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1 ere disease, and were methotrexate treatment-naive.
2 ty-two of 69 study eyes (32%) were treatment naive.
3 Scale=30+/-6) and about half were treatment naive.
4 tment required significantly less C removal (naive=0.42 Tg C, optimized=0.25 Tg C) to achieve the sam
5 o B cells were dispensable for activation of naive 1-DER T cells but necessary for full expansion of
6 older (>/=65 years) patients with treatment-naive acute myeloid leukaemia who were not candidates fo
7 l, multicenter phase II trial, 152 treatment-naive adult solid organ transplant recipients, with CD20
8 tudy evaluated rWN/DEN4Delta30 in flavivirus-naive adults aged 50-65 years and found it to be safe an
9 es (95% confidence interval [CI]) in 815 ARV-naive adults, 136 ARV-experienced adults, and 36 predomi
13 I 82-100]) of 29 of those who were treatment-naive and 29 (100% [88-100]) of 29 who were treatment-ex
14 ug classes for both antiretroviral treatment-naive and antiretroviral treatment-experienced patients,
18 Thus, memory cells embody features of both naive and effector cells, fuelling a long-standing debat
19 NA sequencing of unstimulated and stimulated naive and effector memory CD4(+) T cells from young and
21 ks by the ACK1 inhibitor (R)-9bMS-sensitized naive and enzalutamide-resistant prostate cancer cells a
22 food/water intake and body weight in ethanol-naive and ethanol-trained wild-type (WT), but not Tlr4 K
23 .1 years of age; 55% female) who were statin naive and free of cancer at baseline from the offspring
26 We found that EPNs can differentiate between naive and infected hosts, and that host attractiveness c
27 els of lipids that can differentiate between naive and irradiated samples, as well as providing poten
28 r relatively early (1 d) after activation of naive and memory cells and that demethylation is the pre
31 aling dampened activation of SMX-NO-specific naive and memory T cells, whereas blockade of TIM-3 prod
33 hase was followed by 2 expansion cohorts (PI-naive and PI-exposed patients) at the maximum tolerated
36 ed capacity to uptake allergen and stimulate naive and TH2 effector responses on allergen stimulation
38 -episode psychosis (14 of them antipsychotic naive) and 20 healthy volunteers underwent a high-resolu
39 fied by treatment experience (experienced vs naive) and included block randomisation at nurse level w
42 ation strategies consider movements of young naive animals in addition to those of adults to account
48 te the subpassage of prions from infected to naive astrocyte cultures, indicating the generation of p
52 VH4-34-expressing clones are common in the naive B cell repertoire but are rarely found in IgG memo
54 lie differences in function between MBCs and naive B cells and among MBC subsets and how this leads t
55 al step in this process is the activation of naive B cells expressing germline (gl) antibody precurso
57 ion transcription factors in memory, DN, and naive B cells in SLE show elevated levels of Aiolos, whe
58 ine designs because of the in vivo rarity of naive B cells that recognize broadly neutralizing epitop
59 ived from human immature dendritic cells and naive B cells to assess the expression of CD40-downstrea
61 onsive genes in immature dendritic cells and naive B cells were significantly enriched in synovial ti
62 ic SIV infection is characterized by loss of naive B cells, loss of resting memory B cells due to the
64 ere fully protected against disease, whereas naive baboons developed illness (with 1 death) and leuko
66 truct knowledge graphs: logistic regression, naive Bayes classifier and a Bayesian network using nois
69 L algorithms, specifically, a tree-augmented naive Bayesian network, a random forest algorithm, and a
71 n of the first MPH dose to 40 stimulant drug-naive boys newly diagnosed with ADHD while they performe
72 estigated the role of EGFR signaling in drug-naive cancer cells harboring these oncogene fusions.
75 inhibition of the H3K27 demethylase JMJD3 in naive CD4 T cells demonstrates how critically important
76 ypes of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of
77 odels an abnormal distribution of memory and naive CD4 T cells occurred, and peripheral CD4 and CD8 T
78 urin inhibition leads the most self-reactive naive CD4 T cells to adopt the phenotype of their less s
81 aphylococcal enterotoxin A (SEA)-nonreactive naive CD4 Tcon cells were cocultured with SEA-reactive a
83 n analysis identifies changes in neutrophil, naive CD4(+) T cell, and macrophage populations during p
84 mice, Stat3 is constitutively acetylated and naive CD4(+) T cells are potentiated in Th17/Treg cell d
85 In vitro polarization of DOCK8-deficient naive CD4(+) T cells revealed the TH2 bias and TH17 defe
86 his article, we report that murine and human naive CD4(+) T cells that sequester Pam3Cys4 (CD4(+) T(P
87 duced extensive proliferation of transferred naive CD4(+) T cells, and significant uveoretinitis.
