ライフサイエンスコーパス: myotrophin

1 e transcriptional activity of ANF induced by myotrophin.

2 neonatal or adult myocyte growth induced by myotrophin.

3 as the [3H]leucine incorporation induced by myotrophin.

4 ted the [3H]leucine incorporation induced by myotrophin.

5 ically and immunologically active as natural myotrophin.

6 I kappa B alpha proteins, were identified in myotrophin.

7 nuclear extract proteins and the recombinant myotrophin.

8 transgenic (Tg) mouse model that overexpress myotrophin (a 12-kDa protein that stimulates myocyte gro

9 mouse models with cardiac overexpression of myotrophin (a prohypertrophic molecule) or TNFalpha show

10 Myotrophin, a 12-kDa ankyrin repeat protein, stimulates

11 We identified and cloned myotrophin, a 12-kDa protein from hypertrophied human an

12 mong others, we have isolated and identified myotrophin, a factor that stimulates myocytes growth, fr

13 lved in the hypertrophic response induced by myotrophin, a hypertrophic activator identified from spo

14 Myotrophin, a novel protein that has been shown to stimu

15 We have recently cloned the gene coding for myotrophin and expressed it in Escherichia coli.

16 phin to determine the effect of the loops on myotrophin and p65 localization, induction of protein sy

17 phy thus require nuclear co-translocation of myotrophin and p65, in a manner that depends crucially o

18 Proteomics demonstrated increases in myotrophin and spectrin that could promote hypertrophy a

19 bcellular events whose occurrence was due to myotrophin and translocation of PKC, we studied the effe

20 eonatal and adult myocytes were treated with myotrophin, and Western blot analyses were performed by

21 Our data strongly suggest that myotrophin appears to be a candidate gene for cardiac hy

22 w that the minor kinetic phases observed for myotrophin arise from heterogeneity of the ground states

23 Here we propose myotrophin as a model system to study the folding of ank

24 take place as a result of overexpression of myotrophin at both the cellular and molecular levels wil

25 The highly conserved protein V-1/Myotrophin binds CP tightly in vitro to render it incapa

26 We isolated and characterized various myotrophin cDNA clones corresponding to the multiple tra

27 acetylglucosaminyltransferase, spectrin, and myotrophin, contribute to hypertrophy and functional spa

28 d that, after internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to s

29 Myotrophin does not change PKC isoform expression (both

30 Myotrophin-E33A internalized into myocytes but did not t

31 Our data suggest that myotrophin exerts its action on protein synthesis, possi

32 Recently, myotrophin gene has been mapped and shown to be a novel

33 In the present study, the expression of myotrophin gene was analyzed, and at least seven transcr

34 5, in a manner that depends crucially on the myotrophin hairpin loops.

35 The gene encoding myotrophin has been cloned and expressed in E. coli.

36 f these assays indicate that the recombinant myotrophin has the ability to interact with NF-kappa B/r

37 Recently, the cDNA clones encoding myotrophin have been isolated and expressed in Escherich

38 cal significance, we examined transcripts of myotrophin in SHR heart during progression of hypertroph

39 ophy and HF as a result of overexpression of myotrophin in the heart associated with an elevated leve

40 effects of overexpression of cardio-specific myotrophin in transgenic mice in which cardiac hypertrop

41 ta on the pathophysiological significance of myotrophin in vivo, showing the effects of overexpressio

42 only the PKCepsilon isoform was involved in myotrophin-induced adult myocyte hypertrophy.

43 that activation of NF-kappaB was required in myotrophin-induced cardiac hypertrophy, in spontaneously

44 Importantly, myotrophin-induced expression of two hypertrophic genes

45 ay may play a critical role in mediating the myotrophin-induced hypertrophic response in cardiomyocyt

46 the involvement of protein kinase C (PKC) in myotrophin-induced hypertrophy, PKC activity and its dis

47 myocytes with staurosporine also reduced the myotrophin-induced mRNA levels of c-fos and beta-myosin

48 Myotrophin-induced myocyte growth and initiation of hype

49 and PKCepsilon isoforms participated in the myotrophin-induced neonatal myocyte growth, whereas only

50 f genistein, a tyrosine kinase inhibitor, on myotrophin-induced neonatal myocyte growth.

51 Consistently, myotrophin-induced NF-kappaB activation was enhanced by

52 Furthermore, myotrophin-induced PKC activity was primarily located in

53 Myotrophin is a soluble-12 kilodalton protein isolated f

54 The 118 residue protein myotrophin is composed of four ankyrin repeats that stac

55 Myotrophin is folded over a large pH range and is solubl

56 revealed that one of the ankyrin repeats of myotrophin is highly homologous specifically to those of

57 s highly homologous specifically to those of myotrophin is highly homologous specifically to those of

58 Myotrophin is the first example of a naturally occurring

59 the MPD6-IRES-mediated translation, but not myotrophin-MPD6 transcription, was significantly up-regu

60 The expression of myotrophin-MPD6 transcripts was up-regulated in some tum

61 Northern blot analysis of myotrophin mRNA showed multiple transcripts.

62 ame located in the 3'-untranslated region of myotrophin mRNA.

63 Myotrophin (Mtpn) was predicted to be and validated as a

64 The effect of myotrophin on the stimulation of PKC activity and [3H]le

65 Moreover, our recent study using the myotrophin-overexpressed transgenic mouse (Myo-Tg) model

66 ve further analyzed the primary structure of myotrophin protein and identified significant new struct

67 hus, these results clearly indicate that the myotrophin protein to be a unique rel/NF-kappa B interac

68 Our data show that overexpression of myotrophin results in initiation of cardiac hypertrophy

69 CP-capped filaments, whereas the protein V-1/myotrophin sequesters CP in an inactive complex.

70 Myotrophin significantly stimulated PKC activity in neon

71 While myotrophin-specific antibodies inhibited the formation o

72 n vitro transcripts generated from all these myotrophin-specific cDNA clones translate in vitro to a

73 pecificity of the PKC isoform(s) involved in myotrophin-stimulated myocyte growth, both neonatal and

74 The mechanism by which myotrophin stimulates protein synthesis and initiates my

75 ture-based mutations on the hairpin loops of myotrophin to determine the effect of the loops on myotr

76 Myotrophin treatment stimulated NF-kappaB nuclear transl

77 Myotrophin (V-1) is a 13-kDa ankyrin repeat-containing p

78 Here we demonstrate that myotrophin/V-1 binds directly to CP in a 1:1 molar ratio

79 In vitro studies indicate that myotrophin/V-1 can promote the formation of p50-p50 homo

80 Thus, overexpression of myotrophin/V-1 during NFkappaB activation resulted in a

81 Co-immunoprecipitation studies reveal that myotrophin/V-1 interacts with NFkappaB proteins in vitro

82 Myotrophin/V-1 is a cytosolic protein found at elevated

83 earts, this study cumulatively suggests that myotrophin/V-1 is a regulatory protein for modulating th

84 Because myotrophin/V-1 is found at elevated levels during NFkapp

85 y, we demonstrated that in HeLa cells native myotrophin/V-1 is predominantly present in the cytoplasm

86 -dimensional alignment studies indicate that myotrophin/V-1 resembles a truncated IkappaBalpha withou

87 rmore, adenovirus-mediated overexpression of myotrophin/V-1 resulted in elevated levels of both p50-p

88 Correspondingly, overexpression of myotrophin/V-1 resulted in significantly reduced kappaB-

89 sed in Escherichia coli, and the recombinant myotrophin was found to be as biologically and immunolog

90 Myotrophin (whose gene is localized on human chromosome