ライフサイエンスコーパス: natural killer T-cell

1 group include the gamma-delta T cell and the Natural Killer T cell.

2 velopment of alphabeta T cells and invariant natural killer T cells.

3 n loss of conventional T cells and invariant natural killer T cells.

4 CD1d presents lipid antigens to natural killer T cells.

5 dual host T-cell subsets to favor regulatory natural killer T cells.

6 osis were conventional CD4+CD3+ T cells, not natural killer T cells.

7 II MHC-restricted CD4+ T cells but, rather, natural killer T cells.

8 ntified subgroup of T cells, CD1d-restricted natural killer T cells.

9 ds with high affinity to CD1d and stimulates natural killer T cells.

10 ncomitant to increased cytolytic activity of natural killer T cells.

11 velopment of B, alphabetaT, gammadeltaT, and natural killer T cells.

12 in knockout (beta2M-/-) mice lack CD8+ T and natural killer T cells.

13 nd natural killer cells but lack Valpha14(+) natural killer T cells.

14 to a specialized subset of T cells known as natural killer T cells.

15 e was independent of CTLs, natural killer or natural killer T cells.

16 with the innate immune system and invariant natural killer T cells.

17 s, which are the major endogenous ligands of natural killer T cells.

18 for mucosa-associated invariant T cells and natural killer T cells.

19 roduction of alphabeta T cells and invariant natural killer T cells.

20 sexual transmission of HIV and stimulator of natural killer T-cells.

21 s and presents IL-15 in trans to neighboring natural killer/T cells.

22 Naive CD8 T cells, natural killer T cells and a subset of memory CD4 T cell

23 cluding regulatory T cells, dendritic cells, natural killer T cells and B cells.

24 nnate T-CD4 T cells, together with invariant natural killer T cells and gammadelta T cells, receive s

25 l killer T cell apoptosis, depleting hepatic natural killer T cells and inducing proinflammatory cyto

26 g food allergy include the role of invariant natural killer T cells and influences of dietary compone

27 al other specialized T-cell lineages such as natural killer T cells and innate mucosal-associated inv

28 As natural killer T cells and liver injury are central in l

29 in numbers of microparticles from invariant natural killer T cells and macrophages/monocytes (CD14(+

30 In addition to natural killer T cells and mucosal-associated invariant

31 een mostly confined to TCRs from innate-like natural killer T cells and mucosal-associated invariant

32 CD4 and natural killer T cells and neutrophils were markedly red

33 synthesis (P < 0.01), together with reduced natural killer T cells and raised interleukin (IL)-12 an

34 required for development of CD4(+) T cells, natural killer T cells and regulatory T cells.

35 amma response of natural killer cells and of natural killer T cells and the Th1 polarization of antig

36 17 helper T-cell response, characterized by natural killer T-cell and neutrophilic inflammation.

37 ability to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity.

38 curring CD4+CD25+ Foxp3+ regulatory T cells, natural killer T cells, and approximately 25% of NK cell

39 rtant roles for conventional CD4(+) T cells, natural killer T cells, and CD4(+)CD25(+)FoxP3(+) Tregs

40 dependent on the presence of regulatory host natural killer T cells, and expression of CD1d on donor

41 s (natural killer cells, gammadelta T cells, natural killer T cells, and innate-like CD8+ T cells) ar

42 T-cell repertoire, near-to-absent invariant natural killer T cells, and severely diminished mucosal-

43 ltered residual host T cell subsets favoring natural killer T cells, and the low incidence of GVHD wa

44 lastic large cell; and 1 each had extranodal natural killer/T cell, angioimmunoblastic, and precursor

45 nsufficient norepinephrine increases hepatic natural killer T cell apoptosis, depleting hepatic natur

