ライフサイエンスコーパス: natural killer

1 A novel cell surface epitope, human natural killer 1 (HNK-1), was the target of the antibodi

2 ransferase 2 (B3GAT2), a member of the human natural killer 1 carbohydrate pathway.

3 ognize the carbohydrate epitope HNK-1 (human natural killer-1).

4 ant role in antiviral immunity by regulating natural killer and CD8(+) T cells, epigenetic downregula

5 IR (CD3/CD4/CD8 T, natural killer, and B cells) was measured biweekly until

6 Macrophage (CD68), T (CD3), and Natural Killer (ANK61) cell infiltration as well as intr

7 eeks post-infection correlated with stronger natural killer, CD4+ T and CD8+ T cell responses.

8 ther activating or inhibitory effects during natural killer cell (NK cell) activation.

9 activation, IFNgamma response, CD16-mediated natural killer cell activation, and monocyte/macrophage

10 munological defense, including inhibition of natural killer cell activity with ongoing lowering of Ig

11 nosuppression was an opportunity to discover natural killer cell alloreactions that eradicated acute

12 set involving phagosome formation as well as natural killer cell and IL-3 signaling.

13 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be unc

14 elongation (RTEL1) mutation causing isolated natural killer cell deficiency and mutations in ras-asso

15 Specific natural killer cell depletion 24 hours pre-acute myocard

16 Natural killer cell development and maturation were arre

17 16) report new mechanisms of human and mouse natural killer cell education by inhibitory and activati

18 FU treatment induced TSLP, HLA class II, and natural killer cell group 2D (NKG2D) ligand expression i

19 ting adenosine signaling is found to promote natural killer cell maturation and antitumor immunity an

20 pe with absent T cells and normal B-cell and natural killer cell numbers.

21 Natural killer cell receptors and other genes related to

22 peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis

23 pulmonary pathology, stronger and persistent natural killer cell responses, and the extended inductio

24 nduces the death of CD56(bright) NK cells, a natural killer cell subset whose expansion is correlated

25 altered composition of gammadelta T-cell and natural killer cell subsets.

26 precursor) and lineage (B cell, T cell, and natural killer cell).

27 increased expression of IFNgamma-inducible, natural killer cell, and T cell transcripts, but less ex

28 and T lymphocyte attenuator (BTLA); and the natural killer cell-activating receptor CD160.

29 ile, it still revealed diversity in a set of natural killer cell-associated receptors.

30 infiltrating Kupffer cells, mature activated natural killer cells (CD69+), and PD-1+ effector memory

31 A tissue-resident population of natural killer cells (NK cells) in the liver has recentl

32 Natural killer cells (NK) are highly enriched in the hum

33 ) T-cell ratio and increased CD16(+)CD56(hi) natural killer cells (NK), CD4(+) effector memory T cell

34 ident memory CD8(+) T cells (TRMs), resident natural killer cells (NKRs), and tumor-associated macrop

35 th the frequencies of intrathecal CD56bright natural killer cells (r = 0.28; P = .007).

36 expression profiles of a receptor protein in natural killer cells among donors infected with human cy

37 Type I and II IFNs, as well as natural killer cells and CD8(+) T cells, were indispensi

38 ILCs consist of conventional natural killer cells and helper-like cells (ILC1, ILC2 a

39 unodeficiency characterized by lack of T and natural killer cells and infant death from infection.

40 producers of IL-22 post-PH are conventional natural killer cells and innate lymphoid cells type 1.

41 r cells, and binding to Fcgamma receptors on natural killer cells and macrophages.

42 by complement deposition and accumulation of natural killer cells and monocytes/macrophages in capill

43 of several immune cell populations, such as natural killer cells and virus-specific T cells.

