ライフサイエンスコーパス: naive T cell

1 onses by presenting HLA-epitope complexes to naive T cells.

2 become a cell superbly adapted to activating naive T cells.

3 a(2+) stores that were sensitive to NAADP in naive T cells.

4 nd increased memory T cells while decreasing naive T cells.

5 ant peptides and derived preferentially from naive T cells.

6 ase UBR5, which suppressed DUBA abundance in naive T cells.

7 y of mature DCs produced IL-12 and activated naive T cells.

8 allenge to maintain the functions unique for naive T cells.

9 icipate in the immune response as peripheral naive T cells.

10 s that were indistinguishable from wild-type naive T cells.

11 ted in cocultures with heterologous neonatal naive T cells.

12 e specialized APCs with the ability to prime naive T cells.

13 ssion of CD45RA is generally associated with naive T cells.

14 elta-like ligand 4 (DLL4) amplify priming of naive T cells.

15 g link between Wnt signaling and survival of naive T cells.

16 Cs) since they are also able to prime/induce naive T cells.

17 N TCM cells in similar numbers from the same naive T cells.

18 hrough life via homeostatic proliferation of naive T cells.

19 ls, and IL-6 can induce low-level cycling of naive T cells.

20 otein tyrosine phosphatases as compared with naive T cells.

21 ional maturation to become long-lived mature naive T cells.

22 LNs, despite still resulting in the loss of naive T cells.

23 kappaB activity is shared by mouse and human naive T cells.

24 igen levels that activate these functions in naive T cells.

25 cell counts, but was related to a decline in naive T cells.

26 mory T cells and classical Th22 subsets from naive T cells.

27 Ags linked to the activating PAMP and prime naive T cells.

28 y induction of Treg properties in cocultured naive T cells.

29 erial infection to present Ag information to naive T cells.

30 ls of protein expression in Mettl3-deficient naive T cells.

31 degradation and thereby support survival of naive T cells.

32 SE = 0.59 +/- 0.21, p = .006), but not with naive T cells.

33 tile cell with a limited ability to activate naive T cells.

34 functional, and metabolic differentiation of naive T cells.

35 n the generation of Ca(2+) signals in murine naive T cells.

36 d in the final maturation of thymocytes into naive T cells.

37 rt survival and homeostatic proliferation of naive T cells.

38 mbrane domains, known as protein islands, on naive T cells.

39 des where they present processed antigens to naive T-cells.

40 When cocultured with naive T cells, a2MPhi significantly inhibited T-cell act

41 memory T cells detect low dose antigen, only naive T cells activate cell cycle effectors.

42 zation is associated with T cell priming, as naive T cells activated in vitro were fully capable of p

43 By contrast, type 2 ILCs modulate naive T cell activation in a cell contact-dependent mann

44 The expression of CCR8 during naive T cell activation is controlled by skin-specific f

45 We have shown that naive T cell activation is coupled with rapid glutamine

46 Naive T cell activation is normally restricted to the ly

47 alongside T cell receptor (TCR) ligation for naive T cell activation.

48 dies have shown that hRSV infection prevents naive T-cell activation by antigen-presenting cells, the

49 t to measure the drug-specific activation of naive T cells after perturbation of PD-L1/2/PD-1 binding

50 One hallmark sets naive T cell aging apart from most other tissues except

51 Aging is associated with a gradual loss of naive T cells and a reciprocal increase in the proportio

52 s uncover a Fas-mediated interaction between naive T cells and antigen-experienced T cells that drive

53 We found that in both naive T cells and effector T cells, the tyrosine phospha

54 ary lymphoid organs recruit large numbers of naive T cells and harbor lymphocyte subsets with opposin

55 on pathway predominantly controls priming of naive T cells and hence generation of adaptive memory ce

56 s can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 c

57 esponders had higher percentages of baseline naive T cells and lower percentages of terminally differ

58 n-educated" DCs stimulated the activation of naive T cells and polarized a subset of these cells into

59 understanding on the identification of truly naive T cells and recent thymic emigrants.