46 Natural Killer T cells are a distinct lymphocyte lineage

47 Gammadelta T lymphocytes and CD1d-restricted natural killer T cells are classified as innate T lympho

48 Invariant natural killer T cells are found in low numbers in the a

49 Natural killer T cells are immunoregulatory cells, which

50 Natural killer T cells are mediators of important regula

51 ouse models of allergic asthma indicate that natural killer T cells are required for the development

52 for the autoreactive recognition of CD1d by natural killer T cells, are indispensable for the bindin

53 tes, including both natural killer cells and natural killer T cells, are unusually abundant in the li

54 used CD1d-tetramers, antibodies specific for natural killer T cells, as well as reverse-transcriptase

55 volved in Th2 inflammation such as invariant natural killer T cells, basophils, and interleukin-9 are

56 protein (GFP), revealed CD4+ memory T cells, natural killer T cells, basophils, mast cells, and eosin

57 ghly expressed in activated human CD8(+) and natural killer T cells, both of which have been implicat

58 nal repressor NKAP is required for invariant natural killer T cell but not conventional T cell develo

59 cytotoxic lineage T cells and into invariant natural killer T cells but did not signal the differenti

60 We enumerated invariant natural killer T cells by flow cytometry with the use of

61 nuclear cells before and after activation of natural killer T cells by ligand alpha-galactosylceramid

62 Stimulation of CD1d-restricted semiinvariant natural killer T cells by using the CD1d ligand alpha-ga

63 gammadelta and natural killer T cells can also play a role in protectiv

64 t of naturally occurring regulatory T cells, natural killer T cells, CD4(+) and CD8(+) T lymphocytes,

65 -specific Th2 cells did not require B cells, natural killer T cells, CD8(+) T cells, or IFNgamma.

66 are also deficient in natural killer cells, natural killer T cells, CD8+ T lymphocytes, and TCRgamma

67 gulate cytokines expression of dendritic and natural killer T cells co-culture.

68 Microparticles from CD14(+) and invariant natural killer T cells correlated with levels of alanine

69 The frequency of natural killer T cells correlated with the level of anti

70 njected 4 days before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-

71 Natural killer T cells- deficient or mice injected with

72 Alcohol-fed natural killer T cell-deficient Jalpha281(-/-) mice expr

73 Hepatic natural killer T cell depletion leads to Th-1 polarizati

74 re NKAP conditional knockout mice, invariant natural killer T cell development is blocked at the doub

75 due to a role of the SAP-Fyn interaction in natural killer T cell development through the ability of

76 se 3 causes a similar block in the invariant natural killer T cell development, indicating that NKAP

77 mice have defects in natural killer cell and natural killer T cell development, suggesting a role for

78 ne-1-phosphate receptor S1pr1 as well as for natural killer T cell development.

79 3 functionally interact to control invariant natural killer T cell development.

80 ensing mature thymocytes for trafficking and natural killer T cell development.

81 Stimulation of natural killer T cells during alcohol consumption induce

82 Natural killer T cells express a conserved, semi-invaria

83 The natural killer T cells expressed an invariant T-cell rec

84 Natural killer T cells expressing 'invariant' T cell rec

85 Natural killer T cells expressing an invariant T-cell re

86 s, including regulatory T and CD1d-dependent natural killer T cells, fail to develop.

87 tically, PE DHC enhances EAE in mice lacking natural killer T cells, fails to enhance EAE in Toll-lik

88 This report analyzes the role of natural killer T cells, Fas, and TNF-alpha in a model of

89 -galactosyl ceramide (alpha-GalCer) to mouse natural killer T cells, formally demonstrating both the

90 We show here that natural killer T cells from UV-irradiated donor mice fun

91 hat development of colitis involves not only natural killer T-cell functions, but also requires IL-13

92 Invariant natural killer T cells have a distinct developmental pat

93 ve and qualitative defects in CD1-restricted natural killer T cells have been reported in several aut

94 as been 10 years since the first workshop on natural killer T cells helped to launch a growth phase f

95 Natural killer T cell hybridomas with identical T cell a

96 articular, little is known about the role of natural killer T cells in alcohol-induced liver injury.