44 Natural killer cells are able to directly lyse tumor cel

45 Natural killer cells constitute potent innate lymphoid c

46 Natural killer cells controlled early infection but were

47 Natural killer cells from acute myeloid leukaemia patien

48 Immunologically, natural killer cells had an immature phenotype and impai

49 MSCs significantly decreased natural killer cells in the heart and spleen and neutrop

50 Although the role of T cells and natural killer cells in tumor immunology has been establ

51 the utility of this microfluidic assay with natural killer cells interacting with tumor cells, and o

52 PMVDS stimulated both cytotoxic T cells and natural killer cells of cell-mediated immunity to provid

53 Natural killer cells showed reduced T-bet expression at

54 cytokine-producing dendritic cells (DCs) and natural killer cells than Cd36(-/-) mice.

55 2B8T2M activates natural killer cells to enhance antibody-dependent cellu

56 rated that anti-CD27 stimulated CD8(+) T and natural killer cells to release myeloid chemo-attractant

57 major histocompatibility complex class I and natural killer cells were commonly downregulated in psor

58 pinal fluid (including B cells, T cells, and natural killer cells) (cohort 1).

59 g FcgammaRIIIa (expressed on macrophages and natural killer cells) and FcgammaRIIIb (expressed on neu

60 innate immune cells (antitumor macrophages, natural killer cells) associated with clearance of senes

61 Teffs, natural killer cells, and eosinophils also responded, wi

62 challenge, including monocytes, neutrophils, natural killer cells, and eosinophils.

63 genes with correlated expression in T cells, natural killer cells, and erythroblasts.

64 ype CD4 T cells, reduced T-bet expression by natural killer cells, and expansion of blood monocytes w

65 ures tracking CD8 and CD4 T-cell activation, natural killer cells, and IFN activation associated sign

66 ted, altered in tropism, more susceptible to natural killer cells, and less pathogenic.

67 e examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediat

68 s of immune cells including the conventional natural killer cells, lymphoid tissue inducers, type 1,

69 recruiting cytotoxic effector cells, such as natural killer cells, monocytes, and polymorphonuclear c

70 her organs, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-as

71 atory hepatic macrophage infiltration, while natural killer cells, natural killer T cells, neutrophil

72 roinflammatory cytokine responses by DCs and natural killer cells, Th1 development, phagocytic recept

73 al immune cells, such as T helper type 1 and natural killer cells, to unleash neurotoxicity and infla

74 21R expression on CD8(+) T cells, but not on natural killer cells, was required for optimal anti-ErbB

75 inflammatory signaling initiated by CD160 in natural killer cells.

76 capes of lymphomas that arise from B, T, and natural killer cells.

77 t alone was not able to stimulate T cells or natural killer cells.

78 he presence of T cells, dendritic cells, and natural killer cells.

79 umor-reactive cytotoxic T lymphocytes and/or natural killer cells.

80 sistance to the shear stress and attack from natural killer cells.

81 P) that is produced by cytotoxic T cells and natural killer cells.

82 not dividing, fibroblasts to cytotoxicity by natural killer cells.

83 ll-free virus, and develop susceptibility to natural killer cells.

84 jor forms of lymphomas arising from B, T, or natural killer cells.

85 kely resulted from expansion of a transduced natural killer clone in response to chronic Epstein-Barr

86 SR-1 increased conventional natural killer (cNK) cell differentiation, whereas TCDD

87 Natural killer gene complex-encoded immunomodulatory C-t

88 The natural killer group 2D (NKG2D) receptor is a potent imm

89 hanced binding to the NK-activating receptor natural killer group 2D (NKG2D).

90 ent of B and T cells (CD4(+), gammadelta and natural killer) into the brain of wild-type mice.

91 us mutations within the three genes impaired natural killer lymphocyte cytotoxicity in vivo.

92 ata as the basis for the prognostic index of natural killer lymphoma (PINK), in which patients are st

93 ell as the adaptive immune system, including natural killer (NK) and CD8(+) T cells.

94 on chronic hepatitis B virus (HBV)-infected natural killer (NK) and CD8(+) T cells.

95 nd functionally distinct from adipose mature natural killer (NK) and immature NK cells.

