ライフサイエンスコーパス: nanomolar

1 h-affinity component with a Km of just a few nanomolar.

2 nd to human carbonic anhydrase (HCA) using a nanomolar active site ligand.

3 dual FAAH/ChE inhibitors, with well-balanced nanomolar activities.

4 describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites.

5 h a pan-ErbB kinase inhibitor erlotinib with nanomolar activity against ErbB4 significantly suppresse

6 e lantibiotc (LtnA1 and LtnA2) that displays nanomolar activity against many Gram-positive bacteria.

7 y profiles demonstrate that they possess low nanomolar activity against models of acute myeloid leuke

8 ciparum, excellent parasite selectivity, and nanomolar activity against the earliest forms of gametoc

9 tion provided us with a PORCN inhibitor with nanomolar activity and excellent bioavailability that de

10 ing displayed inhibition of ferroptosis with nanomolar activity and was dubbed ferrostatin-1 (fer-1).

11 p (RGD)-based cyclopentapeptides (cRGD) with nanomolar activity as alphavbeta3/alphavbeta5 integrin a

12 epresentative, compound I, was shown to have nanomolar activity in HIV-1-infected T cells, potency on

13 were synthesized, and several of them showed nanomolar activity in inhibiting the hCA IX and XII isof

14 on conformation, and we show that the potent nanomolar activity of JNJ-53718678, as well as the preli

15 the "completely" methylated compound exerted nanomolar activity, the data revealed that all compounds

16 an analogue (pepstatin hexyl ester) with low nanomolar activity.

17 ed as an agonist for both PAR1 and PAR4 with nanomolar activity.

18 (rcSso7d) scaffold yielded binders with low nanomolar affinities against mouse serum albumin and sev

19 act with multiple sites of thrombin with low nanomolar affinities and show little specificity of inte

20 selective inhibitor 8i (IACS-9571) with low nanomolar affinities for TRIM24 and BRPF1 (ITC Kd = 31 n

21 ionic strength, Gag binds with very similar, nanomolar affinities to both Psi-containing and control

22 inders against the expected peptide with low nanomolar affinities, similar to the binders from the co

23 id-binding properties, including their high (nanomolar) affinities for glucocorticoids, progesterone,

24 d to the iNOS binding site of SPSB2 with low nanomolar affinity (KD 29 nM), a 10-fold improvement ove

25 otective, and long-lasting IgG antibodies of nanomolar affinity against the target glycans in mice.

26 a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ), a nanomolar affinity AhR ligand with immunosuppressive act

27 binds its target with high picomolar to low nanomolar affinity and at least 300-fold specificity.

28 IRAB-B binds to the IR with nanomolar affinity and in the presence of insulin effici

29 The optimized peptides exhibit nanomolar affinity and neutralization against influenza

30 with hen-egg white lysozyme demonstrate how nanomolar affinity binding of asymmetrical antigen is en

31 We conclude that the presence of high-nanomolar affinity binding sites for CaM at its universa

32 rapidly to the discovery and development of nanomolar affinity fluorescent probes for 14 aminergic G

33 inoline-3-carboxamide, a pan antagonist with nanomolar affinity for all four subtypes.

34 HSA Peptide 40, on human serum albumin with nanomolar affinity for all three monoclonal antibodies.

35 via a PX motif at its C-terminus, which has nanomolar affinity for bilayers containing phosphatidyli

36 Results:(18)F-FHNP had nanomolar affinity for ERs, with a 3.5 times higher affi

37 of new hydroxamic acid-based inhibitors with nanomolar affinity for human GCPII.

38 lated variant of STX with unprecedented, low-nanomolar affinity for human NaV1.7 (hNaV1.7), a channel

39 ion of a weak fragment hit to molecules with nanomolar affinity for KEAP1 while maintaining drug-like

40 e used to develop meditope peptides with low nanomolar affinity for other therapeutic antibodies.

