ライフサイエンスコーパス: natural history

1 fractional flow reserve (FFR) in predicting natural history.

2 tered to 4123 men from a cohort study of HPV natural history.

3 and EPN_PFB that have a distinct biology and natural history.

4 eart disease, is associated with unfavorable natural history.

5 ressive autoimmune liver disease with a long natural history.

6 ll as contribute to the understanding of its natural history.

7 l registry of patients with HFpEF to map its natural history.

8 we still know comparatively little about its natural history.

9 or, there are large gaps in knowledge of its natural history.

10 is (AD) is a prevalent disease with variable natural history.

11 specimens relevant to cultural heritage and natural history.

12 n turn requires accurate knowledge of vector natural histories.

13 ations but, paradoxically, can have variable natural histories.

14 ic, collected through the American Museum of Natural History (AMNH)'s Explore21 expedition to the Sol

15 bserved here provide novel insights into the natural history and biology of tau-mediated neurodegener

16 ber for yellow fever in Angola using disease natural history and case report data.

17 physiological exercise and to examine their natural history and clinical course to create a more rob

18 oratory, models of protein function based on natural history and Darwinian evolution.

19 evolved over the last 15 years, altering the natural history and disease course for many, including i

20 We compiled and analyzed a database of natural history and ecological traits of 138 coastal mar

21 een different containment strategies and the natural history and epidemiological dynamics of the path

22 screening tools depends strongly on pathogen natural history and epidemiological features, as well as

23 pends on several factors, including pathogen natural history and epidemiology, human behavior, and ch

24 ents such as patient behaviour, tuberculosis natural history and health systems.

25 Its natural history and management is not clearly defined.

26 The natural history and management of traumatic ICA pseudoan

27 NPHV natural history and molecular virology remain largely un

28 However, the natural history and need for surgery in patients with LG

29 We analyzed the natural history and ophthalmologic characteristics of 4

30 For the first time, the natural history and pathogenesis of these diseases was a

31 e some of these disorders, and outline their natural history and possible differences between managem

32 spontaneously within 5 years in adults, the natural history and predictors of resolution in children

33 ferentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015.

34 to formulate a working hypothesis about the natural history and role of lactobacilli.

35 d or non-ASCVD-related causes based on ASCVD natural history and statin treatment parameters.

36 eport presents a comprehensive review of the natural history and the diagnostic evaluation of asympto

37 The natural history and the evolution dynamics of these zoon

38 H) is a heterogeneous condition with varying natural history and therapeutic response.

39 rovide a basis for further understanding the natural history and transmission dynamics of oral HPV in

40 chastic compartmental model representing the natural history and transmission of cefixime-sensitive a

41 tle was known about this yeast's ecology and natural history, and how this information was vitally im

42 emiology, genetics, pathogenesis, pathology, natural history, and long-term outcomes.

43 We sought to determine the prevalence, natural history, and potential clinical implications of

44 summarizes the importance, characteristics, natural history, and potential prevention and treatments

45 review what is known about the epidemiology, natural history, and public health effects of ZIKV infec

46 olecular basis of SMA, disease pathogenesis, natural history, and recognition of the impact of standa

47 g to DNA barcoding, ecological distribution, natural history, and subtleties of adult color pattern a

48 man actions, understanding host and parasite natural history, and the mechanisms behind the changing

49 studies to better understand M. genitalium's natural history, and then examined the effects of implem

50 The biology, natural history, and therapeutic options for GEP-NETs ar

51 nitoring their progression in describing the natural history, and ultimately as outcome measures to e

52 Its etiology, histopathogenesis and natural history are still not well established.

53 erstanding of key aspects of M. genitalium's natural history before it will be possible to determine

54 Combining predictions based on natural history, behavior of key benthic species and env

55 review, we highlight the complexities of the natural history, biology, and clinical management of thr

56 ethods, we are uncovering a new facet of our natural history by accounting for the vast diversity of

57 illustrate how an appreciation of E. coli's natural history can expand its value as a model organism

58 ier survival curve diverged from a published natural history case series (p=0.0014).

59 vided insights into Ebola's pathogenesis and natural history, clinical expression, treatment, prevent

60 Stratified medicine and natural history cohort approaches may transform the feas

61 d provide similar power in comparison to the natural history cohort.

