ライフサイエンスコーパス: myristoylate

1 N-terminal glycines of these 3A proteins are myristoylated.

2 hSlo1, is internally and posttranslationally myristoylated.

3 s reaction was most efficient when Vac8 is N-myristoylated.

4 hen expressed with a Gag mutant that was not myristoylated.

5 etroviruses, retroviral MAs are N-terminally myristoylated.

6 V Gag is unusual in that it is not naturally myristoylated.

7 Transfection of myristoylated Akt (AktCA) in HK-11 cells induced Akt-Ser

8 Reconstitution of Rictor-null cells with myristoylated AKT (Myr-AKT) rescued vascular assembly in

9 a constitutively active form of the kinase, myristoylated Akt (Myr-Akt), demonstrates an ability to

10 permanently expressing constitutively active myristoylated Akt (myrAkt), we show that activation of A

11 d expression of constitutively active AKT by myristoylated AKT adenovirus results in increased phosph

12 Both constitutively active myristoylated Akt and hRheb(S16H) induce regrowth of axo

13 n-activated protein kinase kinase (MEK) 1 or myristoylated Akt blocked HDACI/perifosine-mediated cera

14 s, and expression of a constitutively active myristoylated Akt blocked the enhancement of ER stress-i

15 Enforced expression of myristoylated Akt but not constitutively active MEK sign

16 basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors.

17 In contrast, Kras(G12D) mice transduced with myristoylated AKT developed GSI-sensitive T-ALLs that ac

18 ansgenic expression of constitutively active myristoylated Akt increased glucose uptake of resting T

19 -regulatable FL5.12 pre-B cell line in which myristoylated Akt is expressed under the control of doxy

20 by expression of constitutively active AKT (myristoylated AKT or AKT-Thr308Asp/Ser473Asp).

21 Angiogenic HA fragments or overexpression of myristoylated Akt or HA receptors blunted these effects

22 iple cancer cell lines, forced expression of myristoylated Akt promoted resistance to ARC-induced apo

23 Overexpression of SHP-2, Gab1, and myristoylated Akt significantly upregulated NF-kappaB tr

24 ort of this model, coexpression of Glut1 and myristoylated Akt transgenes resulted in a synergistic i

25 bitor and restored in cells transfected with myristoylated Akt yet perfused in stiff tubes.

26 stably expressing gain-of-function H-Ras or myristoylated Akt.

27 drophobic motif site in Sin1(-/-) MEFs; both myristoylated-Akt and Akt lacking the PH domain are phos

28 We report that constitutively active, myristoylated-Akt increases FANCL protein level by reduc

29 Expression of myristoylated-Akt rescued 4-MU-induced apoptosis and inh

30 ne bone marrow transplantation model using a myristoylated AKT1 (myr-AKT), recipients develop myelopr

31 A myristoylated Akt1 (MyrAkt1) fusion protein expressed in

32 viruses expressing c-Myc and activated AKT1 (myristoylated AKT1 or myrAKT1) to mimic theMYCamplificat

33 Wild-type and myristoylated Akts (Akt(WT) and Akt(Myr)) suppress TGF-b

34 gene-array, including genes for profilin-1, myristoylated alanine rich protein kinase C substrate li

35 Here, we identify myristoylated alanine-rich C kinase substrate (MARCKS) a

36 ased phosphorylations of PKC at Thr(514) and myristoylated alanine-rich C kinase substrate (MARCKS) a

37 Ca(2+)-PKC) is hypothesized to phosphorylate myristoylated alanine-rich C kinase substrate (MARCKS) a

38 Myristoylated alanine-rich C kinase substrate (MARCKS) i

39 Myristoylated alanine-rich C kinase substrate (MARCKS) i

40 Myristoylated alanine-rich C kinase substrate (MARCKS) i

41 al studies by Gay et al. demonstrated that a myristoylated alanine-rich C kinase substrate (MARCKS) p