41 Compounds 4a-c and 4e showed greater, nanomolar affinity for the GluN1/2A subtype versus GluN1

42 Several compounds possessed nanomolar affinity for the hA2A AR (Ki = 2.9-10 nM) and

43 peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 1

44 functionalizable red calcium indicator with nanomolar affinity for use in cell biology and neuroscie

45 dihydropyridines and phenylalkylamines with nanomolar affinity in a state-dependent manner.

46 d DNA aptamers that exhibit picomolar to low nanomolar affinity in human serum for three diverse prot

47 with micromolar affinity, in contrast to the nanomolar affinity of the N-WASP G protein-binding regio

48 anocarrier to tightly bind antibody with sub-nanomolar affinity regardless of pH and the antibody's o

49 Importantly, NL2 and ST3 interact with nanomolar affinity through their extracellular domains t

50 for is a radiotracer for PET that binds with nanomolar affinity to CXCR4.

51 ar to other beta isoforms, beta1a bound with nanomolar affinity to the alpha-interaction domain, but

52 we demonstrate that Casp8p41 also binds with nanomolar affinity to the antiapoptotic protein Bcl-2, w

53 s is the first reported inhibitor to achieve nanomolar affinity while exhibiting specificity for muta

54 VP40 binds PS-containing membranes with nanomolar affinity, and binding of PS regulates VP40 loc

55 This KDC binds to tumor cells with low-nanomolar affinity, is internalized by an integrin-media

56 ble light and possess overall sigma receptor nanomolar affinity, with one of them (8b) exhibiting rem

57 ting brake and CaM bind each other with high-nanomolar affinity.

58 obodies, for six of the SFK SH2 domains with nanomolar affinity.

59 the delta-antagonist 10 characterized by low nanomolar affinity.

60 e ISS apical loop site-specifically and with nanomolar affinity.

61 3 that binds to the TPR domain of sNASP with nanomolar affinity.

62 GA1 Ig1-Ig2 is sufficient to bind NLGN2 with nanomolar affinity; its crystal structure reveals an unu

63 Two compounds possessed nanomolar agonist potency at the mMC4R, c[Pro-His-DPhe-A

64 tipotent inhibitors showing potencies in the nanomolar and in the low micromolar range for hMAO B and

65 inhibited both rhodesain and falcipain-2, at nanomolar and micromolar levels, respectively.

66 gh size resolution, at concentrations in the nanomolar and picomolar range.

67 double-stranded DNA with high affinity (low nanomolar), and functions as a transcription factor.

68 This feature translated into low nanomolar anti-HIV-1 activity toward two viral strains a

69 ieties with improved stability, single digit nanomolar antiferroptotic activity, and good ADME proper

70 Compound 2 also exhibits nanomolar antifungal activity in synergy with amphoteric

71 ue was found to have double- to single-digit nanomolar antiproliferative IC50 values and showed stati

72 surface plasmon resonance (SPR) revealed low nanomolar antiserum affinity for the key heroin metaboli

73 of the fetal AChR to which it bound with sub-nanomolar apparent affinity, and detected the presence o

74 Providing abcb19 seedlings with nanomolar auxin rescued their low CCS52A2 levels, endocy

75 cells demonstrate that NDD-713 and -825 have nanomolar beta1-AR affinity >500-fold beta1-AR vs beta2-

76 of MDM2 and resulted in identification of a nanomolar binder with improved proteolytic stability and

77 l titration calorimetry (ITC) provided up to nanomolar binding affinities in aqueous solution for the

78 These novel inhibitors exhibit low nanomolar binding affinities to Mcl-1 and >500-fold sele

79 antibody is further optimised to achieve low-nanomolar binding affinity by in silico redesign of the

80 ics studies of m4-1BB disclosed a very tight nanomolar binding affinity to m4-1BBL with an unexpected

81 nship optimization allowed generation of low nanomolar BRPF2 BD inhibitors with strong selectivity ag

82 bound in this pocket to generate a novel low nanomolar chemotype, which did not interact with the cat

83 timized by chemical synthesis into selective nanomolar compounds, thereby preserving the ligand effic

84 fficiently isolate the specifically targeted nanomolar concentrated DNA over 70% from its associate D

85 N-DABOs) are interesting compounds active at nanomolar concentration against wild type of RT and with

86 ppocampal neurons showed that S1P applied at nanomolar concentration alters the distribution of Synap

87 2,4-dichlorophenoxyacetic acid or 2,4-D, at nanomolar concentration directly in water samples.