60 d specific to activated effector T cells, as naive T cells and regulatory T cells did not require lep

61 y APCs that effectively activate Ag-specific naive T cells and restore the responsiveness of anergic

62 in effector T cells as in their counterpart naive T cells and seemed to be equally important for the

63 e in response to lower doses of antigen than naive T cells and with reduced requirements for co-stimu

64 ith higher vs. lower CCR5 levels (memory vs. naive T cells) and in memory T cells with higher vs. low

65 transitional B cells, CD56(bright) NK cells, naive T cells, and accumulation of terminally differenti

66 high proportion of relatively HIV resistant naive T cells, and an unparalleled capacity to regenerat

67 alyzed the gene expression profile of Tregs, naive T cells, and memory T cells in aged mice.

68 utoimmune hemolytic anemia, the reduction in naive T cells, and poor Ab responses to vaccine in sever

69 +) T cells and includes only memory T cells; naive T cells are excluded to limit the potential for al

70 and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.

71 CCR6(+) naive T cells are present in adult peripheral and umbili

72 e periphery, the majority of HDAC3-deficient naive T cells are recent thymic emigrants, indicating a

73 We also show that naive T cells are recruited into the mouse brain by anti

74 e knockdown with RNAi is challenging because naive T cells are refractory to transduction with viral

75 oduction is a signatory effector function of naive T cells, at least in newborns.

76 ed, depleting FAP(+) FRCs causes the loss of naive T cells, B cells, and dendritic cells from LNs, an

77 es against pathogens, such that viability of naive T cells before antigen encounter is critical to pr

78 The viability of naive T cells before antigen recognition is ensured by I

79 evelopment of mature, antigen-inexperienced (naive) T cells begins in the thymus and continues after

80 kingly, they had a substantial deficiency in naive T cells but an over-representation of senescent ef

81 x (MHC) ligands is essential for survival of naive T cells but not memory cells.

82 is essential not only for the circulation of naive T cells, but also for their survival.

83 ogether with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expressi

84 urred during the initial activation phase of naive T cells by an antigenic stimulus.

85 SOCE directs the metabolic reprogramming of naive T cells by regulating the expression of glucose tr

86 -) fraction of the allograft was depleted of naive T cells by using magnetic CD45RA beads.

87 In response to antigen stimulation, naive T cells can differentiate into Th1, Th2, and Th17

88 he biology of CD4 T cells is complex because naive T cells can differentiate into various subpopulati

89 exhaustion of the proliferative capacity of naive T cells causes a sharp decline of their effective

90 sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated

91 In contrast, permanence of naive T cell clones would be determined by their affinit

92 In particular, large naive T-cell clones that were distinct from memory clone

93 Our results show that within naive T cells, codeposition of the permissive H3K4me3 an

94 after the age of approximately 60 y because naive T cells collectively approach replicative senescen

95 The ability to activate naive T cells comes from the capacity of DCs to internal

96 ght on functional differentiation within the naive T cell compartment and the importance of the thymu

97 fe resulted in functional restoration of the naive T cell compartment, implicating the thymus as havi

98 nfected DCs from CD8alpha(-/-) mice, with WT naive T cells contributed to an increase in PD-1 express

99 High frequencies of CD8+CCR9+ naive T cells correlated with prolonged OS, while neutra

100 ly distinct from their more mature but still naive T cell counterparts, because they exhibit dampened

101 The naive T-cell counts were particularly low for age, and m

102 CD3(+), CD4(+), and CD4(+)-naive T-cell counts were significantly higher (P < .001)

103 To find and activate naive T cells, DCs must migrate to lymph nodes, yet the

104 The number of naive T cells decreases and susceptibility to new microb

105 Zfp335(bloto/bloto) mice exhibit a naive T cell deficiency due to an intrinsic developmenta

106 New strategies including naive T-cell depletion, focused cytokine and chemokine i

107 t of potential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, ki

108 and the causative auto-IgM cross-reacts with naive T cells despite the lack of glycan change on T cel