97 cidates the role of vitamin D and CD8(+) and natural killer T cells in asthma exacerbation in a genom

98 ses are generated and the pathogenic role of natural killer T cells in asthma.

99 the current study is to explore the role of natural killer T cells in impaired liver regeneration.

100 association between the number of invariant natural killer T cells in the airway and disease severit

101 We studied the frequency of invariant natural killer T cells in the airways of subjects with m

102 studies in mice indicating a requirement for natural killer T cells in the development of allergen-in

103 Alcohol consumption induces an increase of natural killer T cells in the liver and a high sensitivi

104 to assess the frequency and distribution of natural killer T cells in the lungs and in the circulati

105 ernatively activated hepatic macrophages and natural killer T cells, in the absence of obesity or ins

106 In alcohol-consuming animals, liver natural killer T cells increase, and further activation

107 Using natural killer T cells (iNKT cell) as a model of a T cel

108 Invariant natural killer T cells (iNKT cells) are a small subset o

109 ylceramide (alphaGC) that activate invariant natural killer T cells (iNKT cells) are being developed

110 Invariant natural killer T cells (iNKT cells) are critical for hos

111 Invariant natural killer T cells (iNKT cells) are innate-like lymp

112 Invariant natural killer T cells (iNKT cells) are innate-like T ce

113 Invariant natural killer T cells (iNKT cells) are innate-like T ce

114 Invariant natural killer T cells (iNKT cells) are innate-like T ly

115 Invariant natural killer T cells (iNKT cells) are involved in the

116 Invariant natural killer T cells (iNKT cells) are lipid-sensing in

117 Glycolipid ligands for invariant natural killer T cells (iNKT cells) are loaded onto CD1d

118 rinsic block in the development of invariant natural killer T cells (iNKT cells) at their earliest pr

119 ortant mechanisms of activation of invariant natural killer T cells (iNKT cells) by microbes: direct

120 Invariant natural killer T cells (iNKT cells) can produce copious

121 Invariant natural killer T cells (iNKT cells) express a restricted

122 Invariant natural killer T cells (iNKT cells) have a prominent rol

123 Invariant natural killer T cells (iNKT cells) have an innate immun

124 Mouse invariant natural killer T cells (iNKT cells) provide cognate and

125 Invariant natural killer T cells (iNKT cells) rapidly produce effe

126 Invariant natural killer T cells (iNKT cells) respond to CD1d-pres

127 n that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell r

128 t also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophi

129 -GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found pri

130 d development and proliferation of invariant natural killer T cells (iNKT cells).

131 presenting glycolipid antigens to invariant natural killer T cells (iNKT cells).

132 riant T (iT) cell subsets, such as invariant natural killer T cells (iNKT) and mucosal-associated inv

133 V alpha14 invariant natural killer T cells (iNKT) are localized in periphera

134 but markedly decreased numbers of invariant natural killer T cells (iNKT) as defined by staining wit

135 Invariant natural killer T cells (iNKT) cells are T lymphocytes di

136 requirements for invariant Valpha14-bearing natural killer T cells (iNKT) in the thymus are poorly u

137 (GVHD) are regulated via recipient invariant natural killer T-cell (iNKT) interleukin-4-driven expans

138 Invariant Natural Killer T-cells (iNKT-cells) are an attractive ta

139 CD1d-restricted Valpha24-invariant natural killer T cells (iNKTs) are important in immunore

140 way, we have previously found that invariant natural killer T cells (iNKTs) are involved in CM allerg

141 CD1d-restricted Valpha24-Jalpha18-invariant natural killer T cells (iNKTs) are potentially important

142 Invariant natural killer T cells (iNKTs), a small population chara

143 sets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic

144 ltiple innate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, mucosal-ass

145 ecently identified CD1d-restricted invariant natural killer T cells is a matter of controversy.