96 lymphocytosis marked by massive expansion of natural killer (NK) and T cell compartments.

97 activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its liga

98 as a major determinant of antibody-mediated natural killer (NK) cell activation in HT biopsies; howe

99 e requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral

100 Natural killer (NK) cell activation triggers sequential

101 filtrating T regulatory cells, and decreased natural killer (NK) cell activation.

102 Only the KW cocktail modulated natural killer (NK) cell activity and neutrophil and mon

103 Combining natural killer (NK) cell adoptive transfer with hypometh

104 Donor natural killer (NK) cell alloreactivity in HCT can contr

105 Natural killer (NK) cell alloreactivity is favored after

106 ) to prevent relapse depends partly on donor natural killer (NK) cell alloreactivity.

107 Natural killer (NK) cell and macrophage homeostasis were

108 g on Syk, leading to cellular activation and natural killer (NK) cell degranulation.

109 While distinct stages of natural killer (NK) cell development have been defined,

110 allergen-induced pulmonary inflammation and natural killer (NK) cell effector function.

111 We now identify novel natural killer (NK) cell evasion functions for four memb

112 (MHC) Ib molecule Qa-1 impairs CD8 Treg and natural killer (NK) cell function and promotes a lupus-l

113 We studied the contribution of natural killer (NK) cell functional features in HIV pati

114 ssociated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor (K

115 a HER2-dependent manner, reduced binding by natural killer (NK) cell inhibitory sialic acid-binding

116 on classifications amongst mature T-cell and natural killer (NK) cell neoplasms.

117 (CMV-Tc), CD4+ (CMV-Th) T cell activity, and natural killer (NK) cell number were measured by flow cy

118 iched for interleukin-6 (IL-6)-signaling and natural killer (NK) cell pathways.

119 Mouse liver contains two natural killer (NK) cell populations, one of which recir

120 H6, a stress-induced cellular ligand for the natural killer (NK) cell receptor NKp30.

121 Natural killer (NK) cell receptors (NKRs) play a crucial

122 ) and their capacity to regulate antiporcine natural killer (NK) cell responses.

123 For both vaccine regimens, natural killer (NK) cell signatures negatively correlate

124 The human natural killer (NK) cell surface is naturally coated wit

125 eness of anti-PD-L1/PD-1 agents in enhancing natural killer (NK) cell's function remains largely unkn

126 Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 level

127 h anti-GD2 monoclonal antibody (mAb) directs natural killer (NK) cell-mediated antibody-dependent cel

128 oid tissue-derived Rorc(fm+) ILCs acquire an natural killer (NK) cell/ILC1-like phenotype.

129 Natural killer (NK) cells and cytolytic T lymphocytes (C

130 o enhanced the recruitment and activation of natural killer (NK) cells and cytotoxic CD8(+) T cells t

131 ve and functional defects of innate effector natural killer (NK) cells and cytotoxic T-lymphocyte res

132 ptor NKp44, encoded by NCR2 and expressed on natural killer (NK) cells and innate lymphoid cells, rec

133 In this study, we evaluated the impact of natural killer (NK) cells and myeloid (mDCs) and plasmac

134 pression profile that overlaps with those of natural killer (NK) cells and other ILCs.

135 sufficient development and function of human natural killer (NK) cells and T cell subsets limit the a

136 tive T cells, but whether and how it affects natural killer (NK) cells and their alloreactivity is la

137 Natural killer (NK) cells are critical innate effector c

138 Natural Killer (NK) cells are essential for control of v

139 Human natural killer (NK) cells are generated from CD34(+) pre

140 Natural killer (NK) cells are important in host defense

141 Natural killer (NK) cells are innate immune cells, and t

142 Natural killer (NK) cells are innate lymphocytes that re

143 Natural killer (NK) cells are innate lymphoid cells whic

144 Natural killer (NK) cells are key mediators in the contr

145 Natural killer (NK) cells are located at the periphery o

146 Natural killer (NK) cells are swiftly mobilized to organ

147 Maturation of human natural killer (NK) cells as defined by accumulation of

148 To test the hypothesis that natural killer (NK) cells can decrease the risk of leuke

149 Natural killer (NK) cells can have potent antileukemic a

150 Natural killer (NK) cells can induce liver fibrosis remi

151 Natural Killer (NK) cells confer protection from tumors

152 Natural killer (NK) cells display cytotoxic activity aga

153 Human cytomegalovirus (CMV)-induced adaptive natural killer (NK) cells display distinct phenotypic an

154 bjected to middle cerebral artery occlusion, natural killer (NK) cells display remarkably distinct te