88 ime binding events of the target molecule at nanomolar concentration levels and could be potentially

89 different antibodies of the same isotype at nanomolar concentration levels.

90 ta(1-42) aggregates entered the cells at low nanomolar concentration of Abeta(1-42).

91 n of various pesticide concentrations in the nanomolar concentration range.

92 ced activities at the targets, mostly in the nanomolar concentration range.

93 dide ions in artificial urine samples in the nanomolar concentration range.

94 nt perchlorate in vegetable matrices down to nanomolar concentration.

95 d inhibitor and inhibits irreversibly MPO at nanomolar concentration.

96 rs less toxic than PLTX, its cytotoxicity at nanomolar concentrations after short exposure time rises

97 nd peripheral blood mononuclear cells at low nanomolar concentrations and displays excellent potency

98 1-NaV1.4, NaV1.6-NaV1.7) that are blocked by nanomolar concentrations and TTX-resistant (TTX-r) chann

99 lar helicates inhibit Tat-TAR interaction at nanomolar concentrations by binding to TAR RNA.

100 stability of these complexes in methanol at nanomolar concentrations exceeds that of complexes betwe

101 CGRP-based agents induce effects at nanomolar concentrations in deep tissue and can be engin

102 Nanomolar concentrations of C1572 markedly reduced c-MYC

103 amp recordings in brain slices to reveal how nanomolar concentrations of KYNA alter synaptic transmis

104 ults show that the organic exudate generates nanomolar concentrations of superoxide and hydrogen pero

105 Exposure of myofibroblasts to nanomolar concentrations of the demethylating agent 5-az

106 Efficient cell killing was possible at nanomolar concentrations of TuBB-9 due to the effective

107 urthermore, exposure of endothelial cells to nanomolar concentrations of vorapaxar induces endothelia

108 able to inhibit tumor cell proliferation at nanomolar concentrations when tested against the full NC

109 6 induced degradation of BET proteins at low nanomolar concentrations within 1 hour of exposure, resu

110 es with improved antiproliferative activity (nanomolar concentrations) against several cancer cell li

111 We further show that gingipains, even at low nanomolar concentrations, cleaved SPINK6 in concentratio

112 ermal and requires only nanoliter volumes at nanomolar concentrations, it will allow for the fast scr

113 inhibition by ferrous ions is documented at nanomolar concentrations, which is a potentially physiol

114 cts of exposure to a drug valinomycin at sub-nanomolar concentrations.

115 ALF34, which induces pollen tube bursting at nanomolar concentrations.

116 o amyloid structures and disrupt membrane at nanomolar concentrations.

117 t cell-based antiproliferative activities in nanomolar concentrations.

118 d to the two S. typhymurium OASS isoforms at nanomolar concentrations.

119 cer) and PF-04217903 block their activity at nanomolar concentrations.

120 ncer drugs were sensitive to flubendazole in nanomolar concentrations.

121 depress the cortical network activity at low nanomolar concentrations.

122 -tumor efficacy and safety compared to their nanomolar counterparts.

123 RyR1-G4941K did not fully close at nanomolar cytosolic Ca(2+) concentrations and nearly ful

124 Both enantiomers of kibdeleone C show low nanomolar cytotoxicity toward multiple human cancer cell

125 he structural requirements for the switch to nanomolar cytotoxicity, we systematically synthesized al

126 large proteins (e.g., antibodies) with a low nanomolar detection limit within 10 min.