88 ecombinant IL-2 induced expression of LAP on naive CD4(+) T cells, independent of Foxp3 or exogenous
89 ived mouse dendritic cells (BMDCs), and moDC/naive CD4(+) T-cell cocultures were analyzed by using EL
93 trate that an intracellular pool of LFA-1 in naive CD8(+) T cells plays a key role in T cell activati
94 ly, knockdown of TMEM20 in miR-150-deficient naive CD8(+) T cells reduced intracellular Ca(2+) levels
95 stimulated CTLs directly activated bystander naive CD8(+) T cells to produce interferon-gamma (IFNgam
96 -presentation of Ags and priming the pool of naive CD8(+) T cells within the liver microenvironment.
101 isplay higher ST6Gal-I levels than treatment-naive cells along with a reduced gemcitabine sensitivity
102 cally, the treatment of hormone therapy (HT)-naive cells or HT-treated metabolically dormant populati
103 ngs are consistent with the proposition that naive cells transition to a distinct formative phase of
104 but also have many properties in common with naive cells, including pluripotency and the ability to m
105 of viral or prion proteins from infected to naive cells, it is not clear whether the viral genome is
106 lls using ChIP-Seq and found that unlike the naive cells, the regulatory elements of the cytokine gen
107 celecoxib reduced the proliferation of LLC1 naive cells, while the opposite occurred with placebo-tr
112 formed epigenetic profiling of human resting naive, central and effector memory T cells using ChIP-Se
113 ing >2 x 10(8) TCRB sequences of circulating naive, central memory, regulatory and stem cell-like mem
114 we randomly assigned (1:1) HIV-infected, ART-naive children aged 0-12 years who were eligible for tre
115 experienced adults, and 36 predominantly ARV-naive children were 9.4% (7.5%-11.7%), 12.5% (7.5%-19.3%
117 studied, which included eyes with treatment-naive CNV due to AMD, non-neovascular AMD, and normal co
126 C virus-infected patients who are treatment-naive, do not have cirrhosis, and have a pretreatment vi
127 AN1 upregulation, overexpression of RCAN1 in naive DRG neurons recapitulated the effects of pharmacol
128 in histone), and gene-expression profiles in naive, effector memory (EM), and terminally differentiat
131 g both CRVO and HRVO eyes and both treatment-naive eyes and eyes treated previously with anti-VEGF, w
132 vitreomacular adhesion (VMA) in consecutive naive eyes diagnosed with exudative age-related macular
135 isual stimuli that are presented to visually naive ferrets can influence the parameters of speed tuni
137 ter influenza A infection of immunologically naive ferrets with various H1N1 or H3N2 strains, the acu
143 d users (compared with those who were opioid-naive) had 9.2% higher costs [95% confidence interval (C
145 that, in both sexes, fremanezumab inhibited naive high-threshold (HT) neurons, but not wide-dynamic
149 ial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more
150 h hormone-based therapy for the treatment of naive hormone receptor-positive advanced breast cancer o
156 rythrocyte antibodies in ex vivo cultures of naive human peripheral blood mononuclear cells (PBMC) ex
160 as reduced in epileptic mice but restored to naive levels in epileptic mice receiving MGE transplants
161 (YFV), we show that the recently described 'naive-like' memory population have significantly longer
164 y the mechanism of action of Rh-alpha4beta7, naive macaques were infused with Rh-alpha4beta7 and samp
165 METHOD: Adults aged 18-65 with treatment-naive major depression were randomly assigned with equal
166 tLTD), the predominant form of plasticity in naive male mice, to spike-timing-dependent long-term pot
168 noglobulin heavy chain VDJ rearrangements of naive, mature CD5(+), IgM(+) memory, and class-switched
169 ber 31, 2014, to identify cases of treatment-naive mCNV, which was defined as the presence of myopic
170 ncy fluctuation (ALFF) in first-episode drug-naive MDD patients, using the Seed-based d Mapping metho
172 cision-analysis model was created for biopsy-naive men who had been recommended for prostate biopsy o
173 mally symptomatic patients with chemotherapy-naive metastatic castration-resistant prostate cancer wi
174 sistance to taxanes in men with chemotherapy-naive, metastatic, castration-resistant prostate cancer.