155 Further, we demonstrate that LRBA-null Natural Killer (NK) cells exhibit impaired signaling by

156 RASGRP1-deficient natural killer (NK) cells exhibited impaired cytotoxicit

157 Natural killer (NK) cells express MHC class I (MHC-I)-sp

158 Adult natural killer (NK) cells express only IL2Rbeta and IL2R

159 ing subsequent recruitment of hypercytotoxic natural killer (NK) cells expressing the CXCL16 receptor

160 Here, we demonstrate that natural killer (NK) cells from mice lacking the type I I

161 BACKGROUND & AIMS: Low activity of natural killer (NK) cells has been associated with incre

162 Classically, natural killer (NK) cells have been defined by nonspecif

163 For many years, human peripheral blood natural killer (NK) cells have been divided into functio

164 Natural killer (NK) cells have long been considered shor

165 cells and produce proinflammatory cytokines, natural killer (NK) cells have long been of clinical int

166 eral studies have evaluated the functions of natural killer (NK) cells in experimental animal models

167 The physiological functions of natural killer (NK) cells in human immunity and reproduc

168 s study, we examined a hypothesized role for natural killer (NK) cells in impacting disease progressi

169 trast to the extensive knowledge about human natural killer (NK) cells in peripheral blood, relativel

170 regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic d

171 ls and the percentage of active CD8(+) T and natural killer (NK) cells in the tumor microenvironment,

172 Furthermore, the frequency of natural killer (NK) cells increased, the proportion of N

173 established, its role on the infiltration of natural killer (NK) cells into tumors remains unknown.

174 sh type 1 innate lymphoid cells (ILC1s) from natural killer (NK) cells is a gene signature indicative

175 Natural killer (NK) cells localize in the microcirculati

176 Natural killer (NK) cells mediate important innate immun

177 Multi-cellular cluster formation of natural killer (NK) cells occurs during in vivo priming

178 To kill target cells, natural killer (NK) cells organize signaling from activa

179 Natural killer (NK) cells play a key role in immunity, b

180 Natural killer (NK) cells play a key role in innate immu

181 Natural killer (NK) cells play a major role in anti-vira

182 stems control the spread of virus, for which natural killer (NK) cells play a pivotal role.

183 Natural killer (NK) cells play an essential role in anti

184 Natural killer (NK) cells play an important role in surv

185 a higher percentage of effector T cells and natural killer (NK) cells present in the lung.

186 Natural killer (NK) cells provide protection against inf

187 Natural killer (NK) cells recognize and kill cancer cell

188 Natural killer (NK) cells represent the prototypical mem

189 ler cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating recepto

190 tly to antibody-mediated protection in vivo, natural killer (NK) cells were dispensable for protectiv

191 idled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages resulting in

192 86 expression on peripheral blood monocytes, natural killer (NK) cells, and NK T cells was measured,

193 to generate all known ILC subsets, including natural killer (NK) cells, but not other leukocyte popul

194 c ligand of the activating NKG2D receptor on natural killer (NK) cells, gammadelta-T cells, and NKT c

195 pattern recognition receptors in myeloid and natural killer (NK) cells, has been shown to play both a

196 t patients and retain potential for EOMES(+) natural killer (NK) cells, interferon gamma-positive (IF

197 , however they also inhibit the functions of natural killer (NK) cells, key effectors of the Graft ve

198 several pro-allergic immune cells including natural killer (NK) cells, NKT cells, and memory CD8(+)

199 on of CD7 is largely confined to T cells and natural killer (NK) cells, reducing the risk of off-targ

200 ation, migration, and cytokine production in natural killer (NK) cells, suggesting that surface compo

201 of normal lymphocytes, including subsets of natural killer (NK) cells, T cells, and B cells.

