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1 ced significantly higher GFP expression than naked Ad in both coxsackie and adenovirus receptor (CAR)
2 e therapy, the intravenous administration of naked Ad still encounters unfavorable host responses, no
6 We here explore the therapeutic potential of naked and adeno-associated virus (AAV)-packaged AONs in
7 d regulated budding yeast DNA replication on naked and chromatinized templates in vitro, providing ke
9 ansfection efficiencies of mRNA delivered in naked and nanoparticle format in vitro and in vivo using
10 on of messenger RNA (mRNA) delivered in both naked and nanoparticle formats are actively investigated
11 carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, g
12 stinguish between the movement of so-called "naked" and membrane-associated cytoplasmic alphaherpesvi
15 ity attributes: drug distribution, amount of naked antibody, and average drug to antibody ratio (DAR)
19 tudies thus characterize the reactivity of a naked aryl anion in solution and contrast it with the re
24 Our results challenge the old vision of "naked" chromium species (i.e., low coordinated) as the a
26 ration of heme-peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeT
27 e-wrapped virions are as infectious as their naked counterparts, although they do not express a viral
29 One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), which is a repressor of
30 tumors identified the downregulation of the naked cuticle homolog 2 (NKD2) gene, a negative regulato
33 e first time, the formation of O(4)-POBdT in naked DNA and in genomic DNA of cultured mammalian cells
37 cal pH (pH 7-8), G.C Hoogsteen base pairs in naked DNA have a population of 0.02-0.002%, as compared
38 While the effects of torsional stresses on naked DNA have been well studied, little is known about
40 ndamental question of whether nucleosomal or naked DNA is the preferred substrate of plant and animal
41 dingly, we demonstrate confluent staining of naked DNA molecules presented within microfluidic device
44 n repair factors, the damage is removed from naked DNA or nucleosomes in the form of 24- to 32-nucleo
45 s [(6-4)PPs] from UV-irradiated cellular and naked DNA revealed that the effect of transcription fact
47 relatively little effect on Cas9 cleavage of naked DNA substrates, but strongly inhibit cleavage of n
50 was at least sevenfold greater than that of naked DNA, and chromatin gave patterns of transcription
51 As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex a
55 by using a candidate preventive/therapeutic naked-DNA vaccine that expresses human calreticulin (hCR
56 urdles, we successfully used minicircle (MC) naked-DNA vectors devoid of any viral or bacterial seque
59 and that it is capable of using the size of naked dsDNA as a molecular ruler to distinguish self fro
62 (Zea mays [Zm]) has a single aleurone layer, naked endosperm (nkd) mutants produce multiple outer cel
64 etic parameters are improved compared to the naked enzyme suggesting longer blood circulation after i
66 ssembled monolayer (SAM) was detected by the naked eye and analysed using an image analysis software
67 netic nanobeads moieties was detected by the naked eye and analysed using ImageJ analysis software fo
68 entify significant traces not visible to the naked eye and not detectable by XRF spot measurements or
69 ydrogen mixture is clearly noticeable to the naked eye as a change in the brightness of light transmi
72 show any obvious signs of iridescence to the naked eye but where a highly ordered chloroplast structu
75 etter demonstrates a biosensing platform for naked eye detection of miRNA, fabricated using a poly(vi
78 s is that volume shrinking is visible to the naked eye down to femtomolar concentrations of protein.
81 a stronger ECL, which can be observed by the naked eye in a lighted room, on reduction in the presenc
82 ion of adenosine as a model analyte with the naked eye in buffer samples and undiluted human serum.
88 les such as cancer-biomarker miRNAs with the naked eye is seemingly impossible in molecular diagnosti
89 e target concentration required for reliable naked eye observation with unmodified AuNPs in well-opti
90 source and a colored plastic gel filter, the naked eye or a camera can easily discriminate between po
92 umor phenotypes that fail to be perceived by naked eye that semantic features do not describe and vic
93 diffraction, and the system can read by the naked eye to detect the Apple Stem Pitting Virus (ASPV)
94 This quenching could be visualized by the naked eye under a UV (365 nm) lamp and performed almost
96 s enable the detection of hydrazine with the naked eye well below sub-ppm concentrations (ca. 30 ppb)
97 ntrations of rabbit IgG and human PSA by the naked eye were down to 0.1 and 4 ng/mL, respectively.
98 rations through UV-vis absorption and by the naked eye were estimated to be 0.3 and 60nM, respectivel
100 extent that they become imperceptible to the naked eye yet are not significantly reduced in total mas
101 lue, which allows a prospective use for the "naked eye" detection of Pb(2+) ion over other competitor
102 k bar charts can be directly read out by the naked eye, and the signal shows little interference from
103 ctrode, which is clearly measurable with the naked eye, correlates linearly with an analyte concentra
104 h deposits or cryptotephra, invisible to the naked eye, discovered within Greenland ice-cores, and ra
105 A allows the results to be visualized by the naked eye, enabling instant, cost-efficient, and on-site
106 examining the samples surfaces with both the naked eye, first, and microscopically (10x and 50x), imm
107 he presence of the final DNA amplicon to the naked eye, providing a "sample-to-answer" diagnosis from
108 ary tumors before they become visible to the naked eye, supporting the added value of this technique
110 ponse, which could be followed easily by the naked eye, was found to depend on the specifics of the a
112 blue ECL emission, easily observable even by naked eye, with quantum yield higher than the standard 9
147 he developed mini-column at visible light by naked eye; where MG was seen as compact green band at th
148 otein (AFP) with the lowest concentration of naked-eye detection down to 1.0 x 10(-12) g mL(-1).
