ライフサイエンスコーパス: natural amino acid

1 xtent to which they prevent incorporation of natural amino acids).

2 that substituted its leucine core with each natural amino acid.

3 >2.3-fold improvement over the best possible natural amino acid.

4 pyrrolysine is the 22nd genetically encoded natural amino acid.

5 ude extracts in the face of competition from natural amino acids.

6 d to make (F)Cbz derivatives of 18 of the 20 natural amino acids.

7 coded residue is distinct from any of the 21 natural amino acids.

8 ntially take up the analog compared with the natural amino acids.

9 ially activates the analog compared with the natural amino acids.

10 f the form AcWLL-X-LL, where X is one of the natural amino acids.

11 synthetic peptides, including ones with non-natural amino acids.

12 , with deeper minima than those observed for natural amino acids.

13 orged starting from abundant and inexpensive natural amino acids.

14 acids in length, including d- and other non-natural amino acids.

15 bone, an arrangement that is not found among natural amino acids.

16 r enones with azomethine ylides derived from natural amino acids.

17 th a variety of side chains corresponding to natural amino acids.

18 rk for the design of peptides containing non-natural amino acids.

19 les and the mild synthesis of thiazoles from natural amino acids.

20 ts for the enantioselective synthesis of non-natural amino acids.

21 iling important building blocks of life: the natural amino acids.

22 ne 43 of CD4 and cannot be fully accessed by natural amino acids.

23 ore side-chain diversity well beyond that of natural amino acids.

24 mmon difference between the masses of the 20 natural amino acids.

25 specific unlabeled peptides composed only of natural amino acids.

26 d, but it is still a challenge to obtain non-natural amino acids.

27 d to replace S140 or V141 with several other natural amino acids.

28 ent conjugation in the presence of the other natural amino acids.

29 acyl-1,omega-amino acids (5, 9a-f, 14a-f) of natural amino acids (10a,b) and of dipeptide (10c) are p

30 simulation for the most active analogue with natural amino acids, Ac-V4W/H9A-NH(2).

31 of peptides, and the early evolution of the natural amino acid alphabet.

32 well as peptides composed of natural and non-natural amino acid analogs, thereby enabling screens in

33 Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becom

34 By genetic incorporation of a non-natural amino acid and two compatible bioorthogonal chem

35 Given the fact that Phe CN is a non-natural amino acid and, thus, amenable to incorporation

36 a method using genetic incorporation of non-natural amino acids and bio-orthogonal chemistry to site

37 carboxylate esters belong to the L-series of natural amino acids and catalyze asymmetric Michael addi

38 prepared starting from diamines derived from natural amino acids and commercially available aminoalky

39 carnitines, while deplete in the most common natural amino acids and derivatives.

40 The peptide is composed entirely of natural amino acids and exhibits a marked (42%) change i

41 including quenching interactions with select natural amino acids and Forster resonance energy transfe

42 of vMIP I, a chemokine that contains all 20 natural amino acids and has two disulfide bonds.

43 id within the interacting peptide for all 20 natural amino acids and identified novel binding sequenc

44 e Gap1p sorting, because the addition of all natural amino acids and many amino acid analogs to the g

45 orial library containing 14 unnatural and 19 natural amino acids and screened this library for strept

46 y the types of binary potentials observed in natural amino acids and show that there is a strong bias

47 f the method allowed the synthesis of all 20 natural amino acids and their NCL reactions.

48 theoretical tryptic peptides composed of 20 natural amino acids and with masses limited to 3.5 kDa.

49 t one, or at most, two, point mutations with natural amino acids are all that is required to impart v

50 Electronic nanostructures made from natural amino acids are attractive because of their rela

51 However, most materials derived from natural amino acids are electronically insulating.

52 Peptides constructed with the 20 natural amino acids are generally considered to have lit

53 Hindered, non-natural amino acids are of interest because they import

54 7%) have been achieved by using primary free natural amino acids as catalysts and Et(2)AlCN as nucleo

55 es in a 1 cm(2) area on a microchip using 20 natural amino acids as well as synthetic amino acid anal

56 pounds are the boronic acid analogues of the natural amino acids aspartic acid and glutamic acid with

57 as substitutions more closely related to the natural amino acid at appropriate positions.