109 In hosts with a replete T cell compartment, naive T cells died rapidly in the absence of Zap70 expre

110 cGVHD is mediated by naive T cells differentiating within IL-17-secreting T c

111 We now understand that cGVHD is initiated by naive T cells, differentiating predominantly within high

112 RORgammat, GATA3 and others is essential for naive T cell differentiation into effector T cells.

113 s a positive regulator that is essential for naive T-cell differentiation and in vivo T-cell response

114 pectedly found that EGR2 promotes peripheral naive T-cell differentiation, with delayed T-cell recept

115 ells, while retaining the ability to enhance naive T-cell differentiation.

116 can be understood as mechanisms to maximize naive T cell diversity.

117 Moreover, infusion of SD-4(-/-) naive T cells during EAE induction into Rag2(-/-) mice a

118 How this functional signature relates to naive T cell dynamics and aging is unknown.

119 neral and that are instructive to understand naive T cell dysfunction.

120 Because antigen-stimulated naive T cells either die as effectors or enter the activ

121 olled, and dependent on the context in which naive T cells encounter antigen, can either result in fu

122 s a growing body of evidence that the use of naive T cells enhances the efficacy of adoptive T cell t

123 CD8(+)CD62L(+)CD45RA(+) naive T cells enriched by streptamer-based serial-positi

124 secondary lymphoid environment that impaired naive T cell entry and access to key survival factors.

125 8(+) T cells, reduction in the proportion of naive T cells, evidence of T cell exhaustion and senesce

126 CRTg mice; that is, old VM, but not old true naive, T cells exhibited blunted TCR-mediated, but not I

127 irst, a small population of epitope-specific naive T cells expands by several orders of magnitude.

128 Naive T cells expressed low levels of PD-1; however, a t

129 go positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restr

130 ins mechanistically enforce and maintain the naive T-cell fate.

131 nse to IL-7 signalling in order to reprogram naive T cells for proliferation and differentiation.

132 ted loci and show the advantage of utilizing naive T cells for understanding autoimmune diseases.

133 issue, and elevated thymic T-cell export and naive T-cell frequencies in old mice.

134 able to find a correlation between specific naive T cell frequency and peptide solvent accessibility

135 In studies of immune aging, naive T cells frequently take center stage.

136 Isolation of naive T cells from a murine model of lupus revealed incr

137 -presenting cells and the differentiation of naive T cells from allergic patients.

138 an naive T cells, the selective depletion of naive T cells from allografts might constitute a way of

139 study shows that clinical-grade depletion of naive T cells from an allograft through the use of magne

140 yed T-cell receptor-induced proliferation in naive T cells from Egr2 conditional knockout (CKO) mice

141 Piperacillin-primed naive T cells from healthy volunteers also secreted IFN-

142 Naive T cells from healthy volunteers were primed to pip

143 In this way, naive T cells from HG mice resembled Ag-experienced cell

144 of Ag-experienced T cells, was increased in naive T cells from HG mice.

145 Furthermore, naive T cells from mice lacking CaMK4 did not produce IL

146 b(+)CD16(+) neutrophils, and CD4(+)CD45RA(+) naive T cells from the same 125 healthy individuals.

147 response to acute viral infection, activated naive T cells give rise to effector T cells that clear t

148 On activation, naive T cells grow in size and enter cell cycle to mount

149 We show that naive T cells harness cytoskeletal coupling to transmit

150 Antigen-specific priming of human, naive T cells has been difficult to assess.

151 owever, the role for Wnt signaling in mature naive T cells has not been investigated.

152 Naive T cells have long been regarded as relatively quie

153 Quiescent naive T cells have low basal activity of the transcripti

154 Salsa6f during T cell receptor activation in naive T cells, helper Th17 T cells and regulatory T cell

155 t this molecule is an important regulator of naive T cell homeostasis and it has been linked to immun

156 nt and the importance of the thymus in human naive T cell homeostasis and premature aging.

157 age-dependent changes in factors supporting naive T cells homeostasis may also be involved.

