ライフサイエンスコーパス: myosin-binding protein C

1 7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding protein C).

2 cardiac sarcomere or from the truncation of myosin binding protein C.

3 response to Ca(2+) with glutathionylation of myosin binding protein C.

4 ms of the thick-filament-associated protein, myosin binding protein-C.

5 drugs and in cells expressing low levels of myosin-binding protein C.

6 roteins, the commonest being MYBPC3 encoding myosin-binding protein C.

7 thers, filamin C and the slow isoform of the myosin-binding protein C.

8 osphorylation of its targets, troponin I and myosin-binding protein C.

9 ed PKA phosphorylation of the PKA substrate, myosin-binding protein C.

10 utations) were predicted to truncate cardiac myosin-binding protein C.

11 pendent of AMPK increased phosphorylation of myosin-binding protein C.

12 yses revealed 8 sequence variants in cardiac myosin binding protein-C (1 nonsense, 1 splice acceptor

13 Cardiac myosin-binding protein C, a cardiac-specific myofilament

14 he thin filament: phosphorylation of cardiac myosin binding protein-C accelerates cross bridge bindin

15 Mutations in the gene for cardiac myosin-binding protein C account for approximately 15 pe

16 ies, PKA increased phosphorylation levels of myosin binding protein C and troponin I, and reduced Ca(

17 pectroscopy revealed hyperphosphorylation of myosin-binding protein C and phosphorylation of atypical

18 ple myofibrillar substrates including titin, myosin-binding protein-C and cardiac troponin I (cTnI),

19 enes, most commonly beta myosin heavy chain, myosin binding protein C, and cardiac troponin T.

20 iac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and cardiac troponin I).

21 phosphorylation of cTnI, cTnT, tropomyosin, myosin-binding protein C, and desmin.

22 een the myosin heads, the cardiac isoform of myosin-binding protein-C, and titin will aid in understa

23 r 170 normal chromosomes; 1 variant (cardiac myosin binding protein-C Arg326Gln) also occurred in a h

24 at Ser16, phospholemman at Ser68 and cardiac myosin-binding protein C at Ser282, was unaltered.

25 ol myocytes with phosphorylation of cTnI and myosin binding protein C (C-protein) in myocytes with in

26 Several other proteins such as synemin, myosin binding protein C (C-protein), glycogen debranchi

27 n of troponin T (TnT), troponin I (TnI), and myosin-binding protein C (C-protein).

28 degradation of myosin heavy chain 6, cardiac myosin binding protein C, calcineurin (PPP3CB), and p-MT

29 A-mediated (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) accelerates the kinet

30 rylation of the cardiac myofilament proteins myosin binding protein C (cMyBP-C) and troponin I (cTnI)

31 In the cardiac sarcomere, both cardiac myosin binding protein C (cMyBP-C) and troponin-I (cTnI)

32 Cardiac myosin binding protein C (cMyBP-C) appears to modulate t

33 Cardiac myosin binding protein C (cMyBP-C) has a key regulatory

34 Cardiac myosin binding protein C (cMyBP-C) has three phosphoryla

35 Protein expression of myosin binding protein C (cMyBP-C) was significantly low

36 traction, and its accessory protein, cardiac myosin binding protein C (cMyBP-C), are the two most com

37 Cardiac myosin binding protein C (cMyBP-C), bound to the sarcome

38 The cardiac isoform [cardiac myosin binding protein C (cMyBP-C)] is essential for nor

39 We investigated the influence of cardiac myosin binding protein-C (cMyBP-C) and its constitutivel

40 myofilaments PKA targets troponin I (cTnI), myosin binding protein-C (cMyBP-C) and titin.

41 RLC) by myosin light chain kinase (MLCK) and myosin binding protein-C (cMyBP-C) by protein kinase A (

42 Although mutations in cardiac myosin binding protein-C (cMyBP-C) cause heart disease,

43 Cardiac myosin binding protein-C (cMyBP-C) is a member of the im

44 Myosin binding protein-C (cMyBP-C) is a thick filament a

45 Cardiac myosin binding protein-C (cMyBP-C) is a thick filament a

46 Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament p

47 We examined the effect of cardiac myosin binding protein-C (cMyBP-C) on contractile effici

48 The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in ca

49 Cardiac myosin binding protein-C (cMyBP-C) phosphorylation modul

50 opy, we examined the contribution of cardiac myosin binding protein-C (cMyBP-C) to thick-filament len

51 advances in the molecular biology of cardiac myosin binding protein-C (cMyBP-C), little is understood

52 ns, most often MYBPC3, which encodes cardiac myosin binding protein-C (cMyBP-C).

53 the gene encoding cardiac C-protein [cardiac myosin binding protein-C (cMyBP-C)] are one of the princ

54 23/24) of cardiac troponin I (cTnI), cardiac myosin-binding protein C (cMyBP-C) and titin.