62 Analysis of natural history cohorts showed elevated MMP-9 levels in

63 Two natural history cohorts were studied including 168 longi

64 Finally, we stress the importance of natural history collections as sources of high-quality p

65 Thus, digitisation of natural history collections is providing unprecedented i

66 nce data of >1,300 bird specimens drawn from natural history collections, we track relative ambient c

67 for the uncritical use of specimen data from natural history collections.

68 rogeneous with regard to triggers, severity, natural history, comorbidities, and response to treatmen

69 we provide an overview of host and parasite natural history contexts where IPMs could strengthen inf

70 ogy and treatment, true understanding of its natural history continues to elude us.

71 Natural history data are inherently limited, and a rando

72 ries and observational studies that reported natural history data on UIAs 7 mm and smaller.

73 uroNEXT to provide "real-world," prospective natural history data sets to accelerate public and priva

74 Longitudinal natural history data were used for comparative analysis

75 These SOD1-specific ALS natural history data will be important for the design an

76 The large natural history dataset from this study is a valuable re

77 This effort must involve natural history, ecology, and evolutionary biology in ad

78 s, we analyzed their ecological, genetic and natural history features.

79 s among risk factors produce highly variable natural histories from normal cognition through the prod

80 recovery rates after CRAO compared with the natural history group (31 of 419 [7.4%; 95% CI, 3.7%-11.

81 his review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pur

82 gnosing the disease at earlier stages in its natural history (i.e., early, presymptomatic diagnosis),

83 ic elevation in GFR is observed early in the natural history in 10%-67% and 6%-73% of patients with t

84 n eyes with Intermediate Uveitis (IU), their natural history in mild cases not necessitating treatmen

85 5% CI 1.94 to 2.77), the Neuroprotection and Natural History in Parkinson Plus Syndromes Parkinson Pl

86 s for seven case-study diseases with diverse natural histories, including Ebola, influenza A, and sev

87 The natural history indicates that increased intracranial pr

88 being developed, precise knowledge of their natural history is needed.

89 lium has been advocated, but M. genitalium's natural history is poorly-understood, making screening's

90 The natural history, management, and outcome of takotsubo (s

91 We estimated mortality using natural history models for acute hepatitis infections an

92 ferns and three angiosperms) using digitized natural history museum specimens.

93 nts with P-CID aged 1 to 16 years to compare natural histories of severity-matched patients with/with

94 We sought to compare natural histories of severity-matched patients with/with

95 this study was to prospectively evaluate the natural history of a population with LAR, the potential

96 ecular 'fossil' record, we reconstructed the natural history of a specific retrovirus lineage (ERV-Fc

97 ticle showcases our current knowledge of the natural history of A. thaliana from the perspective of t

98 r ecology and evolution has also brought the natural history of A. thaliana into the limelight.

99 INTRODUCTION: The characteristics and natural history of acute non-vitamin K antagonists oral

100 trating that the APOE*E2 allele modifies the natural history of AD typified by the age of onset in E2

101 urpose of which was to better understand the natural history of AIDS and its determinants.

102 gitudinal population-based studies about the natural history of allergic sensitization are rare.

103 To establish an updated natural history of ALS(SOD1).

104 These results provide new insights into the natural history of Alzheimer disease and evidence for a

105 of resistance elements and reflective of the natural history of antibiotics and resistance.

106 The natural history of aortic diseases in patients with TGFB

107 no pharmacological treatment can modify the natural history of aortic valve stenosis (AS).

108 tics and a variety of studies support a long natural history of associated resistance.

109 nhaled corticosteroid (ICS) could change the natural history of asthma if started in the young child

110 prenatal and postnatal factors altering the natural history of asthma, assessment of asthma control,

111 ht provide unique insight into the cause and natural history of asthma.

112 knowledge about the factors that impact the natural history of asthma.

113 The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regime

114 Natural history of AT differed among the most common for

115 supporting a multifaceted hypothesis of the natural history of atherosclerotic plaque rupture.

116 describes this temporal relationship in the natural history of atopic diseases.

117 e purpose of this study was to determine the natural history of ATTRwt and the predictors of survival

118 These data establish the natural history of ATTRwt, provide statistical basis for

119 d studied their individual influences on the natural history of autoimmune cholangitis in this model.

120 systemic lupus erythematosus (SLE), but the natural history of autoreactive GCs remains unclear.

121 ic inflexibility to dedifferentiation in the natural history of beta-cell failure.

122 ailable clinical information to document the natural history of BHFS.

123 led insights into the clinical phenotype and natural history of BICD2 disease.

124 an that threshold, little is known about the natural history of borderline PH.

