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1 toinhibition, promoting its interaction with myosin VI.
2 of coordination between the heads of dimeric myosin VI.
3 ctural plasticity during force generation by myosin VI.
4 o binding normally regulates dimerization of myosin VI.
5 al dimerization sequences within full-length myosin VI.
6 m generates an extension of the lever arm of myosin VI.
7 l or apical cargo, however, does not involve myosin VI.
8 on that hinders binding of both PlexinD1 and myosin VI.
9 e of the presumed poststroke conformation of myosin VI.
10 a testis-specific light chain of Drosophila myosin VI.
11 h differs from Kinesin-1 and is more akin to myosin VI.
12 P hydrolysis mechanism and motor function of myosin VI.
13 s waltzer mutant mice, which fail to express myosin VI.
14 ver dynamics and the monomer/dimer nature of myosin VI.
15 identify the binding partners of Drosophila myosin VI.
16 the extension by altering the strain path in myosin VI.
17 tor of 2,500 for a bipartite binding site on myosin-VI.
18 ated by binding of the coiled-coil domain to myosin-VI.
19 the light-chain domain of individual dimeric myosin VIs.
23 er development, have consistently shown that myosin VI, a unique actin-based motor, is upregulated in
26 native targeting and activation mechanism of myosin VI, allowing direct inferences on myosin VI funct
27 tein and lipid cargoes cooperate to activate myosin VI, allowing myosin VI to integrate Ca(2+), lipid
32 her supporting the model demonstrate that 1) myosin VI and GIPC1 interactions do not require a mediat
33 mation is characteristic of the single IQ of myosin VI and is common throughout the myosin superfamil
36 for intracellular interactions of GIPC1 with myosin VI and recruitment of overexpressed myosin VI to
38 We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT
39 CFTR co-localized with alpha-AP-2, Dab2, and myosin VI and was identified in a complex with all three
40 o the place where a large insert is found in myosin VI and where several cardiomyopathy mutations hav
41 Single molecule experiments indicate that myosin-VI and myosin-V are processive molecular motors,
43 , as a force transducer in the mechanoenzyme myosin VI, and as a flexible spacer in the Kelch-motif-c
44 icrotubule-associated protein Cornetto bound myosin VI, and we demonstrated a role for both in secret
45 alternative clathrin-adaptor Dab2, dynamin, myosin-VI, and actin are involved in the internalization
46 in VEGFR2 intracellular trafficking requires myosin-VI, and myosin-VI knockout in mice or knockdown i
48 The contractile and enzymatic activities of myosin VI are regulated by calcium binding to associated
49 Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mi
51 Using expression microarrays, we identified myosin VI as one of the top genes that demonstrated canc
52 , a population of supporting cells expressed myosin VI at 78 hours after gentamicin treatment and myo
53 entified optineurin as a binding partner for myosin VI at the Golgi complex and confirmed this intera
54 e phosphatase receptor Q, normally linked to myosin VI at the tapered base of stereocilia, was maldis
56 s do not require a mediating protein; 2) the myosin VI binding domain in GIPC1 is necessary for intra
57 s study refines the model by identifying two myosin VI binding domains in the GIPC1 C terminus, assig
58 us, assigning respective oligomerization and myosin VI binding functions to separate N- and C-termina
60 f Disabled-2 (Dab2), a tumour suppressor and myosin VI-binding partner, inhibits recruitment of myosi
61 or protein of myosin VI, optineurin, and the myosin VI-binding segment from a monomeric cargo adaptor
65 f the interactions among PlexinD1, GIPCs and myosin VI by a series of crystal structures of these pro
66 e created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa pho
68 erse directionality and large powerstroke of myosin VI can be attributed to unusual properties of a s
70 n) minus end-directed unconventional myosin, myosin VI, cause hereditary deafness in mice (Snell's wa
72 Dab2 (Disabled 2) is the binding partner for myosin VI, clathrin, and alpha-AP-2 and directs endocyto
74 tion of GIPC1 with such structures; 3) GIPC1/myosin VI complexes coordinately move within cellular ex
77 arm, we have generated a series of truncated myosin VI constructs and characterized the size and dire