127 free amines of BSA and then employed for the nanomolar detection of Hg(2+) in aqueous medium via sele

128 mphiphilic receptor has been utilized in the nanomolar detection of uric acid at physiological pH in

129 The novel tandem tetramers bound with a nanomolar dissociation constant to 24 bp sequences made

130 We produced more than 20 synbodies with low nanomolar dissociation constants (KD < 10 nM) for GII.4

131 by two polyethylene glycol (PEG) chains with nanomolar dissociation constants in water.

132 Several aptamers were discovered with nanomolar dissociation constants.

133 njugated dsDNA providing the robust "off-on" nanomolar DNA sensing.

134 ys-NH2) led to binding affinities in the low nanomolar domain.

135 At low-nanomolar doses each of these agents induced distinct ef

136 rget-directed ligands (MTDL) displaying both nanomolar dual-binding site (DBS) acetylcholinesterase i

137 ir activity range from low micromolar to sub-nanomolar EC50, the most interesting compounds being 15

138 t cross-presentation by dendritic cells with nanomolar efficacy.

139 initial macrocycles, which were double-digit nanomolar FXIa inhibitors, were further optimized with a

140 llent antiproliferative properties, with low nanomolar GI50 values (16o, mean GI50 of 3.3 nM) against

141 re potent than the globular isomer, with low nanomolar half-maximal inhibitory concentrations (IC50).

142 was able to assemble into capsids when (low-nanomolar) HBc concentrations mimicked those achieved un

143 inogens bound FXIII-A2B2 with high affinity (nanomolar); however, Fibgamma(390-396A) did not bind FXI

144 The compounds have also shown a potent nanomolar human telomerase inhibition activity and apopt

145 g exercise rapidly led to a low single digit nanomolar human vasopressin 1a (hV1a) receptor antagonis

146 to be high affinity ligands for the ER with nanomolar IC50 binding values.

147 As a result, compound 12 showed low nanomolar IC50 for both targets.

148 logical evaluation, compound 1 displayed low nanomolar IC50 in blocking elastase activity and strong

149 The most interesting compound 9 showed nanomolar IC50 values for both proteins, membrane permea

150 compounds 46, 49, and 50 showed single-digit nanomolar IC50 values for in vitro inhibition of KDM1A,

151 Brigatinib displayed low nanomolar IC50s against native ALK and all tested clinic

152 The most potent compound displays nanomolar in vitro and in situ IC50 values and fully inh

153 nM) was optimized to lead molecules with low nanomolar in vitro potency.

154 y inhibits both human and mouse FAP with low nanomolar inhibition constants but does not inhibit clos

155 Low nanomolar inhibition KI values were detected for all of

156 inolizidine-scaffolded iminosugar exhibiting nanomolar inhibition of a glycoenzyme.

157 gands, named ipglycermides, demonstrates sub-nanomolar inhibition of iPGM with complete selectivity o

158 of compound 23 (AMG 337), which demonstrates nanomolar inhibition of MET kinase activity, desirable p

159 4201206, 2014 ] of NaV1.7, which demonstrate nanomolar inhibition of NaV1.7 and exhibit high levels o

160 ng compound ACT-451840 exhibits single-digit nanomolar inhibition of the Plasmodium falciparum asexua

161 benzo-[b]-thiophene-2-boronic acid (BZB), a nanomolar inhibitor of AmpC beta-lactamase (K i = 27 nM)

162 A low nanomolar inhibitor of CYP11B1 (5c) was obtained, endowe

163 arabinogalactan synthesis; 14 proved to be a nanomolar inhibitor of DprE1, and methylation of 14 by R

164 arise through redox modifications, make it a nanomolar inhibitor of protein phosphatase 2A (PP2A).