125 The reported incidence and natural history of both acute and new AWI during follow-

126 ing to confusion in our understanding of the natural history of breast cancer and radiation effects.

127 r, evolution of the cancer genome during the natural history of breast cancer is largely unknown, as

128 By deepening our understanding of the natural history of C. elegans, we establish a broader co

129 rogression is the most relevant stage in the natural history of cancers.

130 primary and secondary stroke prevention, the natural history of central nervous system (CNS) complica

131 brated mathematical model that simulates the natural history of cervical cancer, we estimated the cum

132 inal study of a vaccine cohort to define the natural history of changes in the fecal metagenome in SI

133 These unusual patterns varied over the natural history of CHB, prompting the authors to propose

134 isms by which helper T cells function in the natural history of cholangitis is essential and illustra

135 Since the first description of the natural history of chronic lymphocytic leukemia (CLL) by

136 Little is known about the natural history of chronic obstructive pulmonary disease

137 s, suggesting that safety events reflect the natural history of cirrhosis and are not related to trea

138 hort study, we sought to study in detail the natural history of CKD in primary care to better inform

139 to describe the clinical characteristics and natural history of convergence insufficiency (CI) in a p

140 Advances in the understanding of the natural history of COPD and the development of strategie

141 was designed to uncover the determinants and natural history of coronary heart disease.

142 (FFR) is a more important determinant of the natural history of coronary stenoses than anatomy (DS).

143 Gut microbiota may play a role in the natural history of cow's milk allergy.

144 Understanding the natural history of cryptosporidiosis and the correlates

145 To assess the comorbidities, natural history of CU, and its subtypes in children and

146 We sought to determine the long-term natural history of disease and outcomes in patients in T

147 Essential features of the natural history of disease are poorly understood.

148 These findings are important to the natural history of disease evolution and the spread of d

149 Spatiotemporal natural history of disease was defined and therapeutic d

150 pulations are critical for understanding the natural history of disease.

151 tudy provides a novel insight on the current natural history of DMD, which will be instrumental for t

152 We prospectively studied the natural history of E. histolytica colonization and diarr

153 the 3 most common blood-borne pathogens, the natural history of early HCV infection, and the scientif

154 damentally redefines what is known about the natural history of Ebola virus infection.

155 The natural history of EMF includes an active phase with rec

156 An accurate view of the natural history of EoE is central to discussions with pa

157 activity are needed to fully understand the natural history of EoE.

158 calp-negative seizures and their role in the natural history of epilepsy, their effect on cognitive f

159 ow-up will allow better understanding of the natural history of ERMs and VMT and their relationships

160 Understanding the natural history of familial amyotrophic lateral sclerosi

161 tients with familial SI-NETs enrolled in the Natural History of Familial Carcinoid Tumor study at the

162 After decades of stagnation, the natural history of FL appears to have been favorably imp

163 There is an urgent need to better define the natural history of FPIES and the pathophysiology of non-

164 ive international registry investigating the natural history of Friedreich's ataxia.

165 ill consider these advances, focusing on the natural history of GAS, the evolution of pandemic strain

166 ddress this discrepancy, we investigated the natural history of HBV infection in Greenland by estimat

167 obal HBV epidemic, incorporating data on the natural history of HBV, prevalence, mortality, vaccine c

168 s of HemECs have, in part, recapitulated the natural history of hemangioma regression.

169 We aimed to characterize the natural history of hepatitis C virus (HCV) reinfection a

170 risk factors, the high AF occurrence in the natural history of HFpEF, and the independent contributi

171 h rates of anal disease, we investigated the natural history of high-risk anal human papillomavirus (

172 The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Ther

173 Findings: Based on the natural history of HSV infection, its epidemiology, and

174 The natural history of hypertrophic cardiomyopathy (HCM) is

175 ese findings add to our understanding of the natural history of IAVs and will inform public health de

176 of the information that is reflected in the natural history of ICP changes is no longer apparent bec

177 r SHS exposure affects the manifestation and natural history of imminent pediatric muco-obstructive a

178 us type 2 (HSV-2) in sub-Saharan Africa, the natural history of infection among Africans is not well

179 tical models provide a framework to link the natural history of infection and patient behavior to epi

180 ical outcomes, and better information on the natural history of infection will likely be required bef

181 Little is known about the natural history of infection with this organism and its

182 he conjunctival challenge route to mimic the natural history of infection.

183 Psychological comorbidity could affect the natural history of inflammatory bowel disease.

184 cell therapy has the potential to modify the natural history of intractable critical limb ischemia.