55 Cardiac myosin-binding protein C (cMyBP-C) is a component of the

56 Cardiac myosin-binding protein C (cMyBP-C) is a regulatory prote

57 Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric prote

58 Cardiac myosin-binding protein C (cMyBP-C) is a thick-filament-a

59 The N-terminal modules of cardiac myosin-binding protein C (cMyBP-C) play a regulatory rol

60 Cardiac myosin-binding protein C (cMyBP-C) regulates actin-myosi

61 bait, identified cardiac troponin I (cTnI), myosin-binding protein C (cMyBP-C), and telethonin as PK

62 potential regulator of these motors, cardiac myosin-binding protein C (cMyBP-C), cause hypertrophic c

63 esolve the structure and dynamics of cardiac myosin-binding protein C (cMyBP-C), focusing on the N-te

64 ardiac cells derived from both wild-type and myosin-binding protein C (cMyBP-C)-null mouse hearts.

65 ice with gene targeted deficiency of cardiac myosin-binding protein-C (cMyBP-C(-/-), n=6) or muscle L

66 Phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) by protein kinase A a

67 Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament p

68 Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament-a

69 Cardiac myosin-binding protein-C (cMyBP-C) is a thick-filament-a

70 P sensitivity highly correlated with cardiac myosin-binding protein-C (cMyBP-C) protein level.

71 n is the major regulatory subunit of cardiac myosin-binding protein-C (cMyBP-C) that modulates actin

72 ardiac muscle-specific myofibrillar protein, myosin-binding protein-C (cMyBP-C), is down-regulated.

73 Decreased expression of cardiac myosin binding protein C (cMyBPC) as a result of genetic

74 Decreased expression of cardiac myosin binding protein C (cMyBPC) in the heart has been

75 Cardiac myosin binding protein C (cMyBPC) phosphorylation is ess

76 Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted

77 Homozygous cardiac myosin binding protein C-deficient (Mybpc(t/t)) mice dev

78 This Ag is a novel member of the myosin binding protein-C family, which we call masticato

79 nd heterozygous variant in a candidate gene (myosin binding protein C, fast type [MYBPC2] and vacuola

80 MYBPC3 (Myosin-binding protein C) founder mutations account for

81 hese results suggest that the 40-kDa cardiac myosin-binding protein C fragment, which is produced at

82 Extraction of myosin binding protein-C from skinned muscle normalized

83 Mutations in the cardiac myosin binding protein-C gene (cMyBP-C) are among the mo

84 f 50 years who had a mutation in the cardiac myosin-binding protein C gene (68 of 117 patients) had c

85 heritable nature of mutations in the cardiac myosin-binding protein C gene.

86 re events between the myosin heavy chain and myosin-binding protein C genotype-positive patients.

87 nt rates seen between myosin heavy chain and myosin-binding protein C genotype-positive patients.

88 osin light chain MLY2, myosin heavy chain 6, myosin-binding protein C), glucose metabolism proteins (

89 rs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

90 Ser/Thr phosphorylation of myosin-binding protein C increased primarily by PKCzeta

91 Myosin binding protein C is a thick filament protein of

92 e suggesting that phosphorylation of cardiac myosin binding protein-C is a key regulator of the kinet

93 ression of mutations in the gene for cardiac myosin-binding protein C is often delayed until middle a

94 MYBPC3, encoding cMyBP-C (cardiac myosin-binding protein C), is the most frequently mutate

95 The myosin-binding protein C isoform 3 (MYBPC3) variant Arg5

96 Among these is the myosin-binding protein C (MBP-C).

97 protein-C family, which we call masticatory myosin binding protein-C (mMyBP-C).

98 In this G+LVH- population, cardiac myosin-binding protein C mutation carriers had twice the

99 familial hypertrophic cardiomyopathy mutant myosin binding protein C (MyBP-C(MUT)) expression.

100 eta-adrenergic stimulation increases cardiac myosin binding protein C (MyBP-C) and troponin I phospho

101 quasi-helical order of the myosin heads and myosin binding protein C (MyBP-C) decreased in the sarco

102 (FHC), individuals bearing a mutant cardiac myosin binding protein C (MyBP-C) gene usually have a be

103 The large multidomain muscle protein myosin binding protein C (MyBP-C) has been implicated fo

104 s contractile proteins, troponin-I (TnI) and myosin binding protein C (MyBP-C) in the heart and induc

105 Myosin binding protein C (MyBP-C) is a component of the

106 Myosin binding protein C (MyBP-C) is a thick filament pr

107 Myosin binding protein C (MyBP-C) is an integral part of

108 Myosin binding protein C (MyBP-C) is expressed in striat

109 Myosin binding protein C (MyBP-C) is one of a group of m

110 f mice to reduce the level of troponin I and myosin binding protein C (MyBP-C) phosphorylation in the

111 c proteins, including the cardiac isoform of myosin binding protein C (MyBP-C), and multiple mutation

112 , titin, and the cardiac modulatory protein, myosin binding protein C (MyBP-C).