165 Albicidin is a nanomolar inhibitor of the bacterial DNA gyrase with a s

166 The antimalarial agent cladosporin is a nanomolar inhibitor of the Plasmodium falciparum lysyl-t

167 This resulted in equipotent nanomolar inhibitors of DNA gyrase from Escherichia coli

168 We identified low nanomolar inhibitors of ERAP2 and IRAP that display sele

169 The natural product analogues are nanomolar inhibitors of Mtb phospho-MurNAc-pentapeptide

170 s from commercial chemical libraries yielded nanomolar inhibitors.

171 ethyl)ureido)benzenesulfonamides, showed low nanomolar inhibitory action against hCA II, being less e

172 moylphenyl)acetamide derivatives, showed low nanomolar inhibitory activity against hCA II and hCA VII

173 his new chemotype consistently conferred low nanomolar inhibitory activity against HIV-1.

174 E209 has potent nanomolar inhibitory activity against multiple strains o

175 Phenyl benzo[d]isothiazol-3(2H)-ones display nanomolar inhibitory activity against P. falciparum and

176 0 per epitope, consequently leading to a low-nanomolar inhibitory potency.

177 selectively inhibit HDAC6 while maintaining nanomolar inhibitory potency: N-hydroxy-4-[(N(2-hydroxye

178 particles show no cytotoxicity, and in vitro nanomolar irreversible activity against herpes simplex v

179 h yielded low micromolar KD against GtfB and nanomolar KD against GtfC, demonstrating selectivity tow

180 bind alternative G4DNA topologies with a low nanomolar Kd value of approximately 2 nm, similar to tha

181 new, higher affinity monobodies with single nanomolar KD values targeting the kinase-binding surface

182 complexes with TFB2M or TFAM on LSP with low-nanomolar Kd values, but these two-component complexes l

183 onto LE retrofragment scaffolds produced low nanomolar (KD = 15 nM) CYP121 ligands.

184 f T-HCA led to high-affinity analogs (medium nanomolar Ki) for the GHB high-affinity binding sites as

185 The sensor exhibited nanomolar level of detection, excellent selectivity agai

186 immunosensing, due to sensitivity limits at nanomolar level, whereas the clinical requirement is in

187 be easily observed with the naked eye at the nanomolar level.

188 reconstituted transmembrane proteins at the nanomolar level.

189 the ability of DCM-Cys to provide selective, nanomolar-level in vitro cysteine detection, as demonstr

190 ms for the detection of nitric oxide (NO) at nanomolar levels in the presence and absence of oxygen.

191 LLIN PERCEPTION SENSOR 1 (GPS1), that senses nanomolar levels of bioactive GAs.

192 d Slo1 BK channels are directly activated by nanomolar levels of DHA.

193 rotetrazines can be efficiently catalyzed by nanomolar levels of horseradish peroxidase under peroxid

194 inated by the "on-off" signal change mode at nanomolar levels of the analyzed DNA.

195 is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where i

196 t the same pathogens from 16 to 32 mug/mL to nanomolar levels.

197 Nanomolar misTTR inhibits fibrillogenesis of misfolded T

198 aracterization of a novel class of one-digit nanomolar NAMPT inhibitors based on in vitro characteriz

199 umption revealed significant effects even at nanomolar NO concentrations.

200 apamycin, and cyclosporin, bind PPIases with nanomolar or better affinity.

201 Thus, these compounds exert selective nanomolar or even subnanomolar activity against PI4KB as

202 otective in three fungal infection models at nanomolar or lower concentrations.

203 Many of them were low nanomolar or subnanomolar hCA II, IX, and XII inhibitors

204 The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resist

205 th of many cultured cancer cell lines at low nanomolar-picomolar concentrations.

206 ation of a series of VHL inhibitors with low nanomolar potencies and improved cellular permeability.