185 new therapies and improved knowledge of the natural history of IPF.

186 This national evaluation of the natural history of isolated splenic injuries from index

187 To describe the natural history of isolated splenic injuries in the Unit

188 ows for staging on the basis of the proposed natural history of JOCD to better guide clinical managem

189 sition microsimulation models to reflect the natural history of keratoconus progression and the impac

190 To illustrate the natural history of Leber's hereditary optic neuropathy (

191 The natural history of LHON is not a subacute process, as pr

192 The knowledge about the natural history of local allergic rhinitis (LAR) is limi

193 Their effect on the natural history of lower-risk disease needs to be furthe

194 The natural history of MCRPE is in relation to the role of M

195 findings provide insight into the long-term natural history of medically managed UA/NSTEMI patients

196 Here we delineate the natural history of metastasis in an autochthonous model

197 Compared with the natural history of mucopolysaccharidosis type III syndro

198 l biogenesis may play a critical role in the natural history of nonsevere asthma (Mitasthme study).

199 would capitalize on the peculiarities of the natural history of OMOs and could feasibly be completed

200 To establish the natural history of ophthalmic characteristics in Progeri

201 United States, yet the risk factors for and natural history of oral HPV infection are largely unknow

202 A better understanding of the natural history of patients sent to SNFs after hospitali

203 ically and retrospectively been based on the natural history of patients with medically managed aorti

204 The natural history of patients with newly diagnosed high-ri

205 ternational Study of Efficacy trial, and the natural history of PBC was informed by published clinica

206 The natural history of PDGFRA- and PDGFRB-rearranged neoplas

207 We sought to describe the natural history of peanut allergy between 1 and 4 years

208 We now report the natural history of pneumonic tularemia in female Fischer

209 nding of the epidemiology, pathogenesis, and natural history of primary biliary cirrhosis, discuss ma

210 understanding of the factors that affect the natural history of progression in Alzheimer disease for

211 , perhaps improving our understanding of the natural history of progressive MS, although its ultimate

212 To describe the characteristics and natural history of quiescent choroidal neovascularizatio

213 Few data are available on the natural history of small fiber neuropathy (SNF).

214 ng patients without obvious symptoms and the natural history of subclinical celiac disease.

215 ) coupled to BSA (2OA-BSA) and evaluated the natural history of subsequent disease, compared to contr

216 worldwide and much of what we know about the natural history of substance use comes from cohort studi

217 ever, it is not known at which stages in the natural history of T1D development this haplotype afford

218 We used the model to infer differences in natural history of TB and in future projections of TB.

219 hic factors and potential differences in the natural history of TB.

220 gh-dose cohort with scores in studies of the natural history of the disease (historical cohorts).

221 e approach allows further elucidation of the natural history of the disease and may better guide clin

222 fit, and comprehensive information about the natural history of the disease are essential for regulat

223 m large observational studies addressing the natural history of the disease has contributed to change

224 investigated the impact of iNKT cells in the natural history of the disease in the Emu-Tcl1 (Tcl1) CL

225 ct on response rates and modification of the natural history of the disease, progress will rely on en

226 ZOOR contributes to the understanding of the natural history of the disease.

227 ews (AJ) and appear to have an effect on the natural history of the disease.

228 in patient four, compared with -37.7 in the natural history of the disease.

229 iven accurate information about the expected natural history of the disorder.

230 ctors for transmission, and characterise the natural history of the infection in the region.

231 ing and quarantine depends critically on the natural history of the infectious disease, its inherent

232 Little is known about the natural history of the more recently discovered polyomav

233 eter as part of the multicenter, prospective Natural History of the Progression of Atrophy Secondary

234 linical recognition and understanding of the natural history of these conditions.

235 The natural history of these early invasive lesions is unkno

236 lapse, but data regarding the prevalence and natural history of these mutations are limited.

237 n improving but limited understanding of the natural history of these neoplasms.

238 s of swine IAVs are key to understanding the natural history of these viruses in swine and to selecti

239 y (DMD), it is fundamental to understand the natural history of this disorder to properly design clin

240 ogic event with profound implications on the natural history of this otherwise indolent disease.

241 This study sought to assess whether the natural history of thoracic aortopathy after AVR in pati

242 The natural history of TTR-CM is poorly characterized, which

243 of insulitis in human islets throughout the natural history of type 1 diabetes are limited.

