ライフサイエンスコーパス: myristic acid

1 and high-yield modification of the ELP with myristic acid.

2 ular asses of 37, 35, and 25 kDa) label with myristic acid.

3 CD28 monoclonal antibodies (mAbs) or phorbol myristic acid.

4 labeled only with [35S]methionine, not with myristic acid.

5 nic and oleic acid and to a lesser extent by myristic acid.

6 over through the receptor's interaction with myristic acid.

7 ecrease in hSlo1 plasmalemma localization by myristic acid.

8 ), basic residues in NC, and the presence of myristic acid.

9 d in the X-ray structure of HSA complexed to myristic acid.

10 iolabeled with either [35S]methionine or [3H]myristic acid.

11 e 2 diabetes (HR [95% CI] per SD difference: myristic acid 1.15 [95% CI 1.09-1.22], palmitic acid 1.2

12 10:0) acid (HRSD: 0.93; 95% CI: 0.89, 0.99), myristic acid (14:0) (HRSD: 0.90; 95% CI: 0.83, 0.97), t

13 decreased, the binding affinity was reduced; myristic acid (14:0) bound with a K(d) of 1409 +/- 423 n

14 s with 4-10 carbons, lauric acid (12:0), and myristic acid (14:0) were associated with decreased risk

15 Myristic acid (14:0), 14:1n-9, and 14:2n-6 were all inco

16 Lauric acid (12:0), myristic acid (14:0), and palmitic acid (16:0) are appro

17 :0) and oleic acid (18:1), cholesterol ester myristic acid (14:0), and phospholipid palmitoleic acid

18 ly assessed other DNL fatty acid biomarkers [myristic acid (14:0), palmitoleic acid (16:1n-7), 7-hexa

19 Even-chain SFAs that were measured (14:0 [myristic acid], 16:0 [palmitic acid], and 18:0 [stearic

20 l-CoA, the other products were identified as myristic acid, 2-myristoylmyristic acid, and 14-heptacos

21 cid (10.07%), palmitelaidic acid (9.56%) and myristic acid (8.83%).

22 ion known as myristoylation, the transfer of myristic acid (a 14-carbon saturated fatty acid) to an N

23 Modification of HIV-1 Gag with myristic acid, a saturated 14-carbon fatty acid (14:0),

24 , with the IB isoform containing a potential myristic acid acceptor sequence.

25 NAE 14:0, but not myristic acid, activated phenylalanine ammonia lyase exp

26 otein which prevented incorporation of [(3)H]myristic acid also altered the detergent solubility and

27 These compounds included a myristic acid analog known to interact with Src family k

28 With [3H]myristic acid and [3H]acetate, GPIX was found to be a ma

29 the simultaneous insertion of an N-terminal myristic acid and binding to a Golgi-associated binding

30 ically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transitio

31 Phorbol myristic acid and dimethyloxalylglycine differentially s

32 virus expression system required addition of myristic acid and E9-14 acid precursors to demonstrate t

33 labeling of calcineurin B with radiolabeled myristic acid and electrospray mass spectral analysis co

34 pathways by treatment of cells with phorbol myristic acid and ionomycin rescued up-regulation of Btk

35 GPIb was acylated with about equal mounts of myristic acid and palmitic acids.

36 -translational modifications: acylation with myristic acid and phosphorylation at the C terminus.

37 Myristic acid and positively charged residues within the

38 ence (G2E), which eliminates the addition of myristic acid and the membrane-binding capacity of this

39 Based on evidence that myristic acid and TSP1 each modulate endothelial cell ni

40 nfidence interval: 1.06, 5.38) for saturated myristic acid, and 2.88 (95% confidence interval: 1.24,

41 ng studies using [3H]glycerol, [32P]Pi, [14C]myristic acid, and [14C]linoleic acid indicated that the

42 , the sum of pentadecylic and margaric acid, myristic acid, and SFAs from dairy sources.

43 Surprisingly, only myristic acid, and to a lesser extent palmitic acid, sti

44 udosubstrate-specific peptides with attached myristic acid are cell permeable and can be used to bloc

45 The presence of myristic acid at the N terminus of the Myr1E Gag protein

46 ele (nmt487D) produces temperature-sensitive myristic acid auxotrophy.

47 t of synthetically derived tagged analogs of myristic acid bearing a 'clickable' tag.

48 rs that target either the active site or the myristic acid binding pocket in the kinase domain C-lobe

49 losteric network linking the SH3 domain, the myristic acid binding pocket, and the active site of the

50 pported monohydroxylation of lauric acid and myristic acid, but secondary oxygenation of the primary

51 bolic labeling showed incorporation of [(3)H]myristic acid by wild-type Z protein but not by the G2A

52 fat pad showed a decrease in the content of myristic acid (C14), a principal substrate for protein m

53 ential enzyme that catalyzes the transfer of myristic acid (C14:0) from myristoylCoA to the N-terminu

54 tment of cells expressing hSlo1 with 100 muM myristic acid caused alteration of hSlo1 activation kine

55 se data demonstrate an unexpected link among myristic acid, CD36, AMP kinase, and eNOS activity.

56 ive constructs were used to demonstrate that myristic acid/CD36 stimulation of eNOS activity was depe

57 In vivo, treatment with a myristic acid conjugated trivalent histidine-histidine d

58 Of the fatty acids tested, only exogenous myristic acid contributed to increased intracellular myr

59 dynamics simulations show that luteolin and myristic acid cooperate to stabilize the Omega-loop amon

60 aplsX S. pneumoniae strain was refractory to myristic acid-dependent growth arrest, and unlike the wi

61 The requirement of myristic acid for multimerization was reproduced using t

62 degrees C and in the presence of 1) phorbol myristic acid, forskolin and 3-isobutyl-1-methylxanthine

63 -myristoyltransferase (NMT), which transfers myristic acid from myristoyl coenzyme A to the amino gro

64 T41I/T78I mutant was defective in release of myristic acid from the more hydrophobic core.

65 in the sequence oleic acid > palmitic acid > myristic acid > linoleic acid > linolenic acid.