207 nst a number of cancer cell lines, revealing nanomolar potencies for a number of them against certain

208 ionship of these two scaffolds, resulting in nanomolar potencies in an ATP synthesis inhibition assay

209 h binding affinities to BET proteins and low nanomolar potencies in inhibition of cell growth in acut

210 t 9 resulted in a series of derivatives with nanomolar potencies, good ligand efficiency and selectiv

211 o screening of 26 compounds revealed 22 with nanomolar potency against axenically cultured bloodstrea

212 of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissi

213 of the alternative lead candidate 4ab with a nanomolar potency against CDK2 and CDK9 and potent antip

214 Three chemically distinct hit classes with nanomolar potency and favorable cytotoxicity profiles we

215 The most active compounds exhibited nanomolar potency and high selectivity for HDAC6.

216 -II agonist (nWWK-Tyr(3-NO2)-Abu), shows low nanomolar potency as well as improved metabolic stabilit

217 of COT kinase inhibitors, with unprecedented nanomolar potency for the inhibition of TNFalpha.

218 nd inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays.

219 pyridone inhibitors exhibiting single digit nanomolar potency in both biochemical and cell based ass

220 Novel benzothiophene derivatives with nanomolar potency in breast cancer cell cultures were de

221 as optimized to afford IRAK4 inhibitors with nanomolar potency in cellular assays.

222 s) led to the identification of analogs with nanomolar potency in inhibiting hFPPS.

223 18, that produce peptides with single digit nanomolar potency on NaV1.7 and 500-fold selectivity aga

224 r assays, the compounds exhibit single-digit nanomolar potency toward VEGFR2.

225 xamate, 51, inhibits JAK2 and HDAC6 with low nanomolar potency, is <100 nM potent against HDACs 2 and

226 The best compounds inhibited CSN5 with nanomolar potency, led to degradation of the substrate r

227 th targets produced dual modulators with low nanomolar potency.

228 of quinazoline derivatives with single-digit nanomolar potency.

229 inhibits CFTR chloride conductance with low-nanomolar potency.

230 The study identified a nanomolar potent PEGylated bis-sulfonamide CA inhibitor

231 For the first time nonphenolic and small low nanomolar potent, SAM competitive COMT inhibitors are re

232 X and XII and cytosolic isozymes, identified nanomolar-potent inhibitors against both classes and sev

233 a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions.

234 ompared with DCS with EC50 values in the low nanomolar range (1.7 nM at GluN1/2C).

235 The IC50 values for compounds 1-3 are within nanomolar range (14, 12, and 6 nM, respectively).

236 ancer cell death with IC50 values in the low nanomolar range (3-20 nM), but not affect normal cell vi

237 in cell-based assays with values in the low nanomolar range (3.2-55 nM).

238 of both processes were detectable in the low nanomolar range (5-33 nmolL(-1) O2), but demonstrated a

239 an affinity to the MUC2 CysD2 domain in the nanomolar range and can catalyze its cross-linking.

240 tive activities in the high picomolar to low nanomolar range and caused apoptosis and mitotic arrest

241 Limits of detection (LODs) in the low nanomolar range and excellent intermediate precisions of

242 se compounds exhibited GSK3 IC50s in the low nanomolar range and excellent selectivity.

243 rectly with G4 DNA with Kd values in the low nanomolar range and revealed that the robust binding of

244 anti-HIV and anti-HBV activities in the low nanomolar range and selectivity indexes of more than 300

245 number of compounds that were potent in the nanomolar range and which, on optimization, resulted in

246 PR) with dissociation constants (Kd ) in the nanomolar range for choline and glycine betaine, micromo

247 oline conjugate exhibited an IC50 in the low nanomolar range in 22RV1 cell cultures and induced a com

248 RYM1 showed nanomolar range inhibition constants for several MMPs.

249 Aptamers with dissociation constants (Kd) of nanomolar range were isolated.

250 the cellular EGFR inhibition down to the low nanomolar range with covalently binding inhibitors again

251 ding antiviral activity with IC50 in the sub-nanomolar range!

252 philes that exhibit high-affinity (Kd in low nanomolar range) binding to HSA.