146 It has been shown that the proportion of natural killer T cells is markedly elevated during liver

147 uing member of the innate immune system, the natural killer T cell, is activated during bacterial inf

148 sed on a subset of CD4+ T helper 1 cells and natural killer T cells, is involved in lymphocyte homing

149 sis including the Hut 78 T-cell leukemia, JY natural killer T-cell leukemia, Daudi B-cell lymphoma, H

150 ncy were enhanced by coadministration of the natural killer T-cell ligand 7DW8-5, which heightened th

151 ole for NKAP in selection into the invariant natural killer T cell lineage.

152 The clinical outcome of extranodal natural killer T-cell lymphoma (ENKTL) has improved subs

153 Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a

154 Extranodal natural killer-T-cell lymphoma (NKTCL) of nasal type is

155 large-cell lymphoma (n = 2), and extranodal natural killer/T-cell lymphoma (n = 2).

156 Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare and hete

157 Natural killer/T-cell lymphoma (NKTCL) is a rare, aggres

158 In the current study, using natural killer/T-cell lymphoma (NKTL) as a disease model

159 aberrantly overexpressed in the majority of natural killer/T-cell lymphoma (NKTL), an aggressive lym

160 her incidence of AITL, extranodal nasal-type natural killer/T-cell lymphoma and NK-cell leukemia (ENK

161 ies, including acute lymphoblastic leukemia, natural killer/T-cell lymphoma, and acute myeloid leukem

162 s, as well as non-Hodgkin, Hodgkin and nasal natural killer/T-cell lymphomas, although all three TET

163 t commonly caused by Wegener granulomatosis, natural killer/T-cell lymphomas, cocaine abuse, or infec

164 s have provided evidence that T lymphocytes, natural killer T cells, mast cells, and B cells also ent

165 IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and inn

166 romoting the activation of T lymphocytes and natural killer T cells, maturation of DCs, secretion of

167 colitis remains slow, but IL-13 produced by natural killer T cells may be involved.

168 -like and T helper type 2-like properties of natural killer T cells may originate largely from differ

169 Natural killer T cell-mediated apoptosis proceeds by the

170 ive immunity and compromised the function of natural killer T-cell-mediated innate immunity.

171 Hepatic natural killer T cells modulate liver injury by balancin

172 innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T c

173 o differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macro

174 Depletion of natural killer-T cells, natural killer cells, plasma cel

175 ge infiltration, while natural killer cells, natural killer T cells, neutrophils and dendritic cells

176 ation of a type of white blood cell known as natural killer T cell (NKT cell).

177 family receptors can affect innate immunity [natural killer T cell (NKT) and gamma-delta T-cell recep

178 g in reduced expression of genes critical to natural killer T cell (NKT) and gammadelta T-cell differ

179 b(+)Ly6C(hi)Ly6G(-) cells also enhance liver natural killer T cell (NKT) death in an Fas-dependent ma

180 This glycolipid activates innate Valpha14(+) natural killer T cell (NKT) lymphocytes, which drive DC

181 to an impaired thymic selection of Valpha14 natural killer T cells (NKT cells) and a subsequent redu

182 e T cell antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-prese

183 (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by eith

184 (+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against

185 Natural killer T cells (NKT cells) expressing a semi-inv

186 glycosphingolipids (GSLs) to activate type I natural killer T cells (NKT cells) has been known for 2

187 Natural killer T cells (NKT cells) have stimulatory or i

188 Loss of natural killer T cells (NKT cells) in CD1 knockout mice

189 rpose of this study is to identify invariant natural killer T cells (NKT cells) in cellular infiltrat

190 CD1d-restricted natural killer T cells (NKT cells) possess a wide range

191 Natural killer T cells (NKT cells) recognize glycolipid

192 Natural killer T cells (NKT cells) restricted by the ant

193 ggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).

194 ession and thereby the effector functions of natural killer T cells (NKT cells).