58 osition 460 to His, which corresponds to the natural amino acid at the homologous position in STAT6,

59 ipeptides 33a,b and 35a,b, each containing a natural amino acid at the N-terminus, avoids the low cou

60 ssay quantifies insertion energetics for all natural amino acids at 27 positions across the membrane,

61 analogues have tryptophan or fused-ring non-natural amino acids at position 4 and alanine or an unbr

62 The fused-ring non-natural amino acids at position 4 contribute to the form

63 Systematic analysis of all 20 natural amino acids at position E262 shows that the natu

64 cells, we substituted histidine residues for natural amino acids at the cytoplasmic ends of the TM he

65 ilar to those observed for substitution with natural amino acids at the same site but had little effe

66 ethodology, the undesirable incorporation of natural amino acids at the suppression site.

67 was used to evaluate the full complement of natural amino acids at these positions, and resulted in

68 minimizing such perturbations is to use non-natural amino acid-based FRET pairs.

69 hieve this involves the utilization of a non-natural amino acid by the cell's native translational ap

70 have also shown that thioamide analogues of natural amino acids can be incorporated into full-sized

71 Thioamide analogues of the natural amino acids can be placed in a variety of locati

72 tural amino acids in conjunction with the 20 natural amino acids can be used as building blocks to co

73 ompared to random sequences with uniform and natural amino acid compositions, as observed by a lower

74 A non-natural amino acid containing an aminooxy side chain was

75 ys22 in ShK with the positively charged, non-natural amino acid diaminopropionic acid (ShK-Dap22) and

76 uch as glutathione and cysteine and other 19 natural amino acids do not interfere with such CSH-induc

77 Here we show that taurine, a natural amino acid, drastically boosts the cellular upta

78 Asn-Xaa-Thr/Ser sequon, where Xaa can be any natural amino acid except proline, for N-linked glycosyl

79 P3, and P4 positions) were varied across all natural amino acids (except cysteine and methionine).

80 We have previously improved a natural amino-acid form of a scorpion toxin-derived CD4-

81 codons for the biosynthetic insertion of non-natural amino acids has been developed.

82 unique groups into proteins by means of non-natural amino acids has numerous applications in protein

83 Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular phys

84 of pseudopeptidic macrocycles containing non-natural amino acids have been synthesized.

85 structure of peptides or proteins containing natural amino acids; however, a deficiency in the abilit

86 ino acid redox cofactor with the full set of natural amino acids in protein design.

87 ifts and confirm that the sampling of the 20 natural amino acids in this peptide series is be far fro

88 with a desired unnatural amino acid, but no natural amino acids, in eukaryotic cells.

89 by combining amber suppression-mediated non-natural amino acid incorporation and tubulin overexpress

90 aturation of macrocyclic peptides taking non-natural amino acids into consideration.

91 Incorporation of non-natural amino acids into proteins in vivo expands the sc

92 -tRNA pairs that selectively incorporate non-natural amino acids into proteins; our method uses paral

93 an be engineered to introduce synthetic "non-natural" amino acids into nonribosomal peptides.

94 ing the fact that the average mass defect of natural amino acids is larger than that of oxidized Met.

95 However, high-fidelity incorporation of non-natural amino acids is precluded in this system by misch

96 e hismox is a chiral ligand derived from the natural amino acid l-histidine, are replaced by CH3NH3(+

97 nels with thio-alkyl chains derived from the natural amino acid l-methionine (1) has been rationally

98 ter carbonyl stretching vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and

99 he LH receptor, conversion of Ser-277 to all natural amino acids led to varying degrees of receptor a

100 -CoA (MCPF-CoA), a metabolite derived from a natural amino acid, (methylenecyclopropyl)glycine, again

101 We used site-directed non-natural amino acid mutagenesis to engineer rhodopsin wit

102 wn crystal structure, and 24 natural and non-natural amino acid mutant variants of these peptides.

103 show here the genetic incorporation of a non-natural amino acid (NNAA) followed by chemoselective alb

104 ethod for site-specific incorporation of non-natural amino acids (nnAAs) into proteins in which the o

105 r codon suppression for the insertion of non-natural amino acids (nnAAs) is limited by competition wi

106 perior selectivity for Cys over the other 19 natural amino acids (nonthiol-containing).

