ライフサイエンスコーパス: myosin regulatory light chain

1 odulated by the level and phosphorylation of myosin regulatory light chain.

2 teraction with 14-3-3 and phosphorylation of myosin regulatory light chain.

3 leading to increased phosphorylation of the myosin regulatory light chain.

4 of phosphorylation/dephosphorylation of the myosin regulatory light chain.

5 red by the dephosphorylation of Ser19 in the myosin regulatory light chain.

6 s of energy depletion by phosphorylating the myosin regulatory light chain.

7 , leading to enhanced phosphorylation of the myosin regulatory light chain.

8 dhesion and increased phosphorylation of the myosin regulatory light chain.

9 ugh the RhoA-mediated phosphorylation of the myosin regulatory light chain.

10 nding protein C, troponin T, tropomyosin and myosin regulatory light chain 2 were identified in the h

11 M protein-1 [SLIM1], myomesin, nonsarcomeric myosin regulatory light chain-2 [MLC(2)], and ss-actin);

12 ST-MYPT1 co-precipitated with phospho-20-kDa myosin regulatory light chain 20 and PP1.

13 icient for Ca2+-dependent phosphorylation of myosin regulatory light chain and contraction of stress

14 tants of the smooth muscle (chicken gizzard) myosin regulatory light chain and performing electron pa

15 ects on Rho-dependent phosphorylation of the myosin regulatory light chain and stress fiber formation

16 in part dependent on the phosphorylation of myosin regulatory light chain and the actomyosin contrac

17 TEER was preceded by phosphorylation of the myosin regulatory light chain and was partially dependen

18 RhoA was required to activate myosin-regulatory light chain and localized at the site

19 regulating the phosphorylation of nonmuscle myosin regulatory light chain, and hence the activity of

20 pletion caused an increase of phosphorylated myosin regulatory light chain at the cleavage site in la

21 ly, phosphorylation of distinct sites within myosin regulatory light chain by Rho kinase drove NMII c

22 Ca2+-calmodulin-dependent phosphorylation of myosin regulatory light chains by the catalytic COOH-ter

23 We used phosphorylation of the myosin regulatory light chain (cRLC) by the cardiac isof

24 terminal lobes of the cardiac isoform of the myosin regulatory light chain (cRLC) in the fully dephos

25 o phosphomyosin and thus accelerating 20-kDa myosin regulatory light chain dephosphorylation.

26 The Drosophila myosin regulatory light chain (DMLC2) is homologous to M

27 Phosphorylation of the myosin regulatory light chain eliminates the fraction of

28 uorescent protein (GFP)-tagged human cardiac myosin regulatory light chain (HCRLC) was constructed to

29 that hypothesis using probes attached to the myosin regulatory light chain in demembranated muscle fi

30 ty leads to decreased phosphorylation of the myosin regulatory light chain in fibroblasts and is pred

31 rescent intensity of a probe attached to the myosin regulatory light chain in skinned skeletal fibers

32 nges of troponin C in the thin filaments and myosin regulatory light chain in the thick filaments all

33 s determined using fluorescent probes on the myosin regulatory light chain in the thick filaments and

34 s on troponin C in the thin filaments and on myosin regulatory light chain in the thick filaments to

35 Conversely, phosphorylation of myosin regulatory light chain increased in podocyte foot

36 lymorphism approximately 10 kb downstream of myosin regulatory light chain interacting protein (MYLIP

37 Of these, after E2 exposure, the myosin regulatory light chain interacting protein (MYLIP

38 The E3 ubiquitin ligase, myosin regulatory light chain-interacting protein (Mylip

39 The E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP

40 on findings that p34(cdc2) can phosphorylate myosin regulatory light chain (LC20) on inhibitory sites

41 tracellular Ca2+ concentration ([Ca2+]i) and myosin regulatory light chain (LC20) phosphorylation (ML

42 including myosin III p132 and smooth muscle myosin regulatory light chain (LC20), suggesting that my

43 MLC-4, a nonmuscle myosin regulatory light chain, localizes to small puncta

44 atrix receptor and its ligand, help localize myosin regulatory light chain, making it available for p

45 maging with green fluorescent protein-tagged myosin regulatory light chain (MLC) and correlative bioc

46 Phosphorylation of myosin regulatory light chain (MLC) by MLC kinase (MLCK)

47 nase (ROCK) that mediates phosphorylation of myosin regulatory light chain (MLC) is impaired in GEF-H

48 precipitation of myosin II demonstrated that myosin regulatory light chain (MLC) phosphorylation was

49 because of decreased phosphorylation of the myosin regulatory light chain (MLC), a key regulatory co

50 istry demonstrated the presence of MLCK, the myosin regulatory light chain (MLC), and the IIA and IIB

51 aster are affected by phosphorylation of the myosin regulatory light chain (MLC2).

