ライフサイエンスコーパス: nanogel

1 Electron microscopy confirmed a shell of nanogel.

2 ively, revealed high biocompatibility of the nanogels.

3 es, to produce purely flow-induced permanent nanogels.

4 he synthesis of cross-linked (bio)degradable nanogels.

5 ticle size about 170nm for the double walled nanogels.

6 ty of guest molecules within these polymeric nanogels.

7 to improve the gastrointestinal stability of nanogels.

8 r assessing the penetration potential of the nanogels.

9 yptus oil coated PLGA-chitosan double walled nanogels.

10 ne demonstrated high cytocompatibilty of the nanogels.

11 fluorescence quenching of the coumarin-based nanogels.

12 used to verify iron chelating capability of nanogels.

13 able linkages into the network of micro- and nanogels.

14 gradable and biocompatible polypeptide-based nanogels.

15 morphology, but it reduced surface charge of nanogels.

16 c virus challenge after immunization with PC nanogel-adjuvanted pH1N1 vaccine.

17 Nonetheless, the stability of nanogels against aggregation in gastrointestinal tract r

18 The nanogels also exhibited high thermal stability as analyz

19 Nanogels and nanogel networks were characterized by mult

20 the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.

21 Nanogels, approximately 70 nm in diameter and synthesize

22 Specifically, smart nanogels are interesting because of their ability to res

23 Nanogels are nanosized crosslinked polymer networks capa

24 low density lipoprotein (LDL)/polysaccharide nanogels are newly explored as oral delivery systems wit

25 Our findings suggest that multifunctional nanogels are promising drug delivery carriers for improv

26 Despite their obvious usefulness, nanogels are still not a commonplace occurrence in clini

27 We also observed that using PC nanogel as a vaccine adjuvant had a dose-sparing effect

28 cy of poly-gamma-glutamic acid/chitosan (PC) nanogel as an adjuvant for the influenza vaccine.

29 ight the distinct and unique capabilities of nanogels as carrier systems for the delivery of an array

30 for synthesizing and crosslinking micro- and nanogels, as well as their development for incorporation

31 Our results demonstrate efficacy of nanogel-based lupus therapy and implicate a mechanism by

32 eristics were copolymerized into particulate nanogels bearing internal and external polymerizable fun

33 the release of encapsulated agents, and the nanogels biodegraded into water-soluble polymers in the

34 we designed a long-circulating bioscavenger nanogel by coating equine serum-derived BChE with a zwit

35 Importantly, the nanogel can effectively reduce cellular ferritin express

36 e studies demonstrate that polypeptide-based nanogels can serve as novel nanocarriers for encapsulati

37 The biodegradation of nanogels can trigger the release of encapsulated molecul

38 y using poly(N-isopropylacrylamide) (PNIPAM) nanogel colloidal particles that self-assemble into crys

39 In this context, a hybrid refers to nanogels combined with different polymers and/or with na

40 nthesized and evaluated oral applications of nanogel conjugates of a protected Gemcitabine, the drug

41 have demonstrated a potential of therapeutic nanogel conjugates with the activated and stabilized Gem

42 hiphilic polyvinyl alcohol and dextrin-based nanogel conjugates with the phosphorylated 5-FU nucleosi

43 h orally treated Gemcitabine- or Floxuridine-nanogel conjugates.

44 dulus in the dry state for networks based on nanogels containing a hydrophobic dimethacrylate and hyd

45 Furthermore, nanogels containing both 17-AAG and doxorubicin exhibite

46 HEMA) homopolymer or in networks formed from nanogels copolymerized with HEMA.

47 These nanogels could be used for targeted drug delivery scaffo

48 pared to free antibiotics and non-responsive nanogel counterparts.