158 reatment with IL-7/mAb complexes can restore naive T cell homeostatic proliferation in aged mice.

159 Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment i

160 Similarly, naive T cell IL-10Ralpha expression also allows IL-10 to

161 e frequency of the corresponding Ag-specific naive T cells in A2(+) and A2(-) individuals, as well as

162 Similarly, 2W:I-A(b)-specific naive T cells in different neonatal mice varied signific

163 ning protein coronin 1 in the maintenance of naive T cells in peripheral lymphoid organs.

164 Much is understood of the behavior of naive T cells in response to PIT.

165 The naive T cells in structured lymphoid tissues, once being

166 are present on antigen-presenting cells and naive T cells in the AT, are known to mediate the crosst

167 ll motility suggested that the activation of naive T cells in the lymph node occurs in distinct phase

168 populations are maintained by production of naive T cells in the thymus, clonal expansion of activat

169 ipheral T-cell pool depends on production of naive T cells in the thymus; however, delivery of progen

170 s for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector a

171 and resulted in a linked contraction of all naive T cells, including CD31(+)/CD4(+) putative thymic

172 central memory T cells were reduced, whereas naive T cells increased in treated patients.

173 c reticular cells support the maintenance of naive T cells, induce Ag-specific tolerance, and restric

174 Ag-dependent activation of naive T cells induces dramatic changes in cellular metab

175 or blockade prevented differentiation of the naive T cells into antigen-specific IL-22-secreting cell

176 Furthermore, differentiation of naive T cells into antigen-specific TH22 cells is depend

177 tions with TGF-beta to promote conversion of naive T cells into Foxp3(+) regulatory T cells and, ther

178 Differentiation of naive T cells into T helper 17 cells or regulatory T cel

179 fferent stages during the differentiation of naive T cells into T helper 2 cells.

180 e found that MR regulates differentiation of naive T cells into T-helper type 17 (Th17) effector cell

181 Differentiation of naive T cells into Th17 and Treg subsets is associated w

182 thermore, RA inhibits the differentiation of naive T cells into Th17 cells.

183 In vitro, differentiation of CD4(+) naive T cells into Th17 lymphocytes was decreased by the

184 The generation of naive T cells is dependent on thymic output, but in adul

185 Apc-deficient T cells, we found that loss of naive T cells is due to T cell intrinsic dysregulation o

186 2+) stores targeted by NAADP in conventional naive T cells is less clear.

187 ma, indicating that the continual priming of naive T cells is not required for vitiligo or its associ

188 ason for the pulse of IFN-gamma synthesis by naive T cells is uncertain, but the lack of antiviral im

189 Although memory cells are the progeny of naive T cells, it is unclear that all naive cells from a

190 mmune-related effector gene promoters within naive T cells lacked the permissive H3K4me3 modification

191 in vivo partially restored the abundance of naive T cells, largely 'rescued' the in vitro T cell def

192 products-mediated epigenetic modification of naive T cells leading to p38 MAPK-dependent chromatin de

193 unction of the memory differentiation state (naive T cells < central memory T cells < effector memory

194 + effector memory T cells that reexpress the naive T cell marker CD45RA have many characteristics of

195 To determine the contribution of naive T cell, memory stem T cell, central memory T cell,

196 the production of T cells declines with age, naive T cells must be long-lived.

197 EBV-related T-cell expansions do not impair naive T-cell numbers or maintenance of protective respon

198 the coreceptor from CCR5 to CXCR4 to infect naive T cells or adapting to the use of low levels of CD

199 ized by increased thymopoiesis and increased naive T cell output.

200 ut not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late

201 is, where IL-6R expression was suppressed in naive T cells, paralleled by a significant reduction of

202 ion, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informat

203 Enforced expression of IL-10Ralpha on naive T cells permits an IL-10-generated STAT3 signal eq

204 tenance of immunotherapy-specific memory and naive T-cell phenotypes as early as 3 mo into immunother

205 rmed that the Treg-DC-mediated skewed CD4(+) naive T cell polarization resulted from decreased IL-12

206 nt novel evidence that Treg-DC skewed CD4(+) naive T cell polarization toward a regulatory phenotype

207 mory T cell populations showed that even the naive T cell pool contained self-reactive T cell precurs

208 that homeostatic mechanisms that support the naive T cell pool deteriorate with age.