42 utrophil elastase-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) p

43 The present study reveals that myristoylated alanine-rich C kinase substrate (MARCKS) p

44 ptide comprising the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) w

45 We previously found the myristoylated alanine-rich C kinase substrate (MARCKS),

46 uggest that the basic effector domain of the myristoylated alanine-rich C kinase substrate (MARCKS),

47 Myristoylated Alanine-Rich C Kinase Substrate (MARCKS),

48 Phosphorylation of myristoylated alanine-rich C kinase substrate (phospho-M

49 pears to be the detachment of phosphorylated myristoylated alanine-rich C kinase substrate (pMARCKS)

50 The release of phosphorylated myristoylated alanine-rich C kinase substrate and its su

51 We show that phosphorylation of myristoylated alanine-rich C kinase substrate by membran

52 Strikingly, the lipid ligand MED (myristoylated alanine-rich C kinase substrate effector d

53 PKC-dependent myristoylated alanine-rich C kinase substrate phosphoryl

54 s determined by translocation of eGFP-tagged myristoylated alanine-rich C kinase substrate protein) r

55 Consequently, phosphorylation of myristoylated alanine-rich C kinase substrate was decrea

56 ral biologically important peripheral (e.g., myristoylated alanine-rich C kinase substrate) and integ

57 the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) as a pote

58 The MARCKS protein (myristoylated alanine-rich C kinase substrate) is an act

59 porters, actin binding proteins (radixin and myristoylated alanine-rich C kinase substrate), and Rab

60 cific subunits of AMPA or NMDA receptors and myristoylated alanine-rich C kinase substrate).

61 We could demonstrate that Lck and myristoylated alanine-rich C kinase substrate, two main

62 next identified that the phosphorylation of Myristoylated alanine-rich C-kinase substrate (MARCKS) a

63 Here, we identify the actin-binding protein myristoylated alanine-rich C-kinase substrate (MARCKS) a

64 from the lipid binding domain of the protein myristoylated alanine-rich C-kinase substrate (MARCKS) b

65 two actin-associated proteins, myosin II and myristoylated alanine-rich C-kinase substrate (MARCKS) i

66 crease in a poorly-characterized MK protein, myristoylated alanine-rich C-kinase substrate (MARCKS),

67 The effector domain of myristoylated alanine-rich C-kinase substrate (MARCKS-ED

68 Here, we demonstrate in mice that the myristoylated alanine-rich C-kinase substrate protein (M

69 MARCKS (myristoylated alanine-rich C-kinase substrate) is a majo

70 C) activity and of phosphorylated (inactive) myristoylated alanine-rich C-kinase substrate, a PKC tar

71 hosphorylation of serines 713 and 726 in the myristoylated alanine-rich protein kinase (PK) C substra

72 ular substrate for protein kinase C known as myristoylated alanine-rich protein kinase C substrate (M

73 Myristoylated alanine-rich protein kinase C substrate (M

74 ther (phosphatase and tensin homolog (PTEN), myristoylated alanine-rich protein kinase C substrate (M

75 The activity of myristoylated alanine-rich protein kinase C substrate (M

76 eins we characterized two proteins, :MARCKS (Myristoylated Alanine-Rich protein Kinase C substrate) a

77 e ubiquitinated after rapid preconditioning: myristoylated, alanine-rich C-kinase substrate (MARCKS)

78 and that the major PKC epsilon target is the myristoylated, alanine-rich C-kinase substrate (MARCKS).

79 We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendr

80 t fluorescence changes are consistent with a myristoylated amino terminus in the proximity of the mem

81 This work demonstrates that the myristoylated amino terminus of Galpha il proteins under

82 Overexpression of a myristoylated and active form of A. stephensi and Ae. ae

83 al proteomic tools for identification of the myristoylated and glycosylphosphatidylinositol-anchored

84 Myristoylated and guanosine 5'-3-O-(thio)triphosphate (G

85 L39, and the resulting new N termini were N-myristoylated and N-acetylated, respectively.

86 The L176F substitution improved affinity of myristoylated and non-acylated GCAP1 for the cyclase but

87 The difference in the binding affinity of myristoylated and non-myristoylated proteins to Ca(2+) a

88 he biochemical and biophysical properties of myristoylated and nonmyristoylated mouse methionine sulf

89 rein we demonstrate that HGAL protein can be myristoylated and palmitoylated and that these modificat

90 This study demonstrates that BBLF1 is a myristoylated and palmitoylated protein, as are UL11 and

91 no-acid (aa) tegument protein, pp28, that is myristoylated and phosphorylated.