149 generation, enabling unprecedented one-pot, naked-eye detection of a catalytic reporter from 1 mum d
150 cribes a signal-generation mechanism for the naked-eye detection of analytes at low concentrations wi
154 and avidin-conjugated GOx for the selective naked-eye detection of rabbit immunoglobulin G (IgG) and
155 nt a simple platform that enables sensitive, naked-eye detection of SNPs with minimal reagent and equ
156 a surfactant-induced aggregation, results in naked-eye detection of these common anionic surfactants
158 most cases, the detection is made by simple naked-eye observation of agglutinates without any access
159 assay has some advantages such as useful for naked-eye observation, disposable, not time-consuming, i
160 e proposed plasmonic immunoassay allowed the naked-eye quantification of 0-10 ng/mL PSA at an interva
161 initially describes the design of low-cost, naked-eye quantitative aptamer-based assays by using mic
164 e observed enhanced "turn-on" emission and a naked-eye sensitive blue-green color in the medium is at
165 and Hg(2+) in 1:2 stoichiometry, in which a naked-eye sensitive fluorescent blue color of solution c
166 nt, the proposed method was further used for naked-eye tracking glycolytic inhibition in living cells
167 s are fused in the form of fluorene, allows "naked-eye" detection of fluoride in subppm levels (<1.0
168 can be simply interpreted through the human naked-eye, it provides a simple method for fast-screenin
170 or change from pure blue to red, observed by naked eyes along an incident angle of 20-30 degrees .
171 spray kit to directly spot the explosives by naked eyes, implying great potential for quick, low-cost
177 4h, and most sustained when delivered in the naked format subcutaneously at the base of tail with an
180 illions of DNA backbone hydrolysis events on naked genomic DNA, we show that the intrinsic rate of cl
182 li with purified RlpA resulted in release of naked glycans containing 1,6-anhydro N-acetylmuramic aci
184 cal studies are reviewed which show that the naked group 14 atoms E = C-Pb in the singlet (1)D state
185 he immunologic effectors stimulated by these naked HER2 antibodies provide only modest activity as mo
187 eive either BaCaps with hMSCs, empty BaCaps, naked hMSCs, or saline by using a percutaneous subxiphoi
188 RNAs vectors targeting the IL-8 gene and the naked homologous repair DNA carrying different haplotype
191 t syngeneic CC islets was lower than that of naked islets, we showed that CC (PEG MG) islets from ful
192 , and cancer cell killing effect compared to naked KOX or KOX/PEGbPHF at pH7.4, demonstrating that KO
196 story nicely demonstrates that the future of naked mAbs is to design agents with optimized and tailor
206 developed a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and r
209 K4a/b) is present in both cultured cells and naked mole rat tissues but is absent in human and mouse
210 is consistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.
212 may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regi
213 rs interested in the genome and genes of the naked mole rat, and also to facilitate further studies o
214 t, pALT(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance
219 usion is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenil
224 some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland m
230 erexpressing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant tra
238 as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mec
239 report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments o
242 Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of gly
243 -molecular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity o
244 mers may reflect a further adaptation of the naked mole-rat to living in an environment with high-car
248 oach and examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varyi
249 sites at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include t
250 2 binding, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucle
254 into the neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that
256 dy, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maxim
257 dendritic cells (DCs) efficiently in vitro, naked mRNA could not produce any detectable gene product
259 d of Micro encapsulated (MRT, 8 days) versus naked (MRT, 36 days; P < 0.01) baboon islets transplante
261 e insights enabled the preparation of stable naked NC inks of desorption-susceptible NC compositions
262 s these human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that
263 tumor growth suppression when compared with naked oAd and 9.5 x 10(6)-fold increased tumor-to-liver
265 y clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies.
267 in vivo regardless of the mode of delivery (naked or nanoparticle) or the site of administration.
268 proach and a step toward the development of "naked" or toxin-conjugated KIT antibodies for the treatm
269 ic chemicals was first demonstrated using a "naked" PAO chip placed on solid agar, and later in a chi
271 nd reproducible gene expression of exogenous naked pDNA in human skin using volumes that are consider
272 overwriting the original precursor with the naked peptide m/z and removing all of the glycan-related
275 h HSV or CMV, or transient transfection with naked plasmid DNA, HIRA re-localizes to PML bodies, site
276 onstrate that L alone initiates synthesis on naked RNA and that P serves to enhance the initiation an
277 se of VSV P stimulated RABV RdRP activity on naked RNA but was insufficient to permit initiation on t
283 with serum-containing media when compared to naked siRNA, and 25k-branched-polyethylenimine (bPEI) re
284 ow the properties of AID acting freely on a "naked" ssDNA relate to the constrained action of AID dur
287 the plant cell nucleus, possibly by binding naked T-strands and blocking their conversion into doubl
288 ernalized, consistent with slow recycling of naked TAS2R14 in the absence of the heterodimeric milieu
290 life extension in NMRI mice from t1/2 12min (naked) to t1/2 45min (single cholesteryl) and t1/2 71min
291 ic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither U
293 mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression
294 hown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. si
295 e on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithora
297 he HIRA chaperone complex represses incoming naked viral DNAs through chromatinization as part of int
299 7 degrees C identified numerous examples of naked virus capsids located immediately beneath the plas
300 er, we and others have observed that various naked viruses, such as CVB, can trigger the release of i
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