66 oleic acid, stearic acid, palmitic acid, and myristic acid had little effect.

67 Treatment of ER membranes with myristic acid in the presence of cytosol increases SVIP

68 tide was labeled with [35S]methionine or [3H]myristic acid in the translation reactions, while mutant

69 Mechanistically, metabolism of exogenous myristic acid increased the biosynthesis of myristoyl Co

70 ristoylation by nearly 90% and abolished the myristic acid-induced change in current density.

71 ates that ASFV effectively inhibited phorbol myristic acid-induced synthesis of antiviral, proinflamm

72 In human cells, phorbol myristic acid induces syndecan-1 shedding, resulting in

73 The Lineweaver-Burk plot showed that myristic acid inhibited firefly luciferase in competitio

74 Ueda and Suzuki reported that myristic acid inhibited firefly luciferase in microM ran

75 ndicated that caveolin-1 was not acylated by myristic acid; instead, it was acylated by palmitic acid

76 interleukin- (IL) 2 was measured in phorbol myristic acid-ionomycin-stimulated peripheral lymphocyte

77 These results establish that myristic acid is a primary determinant of the stability

78 Myristic acid is found here to bind Sig-1R as an agonist

79 molecules may adopt a conformation in which myristic acid is hidden and unavailable for membrane int

80 f glycosylphosphatidylinositol biosynthesis, myristic acid is incorporated into the anchor from the d

81 results strongly support the hypothesis that myristic acid is sequestered inside MA prior to capsid-m

82 of well-controlled studies, it appears that myristic acid is the most potent saturated fatty acid.

83 [3H]Myristic acid-labeled cells were lysed by nitrogen cavit

84 detergent-resistant fractions and that [(3)H]myristic acid-labeled HIV Gag showed a nine-to-one enric

85 c acid was confirmed by the detection of [3H]myristic acid labeling and the observation that labeling

86 A saturated fatty acid, myristic acid (MA), had no inhibitory effect on the isop

87 reatment of Sig-1R-KO neurons with exogenous myristic acid mitigates p35 accumulation, diminishes tau

88 d from Gag proteins that lack the N-terminal myristic acid modification or the nucleocapsid (NC) prot

89 Both the myristic acid moiety and additional determinants within

90 coli lipopolysaccharide (LPS) that lacks the myristic acid moiety of lipid A.

91 A single myristic acid molecule simultaneously binds the LBP, sug

92 catalyzes the cotranslational acylation with myristic acid of the NH2-terminal glycines of a number o

93 tic studies demonstrated that the effects of myristic acid on eNOS function were not dependent on PI

94 ng antibody demonstrated that the effects of myristic acid on eNOS required association with CD36.

95 293 cells, when stimulated with oleic acid, myristic acid, or the agonist 4-[[(3-phenoxyphenyl)methy

96 correlation was significant specifically for myristic acid (P < 0.001).

97 r exposure to dexamethasone (DEX) or phorbol myristic acid (PMA), PMA had no effect on expression of

98 Phorbol myristic acid (PMA)-treated U937 cells and elutriated mo

99 s claudin-1 were treated with 200 nM phorbol myristic acid (PMA).

100 C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive i

101 ourse labeling of VV-infected cells with [3H]myristic acid reveals at least three additional putative

102 Metabolic labeling with [3H]myristic acid showed that both the 120- and 160-kDa kine

103 s in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes.

104 the molecular basis of how the metabolism of myristic acid stimulates high-fat diet-mediated prostate

105 Phorbol myristic acid stimulation significantly decreases DiD (1

106 ent acyltransferase which is responsible for myristic acid substitutions at the hydroxy moiety of lip

107 This indicates that myristic acid targets MARCKS to the membrane, where it i

108 ine, threonine, and/or tyrosine residues and myristic acid; this type of esterification was further c

109 lation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to cir

110 myristoylation is the covalent attachment of myristic acid to the N terminus of proteins in eukaryoti

111 N-myristoylation refers to the attachment of myristic acid to the N-terminal glycine of proteins and

112 reversible attachment of a C(14) fatty acid, myristic acid, to the N-terminal glycine of a protein vi

113 Furthermore, we show that myristic acid treatment of hepatocytes increases both VT

114 xpressed in HEK293T cells incorporated [(3)H]myristic acid via a posttranslational mechanism, which i

115 % (IC50) at 13.6 microM, whereas the IC50 of myristic acid was 0.68 microM.

116 Modification of ArgIB by myristic acid was confirmed by the detection of [3H]myri

117 ospray mass spectral analysis confirmed that myristic acid was covalently and stoichiometrically link

118 Myristic acid was detected on cysteine residue(s) (i.e.

119 Myristic acid was linked to GPIX by an amide bond, and t

120 Myristic acid was the only nutrient that appeared to med

121 Trace amounts of myristic acid were also detected in transgenic plants co

122 The K(d) values for palmitic and myristic acid were in the nanomolar range.

123 oleic acid, stearic acid, palmitic acid and myristic acid, were the primary chemicals identified usi

124 d, and the highest activity was observed for myristic acid with a Km of 1.7 mol % and a Vmax of 0.63