209 n of LIP ensures the generation of a diverse naive T cell pool in lymphopenic neonates that is mandat

210 pendent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral

211 nctional competency and enter the long-lived naive T cell pool.

212 strongest support for a model in which both naive T-cell pools contain kinetically distinct subpopul

213 Stochastic numerical simulations of naive T cell population dynamics, based on experimental

214 Naive T cell populations are maintained in the periphery

215 cells, little is known about the effects on naive T cell populations.

216 Preservation of naive T-cell populations by starting therapy early could

217 N TCM cell clones were derived from a common naive T cell precursor after skin immunization, generati

218 Naive T cell precursor frequency determines the magnitud

219 ingle positively selecting ligand influences naive T cell precursor frequency remains undefined.

220 e-related defects--drastic reduction in true naive T cell precursors and impaired proliferative capac

221 ucing T cells can differentiate from CCR6(+) naive T cell precursors in the presence of IL-2, IL-1bet

222 udies investigate the possible phenomenon of naive T cell priming in hosts with melanoma-initiated, s

223 l antigen-presenting cells, are required for naive T-cell priming and activation.

224 LR-2 costimulation also dramatically reduced naive T cell production of the immunosuppressive cytokin

225 Myeloid cells suppress naive T cell proliferation ex vivo and can prevent the g

226 at autoimmune melanocyte destruction induces naive T cell proliferation in skin-draining lymph nodes,

227 is predicts that, without an increase in the naive T cell proliferation rate, this decline will occur

228 Furthermore, cDCs, but not moDCs, stimulated naive T cell proliferation.

229 lling maintains the mitochondrial content of naive T cells, providing cells with the energy to contin

230 ally and the frequency of 2W:I-A(b)-specific naive T cells reached that of adult mice.

231 About half of the patients had less than 10% naive T cells, reduced/absent T-cell proliferation, and

232 Thus, naive T cells regulate B cell survival in a SLAMF6- and

233 Describing the complexity of the human naive T cell repertoire remains a daunting task; however

234 anti-viral T cell response is drawn from the naive T cell repertoire.

235 (EF4.1) expressing a limited, yet polyclonal naive T-cell repertoire was used.

236 Survival of naive T cells requires engagement of TCR with self-pepti

237 Naive T cell responses are eroded with aging.

238 acity of their VM cousins--combine to reduce naive T cell responses with aging.

239 ymic degeneration is associated with loss of naive T cells, restriction of peripheral T-cell diversit

240 s a low number of nucleated cells and mostly naive T cells, resulting in prolonged time to engraftmen

241 antibodies directed at both erythrocytes and naive T cells, revealing a possible mechanistic link bet

242 ow that, compared with more mature but still naive T cells, RTEs are impaired in their ability to per

243 The percentage of naive T cells showed a strong correlation with measured

244 This demonstrates that naive T cells signal during phase I and support the hypo

245 phylaxis showed increased T-cell activation, naive T-cell skewing, and elevated serum CXCL9 and CXCL1

246 Moreover, donor naive T cells specific for exogenous and self/tumor anti

247 ges in chromatin accessibility away from the naive T cell state.

248 n preclinical models, the use of a purified, naive T cell subset enhances persistence and antitumor i

249 only CD8alpha(+) DCs were able to stimulate naive T cells, suggesting that this DC subset cross-pres

250 in vivo differentiation landscapes of human naive T cells, supporting the notion that progenies of s

251 ring life that is responsible for peripheral naive T cell survival and homeostasis.

252 sgammac suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated

253 However, it remains unclear how naive T cells survive for years while constantly travell

254 ergo an additional maturation step to mature naive T cells that circulate through secondary lymphoid

255 rants [RTEs]) are functionally distinct from naive T cells that have completed postthymic maturation.