52 on of RhoA and the spatio-temporal change in myosin regulatory light chain (MLC20) phosphorylation in

53 an essential process for cell migration and myosin regulatory light chain (MLC20) phosphorylation pl

54 OxLDL induced dephosphorylation of myosin regulatory light chain (MRLC) by increasing the a

55 Depletion of LIMCH1 attenuated myosin regulatory light chain (MRLC) diphosphorylation i

56 e or an activated version of the AMPK target myosin regulatory light chain (MRLC) in the dAMPKalpha m

57 Since myosin regulatory light chain (MRLC) is an AMPK downstre

58 Protocols inducing a large increase in myosin regulatory light chain (MRLC) phosphorylation at

59 Mylip mRNA and protein levels, and decreased myosin regulatory light chain (Mrlc) protein.

60 tion regulator hnRNP-K and the mRNA-encoding myosin regulatory light-chain (MRLC)-interacting protein

61 via the phosphorylation of their associated myosin regulatory light chains (MRLCs).

62 attern, we have rescued myosin function in a myosin regulatory light chain null mutant (mlcR-) using

63 hat the regulation of the phosphorylation of myosin regulatory light chains, or dynamic activation an

64 of nonmuscle myosin II with a phosphorylated myosin regulatory light chain (p-MRLC).

65 om), concomitant with a parallel increase in myosin regulatory light chain phosphorylation (MRLC-P(i)

66 We examined the quantitation of myosin regulatory light chain phosphorylation (MRLCP) by

67 However, myosin regulatory light chain phosphorylation (MRLCP) el

68 (PCASM) in which hypoxia decreased force and myosin regulatory light chain phosphorylation (p-MRLC) d

69 The extent of myosin regulatory light chain phosphorylation (RLC) nece

70 However, Abi1 silencing did not affect myosin regulatory light chain phosphorylation at Ser-19

71 ere is little direct evidence on the role of myosin regulatory light chain phosphorylation in ejectin

72 is for the observed physiological effects of myosin regulatory light chain phosphorylation in skinned

73 Modest changes in myosin regulatory light chain phosphorylation occurred i

74 Blocking myosin regulatory light chain phosphorylation with small

75 led us to observe F-actin and phosphorylated myosin regulatory light chain (pMRLC) assembled into a c

76 ed that Cdk5 colocalized with phosphorylated myosin regulatory light chain (pMRLC) on contracting str

77 mbryos show dynamic levels of phosphorylated myosin regulatory light chain (pMRLC).

78 te for MLCK, a phosphorylation sequence from myosin regulatory light chain (pRLC).

79 ion factor-1alpha, F-actin, tropomyosin, and myosin regulatory light chain), Ras family signaling pro

80 Deletion of myosin II motor domain or the myosin regulatory light chain reduced the contraction ra

81 n Ca(2+) binding, such as phosphorylation of myosin regulatory light chain (RLC) also controls contra

82 In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to

83 C terminus of the catalytic core that blocks myosin regulatory light chain (RLC) binding and phosphor

84 characterized the molecular determinants of myosin regulatory light chain (RLC) binding to two major

85 Myosin regulatory light chain (RLC) binds to the lever a

86 almodulin (CaM)-dependent phosphorylation of myosin regulatory light chain (RLC) by myosin light chai

87 Phosphorylation of myosin regulatory light chain (RLC) by myosin light chai

88 )-dependent phosphorylation of smooth muscle myosin regulatory light chain (RLC) by myosin light chai

89 d that the D166V mutation in the ventricular myosin regulatory light chain (RLC) can cause a malignan

90 in the conserved phosphorylation site of the myosin regulatory light chain (RLC) exhibit structural a

91 ino acid residue (E22K) in the human cardiac myosin regulatory light chain (RLC) gene causes familial

92 Hyperphosphorylation of myosin regulatory light chain (RLC) in cardiac muscle is

93 he orientation of the N-terminal lobe of the myosin regulatory light chain (RLC) in demembranated fib

94 To determine the role of myosin regulatory light chain (RLC) in modulating contra

95 Changes in the orientation of the myosin regulatory light chain (RLC) in single muscle fib

96 erminal extension and phosphorylation of the myosin regulatory light chain (RLC) independently improv

97 hysiologically for direct phosphorylation of myosin regulatory light chain (RLC) is not known.