78 TP concentration-dependent processivities of myosin VI constructs containing either native or artific
81 an unexpected change in conformation of the myosin VI converter domain, essential for twisting the l
82 d to determine whether the actin-based motor myosin VI coordinately retracts with NHE3 in response to
83 ibed kinetics, this allows us to explain how myosin VI coordinates its heads processively while maint
84 ation of p53, and consequently, knockdown of myosin VI de-sensitizes MCF7 cells to DNA damage-induced
87 of myosin VI enhances, whereas knockdown of myosin VI decreases, DNA damage-induced stabilization of
88 impairs Golgi complex integrity, which makes myosin VI-deficient cells susceptible to apoptosis upon
89 The findings support alpha-AP-2 in directing myosin VI-dependent endocytosis of CFTR and a requiremen
94 in-coated structures suggests that wild type myosin VI does not function as a stable dimer, but eithe
96 Finally, we showed that overexpression of myosin VI enhances, whereas knockdown of myosin VI decre
98 l interfering RNA-mediated downregulation of myosin VI expression results in a significant reduction
100 ations uncover a novel mechanism mediated by myosin VI for stabilizing long-lived actin structures in
108 about how myosin VI is regulated and whether myosin VI has a function in the DNA damage response.
110 sence of these adaptor proteins, full-length myosin VI has ATPase properties of a dimer, appears as a
112 protein secretion, but the overexpression of myosin VI has no major impact on clathrin-mediated endoc
114 lever arm hypothesis needs modification, or myosin VI has some unique form of extension of its lever
116 d-coil sequences, and reports on full-length myosin VI have failed to demonstrate the existence of di
117 We observe force-induced transitions of myosin VI heads from non-adjacent to adjacent binding, w
118 We considered an alternative model in which myosin VI heads sequentially take 60 nm steps whereas th
120 a p53-dependent manner such that the pool of myosin VI in endocytic vesicles, membrane ruffles, and c
122 re binding partners for CFTR and the role of myosin VI in localizing endocytic adaptors in the intest
123 nt endocytosis of CFTR and a requirement for myosin VI in membrane invagination and coated pit format
125 intenance of Golgi complex integrity and for myosin VI in the p53-dependent prosurvival pathway.
126 pected to produce the pre-powerstroke state, myosin VI in their presence was most similar to the trun
128 y in some tumors, differential regulation of myosin VI in various tumor cells by topoisomerase inhibi
130 caused by a mutation in MYO6 (which encodes myosin VI) in one and by noise exposure, suggesting that
131 ase inhibitors dictates whether knockdown of myosin VI inhibits, rather than enhances, the susceptibi
133 Intracellular targeting seems to involve two myosin VI-interacting proteins, GIPC and LMTK2, both of
136 sity of both myosins and a redistribution of myosin VI into the stereocilia bundle, concurrent with e
148 Herein, we demonstrate that full-length myosin VI is capable of forming stable, processive dimer
150 triggers dimerization, it would appear that myosin VI is designed to function as a dimer in cells.
151 In the sensory hair cells of the cochlea, myosin VI is expressed in the cell bodies and along the
156 depleted from cells using RNA interference, myosin VI is lost from the Golgi complex, the Golgi is f
160 However, very little is known about how myosin VI is regulated and whether myosin VI has a funct
162 show that the intracellular localization of myosin VI is substantially altered by p53 and DNA damage
169 asts derived from the Snell's waltzer mouse (myosin VI knock-out) gives rise to defective clathrin-me
172 ificantly recovers arterial morphogenesis in myosin-VI(-/-) knockdown zebrafish and synectin(-/-) mic
173 cellular trafficking requires myosin-VI, and myosin-VI knockout in mice or knockdown in zebrafish phe
176 placing calmodulin at Insert 2 will increase myosin VI lever arm flexibility, which may favor the com
178 ecifically, intramolecular strain causes the myosin VI lever arm of the lead head to uncouple from th
180 We conclude that Acam and not CaM acts as a myosin VI light chain in the Drosophila testis and hypot
181 cam replaces calmodulin as a tissue-specific myosin VI light chain on the actin cones that mediate D.