113 We have determined the effects of myosin binding protein-C (MyBP-C) and its domains on the

114 We hypothesize that phosphorylation of myosin binding protein-C (MyBP-C) and troponin I (TnI) a

115 Myosin binding protein-C (MyBP-C) exists in three major

116 Myosin binding protein-C (MyBP-C) is a key regulatory pr

117 Myosin binding protein-C (MyBP-C) is a poorly understood

118 Myosin binding protein-C (MyBP-C) is a thick filament-as

119 Myosin binding protein-C (MyBP-C) is a thick-filament pr

120 Myosin binding protein-C (MyBP-C) is localized to the th

121 Among these, mutations that affect myosin binding protein-C (MyBP-C), an abundant component

122 myofilaments proteins, troponin I (TnI) and myosin binding protein-C (MyBP-C), are phosphorylated fo

123 to phosphorylation of troponin I (TnI) or of myosin binding protein-C (MyBP-C).

124 s mutant mice expressing a truncated form of myosin-binding protein C (MyBP-C(t/t)) develop severe di

125 r fasting, atrophying muscles show a loss of myosin-binding protein C (MyBP-C) and myosin light chain

126 ally phosphorylate the myofibrillar proteins myosin-binding protein C (MyBP-C) and the regulatory lig

127 ther changes in the phosphorylation state of myosin-binding protein C (MyBP-C) are a potential cause

128 Myosin-binding protein C (MyBP-C) is a multidomain prote

129 Myosin-binding protein C (MyBP-C) is a thick filament pr

130 Myosin-binding protein C (MyBP-C) is a thick filament pr

131 Myosin-binding protein C (MyBP-C) is an accessory protei

132 Myosin-binding protein C (MyBP-C) is an approximately 13

133 After phosphorylation of myosin-binding protein C (MyBP-C) with protein kinase A

134 ther with a depression in phosphorylation of myosin-binding protein-C (MyBP-C) and troponin I (TnI).

135 To elucidate the role of cardiac myosin-binding protein-C (MyBP-C) in myocardial structur

136 Myosin-binding protein-C (MyBP-C) is a thick filament-as

137 Myosin binding protein C (MyBPC) is a multidomain protei

138 rotein was identified as the 140-kDa cardiac myosin binding protein C (MyBPC).

139 Mutations in cardiac myosin-binding protein C (MyBPC) gene have been associat

140 thm missed a pathogenic 18 bp duplication in myosin binding protein C (MYBPC3) because of low coverag

141 eral sarcomeric genes, including the cardiac myosin binding protein C (MYBPC3) gene.

142 d in several sarcomeric genes, including the myosin binding protein C (MYBPC3) gene.

143 the frequency and phenotype of mutations in myosin binding protein C (MYBPC3) in a large outpatient

144 D cardiomyopathy genes, lamin A/C (LMNA) and myosin binding protein C (MYBPC3).

145 tudies suggest that mutations in the cardiac myosin binding protein-C (MYBPC3) gene cause late-onset,

146 k filament components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together expl

147 -dependent phosphorylation of troponin I and myosin binding protein C on isoproterenol stimulation wa

148 domains of titin and the cardiac isoform of myosin-binding protein-C on the surface of the myosin fi

149 s in thick filament proteins such as cardiac myosin binding protein-C or titin, cause familial hypert

150 The myosin binding protein C, or C protein, has 4 sites that

151 Cardiac myosin binding protein-C phosphorylation plays an import

152 K gene ablation did not affect troponin-I or myosin-binding protein-C phosphorylation in vivo.

153 e myosin-binding motif (m-domain) of cardiac myosin-binding protein-C remains unclear.

154 analysed, myosin heavy and light chains and myosin-binding protein C require Mef2 for normal express

155 MYBPC3, encoding beta-myosin heavy chain and myosin-binding protein C, respectively, are the 2 most c

156 2 domain of obscurin with a novel isoform of myosin binding protein-C slow (MyBP-C slow), correspondi

157 Myosin Binding Protein-C slow (sMyBP-C) is expressed in

158 Myosin Binding Protein-C slow (sMyBP-C), encoded by MYBP

159 Rather, mutations in cardiac myosin binding protein-C, troponin I, and alpha-cardiac

160 Myosin-binding protein C, troponin T, tropomyosin and my

161 phic cardiomyopathy is the recurrent MYBPC3 (myosin-binding protein-C) variant c.1504C>T, p.Arg502Trp

162 mbers with mutations in the gene for cardiac myosin-binding protein C was assessed.

163 of cardiac troponin inhibitor (cTnI) and the myosin-binding protein C was reduced by 26 and 35%, resp

164 DNA sequences encoding cardiac myosin-binding protein C were determined in unrelated pa

165 ble 40-kDa fragment is produced from cardiac myosin-binding protein C when the heart is stressed usin

166 ansgenic (TG) mouse model expressing cardiac myosin binding protein-C with a non-phosphorylatable Ser

167 nd disrupt the interaction of native cardiac myosin-binding protein C with the thin filament.

168 e suggested that the interactions of cardiac myosin-binding protein-C with its binding partners vary