ライフサイエンスコーパス: natural antibody

1 in body cavities and an important source of natural antibody.

2 f complement is dependent in a large part on natural antibody.

3 rs that interact with the Fc portion of this natural antibody.

4 d that phagocyte function can be restored by natural antibody.

5 y nonspecific immunoglobulin, which may be a natural antibody.

6 immune system influencing the production of natural antibodies.

7 e, the major xenoantigen recognized by human natural antibodies.

8 pitope, is the target of a large fraction of natural antibodies.

9 in NOD-scid-beta2 m-, including xenoreactive natural antibodies.

10 sic pathway activation and bound IgG and IgM natural antibodies.

11 onsequently human sera contain anti-alphaGal natural antibodies.

12 izing an ELISA assay for rat anti-guinea pig natural antibodies.

13 oited the postischemia recognition system of natural antibodies.

14 eveloped for adenovirus quantification using natural antibodies.

15 id peroxidation and a major target of innate natural antibodies.

16 printed particles are comparable to those of natural antibodies.

17 t drive the development of B cells producing natural antibodies.

18 DS2, which behaves in a manner comparable to natural antibodies.

19 ,3-galactose (alpha-gal) are highly abundant natural antibodies (Ab) in humans.

20 Human sera contain high levels of natural antibody (Ab) to Galalpha1-3Gal, a terminal glyc

21 Here we show that natural antibodies, acting in concert with complement, a

22 B-1b cells produce IgM natural antibodies against alpha1-3Galbeta1-4GlcNAc (alp

23 e the characterization of xenoreactive human natural antibodies against antigens without the alphaGal

24 ate with peptide microarrays the presence of natural antibodies against known toxic Abeta and amyloid

25 apoA-I mimetic peptides increased titers of natural antibodies against oxidation-specific epitopes.

26 Whereas natural antibodies against these glycans can act as barr

27 ine organ xenograft, due to the existence of natural antibodies against this epitope in human serum.

28 Furthermore, haptens that inhibit natural antibodies also inhibit GS-1-B(4) from binding t

29 t this process is mediated by IgM anti-mouse natural antibodies and activation of the classical pathw

30 B1 B cells secrete most of the circulating natural antibodies and are considered key effector cells

31 of the failure to fully deplete xenoreactive natural antibodies and block complement, or because of p

32 y with beta-glucans was limited by levels of natural antibodies and by tumor escape through eliminati

33 ediated lysis after the binding of preformed natural antibodies and cellular immunity involving both

34 s that were protected from neutralization by natural antibodies and complement although they were una

35 eceptors, including scavenger receptors, IgM natural antibodies and complement factor H, which bind,

36 Xenoreactive natural antibodies and complement were depleted by plasm

37 elds vector particles from neutralization by natural antibodies and complement.

38 ll compartmentalization in the production of natural antibodies and for body cavity immunity.

39 for which B-1 cells, an important source of natural antibodies and host immune responses, have speci

40 ells contribute significantly to circulating natural antibodies and mucosal immunity as well as to im

41 ular degeneration, including the presence of natural antibodies and neoepitopes.

42 , as well as by innate proteins, such as IgM natural antibodies and soluble proteins, such as C-react

43 S107-mu transcripts, with a loss of certain natural antibodies and specific tolerance to phosphorylc

44 enza are discussed here, namely polyreactive natural antibodies and the role and function of germinal

45 ented by strategies directed at xenoreactive natural antibodies and/or complement activation.

46 lts demonstrate a contrasting requirement of natural antibody and complement for opsonophagocytosis o

47 ecent studies indicate an important role for natural antibody and the classical pathway of complement

48 le PRRs, such as CD36, toll-like receptor-4, natural antibodies, and C-reactive protein recognize com

49 t (CD19(-/-)) mice lacked B-1a cells, lacked natural antibodies, and were more susceptible to infecti

50 Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective.