177 utaneous injection of recombinant TWEAK into naive mice induces cutaneous inflammation with histologi
179 of the same subsets of cells harvested from naive mice resulted in inefficient invasion by the bacte
181 rom UV-irradiated mice and transplanted into naive mice, the recipient mice (UV-chimeric) had reduced
182 nt to increase movement in the TST in stress-naive mice, while stimulating above the carrier frequenc
189 patterns and outcomes in eyes with treatment-naive myopic choroidal neovascularization (mCNV) in the
192 can infect virtually all cell types, neither naive nor inflammatory Ly6C(hi) monocytes served as a pr
193 total of 119 patients with advanced EGFR-TKI-naive NSCLC and 15 EGFR-TKI-resistant patients to identi
195 Forty eyes of 40 patients with treatment-naive NVAMD were managed with a TAE regimen of intravitr
197 atients and Methods Patients with ipilimumab-naive or -treated advanced/metastatic melanoma received
199 karyotype, early embryos must remain gender-naive; our findings show that the mir-35 family microRNA
200 in structure from a condensed maternal and a naive paternal genome to generate a totipotent embryo.
202 ured in peripheral blood (PB) from treatment-naive patients in the CLL8, CLL10, and CLL11 clinical tr
203 ] and at risk of viral rebound) or treatment-naive patients initiating their first combination ART re
204 f liver and plasma compartments in treatment naive patients provides insight into viral quasispecies
205 d by 98% (39/40; 95% CI, 87-99) of treatment-naive patients treated for 12 weeks and 96% (45/47; 95%
206 fusion-weighted imaging data of 12 treatment-naive patients with 34 metastases acquired before and at
207 s as predictors of prognosis in chemotherapy-naive patients with advanced NSCLC, we recruited all tho
213 s were analyzed from 38 eyes of 38 treatment-naive patients with macular edema due to RVO, enrolled i
221 estinal mucosa are up-regulated in treatment-naive pediatric patients with UC compared with patients
224 resent heterogeneous populations composed of naive phenotype (NP, CD44(low)) and memory phenotype (MP
225 ur hypothesis, we define 12 key hallmarks of naive pluripotency, five of which are specific to primat
229 eviously shown that E-cadherin regulates the naive pluripotent state of mouse embryonic stem cells (m
233 and induced (i)Treg cells that develop from naive precursors, suppressive IL-17A(+)Foxp3(+) and ex-T
235 in CTCF occupancy during the transition from naive/primed pluripotency to multipotent primary neural
239 ells, further corroborating the value of the naive rabbit antibody library as a rich and virtually un
243 eta, to activate a systemic APR in recipient naive rats, as well as the behavioural consequences of E
251 ubation in the four chemical inhibitors (4i)-naive reprogramming medium and showed transcriptional co
255 Both establishment of and exit from the naive state (differentiation) happened via an XIST-negat
258 tional regulation according to which, in the naive state, polycomb recessive complex 2 repressed the
261 sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated
263 ly distinct from their more mature but still naive T cell counterparts, because they exhibit dampened
265 nt novel evidence that Treg-DC skewed CD4(+) naive T cell polarization toward a regulatory phenotype
267 n-educated" DCs stimulated the activation of naive T cells and polarized a subset of these cells into
268 +) T cells and includes only memory T cells; naive T cells are excluded to limit the potential for al
269 ogether with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expressi
270 nse to IL-7 signalling in order to reprogram naive T cells for proliferation and differentiation.
271 ted loci and show the advantage of utilizing naive T cells for understanding autoimmune diseases.
277 ergo an additional maturation step to mature naive T cells that circulate through secondary lymphoid
278 mune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly
279 PD-1H in mice blocks the differentiation of naive T cells to Foxp3(+) inducible Treg cells (iTreg) w
280 About half of the patients had less than 10% naive T cells, reduced/absent T-cell proliferation, and
285 phylaxis showed increased T-cell activation, naive T-cell skewing, and elevated serum CXCL9 and CXCL1
286 an adoptive-transfer approach, we show that naive Tg CD4 T cells become activated, proliferate, migr
287 Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downreg
288 s before screening who were either treatment naive to or relapsed after interferon-alpha based therap
290 n this study, we hypothesized that MP cells, naive to TCR stimulation, constitute a transient populat
291 FGF4-FGFR1-ETS2 pathway in TECs and converts naive tumor cells to chemoresistant TSCs, thereby facili
293 to visualize the paravascular space (PVS) in naive uninjected mice, we show that a single wave of cor
294 were obtained with DCs obtained from malaria-naive US donors and malaria-experienced donors from Mali
295 parallel with hepcidin in serum from malaria-naive volunteers infected in controlled human malaria in
296 d in vitro, however, IFN-gamma production by naive wild type and tristetraprolin-deficient CD8(+) T-c
298 given in combination with low-dose IL-33 to naive wild-type mice, led to synergistic increases in ai
300 is study assessed neural function among drug-naive youth with a behavioral addiction-Internet gaming
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