195 The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted m

196 relation with an IL-15-mediated increase of natural killer T-cells (NKT) and the up-regulation in li

197 f antigen-presenting cell CD1d with distinct natural killer T-cell ("NKT") populations can induce rap

198 However, after exclusion of natural killer T cells (NKTs) and gammadelta T cells by

199 Valpha24-invariant natural killer T cells (NKTs) localize to tumors and hav

200 IL-9 production from CD4(+) T cells, but not natural killer T cells or innate lymphoid cells, suggest

201 ediated by heat shock proteins, glycolipids, natural killer T cells, or dendritic cells in disease pa

202 vity, our results strongly suggest that CD4+ natural killer T cells play a prominent pathogenic role

203 airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human a

204 Natural killer T cells play an important role in liver r

205 ed indirectly in the expansion of protective natural killer T-cell populations.

206 ines, dendritic cells, and type 1 T cells or natural killer T cells potentially drives pathogenic inf

207 is paramount, which results in expansion of natural killer T cells producing IL-13 (and perhaps IL-5

208 suppressed expression of interferon gamma by natural killer T cells, promoting hepatocyte proliferati

209 ide and antibodies specific to the invariant natural killer T-cell receptor in samples of bronchoalve

210 evidence of gene expression of the invariant natural killer T-cell receptor.

211 xpression of messenger RNA for the invariant natural killer T-cell-receptor domains Valpha24 and Vbet

212 Mouse type I natural killer T cell receptors (iNKT TCRs) use a single

213 secreted following the ligation of invariant natural killer T cell receptors to sphingolipids (SLs).

214 How viruses evade natural killer T cell recognition remains unclear.

215 Tolerance required host natural killer T-cell recognition of CD1d on donor marro

216 Natural killer and natural killer T cells remove virus-infected hepatocytes

217 TIM-1-expressing, but not TIM-1-deficient, natural killer T cells responded to apoptotic airway epi

218 suppression of protective CD4(+) T cells and natural killer T-cell responses against ehrlichiae.

219 ng indicates a role for TCR beta in defining natural killer T cell specificity, despite the more rest

220 ers effector properties resembling invariant natural killer T cells, such as copious production of cy

221 igen-presenting cell-mediated stimulation of natural killer T cells, supporting the idea that this me

222 reducing the activity of natural killer and natural killer T cells that normally contribute to tumor

223 dual host T cell subsets to favor regulatory natural killer T cells that suppress GVHD and prevent or

224 wing host T-cell subsets to favor regulatory natural killer T cells that suppress GvHD by polarizing

225 pattern-recognition receptor, conferring on natural killer T cells the ability to sense and respond

226 The hepatic natural killer T cells themselves are regulated by Kupff

227 irecting the innate-like effector program of natural killer T-cell thymocytes, is prominently associa

228 analysis of the invariant T-cell receptor of natural killer T cells to assess the frequency and distr

229 naive, wild-type CD4(+) Th cells depleted of natural killer T cells to Lck(cre)IL-4Ralpha(-/lox) mice

230 V(alpha)14 invariant natural killer T cells (V(alpha)14iNKT cells) are thymus

231 hich liver gamma-delta T cells and invariant natural killer T cells were found to be involved in IL-1

232 oduced IFN-alpha, whereas natural killer and natural killer T cells were the main source of IFN-gamma

233 Natural killer T cells, which are stimulated by lipids p

234 ages (ie, Kupffer cells), natural killer and natural killer T cells, which constitute the innate immu

235 Glycolipid reactive natural killer T cells with an invariant TCR alpha-chain

236 Two populations of natural killer T cells with invariant TCR alpha-chains (

237 LC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known re

238 ses mediated by IFN-gamma and CD4(+) Th1 and natural killer T cells, with lower IL-10 secretion by T

239 lavage, and sputum induction were invariant natural killer T cells, with no significant differences