98 Myosin regulatory light chain (RLC) is phosphorylated at

99 KEY POINTS: Smooth muscle myosin regulatory light chain (RLC) is phosphorylated by

100 le biology is whether phosphorylation of the myosin regulatory light chain (RLC) is sufficient for re

101 utation in the gene encoding the ventricular myosin regulatory light chain (RLC) is sufficient to cau

102 e revealed that mutations in the ventricular myosin regulatory light chain (RLC) lead to the developm

103 We show that depletion of myosin regulatory light chain (RLC) levels in the embryo

104 Understanding how cardiac myosin regulatory light chain (RLC) phosphorylation alte

105 Neuronal signalling may thus elicit myosin regulatory light chain (RLC) phosphorylation and

106 The effects of myosin regulatory light chain (RLC) phosphorylation and

107 NM myosin regulatory light chain (RLC) phosphorylation but

108 opment in fast-twitch skeletal muscle due to myosin regulatory light chain (RLC) phosphorylation by C

109 f myosin light chain kinase (MLCK) initiates myosin regulatory light chain (RLC) phosphorylation for

110 Myosin regulatory light chain (RLC) phosphorylation in s

111 We examined the role of myosin regulatory light chain (RLC) phosphorylation in t

112 Smooth muscle contraction initiated by myosin regulatory light chain (RLC) phosphorylation is d

113 Smooth muscle contraction initiated by myosin regulatory light chain (RLC) phosphorylation is d

114 of actomyosin stress fibers (SFs) depend on myosin regulatory light chain (RLC) phosphorylation, whi

115 cells, by modulating the Ca2+ sensitivity of myosin regulatory light chain (RLC) phosphorylation.

116 is achieved is through temporally regulated myosin regulatory light chain (RLC) phosphorylation.

117 acid to valine) mutation in the ventricular myosin regulatory light chain (RLC) shown to cause a mal

118 n kinase (MLCK) phosphorylates smooth muscle myosin regulatory light chain (RLC) to initiate contract

119 s in nonmuscle cells where it phosphorylates myosin regulatory light chain (RLC) to promote membrane

120 We have determined the orientation of the myosin regulatory light chain (RLC) using a spin-label b

121 Smooth myosin regulatory light chain (RLC) was exchanged with R

122 Chicken gizzard myosin regulatory light chain (RLC) was labeled at Cys10

123 Gizzard myosin regulatory light chain (RLC) was labeled with the

124 eletal muscle fibers in which the endogenous myosin regulatory light chain (RLC) was partially replac

125 ectively inhibited phosphorylation of the NM myosin regulatory light chain (RLC), NM myosin filament

126 ith a component of the myosin motor protein, myosin regulatory light chain (RLC).

127 ne at known orientations with respect to the myosin regulatory light chain (RLC).

128 e orientation of spin probes attached to the myosin regulatory light chain (RLC).

129 examined before and after phosphorylation of myosin regulatory light chain (RLC).

130 at four sites on the C-terminal lobe of the myosin regulatory light chain (RLC).

131 ng sarcomeric proteins including ventricular myosin regulatory light chain (RLC).

132 tations in sarcomeric proteins including the myosin regulatory light chain (RLC).

133 Here, we studied the role of the cardiac myosin regulatory light chains (RLCs) in the capacity of

134 study, the phosphorylation of smooth muscle myosin regulatory light chain (smRLC) was measured as an

135 e is due to excessive phosphorylation of the myosin regulatory light chain Spaghetti squash rather th

136 or BIG2 enhanced specific phosphorylation of myosin regulatory light chain (T18/S19) and F-actin cont

137 Par-1 thus promotes phosphorylated myosin regulatory light chain, thereby increasing Myo-II

138 tosis would enhance dephosphorylation of the myosin regulatory light chain, thereby leading to the di

139 phosphorylating inhibitory sites within the myosin regulatory light chain, thereby suppressing NMII

140 HUVECs, and phosphorylation of MYPT1 and the myosin regulatory light chain was reduced by Wf-536, pro