92 matrix domain (MA) of HIV-1 Gag protein is N-myristoylated and plays an important role in virus buddi

93 We report the interaction of myristoylated and unmyristoylated HIV-1 Gag MA domains w

94 virion-associated fragments micro1N (4 kDa; myristoylated) and micro1C (72 kDa).

95 the similarity with Nef, we show that S2 is myristoylated, and, as is compatible with a crucial role

96 In addition, mutants that cannot be myristoylated are no longer mono-ubiquitinated but are s

97 Using myristoylated Arf1.GDP as a substrate, the k(cat) was 1.

98 interaction of uncomplexed Brag2 and of the myristoylated Arf1/Brag2 complex with a phosphatidylinos

99 The IA were myristoylated at a glycine penultimate to the N terminus

100 The N-terminus is myristoylated at Gly2 and palmitoylated at Cys3 and Cys2

101 Our results demonstrate that AtCPK5 is myristoylated at its amino terminus and that myristoylat

102 SSP spans the membrane twice and is myristoylated at its cytoplasmic N terminus.

103 We determined that cystin is myristoylated at its G2 residue and that N-myristoylated

104 We demonstrate that Neurl1 is myristoylated at its N terminus, and that myristoylation

105 ll known functions of Nef require that it be myristoylated at its N terminus.

106 e Junin virus GP-C signal peptide subunit is myristoylated at its N-terminal glycine.

107 proteins are permanently, cotranslationally myristoylated at the extreme amino terminus.

108 ChChd3 is myristoylated at the N terminus and has a CHCH domain wi

109 enger], catalase (an H2O2-degrading enzyme), myristoylated autocamtide-2 related inhibitory peptide (

110 ity and was blocked by the CaMKII inhibitor--myristoylated autocamtide-2-related inhibitory peptide (

111 II-alpha with the highly specific antagonist myristoylated autocamtide-2-related inhibitory peptide (

112 nels (CaCC) because simultaneous addition of myristoylated-autocamtide-2-related inhibitory peptide o

113 rotein subunit Gbeta and was mimicked by the myristoylated betagamma-binding/activating peptide mSIRK

114 The cytosolic form of the enzyme is myristoylated, but it is not known to translocate to mem

115 ristoylated c-Abl more potently than that of myristoylated c-Abl by binding to the myristate-binding

116 at GNF-2 inhibits the kinase activity of non-myristoylated c-Abl more potently than that of myristoyl

117 mmunofluorescence reveals a translocation of myristoylated c-Abl to the endoplasmic reticulum in GNF-

118 detectable effect on the localization of non-myristoylated c-Abl.

119 ivity but had enhanced stability compared to myristoylated c-Src.

120 dence that the membrane binding motif of the myristoylated C-subunit of PKA (PKA-C) steers the enzyme

121 ylyl cyclase-activating protein 1 (GCAP1), a myristoylated Ca(2+) sensor in vision, regulates retinal

122 The myristoylated calcium sensor SOS3 and its interacting pr

123 ansion results in the externalization of the myristoylated capsid protein VP4 and the N-terminal exte

124 The affinity between myristoylated cargo and carrier protein, Unc119, varies

125 a similar principle governs the transport of myristoylated cargo by the carrier proteins Unc119a and

126 d that binding of ARL3-GTP serves to release myristoylated cargo from UNC119.

127 analyzed the binding strength of N-terminal myristoylated cargo peptides (GNAT1, NPHP3, Cystin1, RP2

128 erature dependence in the cellular uptake of myristoylated cargo.