184 VI redistribution and support the idea that myosin VI may serve as the molecular motor for NHE3 retr
186 and simulation to demonstrate that multiple myosin VI molecules can coordinate to efficiently transp
194 a and the lamellar edge in S2 cells, whereas myosin VI motility is excluded from the same regions.
195 structures of the unique minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-ADP (5.5
197 m Spudich, on the mechanism of the enigmatic myosin VI motor; and Joe Goldstein, on the function of t
198 alters the conformation and activity of the myosin-VI motor implicated in pivotal steps of these pro
208 oacetamide-labeled actin with strongly bound myosin VI (MVI) and to evaluate the effect of MVI-bound
216 acting partners: vimentin, actin, myosin Va, myosin VI, myosin X, myosin XIV, kinesin 1, Als2cr4, and
218 In this article the effect of the loss of myosin VI no insert isoform (NoI) on endocytosis in nonp
220 e common to both the large insert isoform of myosin VI on clathrin-coated structures and the no-inser
221 fe of an artificially dimerized construct of myosin VI on clathrin-coated structures suggests that wi
222 light and electron microscopy, we identified myosin VI on Rab5-positive early endosomes, as well as o
224 ates that a functional complex consisting of myosin VI, optineurin, and probably the GTPase Rab8 play
225 ing a known dimeric cargo adaptor protein of myosin VI, optineurin, and the myosin VI-binding segment
226 d 4) blocking either GIPC1 interactions with myosin VI or GLUT1 interactions with GIPC1 disrupts norm
227 xpected Mendelian frequency, suggesting that myosin VI participates in processes which contribute to
234 nstrated the most consistent cancer-specific myosin VI protein overexpression, whereas prostate cance
238 t observation that acute hypertension causes myosin VI redistribution and support the idea that myosi
240 sults suggest that in prostate cancer cells, myosin VI regulates protein secretion, but the overexpre
241 fluorescent protein-myosin VI revealed that myosin VI remains bound to F-actin for minutes, suggesti
242 experiments using green fluorescent protein-myosin VI revealed that myosin VI remains bound to F-act
247 was selectively rescued by expression of the myosin VI small insert (SI) isoform, which efficiently t
252 he androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) ligh
260 ing induces a large structural change in the myosin VI tail (31% increase in helicity) and when assoc
263 the 36-nm step-size observed in myosin V and myosin VI that corresponds to the actin pseudohelical re
264 hich may favor the compact monomeric form of myosin VI that functions on the actin cones by facilitat
267 n the motor domain and lever arm that allows myosin VI to accommodate the helical position of binding
269 nstead, we propose that for the two heads of myosin VI to coordinate their processive movement, the l
270 VI-binding partner, inhibits recruitment of myosin VI to endocytic structures at the plasma membrane
271 o the lead head, which makes it possible for myosin VI to function as a processive transporter as wel
272 es cooperate to activate myosin VI, allowing myosin VI to integrate Ca(2+), lipid, and protein cargo
273 h myosin VI and recruitment of overexpressed myosin VI to membrane structures, but not for the associ
274 These results show that optineurin links myosin VI to the Golgi complex and plays a central role
275 LOVDab robustly recruits human full-length myosin VI to various organelles in vivo and hinders pero
277 Surprisingly, we found that the level of myosin VI transcript was slightly increased instead of d
280 shows that CaBP5 interacts with Munc18-1 and myosin VI, two proteins involved in the synaptic vesicle
281 mine force generation by single molecules of myosin VI under physiological nucleotide concentrations.
286 n assay and mass spectrometry, we found that myosin VI was recruited to SGs in a Ca(2+)-dependent man
289 ral model for the redirected power stroke of myosin VI, we have constructed bidirectional myosins thr
290 Furthermore, several molecules of monomeric myosin VI, which are nonprocessive in single molecule as
292 Allelic pairing required a nuclear myosin, myosin VI, which is rapidly recruited to the LT/TNF locu
294 characterization of their interactions with myosin VI will advance our understanding of the roles of
295 ures, understanding the design principles of myosin VI will help guide the study of the functions of
296 e observed that a specific splice isoform of myosin VI with no insert in the tail domain is required
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