107 distributions of peptides composed of the 20 natural amino acids, oxidized Met, and phosphorylated Se

108 ategy that incorporates a photoreactive, non-natural amino acid, p-benzoyl-l-phenylalanine, into vari

109 de proteins with functional variation due to natural amino acid polymorphism.

110 ects of the drug-resistant mutations and the natural amino acid polymorphisms on the Gibbs energy are

111 complete diastereoselectivity achieved with natural amino acid precursors is completely lost with th

112 the reaction rate and the yield of these non-natural amino acid precursors while preserving the remar

113 ng, conformationally disordered chain of the natural amino acids Pro, Ala, and Ser (PASylation)-a bio

114 Recent advances in natural amino acid production have motivated the use of

115 The non-natural amino acids (R)- and (S)-2-amino-3-fluoro-2-meth

116 The spin label is assembled in situ from natural amino acid residues and a metal salt, requires n

117 f protein complexes, often direct mimicry of natural amino acid residues does not lead to potent inhi

118 We replaced natural amino acid residues in Ste2p with Bpa by enginee

119 incorporated into the hydrophobic core using natural amino acids, restricting water access to the lan

120 library, which collectively contained all 20 natural amino acids, revealed that aryl di-O-acetyl comp

121 tem, we describe the utilization of the 21st natural amino acid selenocysteine for the generation of

122 ort, with post-import excision restoring the natural amino acid sequence.

123 igomers that manifest the folding encoded in natural amino acid sequences is a significant challenge.

124 s are presently limited by the repertoire of natural amino acid side chain and carbohydrate functiona

125 The transfer free energies of the twenty natural amino acid side chains from water to phospholipi

126 e., a "hydrophobicity scale") for the twenty natural amino acid side chains measured in the context o

127 A natural amino acid substitution in the human immunodefic

128 contain polar N-terminal extensions and non-natural amino acid substitutions at positions 4 and 9.

129 The catalytic effect of natural and non-natural amino acid substitutions at the P1 position in a

130 rate and product specificities by fixing the natural amino acid substitutions with high frequency.

131 mes is generated by breeding combinations of natural amino-acid substitutions from the cyclic into th

132 amino acid (unAA) substrate from unfavorable natural amino acid substrates.

133 tuents, which mimic the side chains found in natural amino acid systems.

134 s with near-normal sensitivity, although the natural amino acids tested other than Pro produce recept

135 where we identify sites to incorporate a non-natural amino acid that can be chemically modified to mo

136 lained as a result of glycine being the only natural amino acid that can play this role.

137 ate or aspartate substitutions, there are no natural amino acids that can mimic phospho-tyrosine.

138 tegy for designing short peptides containing natural amino acids that function as artificial TADs.

139 This paper reports the use of natural amino acids, the tripeptide beta-strand mimic Ha

140 ay be generally expanded to target different natural amino acids, thus providing diversity and flexib

141 orporation into membrane proteins of the non-natural amino acid TOAC (2,2,6,6-tetramethyl-piperidine-

142 The behavior of 20 natural amino acids under the basic permethylation condi

143 netic code for specification of multiple non-natural amino acids, unique codons for these novel amino

144 All living organisms encode the 20 natural amino acid units of polypeptides using a univers

145 eses of highly enantiomerically enriched non-natural amino acids using a simple chiral amido-thiourea

146 ma-aryl-alpha-amino acids were prepared from natural amino acids using this method.

147 , a macrocyclic peptide 22 involving two non-natural amino acids was evolved showing increased target

148 Only natural amino acids were used as probes, and thus possib

149 m provides a method for incorporation of non-natural amino acids which avoids the use of stop codons.

150 ng aminoacyl tRNAs that are charged with non-natural amino acids, which could be incorporated into pr

151 d calculating the binding energies of the 20 natural amino acids, which shows that tyrosine binds the

152 tructurally very similar to the peptide with natural amino acids, with an rmsd difference of only 1.3

153 rate multiple unnatural amino acids (but not natural amino acids), would eliminate the need to genera