51 Natural antibodies are autoreactive/polyreactive antibod

52 Natural antibodies are frequently elicited to recognize

53 Natural antibodies are those immunoglobulin molecules fo

54 We propose that complement and natural antibody are interdependent: clonal selection an

55 Natural antibodies as coatings were compared with biomim

56 These include a reduction in a natural antibody, B-1 responses to phosphocholine, and s

57 This suggests that once the natural antibody barrier is eliminated by the induction

58 ntained stabilizing interactions observed in natural antibodies between the framework and loops of co

59 Natural antibodies bind fungal organisms and enhance hos

60 Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density

61 orescent protein (GFP), we have mimicked the natural antibody binding footprint to create robust bind

62 rease in the mean channel shift (MCS) of IgM natural antibody binding from pooled human sera, and a 2

63 The MCS for human IgG natural antibody binding to the surface of pig cells dec

64 We hypothesized that IgM natural antibody binds to neoepitopes exposed in the glo

65 Natural antibodies capable of cleaving nucleic acid, pro

66 Although preformed natural antibodies cause hyperacute rejection of primari

67 encoded for amino acids commonly observed in natural antibody CDRs.

68 Natural antibodies contribute to tissue homeostasis and

69 We propose that this function of natural antibodies could be exploited when developing ne

70 Furthermore, we observed that although the natural antibodies cross-reacted with all three variant

71 with complement inhibitors and xenoreactive natural antibody depletion leads to delayed xenograft re

72 idnanomolar affinities and were as stable as natural antibodies, despite having >30 mutations from ma

73 ce showed that B cell production of IL-17 or natural antibodies did not provide any defense against c

74 Natural antibodies directed against cell surface carbohy

75 any effect on the level of alphaGal-reactive natural antibodies, equal numbers (n=12) of A, B, AB, an

76 ion of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by St

77 eactivity of multiple different CLL rAbs and natural antibodies from CMV-seronegative adults with pUL

78 Finally, natural antibodies from human serum also reacted with ME

79 at the high abundance of Tyr, Ser and Gly in natural antibody germ line sequences reflects the intrin

80 architectures, and specific modification of natural antibodies has proven quite challenging.

81 The target of this natural antibody, however, was unknown.

82 rf5(-/-) mice have decreased serum levels of natural antibodies; however, the antigen-specific IgG1 p

83 d its receptors mediating the interaction of natural antibodies (IgM) with pathogens to effect protec

84 ions of complement inhibitors, adsorption of natural antibodies, immunosuppressive therapy, and splen

85 at least in part, to the very low titers of natural antibodies in newborn recipients.

86 demonstrated very low levels of xenoreactive natural antibodies in newborns, suggesting the possibili

87 ell populations producing anti-Gal and other natural antibodies in primates are unknown.

88 ollectively underlie the rapid production of natural antibodies in response to in vivo LPS stimulatio

89 uccessful is rejection mediated by preformed natural antibodies in the host, directed toward a single

90 ce binding to H. influenzae, suggesting that natural antibody, induced through prior exposure to the

91 In this study, we investigated whether natural antibodies influenced the number and/or phenotyp

92 The diversity of natural antibodies is limited by the genetic mechanisms

93 The major source of natural antibody is CD5+ B-1 cells which differ from con

94 presence of anti-Gal(alpha)1-3Gal (alphaGal) natural antibodies leads to the hyperacute rejection of

95 The eventual return of Gal natural antibodies led to the destruction of graft epith

96 restingly, lck-null mice exhibited increased natural antibody levels characteristic of B-1 cells.

97 3-5 d of FtL priming and fade within 1 wk to natural antibody levels that persist indefinitely in the

98 d constitutive immunity testing lysozyme and natural antibody levels, and blood bactericidal and phag

99 Pb exposure in spring reduced natural antibody levels, whereas in autumn, it reduced l

100 production of serum IgM and IgG anti-FtL at natural antibody levels; and (iii) elicits FtL-specific

101 gether, these results show that ingestion of natural antibodies limits the spirochete burden within f

102 re antibody sequence was returned, mimicking natural antibody maturation in silico.

103 f an allograft or xenograft, suggesting that natural antibodies may not be entirely T-cell independen

104 Natural antibodies may therefore have an impact on patho

105 Natural antibody-mediated cytotoxicity to pig endothelia

106 The kinetics of anti-Gal natural antibodies (NAb) and total immunoglobulin levels

107 racute and delayed vascular rejection due to natural antibodies (NAb) present major obstacles in pig-

108 the B-cell subsets that produce xenoreactive natural antibodies (NAb).