49 Stable biodegradable nanogels cross-linked with disulfide linkages were prepa

50 Compared to original uncrosslinked nanogels, crosslinking did not change particle size, pol

51 The nanogels demonstrated extended stability in aqueous medi

52 A new class of nanogel demonstrates modular biodistribution and affinit

53 Nanogel dispersions were stable at high concentrations i

54 Dual drug-loaded nanogels displayed potent cytotoxicity in a breast cance

55 viability, uptake, and physical stability of nanogel-DNA complexes were evaluated under physiological

56 Here, we designed and tested a novel nanogel drug delivery vehicle for the immunosuppressant

57 Surprisingly, these nanogel-drug conjugates were relatively stable in gastri

58 We demonstrated that the RBC-nanogels effectively neutralized MRSA-associated toxins

59 Nanogel electrophoresis is an inexpensive, rapid, and si

60 Phospholipid nanogels enhance the stability and performance of the ex

61 of double walled PLGA-chitosan biodegradable nanogel entrapped with 5-fluororuacil (5-FU) coated with

62 e of applications, well beyond the polymeric nanogel examples studied here.

63 Importantly, imidazoquinoline-ligated nanogels focused the in vivo immune activation on the dr

64 such patients, oxidation-induced degradable nanogels for iron chelation were rationally designed by

65 Several fluorescent molecularly imprinted nanogels for the detection of the anticancer drug suniti

66 tential for the utility of the biodegradable nanogels for treating skin cancers.

67 Cationic nanogels formed monodisperse complexes with oligonucleot

68 d on the target loading of 10mug/mg for both nanogels found to be 84% and 86% for the nHG-SW and nHP-

69 allenges that need to be overcome to advance nanogels further in the field of biomedical applications

70 The nanogels had a uniformly cross-linked network, which can

71 Nanogels had enhanced biodistribution to organs and asso

72 The nano spray dried LDL/CMC/EDC nanogels had relatively poor surface structure with aggl

73 Typical nanogels have an average radius of approximately 230 nm,

74 Biodegradable polypeptide-based nanogels have been developed from amphiphilic block copo

75 Nanogels have emerged as a versatile hydrophilic platfor

76 DCs that internalized nanogels helped mediate immunosuppression, as they had r

77 rategy to enhance the stability of LDL-based nanogels in digestive conditions.

78 sed nowadays on using multifunctional hybrid nanogels in nanomedicine, not only as drug carriers but

79 d sustained release profile from crosslinked nanogels in simulated gastrointestinal fluids.

80 cessful applications of innovative polymeric nanogels in the form of conjugates with activated nucleo

81 Treatment with MPA-loaded nanogels increased the median survival time (MST) of lup

82 ble TLR7/8 agonist, imidazoquinoline-ligated nanogels induce superior antibody and T-cell responses a

83 d to improve the penetration efficacy of the nanogel into stratum corneum.

84 Together, these results suggest that PC nanogel is a promising vaccine adjuvant that could broad

85 The NCPD nanogel is stable in physiological environments while in

86 rm (narrow size distribution), and exhibited nanogels-like behavior.

87 ion enhancers coated biodegradable polymeric nanogels loaded with cytotoxic drugs applied via the top

88 obtained under standard conditions with the nanogel matrix at a 98.5% accuracy of base-calling (for

89 iminary DNA sequencing results show that the nanogel matrixes are capable of delivering significantly

90 The properties and performance of nanogel matrixes are compared here to those of a linear

91 We further investigated the use of the nanogel matrixes in a high-throughput microfabricated DN

92 Moreover, nanogel matrixes require 30% less polymer per unit volum

93 ing polymer NPs, small-molecule organic NPs, nanogels, micelles, vesicles, and biomaterial-based NPs)

94 approach allowed the detection of changes in nanogel molar mass and topology as a function of both te

95 These nanogel nanosecond phenomena may be useful in the design

96 Nanogels and nanogel networks were characterized by multiangle laser

97 Both nanogel networks were characterized in terms of particle

98 rwise rapidly released from common PEG-based nanogel networks.