244 The multivariable and progressive natural history of type 2 diabetes limits the effectiven

245 tastatic spread are very early events in the natural history of urothelial carcinoma; (iii) chemother

246 has become apparent that, as a result of the natural history of venous thrombosis, there are special

247 To describe the anatomic changes and natural history of vitelliform lesions in Best vitellifo

248 To examine the natural history of vitreomacular traction syndrome (VMTS

249 ble insight into asthma risk factors and the natural history of wheezing and asthma through childhood

250 nificant gaps remain in our knowledge of the natural history of ZIKV infection, its effects on neurod

251 analyze the adjustable gastric banding (AGB) natural history on a national basis.

252 is important uncertainty in M. genitalium's natural history parameters, leading to uncertainty in th

253 will facilitate more detailed studies on the natural history, pathogenesis, and immunity of this nove

254 ecades, much remains to be learned about the natural history, pathophysiology, and biologic mechanism

255 lung fibrosis, many gaps in knowledge about natural history, pathophysiology, and treatment remain.

256 pidemiology and cause to clinical diagnosis, natural history, patient stratification and clinical man

257 s more than that observed in our prior acute natural history patients (0.17 logMAR; P < 0.001).

258 reater than that observed in our prior acute natural history patients of 0.21 logMAR (P = 0.053).

259 ah, with potential relevance to the species' natural history, physiological adaptations and unique re

260 case series have helped elucidate the early natural history, presenting characteristics (clinical an

261 dge of the basic pathobiology of PAH and its natural history, prognostic indicators, and therapeutic

262 the use of DTI-based metrics as read-out in natural history, prognostic stratification and multisite

263 5 years from symptom onset, enrolled in the Natural History Project of the Dystonia Coalition, were

264 Study participants, enrolled in a cGVHD Natural History Protocol (NCT00331968, n = 212), underwe

265 atients with chronic GvHD seen under the NIH natural history protocol between 2004 and 2013.

266 Natural history protocols of the PIDTC analyze outcomes

267 each of which was associated with a distinct natural history; SAMD9 and SAMD9L patients often experie

268 m specimens stored at the National Museum of Natural History, Smithsonian Institution, which had been

269 studies of plant hybridization to the Brunn Natural History Society.

270 This paper describes the pattern of pain, natural history, somatosensory profile, psychosocial sta

271 without HIV infection participating in HSV-2 natural history studies (University of Washington Virolo

272 mendations on the use of these modalities in natural history studies and interventional clinical tria

273 Detailed natural history studies of LMNA-associated arrhythmic an

274 dations are based on the literature, ongoing natural history studies, and extensive clinical experien

275 cant vision loss through the availability of natural history studies, the understanding that preventi

276 s and planning of future cross-sectional and natural history studies.

277 substantially lower when compared to earlier natural history studies.

278 were obtained for conservative treatment and natural history studies.

279 rative International Research Group Duchenne Natural History Study (CINRG-DNHS).

280 tional Neuromuscular Research Group Duchenne Natural History Study (CINRG-DNHS).

281 l centres, which is critical for the planned natural history study and future clinical trials.

282 infrastructure highlighted by an NIH-funded natural history study and well-established clinics with

283 of patients with Lyme disease enrolled in a natural history study at the National Institutes of Heal

284 This was a prospective natural history study conducted under the Ugandan RHD re

285 A longitudinal, multicenter, prospective natural history study enrolled 26 SMA infants and 27 con

286 cal syndrome were recruited through the Rett Natural History study from 2006 to 2015.

287 ate of disease progression in a longitudinal natural history study of children with Charcot-Marie-Too

288 report of the baseline findings of a 5-year natural history study of DED, a striking disease burden

289 aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using obj

290 This large GA natural history study provides a strong foundation for f

291 ional Neuromuscular Research Group, Duchenne Natural History Study), 51 patients with DMD and 17 age-

292 ned immunodeficiency (SCID) to a prospective natural history study.

293 summarizes the findings of the Rett syndrome Natural History study.

294 vides an improved description of chlamydia's natural history to inform public health decision making.

295 lative of O. volvulus and shares several key natural history traits with the human pathogen.

296 ous forms of G1D, associated manifestations, natural history, treatment efficacy, and diagnostic proc

297 h or permanent ventilation was compared with natural history using the log-rank test.

298 ith unilateral lesions, differences in their natural history warrant a greater index of suspicion for

299 ilization, as Pliny the Elder remarks in his Natural History, when he describes the various types of

300 vidence is available about its prognosis and natural history, which are crucial to inform clinical pr