myosin V lever arm to myosin VI, with and without the unique insert.

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