202 analyses to define a STAT5 gene signature in natural killer (NK) cells, the prototypical ILC subset,

203 immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastati

204 ADCC is mediated largely by natural killer (NK) cells, which control their activatio

205 ls, but less is known about their effects on natural killer (NK) cells, which help control metastasis

206 suggested a central role for neutrophils and Natural Killer (NK) cells, with underexpression of T- an

207 nalling only on NKG2D-bearing cells, such as natural killer (NK) cells, without broadly activating IL

208 epends on interferon-(IFN)-gamma produced by natural killer (NK) cells.

209 latory receptor expressed on activated T and natural killer (NK) cells.

210 ry inflammation by monocytes/macrophages and natural killer (NK) cells.

211 ntial for the development and maintenance of natural killer (NK) cells.

212 e response involving both CD8(+) T cells and natural killer (NK) cells.

213 but leaves the cells vulnerable to lysis by natural killer (NK) cells.

214 of STAT1 GOF mutations on the functioning of natural killer (NK) cells.

215 ibitory receptor expressed on the surface of natural killer (NK) cells.

216 function of cytotoxic lymphocytes, including natural killer (NK) cells.

217 ilder expansion of CD56(dim) NKG2A(+) KIR(-) natural killer (NK) cells.

218 Phi), Langerin(+) dendritic cells (LDC), and natural killer (NK) cells.

219 elease by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.

220 ytotoxic lymphocyte function, mainly that of natural killer (NK) cells.

221 on was tested in lentiviral-transduced NK-92 natural killer (NK) cells.

222 eficient AD mouse model that lacks T, B, and natural killer (NK) cells.

223 ing dendritic cells, monocytes, B cells, and natural killer (NK) cells.

224 s a checkpoint that limits the maturation of natural killer (NK) cells.

225 umor-infiltrating interferon gamma-producing natural killer (NK) cells.

226 activation of LILRB1-expressing B cells and natural killer (NK) cells.

227 in immune cells acting against the virus are Natural Killer (NK) cells.

228 e for key immune cells including T cells and natural killer (NK) cells.

229 out the expression/function of PD-1 on human natural killer (NK) cells.

230 e characterized plasmacytoid dendritic cell, natural killer (NK), and T-cell activation using flow cy

231 s showed that genes known to be expressed by natural killer (NK), lymphoid tissue inducer (LTi), and

232 Natural killer (NK)-cell cytotoxicity assays can quickly

233 infections associated with myeloid, B-, and natural killer (NK)-cell deficiency.

234 antly induced both autologous and allogeneic natural killer (NK)-cell degranulation and NK-cell-media

235 T) cures the T-lymphocyte, B-lymphocyte, and natural killer (NK)-cell differentiation defect in inter

236 hocytes (IELs) lacking classical B-, T-, and natural killer (NK)-cell lineage markers (Lin(-)IELs) in

237 uce T-cell commitment by repressing residual natural killer (NK)-cell potential.

238 activating receptors that are engaged during natural killer (NK)-target cell contact remains undefine

239 (two clusters), serpins, cathepsins, and the natural killer (NK)/C-type lectin (CLEC) complex [6-12].

