1 development of new antimalarials targeting N-
myristoyltransferase.
2 (M)GXXX(S/T/A) in a reaction catalyzed by N-
myristoyltransferase.
3 nd NMT-2 comprise two distinct families of N-
myristoyltransferases.
4 N-myristoylation of AMPKbeta by the type-I N-
myristoyltransferase 1 (NMT1).
5 lated with the catalytic efficiency of the N-
myristoyltransferase acting at the N terminus of the TRX
6 o increased in nmt1-181 yeast with reduced N-
myristoyltransferase activity.
7 of both proteins was attempted using human N-
myristoyltransferase and [(3)H]myristoyl-CoA.
8 AtCPK5 was a substrate for plant N-
myristoyltransferase and myristoylation was prevented by
9 Our studies validate T. brucei N-
myristoyltransferase as a promising therapeutic target f
10 Northern and Western blot analyses plus N-
myristoyltransferase assays showed that Nmt is normally
11 opment, likely because it is the principal N-
myristoyltransferase in early embryogenesis.
12 red proteome with selective small-molecule N-
myristoyltransferase inhibitors.
13 MyristoylCoA:protein N-
myristoyltransferase is a member of the superfamily of G
14 We demonstrate that N-
myristoyltransferase is an essential and chemically trac
15 Inhibition of this target-T. brucei N-
myristoyltransferase-
leads to rapid killing of trypanoso
16 The trypanosomatids possess a single N-
myristoyltransferase (
NMT) and multiple palmitoyl acyltr
17 MyristoylCoA:protein N-
myristoyltransferase (
Nmt) attaches myristate to the N-t
18 N-
Myristoyltransferase (
NMT) catalyses the attachment of t
19 N-
Myristoyltransferase (
NMT) catalyzes the cotranslational
20 MyristoylCoA:protein N-
myristoyltransferase (
NMT) covalently attaches the 14-ca
21 cs combined with potent and specific human N-
myristoyltransferase (
NMT) inhibition.
22 N-
Myristoyltransferase (
NMT) is a prospective drug target
23 to determine whether myristoyl-CoA:protein N-
myristoyltransferase (
Nmt) is a target for development o
24 N-
Myristoyltransferase (
NMT) is an attractive antiprotozoa
25 N-
Myristoyltransferase (
NMT) is an essential eukaryotic en
26 N-
Myristoyltransferase (
NMT) represents a promising drug t
27 N-
Myristoyltransferase (
NMT) represents a promising drug t
28 ns produces a single myristoyl-CoA:protein N-
myristoyltransferase (
Nmt) that is essential for its via
29 N-
Myristoyltransferase (
NMT) transfers myristate to an ami
30 Inhibitors of Leishmania N-
myristoyltransferase (
NMT), a potential target for the t
31 Design of inhibitors for N-
myristoyltransferase (
NMT), an enzyme responsible for pr
32 yzed by myristoyl-coenzyme A (CoA):protein N-
myristoyltransferase (
NMT), an enzyme ubiquitous in euka
33 Protein N-myristoylation is catalysed by N-
myristoyltransferase (
NMT), an essential and druggable t
34 lation is catalyzed by an enzyme activity, N-
myristoyltransferase (
NMT), which transfers myristic aci
35 alyzed by the enzyme myristoyl-CoA:protein N-
myristoyltransferase (
NMT).
36 MyristoylCoA:protein N-
myristoyltransferase (
Nmt, EC 2.3.1.97), a member of the
37 ivity by blockade of myristoylCoA: protein N-
myristoyltransferase (
NMT; EC 2.1.3.97).
38 N-
myristoyltransferases (
NMT) catalyze co- or posttranslat
39 pharmacologic evidence that inhibiting the N-
myristoyltransferase NMT1 suppresses cell-cycle progress
40 ristoylation enzymes, involving one or two N-
myristoyltransferases (
NMT1 and NMT2), among which NMT1
41 haromyces cerevisiae myristoyl-CoA:protein N-
myristoyltransferase (
Nmt1p) is an essential 455-residue
42 charomyces cerevisiae myristoylCoA:protein N-
myristoyltransferase (
Nmt1p) is an essential enzyme that
43 MyristoylCoA:protein N-
myristoyltransferase (
Nmt1p) is an essential enzyme whos
44 he essential enzyme, myristoyl-CoA:protein N-
myristoyltransferase (
Nmt1p).
45 This reaction is catalyzed by N-
myristoyltransferases (
NMTs), which transfer myristate f
46 ipid A, we overexpressed the lauroyl- or the
myristoyltransferase of lipid A biosynthesis, encoded by
47 y, coexpression of a K7,9A-Fyn mutant with N-
myristoyltransferase restored myristoylation, membrane b
48 results from retinal enrichment of unusual N-
myristoyltransferase substrates.
49 Trypanosoma brucei N-
myristoyltransferase (
TbNMT) is an attractive therapeuti
50 This reaction is catalyzed by a N-
myristoyltransferase that uses myristoyl-coenzyme A as s
51 The method uses the eukaryotic enzyme N-
myristoyltransferase to modify the N-terminus of the pro
52 One such putative target is the enzyme N-
myristoyltransferase,
which catalyses the attachment of
53 By co-expressing yeast N-
myristoyltransferase with an elastin-like polypeptide (E