253 otent MMP inhibitors with IC50 values in the nanomolar range, also demonstrating no off-target effect

254 ven compounds were found to be active in the nanomolar range, and some of them showed selectivity tow

255 e titrations that the Kd value is in the low nanomolar range, and the Fe(3+)-heme off-rate is on the

256 ng compounds have Ki values in the two-digit nanomolar range, are not cytotoxic, and inhibit virus re

257 eceptor affinities with Ki values in the low nanomolar range, even when bulky fluorophores had been a

258 ystal-binding site is estimated to be in the nanomolar range, with lattices of known protein crystals

259 ,20-lyase activities with IC50 values in the nanomolar range, without affinity for the major drug-met

260 eversible CE inhibitor with Ki values in the nanomolar range.

261 orescence-based assays showing values in the nanomolar range.

262 tion and cell stasis with IC50 values in the nanomolar range.

263 owed KIs spanning between the low and medium nanomolar range.

264 irus genotype, with their IC50 values in the nanomolar range.

265 alogues possessing cytotoxic activity in the nanomolar range.

266 g pocket for DFG in SocA with an affinity in nanomolar range.

267 ating drug that blocks ERK signalling in the nanomolar range.

268 potently activated mGlu4,6,8 in the low-mid nanomolar range.

269 n of peripheral and cerebral COMT within the nanomolar range.

270 858R/T790M/C797S with IC50 values in the low nanomolar range.

271 revealed compounds with IC50 values in high nanomolar range.

272 icial saliva with limits of detection in the nanomolar range.

273 owing dissociation constants (KD) in the low nanomolar range.

274 g-like domain of LSR with an affinity in the nanomolar range.

275 his enzyme, with IC50 values measured in the nanomolar range.

276 ty and IC50 values, both of which are in the nanomolar range.

277 165 by Nek2, and killing cancer cells at the nanomolar range.

278 epresentatives displayed activity in the low nanomolar range.

279 b 53, that bind EphA4 with affinities in the nanomolar range.

280 enzothiadiazine dioxide AMPApam to reach the nanomolar range.

281 Nanomolar-range concentrations of ziram caused selective

282 Dissociation constants in the nanomolar regime were determined and match both results

283 achieves sensitivities down to 0.07 and 0.33 nanomolar, respectively.

284 This resulted in the first reported low-nanomolar, selective and cell permeable chemical probe f

285 ng, we discovered DNA aptamer pairs with low-nanomolar sensitivity in dilute serum and excellent spec

286 oduce a novel FRET-based cAMP biosensor with nanomolar sensitivity that is out of reach for other sen

287 and H3K4me3 and identified A366 as the first nanomolar small-molecule ligand of a Tudor domain contai

288 Best inhibitory activity (in the low nanomolar-subnanomolar range) was observed for isoforms

289 ed hCA IX and XII, with KI values in the low nanomolar-subnanomolar ranges.

290 upported this hypothesis, highlighting a low nanomolar/subnanomolar affinity of these ligands, togeth

291 CD1, and the SLiM affinities ranged from low nanomolar to 50 times higher Kd values.

292 t was transformed to a series of very potent nanomolar to picomolar catechol diethers.

293 ng affinity by approximately 1000-fold (from nanomolar to picomolar).

294 panehydrazonamides provided new analogs with nanomolar to subnanomolar antiplasmodial activity agains

295 decahydroquinoxalines 5-8 show single-digit nanomolar to subnanomolar kappa-opioid receptor affinity

296 this FGFR2-ADC exhibited potency in the low nanomolar to subnanomolar range and was more than 100-fo

297 we identified compounds with consistent low nanomolar transmission-blocking activity, some of which

298 The effects of nanomolar versus micromolar concentrations of phlorogluc

299 th high affinity (dissociation constant = 77 nanomolar), whereas the alpha-syn monomer exhibited mini

300 nal selectivity and sensitivity (down to 250 nanomolar with a time constant of 1 millisecond).