129 t as displacement factors for prenylated and myristoylated cargo.

130 also inhibited membrane translocation of the myristoylated CD36 signaling target Fyn and activation o

131 t not that of Arl2, regulates the release of myristoylated ciliary proteins from the GDI-like solubil

132 effector UNC119 as a binding partner of the myristoylated ciliopathy protein nephrocystin-3 (NPHP3).

133 virus 1 transduction with a gene encoding a myristoylated, constitutively active form of the oncopro

134 AECs with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking p

135 s myristoylated at its G2 residue and that N-myristoylated cystin fractionates with membrane microdom

136 dinucleoside glutamate ester derivatives, N-myristoylated derivatives showed significantly higher an

137 otein 1 (CHP1) is a widely expressed, 22-kDa myristoylated EF-hand Ca(2+)-binding protein that shares

138 Yeast frequenin (Frq1), a small N-myristoylated EF-hand protein, activates phosphatidylino

139 alcineurin B homologous proteins (CHP) are N-myristoylated, EF-hand Ca(2+)-binding proteins that regu

140 Myristoylated ELPs provide a versatile platform for gene

141 L1 is a myristoylated envelope protein that is a potent target f

142 Vaccinia virus (VACV) L1 is a myristoylated envelope protein which is required for cel

143 Uptake of a myristoylated, fluorescent peptide was efficient in the

144 A constitutively active myristoylated form of Akt1 did not induce high-grade gli

145 hyperalgesic by SNL lost sensitivity to the myristoylated form of autocamtide-2-related inhibitory p

146 At the membrane, the myristoylated form of neurocalcin delta senses submicrom

147 he later identification of a membrane bound, myristoylated form of OCA-B suggested additional, unique

148 or both forms of the enzyme, except that the myristoylated form reduced methionine sulfoxide in prote

149 roteasomal degradation in its membrane-bound myristoylated form.

150 en residues 42 and 43, yielding N-terminal N-myristoylated fragment mu1N and C-terminal fragment mu1C

151 d that whole virus particles, as well as the myristoylated fragment mu1N that is released from partic

152 Interference of Galpha13 expression or a myristoylated fragment of Galpha13 that inhibited intera

153 ificity, palmitoylating H- and N-Ras but not myristoylated G (alphai1) or GAP-43, proteins with N-ter

154 Activation of G betagamma subunits using myristoylated G betagamma-binding peptide (mSIRK) caused

155 on apparatus targets the fully mature, fully myristoylated G protein for mono-ubiquitination and deli

156 an in vitro binding assay using full-length myristoylated Gag and liposome-associated PI(4,5)P(2).

157 less-severe impacts on FRET between normally myristoylated Gag proteins than do CA-CTD mutations.

158 ly, disruption of PP1c-Gbeta1 complexes with myristoylated Gbeta1 peptides containing the PP1c bindin

159 (max) and K(m) values for both the peptide N-myristoylated-GCG and palmitoyl-coenzyme A.

160 s at the +2 and +3 positions relative to the myristoylated glycine for high and low affinities.

161 a flexneri protease IpaJ was found to cleave myristoylated glycine of eukaryotic proteins, yet the di

162 ion of CNB myristoylation by mutation of the myristoylated glycine triggered constitutive expression

163 that IpaJ cleaved the peptide bond between N-myristoylated glycine-2 and asparagine-3 of human ARF1,

164 In contrast, myristoylated GRASP promoted tethering and exhibited a u

165 s eliminates membrane association of the non-myristoylated gravin, the sensitivity to Ca2+/calmodulin

166 Binding of long-chain FFA and myristoylated H3 peptide is mutually exclusive.

167 Using fluorescein isothiocyanate-labeled, myristoylated HBV preS1-peptides we demonstrate (1) the

168 In contrast, although myristoylated HDAg-S was incorporated into VLPs far more

169 y at the plasma membrane, is mediated by the myristoylated, highly basic matrix (MA) domain, which in

170 Extracellular myristoylated HIV Nef inhibited cholesterol efflux from

171 ally by determining the affinity of purified myristoylated HIV-1 MA for liposomes of defined composit

172 were qualitatively recapitulated by purified myristoylated HIV-1 MA.