99 Nanogels (NGs) based on polyethylene glycol (PEG) macrom

100 In the last few decades, hybrid nanogels or composites have been developed to overcome t

101 s self-cross-link at low concentrations into nanogels or form macroscopic hydrogel networks at higher

102 A novel stabilized aggregated nanogel particle (SANP) drug delivery system was prepare

103 T-jump from 30 to 35 degrees C actuates the nanogel particle shrinkage; the resulting increased diff

104 Aggregated nanogel particles (ANPs) were generated by aggregating G

105 In this review, we will describe nanogels, particularly in the form of composites or hybr

106 drogel which permits the individual embedded nanogel PNIPAM particles to coherently and synchronously

107 controlled degradability indicated that the nanogels prepared by ATRP were superior to their corresp

108 The nanogels prepared with the one-pot method showed favorab

109 We reported an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antiviru

110 or ultrahigh molar mass LPA to the optimized nanogel sequencing matrix further improves read length a

111 intracellular reducing environment, the RBC-nanogels showed an accelerated drug release profile, whi

112 PC nanogel significantly enhanced antigen-specific cross-pr

113 ed with intracellular MRSA bacteria, the RBC-nanogels significantly inhibited bacterial growth compar

114 FA-decorated nanogels significantly suppressed the growth of intraper

115 ditionally, we confirmed the conservation of nanogel stimuli-responsivity through turbidity measureme

116 We have developed sparsely cross-linked "nanogels", subcolloidal polymer structures composed of c

117 the internally cross-linked structure of the nanogels, substantially longer average read lengths are

118 erosion was evident from both an increase in nanogel swelling and a decrease in scattering intensity

119 The nanogels synthesized in this study demonstrate potential

120 ults indicate the great potential of the RBC-nanogel system as a new and effective antimicrobial agen

121 an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antivirulence and res

122 ed an approach to network formation based on nanogels that are dispersed in inert solvent and directl

123 the host-guest characteristics of polymeric nanogels that contains these acetal or ketal moieties as

124 synthesis and characterization of degradable nanogels that display bulk erosion under physiologic con

125 ave demonstrated the synthesis of degradable nanogels that erode under conditions and on time scales

126 method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrop

127 esponse at the site of action, which imparts nanogels the ability to participate actively in the inte

128 agonist to 50-nm-sized degradable polymeric nanogels the potency of the agonist to activate TLR7/8 i

129 With nanogels, there is no need to covalently immobilize the

130 and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (

131 s to control the pH and thermal responses of nanogels, this work illustrates a new way to design soft

132 positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl

133 evealed a prevalent passive diffusion of the nanogels to the draining lymph node.

134 s, which significantly improved stability of nanogels under simulated gastrointestinal conditions.

135 ynthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking r

136 Polymeric nanogel vectors were developed for cellular gene and ant

137 RBC membrane was coated onto the nanogel via a membrane vesicle templated in situ gelatio

138 surface modified biodegradable double walled nanogel was characterized for particle size, charge and

139 The number of biotin molecules in each nanogel was determined to be 142,000, and the formation

140 f fully hydrated networks formed solely from nanogels was shown to equal or exceed the modulus in the

141 ar microenvironment for curcumin embedded in nanogels was strengthened, which therefore enhanced enca

142 ity, stability, and swelling behavior of the nanogels were investigated by NMR, light scattering, tra

143 Further, OH-functionalized nanogels were prepared to demonstrate facile applicabili

144 Monodisperse nonionic and cationic nanogels were produced with controllable sizes ranging f

145 Drug-loaded nanogels were surface-functionalized with folic acid (FA

146 Erodible poly(N-isopropylmethacrylamide) nanogels were synthesized by copolymerization with N,O-(

147 Nanogels were synthesized via inverse emulsion (water-in

148 Smaller nanogels will show even faster volume phase transitions.

149 Cross-linked nanogels with a uniformly cross-linked network were prep

150 tion confirmed efficient 17-AAG release from nanogels with activity comparable to free 17-AAG.

151 2,000, and the formation of bioconjugates of nanogels with avidin was confirmed using optical fluores

152 ion was utilized to synthesize biocompatible nanogels with controlled size, morphology, and compositi

153 Loading efficiency for both of the nanogels with NR was determined by spectrophotometry to

154 1) vaccine was substantially increased by PC nanogel, with increased hemagglutination-inhibition tite

155 CD4-targeted nanogels yielded similar therapeutic results compared wi