256 mune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly

257 Upon primary infection, naive T cells that recognize their cognate antigen becom

258 It enables infiltration by naive T cells that significantly delay tumour outgrowth

259 We previously reported that in naive T cells, the IFN-gamma locus is associated with th

260 alloreactivity is mainly derived from human naive T cells, the selective depletion of naive T cells

261 ections are due to diminished recruitment of naive T cells through infection-induced decreases in che

262 a hallmark of which is the profound loss of naive T cells (TN) associated with decline in thymic out

263 In mice, naive T cells (TN) cause more severe GVHD than memory T

264 lity to mount a more effective response than naive T cells (TN).

265 aft-versus-host disease (GVHD) compared with naive T cells (TN).

266 s of plasmacytoid dendritic cells (pDCs) and naive T cells (Tns) in BM allografts were independently

267 to the draining lymph node where they primed naive T cells to differentiate into Th2 cells.

268 ditioned medium of treated keratinocytes and naive T cells to disclose the molecular details that reg

269 PD-1H in mice blocks the differentiation of naive T cells to Foxp3(+) inducible Treg cells (iTreg) w

270 ipients had diminished ability compared with naive T cells to increase donor chimerism when transferr

271 e of T cell-intrinsic CD18 in trafficking of naive T cells to secondary lymphoid organs and in Ag-dep

272 n an increase in the intrinsic reactivity of naive T cells to self-antigens, it did not cause spontan

273 mia modifies the intrinsic responsiveness of naive T cells to TCR stimulation.

274 on is required for efficient polarization of naive T cells to Th1 effector cells in vitro, as well as

275 -subunit (CD127), enabling responsiveness of naive T cells to the prosurvival effects of IL-7 and all

276 For effective induction, exposure of naive T cells to these epidermal factors needed to occur

277 rocess, allowing differentiation of neonatal naive T cells toward IFN-gamma-producing TH1 cells.

278 rophages and to favor the differentiation of naive T cells toward regulatory T cells.

279 Enhancer deletion skewed polarization of naive T cells towards a pro-inflammatory T helper (TH17)

280 equired for normal T-cell development or for naive T-cell trafficking to lymph nodes and spleen.

281 by a progressive harmonization of memory and naive T cell traits, is broadly amenable to experimental

282 During immune responses, naive T cells transition from small quiescent cells to r

283 depletion in naive CD4(+) T-cells, although naive T-cell turnover was relatively unaffected by eithe

284 butes to the recruitment of CD4(+) CD45RA(+) naive T cells under in vitro defined flow conditions.

285 been shown that in a lymphopenic environment naive T cells undergo expansion due, at least in part, t

286 Naive T cells undergo metabolic reprogramming to support

287 a), and may be driven by a reduced number of naive T cells unmasking underlying memory clonality.

288 Loss of G9A in naive T cells was associated with increased chromatin ac

289 The T memory-induced conversion of naive T cells was mediated by a nonapoptotic Fas signal,

290 tantly, expression of beta-catenin in mature naive T cells was sufficient to drive integrin alpha4bet

291 proliferative response and reduced counts of naive T cells were observed in addition to a restricted

292 Tonsil naive T cells were readily chemoattracted by S1P in an F

293 Importantly, numbers of naive T cells were reduced in spleens and lymph nodes of

294 response to LPS but were unable to activate naive T cells, whereas the majority of mature DCs produc

295 mal T cell function, including reductions in naive T cells, which correlate with clinical severity.

296 persistent autoimmune-mediated depletion of naive T cells, which is induced by changes in erythrocyt

297 phenotype and promoted a Th2 polarization of naive T cells with increased IL-4 production.

298 as in vitro during differentiation assays of naive T cells with specific inhibitor of Foxo1 or inhibi

299 We found that naive T cells with TCRs specific for the 2W:I-A(b) epito

300 exclusively regulates homeostasis of mature naive T cells without affecting thymocytes and/or recent