173 We have examined the binding of naturally myristoylated HIV-1 matrix (MyrMA) and matrix plus capsi

174 ize just such a conformational change in the myristoylated HIV-1 Nef protein (myrNef): at high lipid

175 increased statin sensitivity, expression of myristoylated HRAS did not rescue this effect.

176 Abnormal processing or production of this myristoylated HTT fragment might be involved in the path

177 Myristoylated HTT553-585-EGFP, but not its non-myristoyl

178 Our results suggest that accumulation of myristoylated HTT553-586 in cells may alter the rate of

179 A replication in G144 cells is stimulated by myristoylated (i.e., constitutively active) Akt and redu

180 formation implies that the VV ATI protein is myristoylated in a sequence-independent manner.

181 blished that 0.43-0.46% of the proteome is N-myristoylated in T. cruzi approaching that of other euka

182 Furthermore, Pto was myristoylated in vivo dependent on the presence of Gly-2

183 Protein-tyrosine kinase 6 (PTK6) is a non-myristoylated intracellular tyrosine kinase evolutionari

184 A myristoylated isoform is activated by Ca(2+) to initiate

185 Finally, a non-myristoylated isoform is essential to complete cytokines

186 s observed that when HDAg-S was artificially myristoylated, it could efficiently inhibit HDV RNA repl

187 ed alanine-rich C kinase substrate, two main myristoylated kinases in T cells, were mislocalized in t

188 e main structural protein Gag depends on its myristoylated MA domain and PM PI(4,5)P2.

189 ontains three major domains: the N-terminal, myristoylated MA domain that targets the protein to the

190 anchoring of human immunodeficiency virus-1 myristoylated MA protein using a coarse-grained represen

191 specific interactions between the N-terminal myristoylated matrix (MA) domain and phosphatidylinosito

192 ne targeting is mediated by the N-terminally myristoylated matrix (MA) domain of Gag and is dependent

193 osphate (PI(4,5)P(2)) and Gag's N-terminally myristoylated matrix (MA) domain.

194 on calcium and is mediated by the N-terminal-myristoylated matrix (myr(+)MA) domain.

195 calcium and is mediated by the N-terminally myristoylated matrix (myr(+)MA) domain.

196 ediated by specific interactions between the myristoylated matrix [myr(+)MA] domain of Gag and phosph

197 ed a novel mechanism for the function of the myristoylated, membrane-bound form of OCA-B/p35 as a sig

198 Synthetic myristoylated micro1N peptide forms size-selective pores

199 on lateral association was abolished if the myristoylated moiety at the C-terminus was replaced by a

200 We further show that a conserved N-terminal myristoylated motif of both invertebrate and vertebrate

201 ation releases two virally encoded peptides, myristoylated mu1N (myr-mu1N) and Phi.

202 A non-myristoylated mutant of cGKII did not support cGMP inhib

203 to overexpress either constitutively active myristoylated (Myr)-Akt or a dominant-negative CAAX-Akt

204 iac-specific expression of either activated (myristoylated [myr]) or dominant-negative (dn) Akt and a

205 Further, constitutively activated Akt (myristoylated [myr]Akt) or human NgBR can rescue the NgB

206 cludes membrane interactions mediated by the myristoylated N terminus of Gag, protein-protein interac

207 ficity of UNC119 is unique: UNC119 bound the myristoylated N terminus of Galpha(t1) with much higher

208 Recoverin has two functional EF hands and a myristoylated N terminus.

209 nes, a process that involves exposure of the myristoylated N-terminal amphipathic alpha-helix upon ac

210 tic removal of sigma3 lead to release of the myristoylated N-terminal cleavage fragment micro1N and u

211 The exceptionally small, myristoylated N-terminal ectodomain of p15 lacks any of

212 Both myristoylated N-terminal fragment mu1N and C-terminal fr

213 The myristoylated N-terminal preS1 domain of the L protein s

214 is mediated through specific binding of the myristoylated N-terminal preS1-domain of the HBV L-prote

215 eir conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, a

216 Two major conformations of the myristoylated N-terminus are the most populated: a long

217 e data indicate an important role(s) for the myristoylated N-terminus in Pto signalling.