109 nized by more than 80% of human anti-porcine natural antibodies (NAb).

110 ous studies have implicated xenoreactive IgM natural antibody (nAb) as the predominant immunoglobulin

111 ding a disproportionate induction of the IgM natural antibody (NAb) E06/T15 to oxidized phospholipids

112 Natural antibodies (NAbs) against a terminal alpha1-3 ga

113 However, natural antibodies (NAbs) against Galalpha1,3Gal (Gal) p

114 n and physiological production of protective natural antibodies (NAbs) have been associated with expo

115 Glycan-reactive natural antibodies (NAbs) have been reported to play pro

116 to the presence of anti-Galalpha1-3Gal (Gal) natural antibodies (NAbs) in their sera.

117 will establish the fundamental importance of natural antibodies not only in defense, but in regulatio

118 ed throughout evolution, we propose that the natural antibodies of sharks, the most anciently emerged

119 but may be due to low-affinity, polyreactive natural antibodies of the IgG subclass.

120 nal and cardiac xenografts is initiated when natural antibodies of the recipient bind to donor endoth

121 is initiated by the binding of xenoreactive natural antibodies of the recipient to blood vessels in

122 Interestingly, natural antibody of the adaptive immune system provides

123 ere utilized for creating positive images of natural antibodies on polymer layers.

124 rneal xenograft rejection is mediated not by natural antibodies or CD8+ T cells directly, but by CD4+

125 Strategies that reduce IgM natural antibody or that prevent complement activation m

126 d rabbits and by their immunoreactivity with natural antibodies present in ApoE null mice.

127 xenotransplantation is the reaction between natural antibodies present in humans and Old World monke

128 Natural antibodies, present in the tear film before immu

129 a large proportion of CLL clones emerge from natural antibody-producing cells expressing immunoglobul

130 B-1a cells are primarily thought of as natural antibody-producing cells.

131 d regulatory pathways that enable continuous natural antibody production by B-1 cells, the main cellu

132 xposure per se is not sufficient to increase natural antibody production.

133 to initiate the complement cascade following natural antibody recognition of neoepitopes, which is th

134 raft rejection mediated by complement-fixing natural antibodies recognizing alpha(1,3)-galactosyl epi

135 ive baboon sera, which has preformed antipig natural antibodies, reduced SMPDL-3b expression, disrupt

136 tive antibodies are a major component of the natural antibody repertoire and bind to a variety of str

137 g the effects of childhood infections on the natural antibody repertoire and the mechanisms of antibo

138 and phospholipids permanently reprograms the natural antibody repertoire directed toward these antige

139 mbranes, represent a large proportion of the natural antibody repertoire in mice.

140 that the broad antibacterial activity of the natural antibody repertoire is largely due to polyreacti

141 sequence-wise featureless epitopes and how a natural antibody repertoire with limited variants can re

142 eactive antibodies, a major component of the natural antibody repertoire, bind with low affinity to a

143 ion model in which recipients contain a full natural antibody repertoire, both constructs blocked gra

144 The similarities between mouse and human natural antibody repertoires suggest that reduced microb

145 ositional amino acid frequencies observed in natural antibody repertoires.

146 The absence of a natural antibody response will allow investigation of th

147 cine xenoantigens whose recognition by human natural antibodies results in hyperacute rejection would

148 Thus, the pool of natural antibody-secreting B-1 cells is heterogeneous an

149 these findings show that memory B cells and natural antibody-secreting cells are BLyS-independent an

150 ed by anti-BLyS treatment, yet the number of natural antibody-secreting cells remained constant.