240 pressed genes, particularly those related to natural killer (NK)/CD8+ T-cell cytotoxicity, separated

241 This response was independent of CTLs, natural killer or natural killer T cells.

242 CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency

243 Invariant Natural Killer T (iNKT) cells are a unique subset of T l

244 Invariant natural killer T (iNKT) cells are innate-like T cells th

245 Invariant natural killer T (iNKT) cells are innate-like T cells th

246 CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T lymphocy

247 (2017) reveal a critical role for invariant natural killer T (iNKT) cells in switching inflammation

248 Invariant Natural killer T (iNKT) cells rapidly produce copious am

249 Invariant natural killer T (iNKT) cells recognize endogenous and e

250 Invariant natural killer T (iNKT) cells recognize lipid antigens p

251 ors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of i

252 Whether innate-like invariant natural killer T (iNKT) cells, with remarkable immunomod

253 d antigens (alphaGalCer or OCH) to invariant natural killer T (iNKT) cells.

254 by unfractionated conventional T, invariant natural killer T (iNKT) or gammadelta T cells, and is ch

255 Natural killer T (NKT) -cells activated with the glycoli

256 improved muscle strength as well as reduced natural killer T (NKT) cell counts.

257 Crucial to Natural Killer T (NKT) cell function is the interaction

258 und a potential association between absolute natural killer T (NKT) cell numbers and the subsequent d

259 the anti-influenza efficacy of the invariant natural killer T (NKT) cell superagonist, alpha-galactos

260 Natural killer T (NKT) cells are innate lymphocytes that

261 Semi-invariant natural killer T (NKT) cells are innate-like lymphocytes

262 Our mouse model required host natural killer T (NKT) cells to induce tolerance.

263 ponses can be enhanced by engaging help from natural killer T (NKT) cells.

264 d with strongly reduced numbers of invariant natural killer T and regulatory T (Treg) cells and alter

265 associated with reduced numbers of invariant natural killer T and Treg cells that likely contribute t

266 g in reduced expression of genes critical to natural killer T cell (NKT) and gammadelta T-cell differ

267 ltiple innate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, mucosal-ass

268 group include the gamma-delta T cell and the Natural Killer T cell.

269 Invariant natural killer T cells (iNKT cells) are innate-like lymp

270 n that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell r

271 d development and proliferation of invariant natural killer T cells (iNKT cells).

272 way, we have previously found that invariant natural killer T cells (iNKTs) are involved in CM allerg

273 Invariant natural killer T cells (iNKTs), a small population chara

274 e T cell antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-prese

275 Natural killer T cells (NKT cells) have stimulatory or i

276 ggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).

277 Valpha24-invariant natural killer T cells (NKTs) localize to tumors and hav

278 sets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic

279 As natural killer T cells and liver injury are central in l

280 CD4 and natural killer T cells and neutrophils were markedly red

281 The frequency of natural killer T cells correlated with the level of anti

282 the current study is to explore the role of natural killer T cells in impaired liver regeneration.

283 It has been shown that the proportion of natural killer T cells is markedly elevated during liver

284 Natural killer T cells play an important role in liver r

285 innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T c

286 ge infiltration, while natural killer cells, natural killer T cells, neutrophils and dendritic cells

287 njected 4 days before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-

288 Natural killer T cells- deficient or mice injected with

289 to a specialized subset of T cells known as natural killer T cells.

290 e was independent of CTLs, natural killer or natural killer T cells.

291 (GVHD) are regulated via recipient invariant natural killer T-cell (iNKT) interleukin-4-driven expans

292 The clinical outcome of extranodal natural killer T-cell lymphoma (ENKTL) has improved subs

293 ed indirectly in the expansion of protective natural killer T-cell populations.

294 Invariant Natural Killer T-cells (iNKT-cells) are an attractive ta

295 Natural killer/T-cell lymphoma (NKTCL) is a rare, aggres

296 In the current study, using natural killer/T-cell lymphoma (NKTL) as a disease model

297 her incidence of AITL, extranodal nasal-type natural killer/T-cell lymphoma and NK-cell leukemia (ENK

298 ies, including acute lymphoblastic leukemia, natural killer/T-cell lymphoma, and acute myeloid leukem

299 s, as well as non-Hodgkin, Hodgkin and nasal natural killer/T-cell lymphomas, although all three TET

300 bitory receptor-mediated role for unlicensed natural killer (U-NK) cells in allogeneic graft facilita