218 onally showed that this cleavage allowed the myristoylated, N-terminal micro1N fragment to be release

219 ng entry-related uncoating, analogous to the myristoylated, N-terminal VP4 fragment of picornavirus c

220 eases the degree of cooperativity; thus, the myristoylated NCS-1 binds Ca(2+) more strongly (with thr

221 (3) N-Terminally myristoylated NCS-1 dimerizes in a calcium-dependent man

222 Determination of the x-ray structure of myristoylated NPHP3 peptide in complex with Unc119a reve

223 NKD2 is myristoylated on glycine, the second residue.

224 Nef is myristoylated on the N-terminus, associates with membran

225 ith three Ca(2+) binding sites) than the non-myristoylated one (with two Ca(2+) binding sites).

226 he HIV-1 replication cycle, the N-terminally myristoylated p17 domain targets the Gag polyprotein to

227 Vac8p is the first N-myristoylated, palmitoylated protein identified as a sub

228 A myristoylated peptide based on the autoinhibitory pseudo

229 understanding the intracellular delivery of myristoylated peptide cargoes for cell-based biochemical

230 The myristoylated peptide did not adversely affect cell viab

231 e effectively reversed by 50 nm H89 or 50 nm myristoylated peptide inhibitor (MPI), specific inhibito

232 A myristoylated peptide that blocks importin 7-mediated ER

233 n mu1 allows the release of its N-terminally myristoylated peptide, mu1N (4 kDa), which probably then

234 protein PrBP/delta did not interact with the myristoylated peptide.

235 yrate did not enhance cellular uptake of the myristoylated peptide.

236 Previous findings showed that N-terminally myristoylated peptides constituting a receptor binding d

237 Myristoylated peptides with either positive or negative

238 of resolving hydrophobic and acylated (e.g., myristoylated) peptides by optimizing the steps in a mas

239 upled receptor kinase 2 or membrane-targeted myristoylated-phosducin-attenuated or abolished Cav2.3 m

240 e human cytomegalovirus UL99-coded pp28 is a myristoylated phosphoprotein located in the virion tegum

241 amma kinase-dead mutants, and potentiated by myristoylated PI3Kgamma.

242 maleimide I, Go-7874 or Go-6976, or with the myristoylated PKA inhibitor, PKI-(14-22)-amide failed to

243 inase A (PKA) inhibitors (H-89, KT-5720, and myristoylated PKA inhibitory peptide 14-22) failed to pr

244 myocytes, adenovirus-mediated expression of myristoylated PKBalpha (myr-PKBalpha) increased cellular

245 Myristoylated PKC (zeta/lambda) pseudosubstrate and DN P

246 hibition of cAMP-induced PKCzeta activity by myristoylated PKC (zeta/lambda) pseudosubstrate, a speci

247 of HPAECs with dnPKC-zeta, or treatment with myristoylated PKC-zeta peptide inhibitor abrogated S1P-i

248 Expression of myristoylated-PKCalpha in S4(-/-) cells restores rictor,

249 allel, inhibition of the atypical PKCzeta by myristoylated PKCzeta pseudosubstrate inhibitor signific

250 uppressed by a PKCzeta specific inhibitor (a myristoylated PKCzeta pseudosubstrate peptide).

251 ein kinase inhibitor (PKI) (6-22) amide, and myristoylated PKI (14-22), applied alone or in combinati

252 100 microm m-iodobenzylguanidine or 5 microm myristoylated PKI amide did not alter the activation of

253 emonstrated using the PKA inhibitors H89 and myristoylated PKI(6-22) amide.

254 ted by the protein kinase A (PKA) inhibitor, myristoylated PKI, but was not dependent on PI3K-Akt sig

255 effects are prevented by the PKA inhibitor, myristoylated PKI.