151 roach could be used to prevent production of natural antibodies specific for alphaGal, the ability to

152 nse that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized

153 n in vitro, which is similar to findings for natural antibodies that are subjected to somatic hypermu

154 Natural antibodies that bind the carbohydrate antigen Ga

155 Since human natural antibodies that bind to porcine cells are polyre

156 formed antibodies that may be related to the natural antibodies that formulate a first line of defens

157 s, as they minimize inherent complexities of natural antibodies that have hindered the establishment

158 B-1 B cells produce circulating natural antibodies that provide "innate-like" protection

159 sing CD19 (hCD19Tg) generated B-1a cells and natural antibodies that provided protection during infec

160 Natural antibodies that react with galactose-alpha(1,3)g

161 s is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaG

162 1 cells are known to contribute most of the "natural antibodies" that are secreted in the steady stat

163 ion of one of these monoclonal, polyreactive natural antibodies, the IgM clone 9H4, revealed its abil

164 Natural antibody titers against M2FA are elevated in ath

165 reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the l

166 d detection were conducted using plastic and natural antibodies to compare three different strategies

167 resulted in reduced binding of xenoreactive natural antibodies to endothelial cells of transgenic mi

168 sured in 114 MM patients and 31 HDs, because natural antibodies to MUC1 have been detected in patient

169 ibody responses to TNP-Ficoll, production of natural antibodies to phosphocholine, and survival after

170 Human natural antibodies to pig endothelial cell antigens appe

171 Non-opsonic natural antibodies to PNAG found in NHS interfered with

172 h immunization-induced animal antibodies and natural antibodies to PNAG in NHS interfere with the pro

173 cells into the circulation after removal of natural antibodies to the antigen.

174 cies is a result of the binding of preformed natural antibodies to the endothelium of the donor organ

175 Since normal nonalloimmunized males have natural antibodies to the heavy chains (HCs) of HLA anti

176 Levels of natural antibodies to the pneumococcal polysaccharide co

177 ted by the binding of preformed xenoreactive natural antibodies to the vascular endothelium of the gr

178 Here we evaluated whether natural antibody to PNAG in normal human serum (NHS) had

179 Natural antibody to PNAG is common in humans and animals

180 nd in serum samples of healthy subjects with natural antibody to PNAG, to which immunization-induced

181 women is associated with decreased levels of natural antibody to selected pneumococcal capsular serot

182 This phenomenon depends on the binding of natural antibody to the vascular endothelium, fixation o

183 n Africa exist concerning the development of natural antibody to these antigens, however.

184 t mice, which, like humans, produce anti-Gal natural antibodies, to investigate the ability of mixed

185 Estimates of the mean time to loss of natural antibodies varied by model, ranging from 49 to 1

186 Studies in the 1980s first showed that some natural antibodies were "catalytic" and able to hydrolyz

187 alphaGal-specific natural antibodies were detectable by enzyme-linked immu

188 ntrast, only low titers of alphaGal-specific natural antibodies were detectable only in the serum of

189 Monkey anti-pig natural antibodies were immunoadsorbed by extracorporeal

190 inity and selectivity comparable to those of natural antibodies, were prepared by combining a functio

191 ochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sca

192 ucidate a novel homeostatic pathway by which natural antibodies, which are products of the adaptive i

193 ently limitless range of foreign proteins by natural antibodies, which has been exploited to develop

194 Again, this is consistent with studies of natural antibodies, which have shown that nonspecific, s

195 Natural antibody, which represents a collection of germl

196 y diverse strains was limited by preexisting natural antibody with a lesser contribution of complemen

197 area of cell-based xenotransplant therapies, natural antibodies (XNA) and complement have also been c

198 human, is rejection mediated by xenoreactive natural antibodies (XNA) that bind the carbohydrate epit

199 y protein-G chromatography, and xenoreactive natural antibodies (XNA) were depleted by passing the Ig

200 In additional groups, xenoreactive natural antibodies (XNA) were depleted by pig lung perfu

201 Human xenoreactive natural antibodies (XNA), both IgM and IgG subtypes, whi

202 Human xenoreactive natural antibodies (XNA), of IgM and IgG subtypes, capab

203 ute rejection (HAR) mediated by xenoreactive natural antibodies (XNA), which are thought to develop i

204 nized on porcine cells by human xenoreactive natural antibodies (XNA).

205 nt inhibitors without eliminating xenogeneic natural antibody (XNA) reactivity may provide insufficie

206 Xenoreactive natural antibodies (XNAs) and complement mediate hyperac