256 gene expression in deletion mutants of two N-myristoylated PPs.

257 ral Gag proteins are synthesized as soluble, myristoylated precursors that traffic to the plasma memb

258 iral drug evaluation, the GMP version of the myristoylated preS-peptide (Myrcludex-B), a lipopeptide

259 We determined the solution structure of the myristoylated protein and found that the myristoyl group

260 e observed with the peptide melittin and the myristoylated protein Arf-1.

261 oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.

262 or that of Meh1, another palmitoylated and N-myristoylated protein in yeast.

263 d consequently, binding of Ca(2+) to the non-myristoylated protein is not cooperative.

264 endent (insensitive to 30 muM H-89 or 100 nM myristoylated protein kinase A inhibitor).

265 in [Tor] complex 2)-mediated activation of a myristoylated protein kinase B (PKB; PKBR1) and the phos

266 The specific inhibitory peptide, myristoylated protein kinase C-zeta pseudosubstrate, als

267 ciliary localization, we identified CIL-7, a myristoylated protein that regulates EV biogenesis.

268 re inaccessibility of the fluorophore in the myristoylated protein.

269 ith a lipid probe for affinity enrichment of myristoylated proteins and direct detection of lipid-mod

270 Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively s

271 istic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of

272 otease is highly promiscuous among diverse N-myristoylated proteins in vitro but is remarkably specif

273 demonstrate that IpaJ cleaves an array of N-myristoylated proteins involved in cellular growth, sign

274 the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to spec

275 he binding affinity of myristoylated and non-myristoylated proteins to Ca(2+) also was reflected by T

276 embrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and sugge

277 optosis allowed the identification of >100 N-myristoylated proteins, >95% of which are identified for

278 ontrast to all known examples of CaM-binding myristoylated proteins, our data show that the myr group

279 Here, we report the global N-myristoylated proteome in human cells determined using q

280 nables high-confidence identification of the myristoylated proteome on an unprecedented scale in cell

281 te a bulky hydrophobic moiety at C-terminus, myristoylated PrP can still incorporate into fibrillar s

282 reformed PrP fibrils were provided as seeds, myristoylated PrP supported fibril elongation and format

283 us been proposed for the membrane binding of myristoylated recoverin in the presence of calcium.

284 owed confirmation of the specific binding of myristoylated recoverin to phosphatidylserine, whereas t

285 t cooperativity for binding of Ca(2+) to non-myristoylated recoverin.

286 The myristoylated-SIRKALNILGYPDYD peptide-induced responses

287 Finally, a myristoylated SR2 peptide shows demonstrable decrease in

288 reased the biosynthesis of myristoyl CoA and myristoylated Src and promoted Src kinase-mediated oncog

289 ontributions governing the interactions of a myristoylated Src peptide with zwitterionic and anionic

290 viral envelope glycoproteins, GPC contains a myristoylated stable signal peptide (SSP) as an essentia

291 However, a mutant PKGII (G2A) that was not myristoylated substituted for functional PKGI, suggestin

292 Although this cytosolic protein is clearly myristoylated, the protein does not have the N-terminal

293 ristoylated HTT553-585-EGFP, but not its non-myristoylated variant, initially localized to the ER, in

294 F3) = 0.1 muM and K(EF2) = 1-4 muM), whereas myristoylated VILIP-1 binds two Ca(2+) with lower affini

295 MA is myristoylated, which enhances membrane binding, and spec

296 tured myoblasts (in which AChRs are absent), myristoylated WT rapsyn mostly localizes to lysosomes an

297 rmacological PKM-zeta inhibitors such as the myristoylated zeta inhibitory peptide (ZIP) or cheleryth

298 Myristoylated zeta inhibitory peptide had no effect on s

299 Furthermore, intracranial infusion of myristoylated zeta inhibitory peptide in the VTA disrupt

300 PKMzeta inhibition by chelerythrine or myristoylated zeta inhibitory peptide significantly atte